A peptidomimetic antagonist of the αvβ3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo

Journal of Clinical Investigation

Volumn 99, Issue 9, 1997, Pages 2284-2292

  Engleman, V Wayne ^a   Nickols, G Allen ^a   Ross, F Patrick ^b   Horton, Michael A ^c   Griggs, David W ^a   Settle, Steven L ^a   Ruminski, Peter G ^a   Teitelbaum, Steven L ^b,d  

^a PFIZER INC   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

^d BARNES JEWISH HOSPITAL   (United States)

Author keywords

integrin; osteoclasts; osteoporosis; peptidomimetic

Indexed keywords

INTEGRIN; PEPTIDE DERIVATIVE; PROPIONIC ACID DERIVATIVE; SC 56631; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MATRIX; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG URINE LEVEL; ESTROGEN DEFICIENCY; FEMALE; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; RAT;

EID: 0030924375     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119404     Document Type: Article

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