Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors

Molecular Pharmacology

Volumn 73, Issue 1, 2008, Pages 94-103

  Bakker, Remko A ^a,b,f   Jongejan, Aldo ^a   Sansuk, Kamonchanok ^a   Hacksell, Uli ^b   Timmerman, Henk ^a   Brann, Mark R ^b,c   Weiner, Dave M ^b,c,d,g   Pardo, Leonardo ^a,e   Leurs, Rob ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b ACADIA PHARMACEUTICALS INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^g MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARAGINE; ASTEMIZOLE; CHLORPHENIRAMINE; CYPROHEPTADINE; DOXEPIN; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; GLYCINE; HISTAMINE H1 RECEPTOR; ISOLEUCINE; KETOTIFEN; LEVOCABASTINE; LORATADINE; MEPYRAMINE; MIANSERIN; MIRTAZAPINE; MUTANT PROTEIN; RHODOPSIN; SERINE; TRIPELENNAMINE; TRIPROLIDINE;

ACIDITY; ANIMAL CELL; ARTICLE; DRUG RECEPTOR BINDING; GENE MUTATION; GENETIC CONSERVATION; HYDROPHOBICITY; MOLECULAR MODEL; MOUSE; MULTIGENE FAMILY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; RECEPTOR UPREGULATION;

ASPARAGINE; MUTAGENESIS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE H1;

EID: 37349033724     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.038547     Document Type: Article

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