Simultaneous central nervous system distribution and pharmacokinetic- pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats

British Journal of Pharmacology

Volumn 142, Issue 2, 2004, Pages 323-330

  Chenel, Marylore ^a,b   Marchand, Sandrine ^a   Dupuis, Antoine ^a,b   Lamarche, Isabelle ^a   Paquereau, Joël ^c   Pariat, Claudine ^a   Couet, William ^a  

^a Laboratoire de Biochimie   (France)

^b POITIERS UNIVERSITY HOSPITAL   (France)

^c PBS   (France)

Author keywords

Electroencephalogram; Fluoroquinolones; Microdialysis; PK PD modelling; Rat; Seizures

Indexed keywords

NORFLOXACIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; BODY FLUID; BOLUS INJECTION; CENTRAL NERVOUS SYSTEM; COMPARATIVE STUDY; CONTROLLED STUDY; CONVULSION; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; DRUG TRANSPORT; ELECTROENCEPHALOGRAM; ELECTROENCEPHALOGRAPHY; EXTRACELLULAR FLUID; HEMOCONCENTRATION; HYSTERESIS; MALE; MICRODIALYSIS; MODEL; NONHUMAN; PARAMETER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RECORDING; TIME;

ANIMALS; CENTRAL NERVOUS SYSTEM; CONVULSANTS; ELECTROENCEPHALOGRAPHY; MALE; MODELS, NEUROLOGICAL; NORFLOXACIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 2942608904     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705748     Document Type: Article

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