New potent 5-nitrofuryl derivatives as inhibitors of Trypanosoma cruzi growth. 3D-QSAR (CoMFA) studies

European Journal of Medicinal Chemistry

Volumn 41, Issue 4, 2006, Pages 457-466

  Aguirre, Gabriela ^a   Boiani, Mariana ^a   Cabrera, Eliana ^a   Cerecetto, Hugo ^a   Di Maio, Rossanna ^a   González, Mercedes ^a   Denicola, Ana ^b   Sant'Anna, Carlos Mauricio R ^c   Barreiro, Eliezer J ^d  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

5 nitrofuryl derivatives; Anti T. cruzi compounds; CoMFA

Indexed keywords

4 (2 METHOXYETHYL) 1 [3 (5 NITROFURYL) 2 PROPEN 1 ILIDENE]SEMICARBAZIDE; 4 (2 NAPHTHYL) 1 [3 (5 NITROFURYL) 2 PROPEN 1 ILIDENE]SEMICARBAZIDE; 4 (BUTYL) 1 [3 (5 NITROFURYL) 2 PROPEN 1 ILIDENE]SEMICARBAZIDE; 4 (HEXYL) 1 [3 (5 NITROFURYL) 2 PROPEN 1 ILIDENE]SEMICARBAZIDE; ANTIPARASITIC AGENT; ANTIPROTOZOAL AGENT; BUTYL 4 [3 (5 NITROFURYL) 2 PROPEN 1 ILIDENE]CARBAZATE; CARBONYL DERIVATIVE; HEPTYL 4 [3 (5 NITROFURYL) 2 PROPEN 1 ILIDENE]CARBAZATE; HEXYL 4 [3 (5 NITROFURYL) 2 PROPEN 1 ILIDENE]CARBAZATE; METHYL 4 [3 (5 NITROFURYL) 2 PROPEN 1 ILIDENE]CARBAZATE; NIFURTIMOX; OCTYL 4 [3 (5 NITROFURYL) 2 PROPEN 1 ILIDENE]CARBAZATE; SEMICARBAZONE DERIVATIVE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CHAGAS DISEASE; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; EPIMASTIGOTE; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; OXIDATIVE STRESS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING; TRYPANOSOMA CRUZI;

ANIMALS; CHROMATOGRAPHY, THIN LAYER; DOSE-RESPONSE RELATIONSHIP, DRUG; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; NITROFURANS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROPHOTOMETRY, INFRARED; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 33646164422     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.11.008     Document Type: Article

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