ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: Implications for the pathogenesis of anthrax infection

American Journal of Physiology - Cell Physiology

Volumn 288, Issue 6 57-6, 2005, Pages

  Bonuccelli, Gloria ^a   Sotgia, Federica ^a   Frank, Philippe G ^a   Williams, Terence M ^a   De Almeida, Cecilia J ^a   Tanowitz, Herbert B ^a   Scherer, Philipp E ^a   Hotchkiss, Kylie A ^a   Terman, Bruce I ^a   Rollman, Brent ^b   Alileche, Abdelkrim ^a   Brojatsch, Jürgen ^a   Lisanti, Michael P ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Affinity BioReagents   (United States)

Author keywords

Anthrax; Bacterial pathogenesis; Epithelia; Intestine; Lung; Receptor; Skin; Toxin entry

Indexed keywords

ANTHRAX TOXIN; ANTHRAX TOXIN RECEPTOR; ISOPROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; ANTHRAX TOXIN RECEPTOR 1, HUMAN; CELL SURFACE RECEPTOR; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL SPORE; EPITHELIUM CELL; GENE; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; TEM8 GENE; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CHEMISTRY; CHO CELL; CRICETULUS; HAMSTER; INTESTINE; LUNG; METABOLISM; MOLECULAR GENETICS; PATHOPHYSIOLOGY; PHYSIOLOGY; SKIN;

BACILLUS ANTHRACIS;

AMINO ACID SEQUENCE; ANIMALS; ANTHRAX; CHO CELLS; CRICETINAE; CRICETULUS; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; INTESTINES; LUNG; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PROTEIN ISOFORMS; RECEPTORS, CELL SURFACE; SKIN;

EID: 22244443676     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00582.2004     Document Type: Article

References (25)

1. Abrami L, Fivaz M, and van der Goot FG. Adventures of a pore-forming toxin at the target cell surface. Trends Microbiol 8: 168-172, 2000.
2. Abrami L, Liu S, Cosson P, Leppla SH, and van der Goot FG. Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process. J Cell Biol 160: 321-328, 2003.
3. Beauregard KE, Wimer-Mackin S, Collier RJ, and Lencer WI. Anthrax toxin entry into polarized epithelial cells. Infect Immun 67: 3026-3030, 1999.
4. Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, and Davis GE. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J Cell Sci 114: 2755-2773, 2001.
5. Bradley KA, Mogridge J, Jonah G, Rainey A, Batty S, and Young JA. Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions. J Biol Chem 278: 49342-49347, 2003.
6. Bradley KA, Mogridge J, Mourez M, Collier RJ, and Young JA. Identification of the cellular receptor for anthrax toxin. Nature 414: 225-229, 2001.
7. Bradley KA and Young JA. Anthrax toxin receptor proteins. Biochem Pharmacol 65: 309-314, 2003.
8. Capozza F, Williams TM, Schubert W, McClain S, Bouzahzah B, Sotgia F, and Lisanti MP. Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. Am J Pathol 162: 2029-2039, 2003.
9. Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, and St Croix B. Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res 61: 6649-6655, 2001.
10. Collier RJ and Young JA. Anthrax toxin. Annu Rev Cell Dev Biol 19: 45-70, 2003.
11. Dixon TC, Meselson M, Guillemin J, and Hanna PC. Anthrax. N Engl J Med 341: 815-826, 1999.
12. Drum CL, Yan SZ, Bard J, Shen YQ, Lu D, Soelaiman S, Grabarek Z, Bohm A, and Tang WJ. Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature 415: 396-402, 2002.
13. Galbiati F, Volonté D, Engelman JA, Watanabe G, Burk R, Pestell RG, and Lisanti MP. Targeted down-regulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J 17: 6633-6648, 1998.
14. Kurzchalia T. Anthrax toxin rafts into cells. J Cell Biol 160: 295-296, 2003.
15. Lacy DB, Wigelsworth DJ, Scobie HM, Young JA, and Collier RJ. Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Proc Natl Acad Sci USA 101: 6367-6372, 2004.
16. Moayeri M and Leppla SH. The roles of anthrax toxin in pathogenesis. Curr Opin Microbiol 7: 19-24, 2004.
17. Mock M and Fouet A. Anthrax. Annu Rev Microbiol 55: 647-671, 2001.
18. Mourez M, Kane RS, Mogridge J, Metallo S, Deschatelets P, Sellman BR, Whitesides GM, and Collier RJ. Designing a polyvalent inhibitor of anthrax toxin. Nat Biotechnol 19: 958-961, 2001.
19. Nanda A, Carson-Walter EB, Seaman S, Barber TD, Stampfl J, Singh S, Vogelstein B, Kinzler KW, and St Croix B. TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI). Cancer Res 64: 817-820, 2004.
20. Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P, and Liddington RC. Crystal structure of the anthrax lethal factor. Nature 414: 229-233, 2001.
21. Petosa C, Collier RJ, Klimpel KR, Leppla SH, and Liddington RC. Crystal structure of the anthrax toxin protective antigen. Nature 385: 833-838, 1997.
22. Scobie HM, Rainey GJ, Bradley KA, and Young JA. Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci USA 100: 5170-5174, 2003.
23. Sellman BR, Mourez M, and Collier RJ. Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax. Science 292: 695-697, 2001.
24. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, and Kinzler KW. Genes expressed in human tumor endothelium. Science 289: 1197-1202, 2000.
25. Wigelsworth DJ, Krantz BA, Christensen KA, Lacy DB, Juris SJ, and Collier RJ. Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. J Biol Chem 279: 23349-23356, 2004.