Application of triple-probe microdialysis for fast pharmacokinetic/ pharmacodynamic evaluation of dopamimetic activity of drug candidates in the rat brain

Journal of Neuroscience Methods

Volumn 140, Issue 1-2 SPEC. ISS., 2004, Pages 59-65

  Weikop, Pia ^a   Egestad, Börje ^a   Kehr, Jan ^b  

^a NEUROSEARCH A S   (Denmark)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cocaine; Dopamine; Drug abuse; HPLC; In vivo; Methylphenidate; Microdialysis; PK PD; Psychostimulants

Indexed keywords

COCAINE; DOPAMINE; METHYLPHENIDATE; PSYCHOSTIMULANT AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DOPAMINERGIC ACTIVITY; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG METABOLISM; DRUG MONITORING; MALE; MICRODIALYSIS; NEUROCHEMISTRY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; REINFORCEMENT;

ANIMALS; BLOOD; BLOOD-BRAIN BARRIER; BRAIN; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCAINE; DOPAMINE; DOPAMINE AGONISTS; DRUG ADMINISTRATION SCHEDULE; EXTRACELLULAR FLUID; MALE; METABOLIC CLEARANCE RATE; METHYLPHENIDATE; MICRODIALYSIS; MICROELECTRODES; NEUROCHEMISTRY; RATS; RATS, WISTAR; TIME FACTORS; UP-REGULATION;

EID: 10344265982     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2004.06.017     Document Type: Conference Paper

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