Can NOD2/CARD15 mutations predict intestinal graft-versus-host disease and aid our understanding of Crohn's disease?

Nature Clinical Practice Gastroenterology and Hepatology

Volumn 1, Issue 2, 2004, Pages 62-63

  Rogler, Gerhard ^a   Holler, Ernst ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANTIGEN PRESENTING CELL; CROHN DISEASE; GENE IDENTIFICATION; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOMODULATION; INTESTINE MUCOSA; PATHOPHYSIOLOGY; PREDICTION; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE ACTIVATION;

CROHN DISEASE; GRAFT VS HOST DISEASE; HUMANS; INTESTINE, SMALL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTATION; NOD2 SIGNALING ADAPTOR PROTEIN; ORGAN TRANSPLANTATION;

EID: 20444440307     PISSN: 17434378     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncpgasthep0042     Document Type: Review

References (10)

1. Reddy P and Ferrara JL (2003) Immunobiology of acute graft-versus-host disease. Blood Rev 17: 187-194
2. Piguet PF et al. (1987) Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs-host disease. J Exp Med 166: 1280-1289
3. Murai M et al. (2003) Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction, Nat Immunol 4: 154-160
4. Lin MT et al. (2003) Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. N Engl J Med 349: 2201-2210
5. Hugot JP et al. (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411: 599-603
6. Cho JH (2001) The Nod2 gene in Crohn's disease: implications for future research into the genetics and immunology of Crohn's disease. Inflamm Bowel Dis 7: 271-275
7. Lala S et al. (2003) Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology 125: 47-57
8. Holler E et al. (2004) Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 104: 889-894
9. Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-808
10. Kashyap A and Forman SJ (1998) Autologous bone marrow transplantation for non-Hodgkin's lymphoma resulting in long-term remission of coincidental Crohn's disease. Br J Haematol 103: 651-652