A core folding model for catalysis by the hammerhead ribozyme accounts for its extraordinary sensitivity to abasic mutations

Biochemistry

Volumn 37, Issue 42, 1998, Pages 14765-14775

  Peracchi, Alessio ^a,b   Karpeisky, Alexander ^c   Maloney, Lara ^c   Beigelman, Leonid ^c   Herschlag, Daniel ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF PARMA   (Italy)

^c Sirna Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOZYME;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; PRIORITY JOURNAL; PROTEIN FOLDING;

BASE PAIRING; BASE SEQUENCE; CATALYSIS; HYDROLYSIS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; OLIGONUCLEOTIDES; PROTEIN FOLDING; RNA; RNA, CATALYTIC; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 0032552962     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980867y     Document Type: Article

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