메뉴 건너뛰기




Volumn 1, Issue 2, 2007, Pages 53-60

The effects of NOD2/CARD15 mutations on the function of the intestinal barrier

Author keywords

Defensins; ; Epithelial barrier; ; GvHD; Intestinal epethelial cellls; ; Intestinal macrophages (IMACs); ; Intestinal permeability; ; NOD2 CARD15; ; Pattern recognition receptors (PRRs);

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CYTOKINE; DEFENSIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MURAMYL DIPEPTIDE; PATTERN RECOGNITION RECEPTOR; POLYPEPTIDE ANTIBIOTIC AGENT; TRANSCRIPTION FACTOR;

EID: 37249066691     PISSN: 18739946     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.crohns.2007.08.008     Document Type: Review
Times cited : (18)

References (79)
  • 1
    • 13344259990 scopus 로고    scopus 로고
    • Mapping of a susceptibility locus for Crohn's disease on chromosome 16
    • Hugot J.P., Laurent-Puig P., Gower-Rousseau C., et al. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 379 (1996) 821-823
    • (1996) Nature , vol.379 , pp. 821-823
    • Hugot, J.P.1    Laurent-Puig, P.2    Gower-Rousseau, C.3
  • 2
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y., Bonen D.K., Inohara N., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411 (2001) 603-606
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 3
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot J.P., Chamaillard M., Zouali H., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411 (2001) 599-603
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 4
    • 0035897904 scopus 로고    scopus 로고
    • Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
    • Hampe J., Cuthbert A., Croucher P.J., et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 357 (2001) 1925-1928
    • (2001) Lancet , vol.357 , pp. 1925-1928
    • Hampe, J.1    Cuthbert, A.2    Croucher, P.J.3
  • 5
    • 30344445931 scopus 로고    scopus 로고
    • Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities
    • Hanauer S.B. Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflamm Bowel Dis 12 Suppl 1 (2006) S3-S9
    • (2006) Inflamm Bowel Dis , vol.12 , Issue.SUPPL. 1
    • Hanauer, S.B.1
  • 7
    • 3042683170 scopus 로고    scopus 로고
    • Update in inflammatory bowel disease pathogenesis
    • Rogler G. Update in inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol 20 (2004) 311-317
    • (2004) Curr Opin Gastroenterol , vol.20 , pp. 311-317
    • Rogler, G.1
  • 8
    • 33344466383 scopus 로고    scopus 로고
    • Defective acute inflammation in Crohn's disease: a clinical investigation
    • Marks D.J., Harbord M.W., MacAllister R., et al. Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet 367 (2006) 668-678
    • (2006) Lancet , vol.367 , pp. 668-678
    • Marks, D.J.1    Harbord, M.W.2    MacAllister, R.3
  • 9
    • 27144489085 scopus 로고    scopus 로고
    • NOD2/CARD15 gene polymorphisms in Crohn's disease: a genotype-phenotype analysis in Danish and Portuguese patients and controls
    • Vind I., Vieira A., Hougs L., et al. NOD2/CARD15 gene polymorphisms in Crohn's disease: a genotype-phenotype analysis in Danish and Portuguese patients and controls. Digestion 72 (2005) 156-163
    • (2005) Digestion , vol.72 , pp. 156-163
    • Vind, I.1    Vieira, A.2    Hougs, L.3
  • 10
    • 2542574746 scopus 로고    scopus 로고
    • Mutations in the NOD2/CARD15 gene in Crohn's disease are associated with ileocecal resection and are a risk factor for reoperation
    • Buning C., Genschel J., Buhner S., et al. Mutations in the NOD2/CARD15 gene in Crohn's disease are associated with ileocecal resection and are a risk factor for reoperation. Aliment Pharmacol Ther 19 (2004) 1073-1078
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 1073-1078
    • Buning, C.1    Genschel, J.2    Buhner, S.3
  • 11
    • 0036202885 scopus 로고    scopus 로고
    • The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
    • Cuthbert A.P., Fisher S.A., Mirza M.M., et al. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology 122 (2002) 867-874
    • (2002) Gastroenterology , vol.122 , pp. 867-874
    • Cuthbert, A.P.1    Fisher, S.A.2    Mirza, M.M.3
  • 12
    • 18444381172 scopus 로고    scopus 로고
    • CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure
    • Vermeire S., Wild G., Kocher K., et al. CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure. Am J Hum Genet 71 (2002) 74-83
    • (2002) Am J Hum Genet , vol.71 , pp. 74-83
    • Vermeire, S.1    Wild, G.2    Kocher, K.3
  • 13
    • 33646789498 scopus 로고    scopus 로고
    • Relationship between CARD15, SLC22A4/5, and DLG5 polymorphisms and early-onset inflammatory bowel diseases: an Italian multicentric study
    • Ferraris A., Torres B., Knafelz D., et al. Relationship between CARD15, SLC22A4/5, and DLG5 polymorphisms and early-onset inflammatory bowel diseases: an Italian multicentric study. Inflamm Bowel Dis 12 (2006) 355-361
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 355-361
    • Ferraris, A.1    Torres, B.2    Knafelz, D.3
  • 14
    • 33748654515 scopus 로고    scopus 로고
    • Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis
    • Seiderer J., Schnitzler F., Brand S., et al. Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis. Scand J Gastroenterol 41 (2006) 1421-1432
    • (2006) Scand J Gastroenterol , vol.41 , pp. 1421-1432
    • Seiderer, J.1    Schnitzler, F.2    Brand, S.3
  • 15
    • 0036725827 scopus 로고    scopus 로고
    • Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
    • Abreu M.T., Taylor K.D., Lin Y.C., et al. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease. Gastroenterology 123 (2002) 679-688
    • (2002) Gastroenterology , vol.123 , pp. 679-688
    • Abreu, M.T.1    Taylor, K.D.2    Lin, Y.C.3
  • 16
    • 27644562698 scopus 로고    scopus 로고
    • Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence
    • Alvarez-Lobos M., Arostegui J.I., Sans M., et al. Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence. Ann Surg 242 (2005) 693-700
    • (2005) Ann Surg , vol.242 , pp. 693-700
    • Alvarez-Lobos, M.1    Arostegui, J.I.2    Sans, M.3
  • 17
    • 1542380052 scopus 로고    scopus 로고
    • Innate immunity and mucosal bacterial interactions in the intestine
    • Eckmann L. Innate immunity and mucosal bacterial interactions in the intestine. Curr Opin Gastroenterol 20 (2004) 82-88
    • (2004) Curr Opin Gastroenterol , vol.20 , pp. 82-88
    • Eckmann, L.1
  • 18
    • 0036828844 scopus 로고    scopus 로고
    • Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation
    • Gutierrez O., Pipaon C., Inohara N., et al. Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation. J Biol Chem 277 (2002) 41701-41705
    • (2002) J Biol Chem , vol.277 , pp. 41701-41705
    • Gutierrez, O.1    Pipaon, C.2    Inohara, N.3
  • 19
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
    • Ogura Y., Inohara N., Benito A., Chen F.F., Yamaoka S., and Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276 (2001) 4812-4818
    • (2001) J Biol Chem , vol.276 , pp. 4812-4818
    • Ogura, Y.1    Inohara, N.2    Benito, A.3    Chen, F.F.4    Yamaoka, S.5    Nunez, G.6
  • 20
    • 0038109983 scopus 로고    scopus 로고
    • Crohn's disease and the NOD2 gene: a role for Paneth cells
    • Lala S., Ogura Y., Osborne C., et al. Crohn's disease and the NOD2 gene: a role for Paneth cells. Gastroenterology 125 (2003) 47-57
    • (2003) Gastroenterology , vol.125 , pp. 47-57
    • Lala, S.1    Ogura, Y.2    Osborne, C.3
  • 21
    • 0038237665 scopus 로고    scopus 로고
    • Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon
    • Berrebi D., Maudinas R., Hugot J.P., et al. Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon. Gut 52 (2003) 840-846
    • (2003) Gut , vol.52 , pp. 840-846
    • Berrebi, D.1    Maudinas, R.2    Hugot, J.P.3
  • 22
    • 10744222688 scopus 로고    scopus 로고
    • Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis
    • Ogura Y., Lala S., Xin W., et al. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut 52 (2003) 1591-1597
    • (2003) Gut , vol.52 , pp. 1591-1597
    • Ogura, Y.1    Lala, S.2    Xin, W.3
  • 23
    • 34247239745 scopus 로고    scopus 로고
    • Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines
    • Uehara A., Fujimoto Y., Fukase K., and Takada H. Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines. Mol Immunol 44 (2007) 3100-3111
    • (2007) Mol Immunol , vol.44 , pp. 3100-3111
    • Uehara, A.1    Fujimoto, Y.2    Fukase, K.3    Takada, H.4
  • 24
    • 34250193324 scopus 로고    scopus 로고
    • Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion
    • Rosenstiel P., Sina C., End C., et al. Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion. J Immunol 178 (2007) 8203-8211
    • (2007) J Immunol , vol.178 , pp. 8203-8211
    • Rosenstiel, P.1    Sina, C.2    End, C.3
  • 25
    • 33750380844 scopus 로고    scopus 로고
    • Expression and function of TLR2, TLR4, and Nod2 in primary canine colonic epithelial cells
    • Swerdlow M.P., Kennedy D.R., Kennedy J.S., et al. Expression and function of TLR2, TLR4, and Nod2 in primary canine colonic epithelial cells. Vet Immunol Immunopathol 114 (2006) 313-319
    • (2006) Vet Immunol Immunopathol , vol.114 , pp. 313-319
    • Swerdlow, M.P.1    Kennedy, D.R.2    Kennedy, J.S.3
  • 26
    • 0037379915 scopus 로고    scopus 로고
    • TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells
    • Rosenstiel P., Fantini M., Brautigam K., et al. TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology 124 (2003) 1001-1009
    • (2003) Gastroenterology , vol.124 , pp. 1001-1009
    • Rosenstiel, P.1    Fantini, M.2    Brautigam, K.3
  • 28
    • 0036080092 scopus 로고    scopus 로고
    • Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation
    • Hausmann M., Kiessling S., Mestermann S., et al. Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology 122 (2002) 1987-2000
    • (2002) Gastroenterology , vol.122 , pp. 1987-2000
    • Hausmann, M.1    Kiessling, S.2    Mestermann, S.3
  • 29
    • 0031802150 scopus 로고    scopus 로고
    • Isolation and phenotypic characterization of colonic macrophages
    • Rogler G., Hausmann M., Vogl D., et al. Isolation and phenotypic characterization of colonic macrophages. Clin Exp Immunol 112 (1998) 205-215
    • (1998) Clin Exp Immunol , vol.112 , pp. 205-215
    • Rogler, G.1    Hausmann, M.2    Vogl, D.3
  • 30
    • 0041827164 scopus 로고    scopus 로고
    • Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation
    • Chamaillard M., Girardin S.E., Viala J., and Philpott D.J. Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol 5 (2003) 581-592
    • (2003) Cell Microbiol , vol.5 , pp. 581-592
    • Chamaillard, M.1    Girardin, S.E.2    Viala, J.3    Philpott, D.J.4
  • 31
    • 22444433175 scopus 로고    scopus 로고
    • NLRs join TLRs as innate sensors of pathogens
    • Martinon F., and Tschopp J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26 (2005) 447-454
    • (2005) Trends Immunol , vol.26 , pp. 447-454
    • Martinon, F.1    Tschopp, J.2
  • 32
    • 27444440273 scopus 로고    scopus 로고
    • Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis
    • Strauch U.G., Obermeier F., Grunwald N., et al. Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis. Gut 54 (2005) 1546-1552
    • (2005) Gut , vol.54 , pp. 1546-1552
    • Strauch, U.G.1    Obermeier, F.2    Grunwald, N.3
  • 33
    • 25444452680 scopus 로고    scopus 로고
    • In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4 +CD62L + T cells which prevent intestinal inflammation in the SCID transfer model of colitis
    • Obermeier F., Strauch U.G., Dunger N., et al. In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4 +CD62L + T cells which prevent intestinal inflammation in the SCID transfer model of colitis. Gut 54 (2005) 1428-1436
    • (2005) Gut , vol.54 , pp. 1428-1436
    • Obermeier, F.1    Strauch, U.G.2    Dunger, N.3
  • 34
    • 0242606051 scopus 로고    scopus 로고
    • Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis
    • Obermeier F., Dunger N., Strauch U.G., et al. Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis. Clin Exp Immunol 134 (2003) 217-224
    • (2003) Clin Exp Immunol , vol.134 , pp. 217-224
    • Obermeier, F.1    Dunger, N.2    Strauch, U.G.3
  • 35
    • 0034900527 scopus 로고    scopus 로고
    • Subtractive screening reveals up-regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages
    • Hausmann M., Spottl T., Andus T., et al. Subtractive screening reveals up-regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages. Clin Exp Immunol 125 (2001) 48-55
    • (2001) Clin Exp Immunol , vol.125 , pp. 48-55
    • Hausmann, M.1    Spottl, T.2    Andus, T.3
  • 36
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi K.S., Chamaillard M., Ogura Y., et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 (2005) 731-734
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1    Chamaillard, M.2    Ogura, Y.3
  • 37
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
    • Inohara N., Ogura Y., Fontalba A., et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 278 (2003) 5509-5512
    • (2003) J Biol Chem , vol.278 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3
  • 38
    • 0012722659 scopus 로고    scopus 로고
    • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    • Girardin S.E., Boneca I.G., Viala J., et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278 (2003) 8869-8872
    • (2003) J Biol Chem , vol.278 , pp. 8869-8872
    • Girardin, S.E.1    Boneca, I.G.2    Viala, J.3
  • 39
    • 0038624558 scopus 로고    scopus 로고
    • NODs: intracellular proteins involved in inflammation and apoptosis
    • Inohara N., and Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 3 (2003) 371-382
    • (2003) Nat Rev Immunol , vol.3 , pp. 371-382
    • Inohara, N.1    Nunez, G.2
  • 40
    • 0032524908 scopus 로고    scopus 로고
    • RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis
    • Inohara N., del Peso L., Koseki T., Chen S., and Nunez G. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J Biol Chem 273 (1998) 12296-12300
    • (1998) J Biol Chem , vol.273 , pp. 12296-12300
    • Inohara, N.1    del Peso, L.2    Koseki, T.3    Chen, S.4    Nunez, G.5
  • 41
    • 0034623225 scopus 로고    scopus 로고
    • An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways
    • Inohara N., Koseki T., Lin J., et al. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem 275 (2000) 27823-27831
    • (2000) J Biol Chem , vol.275 , pp. 27823-27831
    • Inohara, N.1    Koseki, T.2    Lin, J.3
  • 42
    • 22244465576 scopus 로고    scopus 로고
    • Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition
    • Barnich N., Aguirre J.E., Reinecker H.C., Xavier R., and Podolsky D.K. Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J Cell Biol 170 (2005) 21-26
    • (2005) J Cell Biol , vol.170 , pp. 21-26
    • Barnich, N.1    Aguirre, J.E.2    Reinecker, H.C.3    Xavier, R.4    Podolsky, D.K.5
  • 43
    • 33645532087 scopus 로고    scopus 로고
    • NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway
    • Pan Q., Kravchenko V., Katz A., et al. NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway. Infect Immun 74 (2006) 2121-2127
    • (2006) Infect Immun , vol.74 , pp. 2121-2127
    • Pan, Q.1    Kravchenko, V.2    Katz, A.3
  • 44
    • 26844557333 scopus 로고    scopus 로고
    • Nod2 in normal and abnormal intestinal immune function
    • Abreu M.T. Nod2 in normal and abnormal intestinal immune function. Gastroenterology 129 (2005) 1302-1304
    • (2005) Gastroenterology , vol.129 , pp. 1302-1304
    • Abreu, M.T.1
  • 46
    • 33646887917 scopus 로고    scopus 로고
    • Sensor molecules in intestinal innate immunity against bacterial infections
    • Eckmann L. Sensor molecules in intestinal innate immunity against bacterial infections. Curr Opin Gastroenterol 22 (2006) 95-101
    • (2006) Curr Opin Gastroenterol , vol.22 , pp. 95-101
    • Eckmann, L.1
  • 47
    • 34247373897 scopus 로고    scopus 로고
    • IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation
    • Chen L.W., Chen P.H., Chang W.J., Wang J.S., Karin M., and Hsu C.M. IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation. Crit Care Med 35 (2007) 1332-1340
    • (2007) Crit Care Med , vol.35 , pp. 1332-1340
    • Chen, L.W.1    Chen, P.H.2    Chang, W.J.3    Wang, J.S.4    Karin, M.5    Hsu, C.M.6
  • 48
    • 33947573767 scopus 로고    scopus 로고
    • Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis
    • Zaph C., Troy A.E., Taylor B.C., et al. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature 446 (2007) 552-556
    • (2007) Nature , vol.446 , pp. 552-556
    • Zaph, C.1    Troy, A.E.2    Taylor, B.C.3
  • 49
    • 34047173496 scopus 로고    scopus 로고
    • Epithelial NEMO links innate immunity to chronic intestinal inflammation
    • Nenci A., Becker C., Wullaert A., et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446 (2007) 557-561
    • (2007) Nature , vol.446 , pp. 557-561
    • Nenci, A.1    Becker, C.2    Wullaert, A.3
  • 51
    • 0142247096 scopus 로고    scopus 로고
    • Epithelial transport and gut barrier function in colitis
    • McCole D.F., and Barrett K.E. Epithelial transport and gut barrier function in colitis. Curr Opin Gastroenterol 19 (2003) 578-582
    • (2003) Curr Opin Gastroenterol , vol.19 , pp. 578-582
    • McCole, D.F.1    Barrett, K.E.2
  • 53
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    • Zeissig S., Burgel N., Gunzel D., et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56 (2007) 61-72
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Burgel, N.2    Gunzel, D.3
  • 54
    • 33645824969 scopus 로고    scopus 로고
    • Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed
    • Shen L., and Turner J.R. Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed. Am J Physiol Gastrointest Liver Physiol 290 (2006) G577-G582
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Shen, L.1    Turner, J.R.2
  • 55
    • 33749007683 scopus 로고    scopus 로고
    • Inflammatory bowel disease and the apical junctional complex
    • Bruewer M., Samarin S., and Nusrat A. Inflammatory bowel disease and the apical junctional complex. Ann N Y Acad Sci 1072 (2006) 242-252
    • (2006) Ann N Y Acad Sci , vol.1072 , pp. 242-252
    • Bruewer, M.1    Samarin, S.2    Nusrat, A.3
  • 56
    • 17044385039 scopus 로고    scopus 로고
    • TLR signaling in the gut in health and disease
    • Abreu M.T., Fukata M., and Arditi M. TLR signaling in the gut in health and disease. J Immunol 174 (2005) 4453-4460
    • (2005) J Immunol , vol.174 , pp. 4453-4460
    • Abreu, M.T.1    Fukata, M.2    Arditi, M.3
  • 57
    • 0037417315 scopus 로고    scopus 로고
    • Microbiology: Gut defence
    • Ganz T. Microbiology: Gut defence. Nature 422 (2003) 478-479
    • (2003) Nature , vol.422 , pp. 478-479
    • Ganz, T.1
  • 58
    • 16844382886 scopus 로고    scopus 로고
    • Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease
    • Wehkamp J., Schmid M., Fellermann K., and Stange E.F. Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease. J Leukoc Biol 77 (2005) 460-465
    • (2005) J Leukoc Biol , vol.77 , pp. 460-465
    • Wehkamp, J.1    Schmid, M.2    Fellermann, K.3    Stange, E.F.4
  • 59
    • 2442484929 scopus 로고    scopus 로고
    • Effects of cytokines and heat shock on defensin levels of cultured keratinocytes
    • Bick R.J., Poindexter B.J., Bhat S., Gulati S., Buja M., and Milner S.M. Effects of cytokines and heat shock on defensin levels of cultured keratinocytes. Burns 30 (2004) 329-333
    • (2004) Burns , vol.30 , pp. 329-333
    • Bick, R.J.1    Poindexter, B.J.2    Bhat, S.3    Gulati, S.4    Buja, M.5    Milner, S.M.6
  • 60
    • 33644749261 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa- and IL-1beta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1
    • Wehkamp K., Schwichtenberg L., Schroder J.M., and Harder J. Pseudomonas aeruginosa- and IL-1beta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1. J Invest Dermatol 126 (2006) 121-127
    • (2006) J Invest Dermatol , vol.126 , pp. 121-127
    • Wehkamp, K.1    Schwichtenberg, L.2    Schroder, J.M.3    Harder, J.4
  • 62
    • 33749038364 scopus 로고    scopus 로고
    • A new look at Crohn's disease: breakdown of the mucosal antibacterial defense
    • Wehkamp J., and Stange E.F. A new look at Crohn's disease: breakdown of the mucosal antibacterial defense. Ann N Y Acad Sci 1072 (2006) 321-331
    • (2006) Ann N Y Acad Sci , vol.1072 , pp. 321-331
    • Wehkamp, J.1    Stange, E.F.2
  • 63
    • 33644849605 scopus 로고    scopus 로고
    • NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2
    • Voss E., Wehkamp J., Wehkamp K., Stange E.F., Schroder J.M., and Harder J. NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. J Biol Chem 281 (2006) 2005-2011
    • (2006) J Biol Chem , vol.281 , pp. 2005-2011
    • Voss, E.1    Wehkamp, J.2    Wehkamp, K.3    Stange, E.F.4    Schroder, J.M.5    Harder, J.6
  • 64
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    • Wehkamp J., Harder J., Weichenthal M., et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 53 (2004) 1658-1664
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 65
    • 0142026070 scopus 로고    scopus 로고
    • Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis
    • Wehkamp J., Harder J., Weichenthal M., et al. Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 9 (2003) 215-223
    • (2003) Inflamm Bowel Dis , vol.9 , pp. 215-223
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 66
    • 0028972499 scopus 로고
    • Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
    • Hermiston M.L., and Gordon J.I. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 270 (1995) 1203-1207
    • (1995) Science , vol.270 , pp. 1203-1207
    • Hermiston, M.L.1    Gordon, J.I.2
  • 67
    • 20444486755 scopus 로고    scopus 로고
    • GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells
    • Barnich N., Hisamatsu T., Aguirre J.E., Xavier R., Reinecker H.C., and Podolsky D.K. GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. J Biol Chem 280 (2005) 19021-19026
    • (2005) J Biol Chem , vol.280 , pp. 19021-19026
    • Barnich, N.1    Hisamatsu, T.2    Aguirre, J.E.3    Xavier, R.4    Reinecker, H.C.5    Podolsky, D.K.6
  • 68
    • 0027161142 scopus 로고
    • Permeability in Crohn's disease: altered barrier functions in healthy relatives?
    • Hollander D. Permeability in Crohn's disease: altered barrier functions in healthy relatives?. Gastroenterology 104 (1993) 1848-1851
    • (1993) Gastroenterology , vol.104 , pp. 1848-1851
    • Hollander, D.1
  • 69
    • 0027185977 scopus 로고
    • Intestinal permeability compared in pediatric and adult patients with inflammatory bowel disease
    • Issenman R.M., Jenkins R.T., and Radoja C. Intestinal permeability compared in pediatric and adult patients with inflammatory bowel disease. Clin Invest Med 16 (1993) 187-196
    • (1993) Clin Invest Med , vol.16 , pp. 187-196
    • Issenman, R.M.1    Jenkins, R.T.2    Radoja, C.3
  • 70
    • 0032991667 scopus 로고    scopus 로고
    • Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease?
    • Soderholm J.D., Peterson K.H., Olaison G., et al. Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease?. Gastroenterology 117 (1999) 65-72
    • (1999) Gastroenterology , vol.117 , pp. 65-72
    • Soderholm, J.D.1    Peterson, K.H.2    Olaison, G.3
  • 72
    • 0030823372 scopus 로고    scopus 로고
    • Clustering of increased small intestinal permeability in families with Crohn's disease
    • Peeters M., Geypens B., Claus D., et al. Clustering of increased small intestinal permeability in families with Crohn's disease. Gastroenterology 113 (1997) 802-807
    • (1997) Gastroenterology , vol.113 , pp. 802-807
    • Peeters, M.1    Geypens, B.2    Claus, D.3
  • 73
    • 33646246756 scopus 로고    scopus 로고
    • Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease
    • D'Inca R., Annese V., di Leo V., et al. Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease. Aliment Pharmacol Ther 23 (2006) 1455-1461
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1455-1461
    • D'Inca, R.1    Annese, V.2    di Leo, V.3
  • 74
    • 33144473772 scopus 로고    scopus 로고
    • Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?
    • Buhner S., Buning C., Genschel J., et al. Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?. Gut 55 (2006) 342-347
    • (2006) Gut , vol.55 , pp. 342-347
    • Buhner, S.1    Buning, C.2    Genschel, J.3
  • 75
    • 4344609471 scopus 로고    scopus 로고
    • Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair
    • Finch P.W., and Rubin J.S. Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Adv Cancer Res 91 (2004) 69-136
    • (2004) Adv Cancer Res , vol.91 , pp. 69-136
    • Finch, P.W.1    Rubin, J.S.2
  • 76
    • 2542465864 scopus 로고    scopus 로고
    • Probiotic effects on experimental graft-versus-host disease: let them eat yogurt
    • Gerbitz A., Schultz M., Wilke A., et al. Probiotic effects on experimental graft-versus-host disease: let them eat yogurt. Blood 103 (2004) 4365-4367
    • (2004) Blood , vol.103 , pp. 4365-4367
    • Gerbitz, A.1    Schultz, M.2    Wilke, A.3
  • 77
    • 33646591889 scopus 로고    scopus 로고
    • Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination
    • Holler E., Rogler G., Brenmoehl J., et al. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 107 (2006) 4189-4193
    • (2006) Blood , vol.107 , pp. 4189-4193
    • Holler, E.1    Rogler, G.2    Brenmoehl, J.3
  • 78
    • 20444440307 scopus 로고    scopus 로고
    • Can NOD2/CARD15 mutations predict intestinal graft-versus-host disease and aid our understanding of Crohn's disease?
    • Rogler G., and Holler E. Can NOD2/CARD15 mutations predict intestinal graft-versus-host disease and aid our understanding of Crohn's disease?. Nat Clin Pract Gastroenterol Hepatol 1 (2004) 62-63
    • (2004) Nat Clin Pract Gastroenterol Hepatol , vol.1 , pp. 62-63
    • Rogler, G.1    Holler, E.2
  • 79
    • 3242771408 scopus 로고    scopus 로고
    • Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation
    • Holler E., Rogler G., Herfarth H., et al. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 104 (2004) 889-894
    • (2004) Blood , vol.104 , pp. 889-894
    • Holler, E.1    Rogler, G.2    Herfarth, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.