A Conserved Asn in Transmembrane Helix 7 Is an On/Off Switch in the Activation of the Thyrotropin Receptor

Journal of Biological Chemistry

Volumn 276, Issue 25, 2001, Pages 22991-22999

  Govaerts, Cédric ^a   Lefort, Anne ^a   Costagliola, Sabine ^a   Wodak, Shoshana J ^a   Ballesteros, Juan A ^c   Van Sande, Jacqueline ^a   Pardo, Leonardo ^b   Vassart, Gilbert ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c Novasite Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CHEMICAL ACTIVATION; CONFORMATIONS; MUTAGENESIS; PROTEINS;

MUTATIONS; TRANSMEMBRANE HELIX;

BIOCHEMISTRY;

ASPARAGINE; ASPARTIC ACID; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; HORMONE RECEPTOR; RHODOPSIN; THYROTROPIN RECEPTOR; MEMBRANE PROTEIN; THYROTROPIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENETIC CONSERVATION; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FAMILY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; TRANSMEMBRANE HELIX 6; TRANSMEMBRANE HELIX 7; ANIMAL; CELL STRAIN COS1; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; SEQUENCE HOMOLOGY;

ANIMALIA;

ANIMALS; ASPARAGINE; COS CELLS; CYCLIC AMP; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECEPTORS, THYROTROPIN; SEQUENCE HOMOLOGY, AMINO ACID; THYROTROPIN;

EID: 0035933839     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102244200     Document Type: Article

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