Critical role of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3β signaling pathway in recovery from anthrax lethal toxin-induced cell cycle arrest and MEK cleavage in macrophages

Journal of Biological Chemistry

Volumn 282, Issue 50, 2007, Pages 36230-36239

  Ha, Soon Duck ^a   Ng, Dennis ^a   Pelech, Steven L ^b,c   Sung, Ouk Kim ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b Kinexus Bioinformatics Corporation   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACILLUS ANTHRACIS; IMMUNE SUPPRESSION; MONONUCLEAR CELLS; PERITONEAL MACROPHAGES;

BLOOD; CELL PROLIFERATION; IMMUNIZATION; MACROPHAGES; TOXIC MATERIALS;

BACTERIA;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRAX TOXIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHECKPOINT KINASE 1; CYCLIN D1; CYCLIN D2; GLYCOGEN SYNTHASE KINASE 3BETA; LETHAL TOXIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; SB 218078; SERINE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ANIMAL CELL; ARTICLE; BACILLUS ANTHRACIS; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; CYCLINS; DOWN-REGULATION; G0 PHASE; G1 PHASE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MAP KINASE KINASE 1; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS; VIRULENCE FACTORS;

BACILLUS ANTHRACIS;

EID: 37549008343     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707622200     Document Type: Article

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