Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: Discovery of TR-14035, a dual α4β7/α4β1 integrin antagonist

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 6, 2002, Pages 2051-2066

  Sircar, Ila ^a   Gudmundsson, Kristjan S ^a   Martin, Richard ^a   Liang, Jimmy ^a   Nomura, Sumihiro ^a   Jayakumar, Honnappa ^a   Teegarden, Bradley R ^a   Nowlin, Dawn M ^a   Cardarelli, Pina M ^a   Mah, Jason R ^a   Connell, Samuel ^a   Griffith, Ronald C ^a   Lazarides, Elias ^a  

^a Tanabe Research Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4BETA7 INTEGRIN; INTEGRIN; N (2,6 DICHLOROBENZOYL) 4 (2,6 DIMETHOXYPHENYL)PHENYLALANINE; N (4 CARBOXY 2,6 DICHLOROBENZOYL) 4 (2,6 DIMETHOXYPHENYL)PHENYLALANINE; PHENYLALANINE DERIVATIVE; PROTEIN INHIBITOR; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4; DRUG DERIVATIVE; INTEGRIN ALPHA4BETA7; N (2,6 DICHLOROBENZOYL) 4 (2',6' BISMETHOXYPHENYL)PHENYLALANINE; N-(2,6-DICHLOROBENZOYL)-4-(2',6'-BISMETHOXYPHENYL)PHENYLALANINE; PHENYLALANINE;

ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION; CELL ADHESION; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; LEUKEMIA CELL LINE; SYNTHESIS;

CELL ADHESION; HUMANS; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHA4BETA1; INTEGRINS; JURKAT CELLS; MOLECULAR STRUCTURE; PHENYLALANINE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0036009903     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00021-4     Document Type: Article

References (39)