메뉴 건너뛰기




Volumn 14, Issue 1, 2008, Pages 43-54

Minimal and extended hammerheads utilize a similar dynamic reaction mechanism for catalysis

Author keywords

Catalytic RNA; Conformational change; Ribozyme

Indexed keywords

HAMMERHEAD RIBOZYME; OLIGONUCLEOTIDE; RNA;

EID: 38049029204     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.717908     Document Type: Article
Times cited : (40)

References (61)
  • 1
    • 36048948209 scopus 로고    scopus 로고
    • NMR studes of the effect of GA-AG base pairs to the active conformation of the hammerhead ribozyme
    • Amano, M. 2006. NMR studes of the effect of GA-AG base pairs to the active conformation of the hammerhead ribozyme. Nucleic Acids Symp. Ser. 50: 43-44.
    • (2006) Nucleic Acids Symp. Ser , vol.50 , pp. 43-44
    • Amano, M.1
  • 2
    • 0031053277 scopus 로고    scopus 로고
    • A kinetic and thermodynamic analysis of cleavage site mutations in the hammerhead ribozyme
    • Baidya, N. and Uhlenbeck, O.C. 1997. A kinetic and thermodynamic analysis of cleavage site mutations in the hammerhead ribozyme. Biochemistry 36: 1108-1114.
    • (1997) Biochemistry , vol.36 , pp. 1108-1114
    • Baidya, N.1    Uhlenbeck, O.C.2
  • 3
    • 0030752599 scopus 로고    scopus 로고
    • Functional groups on the cleavage site pyrimidine nucleotide are required for stabilization of the hammerhead transition state
    • Baidya, N., Ammons, G.E., Matulic-Adamic, J., Karpeisky, A.M., Beigelman, L., and Uhlenbeck, O.C. 1997. Functional groups on the cleavage site pyrimidine nucleotide are required for stabilization of the hammerhead transition state. RNA 3: 1135-1142.
    • (1997) RNA , vol.3 , pp. 1135-1142
    • Baidya, N.1    Ammons, G.E.2    Matulic-Adamic, J.3    Karpeisky, A.M.4    Beigelman, L.5    Uhlenbeck, O.C.6
  • 4
    • 0037188361 scopus 로고    scopus 로고
    • Internal equilibrium of the hammerhead ribozyme is altered by the length of certain covalent crosslinks
    • Blount, K.F. and Uhlenbeck, O.C. 2002. Internal equilibrium of the hammerhead ribozyme is altered by the length of certain covalent crosslinks. Biochemistry 41: 6834-6841.
    • (2002) Biochemistry , vol.41 , pp. 6834-6841
    • Blount, K.F.1    Uhlenbeck, O.C.2
  • 5
    • 19644363114 scopus 로고    scopus 로고
    • The structure-function dilemma of the hammerhead ribozyme
    • Blount, K.F. and Uhlenbeck, O.C. 2005. The structure-function dilemma of the hammerhead ribozyme. Annu. Rev. Biophys. Biomol. Struct. 34: 415-440.
    • (2005) Annu. Rev. Biophys. Biomol. Struct , vol.34 , pp. 415-440
    • Blount, K.F.1    Uhlenbeck, O.C.2
  • 6
    • 0023055382 scopus 로고
    • Nucleotide sequence and newly formed phosphodiester bond of spontaneously ligated satellite tobacco ringspot virus RNA
    • doi: 10.1093/nar/14.24.9729
    • Buzayan, J.M., Hampel, A., and Bruening, G. 1986. Nucleotide sequence and newly formed phosphodiester bond of spontaneously ligated satellite tobacco ringspot virus RNA. Nucleic Acids Res. 14: 9729-9743. doi: 10.1093/nar/14.24.9729.
    • (1986) Nucleic Acids Res , vol.14 , pp. 9729-9743
    • Buzayan, J.M.1    Hampel, A.2    Bruening, G.3
  • 8
    • 33947645368 scopus 로고    scopus 로고
    • Efficient ligation of the Schistosoma hammerhead ribozyme
    • Canny, M.D., Jucker, F.M., and Pardi, A. 2007. Efficient ligation of the Schistosoma hammerhead ribozyme. Biochemistry 46: 3826-3834.
    • (2007) Biochemistry , vol.46 , pp. 3826-3834
    • Canny, M.D.1    Jucker, F.M.2    Pardi, A.3
  • 9
    • 33750996429 scopus 로고    scopus 로고
    • Effects of the trinucleotide preceding the self-cleavage site on eggplant latent viroid hammerheads: Differences in co- and post-transcriptional self-cleavage may explain the lack of trinucleotide AUC in most natural hammerheads
    • doi: 10.1093/nar/gkl717
    • Carbonell, A., De la Pena, M., Flores, R., and Gago, S. 2006. Effects of the trinucleotide preceding the self-cleavage site on eggplant latent viroid hammerheads: Differences in co- and post-transcriptional self-cleavage may explain the lack of trinucleotide AUC in most natural hammerheads. Nucleic Acids Res. 34: 5613-5622. doi: 10.1093/nar/gkl717.
    • (2006) Nucleic Acids Res , vol.34 , pp. 5613-5622
    • Carbonell, A.1    De la Pena, M.2    Flores, R.3    Gago, S.4
  • 10
    • 0142105383 scopus 로고    scopus 로고
    • Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity
    • De la Pena, M., Gago, S., and Flores, R. 2003. Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity. EMBO J. 22: 5561-5570.
    • (2003) EMBO J , vol.22 , pp. 5561-5570
    • De la Pena, M.1    Gago, S.2    Flores, R.3
  • 11
    • 0035802131 scopus 로고    scopus 로고
    • In vitro selection of hammerhead ribozyme sequence variants
    • Eckstein, F., Kore, A.R., and Nakamaye, K.L. 2001. In vitro selection of hammerhead ribozyme sequence variants. ChemBioChem 2: 629-635.
    • (2001) ChemBioChem , vol.2 , pp. 629-635
    • Eckstein, F.1    Kore, A.R.2    Nakamaye, K.L.3
  • 12
    • 0034808172 scopus 로고    scopus 로고
    • Hammerhead ribozyme structure and function in plant RNA replication
    • Flores, R., Hernandez, C., de la Pena, M., Vera, A., and Daros, J.A. 2001. Hammerhead ribozyme structure and function in plant RNA replication. Methods Enzymol. 341: 540-552.
    • (2001) Methods Enzymol , vol.341 , pp. 540-552
    • Flores, R.1    Hernandez, C.2    de la Pena, M.3    Vera, A.4    Daros, J.A.5
  • 13
    • 0023663396 scopus 로고
    • Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites
    • Forster, A.C. and Symons, R.H. 1987a. Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites. Cell 49: 211-220.
    • (1987) Cell , vol.49 , pp. 211-220
    • Forster, A.C.1    Symons, R.H.2
  • 14
    • 0023643095 scopus 로고
    • Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site
    • Forster, A.C. and Symons, R.H. 1987b. Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site. Cell 50: 9-16.
    • (1987) Cell , vol.50 , pp. 9-16
    • Forster, A.C.1    Symons, R.H.2
  • 15
    • 0029954588 scopus 로고    scopus 로고
    • Novel requirements in peripheral structures of the extended satellite 2 hammerhead
    • Garrett, T.A., Pabâon-Peäna, L.M., Gokaldas, N., and Epstein, L.M. 1996. Novel requirements in peripheral structures of the extended satellite 2 hammerhead. RNA 2: 699-706.
    • (1996) RNA , vol.2 , pp. 699-706
    • Garrett, T.A.1    Pabâon-Peäna, L.M.2    Gokaldas, N.3    Epstein, L.M.4
  • 16
    • 0028216716 scopus 로고    scopus 로고
    • Herschlag, D., Khosla, M., Tsuchihashi, Z., and Karpel, R.L. 1994. An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis. EMBO J. 13: 2913-2924 [erratum 13: 3926].
    • Herschlag, D., Khosla, M., Tsuchihashi, Z., and Karpel, R.L. 1994. An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis. EMBO J. 13: 2913-2924 [erratum 13: 3926].
  • 17
    • 0028906353 scopus 로고
    • The internal equilibrium of the hammerhead ribozyme reaction
    • Hertel, K.J. and Uhlenbeck, O.C. 1995. The internal equilibrium of the hammerhead ribozyme reaction. Biochemistry 34: 1744-1749.
    • (1995) Biochemistry , vol.34 , pp. 1744-1749
    • Hertel, K.J.1    Uhlenbeck, O.C.2
  • 18
    • 0028288686 scopus 로고
    • A kinetic and thermodynamic framework for the hammerhead ribozyme reaction
    • Hertel, K.J., Herschlag, D., and Uhlenbeck, O.C. 1994. A kinetic and thermodynamic framework for the hammerhead ribozyme reaction. Biochemistry 33: 3374-3385.
    • (1994) Biochemistry , vol.33 , pp. 3374-3385
    • Hertel, K.J.1    Herschlag, D.2    Uhlenbeck, O.C.3
  • 19
    • 0030013338 scopus 로고    scopus 로고
    • Specificity of hammerhead ribozyme cleavage
    • Hertel, K.J., Herschlag, D., and Uhlenbeck, O.C. 1996. Specificity of hammerhead ribozyme cleavage. EMBO J. 15: 3751-3757.
    • (1996) EMBO J , vol.15 , pp. 3751-3757
    • Hertel, K.J.1    Herschlag, D.2    Uhlenbeck, O.C.3
  • 21
    • 0026027594 scopus 로고
    • Nuclear magnetic resonance studies of the hammerhead ribozyme domain. Secondary structure formation and magnesium ion dependence
    • Heus, H.A. and Pardi, A. 1991. Nuclear magnetic resonance studies of the hammerhead ribozyme domain. Secondary structure formation and magnesium ion dependence. J. Mol. Biol. 217: 113-124.
    • (1991) J. Mol. Biol , vol.217 , pp. 113-124
    • Heus, H.A.1    Pardi, A.2
  • 22
    • 23044431628 scopus 로고    scopus 로고
    • Hodak, J.H., Downey, C.D., Fiore, J.L., Pardi, A., and Nesbitt, D.J. 2005. Docking kinetics and equilibrium of a GAAA tetraloop-receptor motif probed by single-molecule FRET. Proc. Natl. Acad. Sci. 102: 10505-10510 [erratum 13: 13351].
    • Hodak, J.H., Downey, C.D., Fiore, J.L., Pardi, A., and Nesbitt, D.J. 2005. Docking kinetics and equilibrium of a GAAA tetraloop-receptor motif probed by single-molecule FRET. Proc. Natl. Acad. Sci. 102: 10505-10510 [erratum 13: 13351].
  • 23
    • 0023047510 scopus 로고
    • Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid
    • doi: 10.1093/nar/14.9.3627
    • Hutchins, C.J., Rathjen, P.D., Forster, A.C., and Symons, R.H. 1986. Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid. Nucleic Acids Res. 14: 3627-3640. doi: 10.1093/nar/14.9.3627.
    • (1986) Nucleic Acids Res , vol.14 , pp. 3627-3640
    • Hutchins, C.J.1    Rathjen, P.D.2    Forster, A.C.3    Symons, R.H.4
  • 24
    • 0043009734 scopus 로고    scopus 로고
    • Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity
    • Khvorova, A., Lescoute, A., Westhof, E., and Jayasena, S.D. 2003. Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity. Nat. Struct. Biol. 10: 708-712.
    • (2003) Nat. Struct. Biol , vol.10 , pp. 708-712
    • Khvorova, A.1    Lescoute, A.2    Westhof, E.3    Jayasena, S.D.4
  • 25
    • 0025821094 scopus 로고
    • Effects of phosphorothioate and 2-amino groups in hammerhead ribozymes on cleavage rates and Mg2+ binding
    • Koizumi, M. and Ohtsuka, E. 1991. Effects of phosphorothioate and 2-amino groups in hammerhead ribozymes on cleavage rates and Mg2+ binding. Biochemistry 30: 5145-5150.
    • (1991) Biochemistry , vol.30 , pp. 5145-5150
    • Koizumi, M.1    Ohtsuka, E.2
  • 26
    • 0023788268 scopus 로고
    • Cleavage of specific sites of Rna by designed ribozymes
    • Koizumi, M., Iwai, S., and Ohtsuka, E. 1988a. Cleavage of specific sites of Rna by designed ribozymes. FEBS Lett. 239: 285-288.
    • (1988) FEBS Lett , vol.239 , pp. 285-288
    • Koizumi, M.1    Iwai, S.2    Ohtsuka, E.3
  • 27
    • 0024286910 scopus 로고
    • Construction of a series of several self-cleaving Rna duplexes using synthetic 21-mers
    • Koizumi, M., Iwai, S., and Ohtsuka, E. 1988b. Construction of a series of several self-cleaving Rna duplexes using synthetic 21-mers. FEBS Lett. 228: 228-230.
    • (1988) FEBS Lett , vol.228 , pp. 228-230
    • Koizumi, M.1    Iwai, S.2    Ohtsuka, E.3
  • 28
    • 0034283351 scopus 로고    scopus 로고
    • In vitro evolution of the hammerhead ribozyme to a purine-specific ribozyme using mutagenic PCR with two nucleotide analogues
    • Kore, A.R., Vaish, N.K., Morris, J.A., and Eckstein, F. 2000. In vitro evolution of the hammerhead ribozyme to a purine-specific ribozyme using mutagenic PCR with two nucleotide analogues. J. Mol. Biol. 301: 1113-1121.
    • (2000) J. Mol. Biol , vol.301 , pp. 1113-1121
    • Kore, A.R.1    Vaish, N.K.2    Morris, J.A.3    Eckstein, F.4
  • 29
    • 0033575087 scopus 로고    scopus 로고
    • Kinetics of RNA degradation by specific base catalysis of transesterification involving the 2′-hydroxyl group
    • Li, Y.F. and Breaker, R.R. 1999. Kinetics of RNA degradation by specific base catalysis of transesterification involving the 2′-hydroxyl group. J. Am. Chem. Soc. 121: 5364-5372.
    • (1999) J. Am. Chem. Soc , vol.121 , pp. 5364-5372
    • Li, Y.F.1    Breaker, R.R.2
  • 30
    • 34547892257 scopus 로고    scopus 로고
    • Dissecting the multistep reaction pathway of an RNA enzyme by singlemolecule kinetic fingerprinting
    • Liu, S., Bokinsky, G., Walter, N., and Zhuang, X. 2007. Dissecting the multistep reaction pathway of an RNA enzyme by singlemolecule kinetic "fingerprinting." Proc. Natl. Acad. Sci. 104: 12634-12639.
    • (2007) Proc. Natl. Acad. Sci , vol.104 , pp. 12634-12639
    • Liu, S.1    Bokinsky, G.2    Walter, N.3    Zhuang, X.4
  • 31
    • 33746228126 scopus 로고    scopus 로고
    • Tertiary contacts distant from the active site prime a ribozyme for catalysis
    • Martick, M. and Scott, W.G. 2006. Tertiary contacts distant from the active site prime a ribozyme for catalysis. Cell 126: 309-320.
    • (2006) Cell , vol.126 , pp. 309-320
    • Martick, M.1    Scott, W.G.2
  • 32
    • 0029949701 scopus 로고    scopus 로고
    • Structure and function of the hammerhead ribozyme: An unfinished story
    • McKay, D.B. 1996. Structure and function of the hammerhead ribozyme: An unfinished story. RNA 2: 395-403.
    • (1996) RNA , vol.2 , pp. 395-403
    • McKay, D.B.1
  • 33
    • 0024819449 scopus 로고
    • Synthesis of small RNAs using T7 RNA polymerase
    • Milligan, J.F. and Uhlenbeck, O.C. 1989. Synthesis of small RNAs using T7 RNA polymerase. Methods Enzymol. 180: 51-62.
    • (1989) Methods Enzymol , vol.180 , pp. 51-62
    • Milligan, J.F.1    Uhlenbeck, O.C.2
  • 34
    • 0028807644 scopus 로고
    • The roles of the conserved pyrimidine bases in hammerhead ribozyme catalysis: Evidence for a magnesium ion-binding site
    • Murray, J.B., Adams, C.J., Arnold, J.R., and Stockley, P.G. 1995. The roles of the conserved pyrimidine bases in hammerhead ribozyme catalysis: Evidence for a magnesium ion-binding site. Biochem. J. 311: 487-494.
    • (1995) Biochem. J , vol.311 , pp. 487-494
    • Murray, J.B.1    Adams, C.J.2    Arnold, J.R.3    Stockley, P.G.4
  • 36
    • 0033860560 scopus 로고    scopus 로고
    • Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction
    • Murray, J.B., Szoke, H., Szoke, A., and Scott, W.G. 2000. Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction. Mol. Cell 5: 279-287.
    • (2000) Mol. Cell , vol.5 , pp. 279-287
    • Murray, J.B.1    Szoke, H.2    Szoke, A.3    Scott, W.G.4
  • 37
    • 27644432146 scopus 로고    scopus 로고
    • Hammerheads derived from sTRSV show enhanced cleavage and ligation rate constants
    • Nelson, J.A., Shepotinovskaya, I., and Uhlenbeck, O.C. 2005. Hammerheads derived from sTRSV show enhanced cleavage and ligation rate constants. Biochemistry 44: 14577-14585.
    • (2005) Biochemistry , vol.44 , pp. 14577-14585
    • Nelson, J.A.1    Shepotinovskaya, I.2    Uhlenbeck, O.C.3
  • 38
    • 0035001461 scopus 로고    scopus 로고
    • Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations
    • O'Rear, J.L., Wang, S., Feig, A.L., Beigelman, L., and Uhlenbeck, O.C. 2001. Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations. RNA 7: 537-545.
    • (2001) RNA , vol.7 , pp. 537-545
    • O'Rear, J.L.1    Wang, S.2    Feig, A.L.3    Beigelman, L.4    Uhlenbeck, O.C.5
  • 39
    • 0029859191 scopus 로고    scopus 로고
    • Rescue of abasic hammerhead ribozymes by exogenous addition of specific bases
    • Peracchi, A., Beigelman, L., Usman, N., and Herschlag, D. 1996. Rescue of abasic hammerhead ribozymes by exogenous addition of specific bases. Proc. Natl. Acad. Sci. 93: 11522-11527.
    • (1996) Proc. Natl. Acad. Sci , vol.93 , pp. 11522-11527
    • Peracchi, A.1    Beigelman, L.2    Usman, N.3    Herschlag, D.4
  • 40
    • 0030876444 scopus 로고    scopus 로고
    • Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation
    • Peracchi, A., Beigelman, L., Scott, E.C., Uhlenbeck, O.C., and Herschlag, D. 1997. Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation. J. Biol. Chem. 272: 26822-26826.
    • (1997) J. Biol. Chem , vol.272 , pp. 26822-26826
    • Peracchi, A.1    Beigelman, L.2    Scott, E.C.3    Uhlenbeck, O.C.4    Herschlag, D.5
  • 41
    • 0032552962 scopus 로고    scopus 로고
    • A core folding model for catalysis by the hammerhead ribozyme accounts for its extraordinary sensitivity to abasic mutations
    • Peracchi, A., Karpeisky, A., Maloney, L., Beigelman, L., and Herschlag, D. 1998. A core folding model for catalysis by the hammerhead ribozyme accounts for its extraordinary sensitivity to abasic mutations. Biochemistry 37: 14765-14775.
    • (1998) Biochemistry , vol.37 , pp. 14765-14775
    • Peracchi, A.1    Karpeisky, A.2    Maloney, L.3    Beigelman, L.4    Herschlag, D.5
  • 42
    • 0028063567 scopus 로고
    • Three-dimensional structure of a hammerhead ribozyme
    • Pley, H.W., Flaherty, K.M., and McKay, D.B. 1994. Three-dimensional structure of a hammerhead ribozyme. Nature 372: 68-74.
    • (1994) Nature , vol.372 , pp. 68-74
    • Pley, H.W.1    Flaherty, K.M.2    McKay, D.B.3
  • 43
    • 34748891942 scopus 로고    scopus 로고
    • The tolerance to exchanges of the Watson-Crick base pair in the hammerhead ribozyme core is determined by surrounding elements
    • Przybilski, R. and Hammann, C. 2007. The tolerance to exchanges of the Watson-Crick base pair in the hammerhead ribozyme core is determined by surrounding elements. RNA 13: 1625-1630.
    • (2007) RNA , vol.13 , pp. 1625-1630
    • Przybilski, R.1    Hammann, C.2
  • 44
    • 33749267488 scopus 로고    scopus 로고
    • Extraordinary rates of transition metal ion-mediated ribozyme catalysis
    • Roychowdhury-Saha, M. and Burke, D.H. 2006. Extraordinary rates of transition metal ion-mediated ribozyme catalysis. RNA 12: 1846-1852.
    • (2006) RNA , vol.12 , pp. 1846-1852
    • Roychowdhury-Saha, M.1    Burke, D.H.2
  • 45
    • 0041972623 scopus 로고    scopus 로고
    • 2+ ions slightly reorient stems I and II of the hammerhead ribozyme to increase the probability of formation of the catalytic core
    • 2+ ions slightly reorient stems I and II of the hammerhead ribozyme to increase the probability of formation of the catalytic core. Biochemistry 42: 9924-9936.
    • (2003) Biochemistry , vol.42 , pp. 9924-9936
    • Rueda, D.1    Wick, K.2    McDowell, S.E.3    Walter, N.G.4
  • 46
    • 0025695458 scopus 로고
    • Sequence requirements of the hammerhead RNA self-cleavage reaction
    • Ruffner, D.E., Stormo, G.D., and Uhlenbeck, O.C. 1990. Sequence requirements of the hammerhead RNA self-cleavage reaction. Biochemistry 29: 10695-10702.
    • (1990) Biochemistry , vol.29 , pp. 10695-10702
    • Ruffner, D.E.1    Stormo, G.D.2    Uhlenbeck, O.C.3
  • 47
    • 9344265166 scopus 로고    scopus 로고
    • Artificial tertiary motifs stabilize trans-cleaving hammerhead ribozymes under conditions of submillimolar divalent ions and high temperatures
    • Saksmerprome, V., Roychowdhury-Saha, M., Jayasena, S., Khvorova, A., and Burke, D.H. 2004. Artificial tertiary motifs stabilize trans-cleaving hammerhead ribozymes under conditions of submillimolar divalent ions and high temperatures. RNA 10: 1916-1924.
    • (2004) RNA , vol.10 , pp. 1916-1924
    • Saksmerprome, V.1    Roychowdhury-Saha, M.2    Jayasena, S.3    Khvorova, A.4    Burke, D.H.5
  • 48
    • 0029073091 scopus 로고
    • The crystal structure of an all-RNA hammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage
    • Scott, W.G., Finch, J.T., and Klug, A. 1995. The crystal structure of an all-RNA hammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage. Cell 81: 991-1002.
    • (1995) Cell , vol.81 , pp. 991-1002
    • Scott, W.G.1    Finch, J.T.2    Klug, A.3
  • 49
    • 0030476765 scopus 로고    scopus 로고
    • Capturing the structure of a catalytic RNA intermediate: The hammerhead ribozyme
    • Scott, W.G., Murray, J.B., Arnold, J.R., Stoddard, B.L., and Klug, A. 1996. Capturing the structure of a catalytic RNA intermediate: The hammerhead ribozyme. Science 274: 2065-2069.
    • (1996) Science , vol.274 , pp. 2065-2069
    • Scott, W.G.1    Murray, J.B.2    Arnold, J.R.3    Stoddard, B.L.4    Klug, A.5
  • 51
    • 0026102040 scopus 로고
    • Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes
    • doi: 10.1093/nar/19.6.1183
    • Slim, G. and Gait, M.J. 1991. Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes. Nucleic Acids Res. 19: 1183-1188. doi: 10.1093/nar/19.6.1183.
    • (1991) Nucleic Acids Res , vol.19 , pp. 1183-1188
    • Slim, G.1    Gait, M.J.2
  • 52
    • 0032831634 scopus 로고    scopus 로고
    • Relationship between internucleotide linkage geometry and the stability of RNA
    • Soukup, G.A. and Breaker, R.R. 1999. Relationship between internucleotide linkage geometry and the stability of RNA. RNA 5: 1308-1325.
    • (1999) RNA , vol.5 , pp. 1308-1325
    • Soukup, G.A.1    Breaker, R.R.2
  • 53
    • 0031828144 scopus 로고    scopus 로고
    • Hammerhead ribozyme kinetics
    • Stage-Zimmermann, T.K. and Uhlenbeck, O.C. 1998. Hammerhead ribozyme kinetics. RNA 4: 875-889.
    • (1998) RNA , vol.4 , pp. 875-889
    • Stage-Zimmermann, T.K.1    Uhlenbeck, O.C.2
  • 54
    • 0034814785 scopus 로고    scopus 로고
    • A covalent crosslink converts the hammerhead ribozyme from a ribonuclease to an RNA ligase
    • Stage-Zimmermann, T.K. and Uhlenbeck, O.C. 2001. A covalent crosslink converts the hammerhead ribozyme from a ribonuclease to an RNA ligase. Nat. Struct. Biol. 8: 863-867.
    • (2001) Nat. Struct. Biol , vol.8 , pp. 863-867
    • Stage-Zimmermann, T.K.1    Uhlenbeck, O.C.2
  • 55
    • 0027426257 scopus 로고    scopus 로고
    • Tuschl, T., Ng, M.M., Pieken, W., Benseler, F., and Eckstein, F. 1993. Importance of exocyclic base functional groups of central core guanosines for hammerhead ribozyme activity. Biochemistry 32: 11658-11668 [erratum 33: 848].
    • Tuschl, T., Ng, M.M., Pieken, W., Benseler, F., and Eckstein, F. 1993. Importance of exocyclic base functional groups of central core guanosines for hammerhead ribozyme activity. Biochemistry 32: 11658-11668 [erratum 33: 848].
  • 56
    • 0023221419 scopus 로고
    • A small catalytic oligoribonucleotide
    • Uhlenbeck, O.C. 1987. A small catalytic oligoribonucleotide. Nature 328: 596-600.
    • (1987) Nature , vol.328 , pp. 596-600
    • Uhlenbeck, O.C.1
  • 57
    • 0032478070 scopus 로고    scopus 로고
    • In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme
    • Vaish, N.K., Heaton, P.A., Fedorova, O., and Eckstein, F. 1998. In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme. Proc. Natl. Acad. Sci. 95: 2158-2162.
    • (1998) Proc. Natl. Acad. Sci , vol.95 , pp. 2158-2162
    • Vaish, N.K.1    Heaton, P.A.2    Fedorova, O.3    Eckstein, F.4
  • 58
    • 0025335881 scopus 로고
    • Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration
    • doi: 10.1093/nar/18.8.1971
    • van Tol, H., Buzayan, J.M., Feldstein, P.A., Eckstein, F., and Bruening, G. 1990. Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration. Nucleic Acids Res. 18: 1971-1975. doi: 10.1093/nar/18.8.1971.
    • (1990) Nucleic Acids Res , vol.18 , pp. 1971-1975
    • van Tol, H.1    Buzayan, J.M.2    Feldstein, P.A.3    Eckstein, F.4    Bruening, G.5
  • 59
    • 0031322028 scopus 로고    scopus 로고
    • Structure-function studies of the hammerhead ribozyme
    • Verma, S., Vaish, N.K., and Eckstein, F. 1997. Structure-function studies of the hammerhead ribozyme. Curr. Opin. Chem. Biol. 1: 532-536.
    • (1997) Curr. Opin. Chem. Biol , vol.1 , pp. 532-536
    • Verma, S.1    Vaish, N.K.2    Eckstein, F.3
  • 60
    • 0033607198 scopus 로고    scopus 로고
    • Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate
    • Wang, S., Karbstein, K., Peracchi, A., Beigelman, L., and Herschlag, D. 1999. Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate. Biochemistry 38: 14363-14378.
    • (1999) Biochemistry , vol.38 , pp. 14363-14378
    • Wang, S.1    Karbstein, K.2    Peracchi, A.3    Beigelman, L.4    Herschlag, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.