Isoxazolines as potent antagonists of the integrin α(v)β3

Journal of Medicinal Chemistry

Volumn 43, Issue 1, 2000, Pages 27-40

  Pitts, William J ^a,b   Wityak, John ^a,b   Smallheer, Joanne M ^a   Tobin, A Ewa ^a   Jetter, James W ^a   Buynitsky, Jennifer S ^a   Harlow, Patricia P ^a   Solomon, Kimberly A ^a   Corjay, Martha H ^a   Mousa, Shaker A ^a   Wexler, Ruth R ^a   Jadhav, Prabhakar K ^a  

^a DUPONT COMPANY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4,6 TRIMETHYLBENZENESULFONYLAMINO) 3 [5 [4 (IMIDAZOL 2 YLAMINO) 4 OXO 3 AZABUTYL]ISOXAZOLIN 3 YL]AMINOPROPIONIC ACID TRIFLUOROACETATE; 2 (2,4,6 TRIMETHYLPHENYLSULFONYLAMINO) 3 [5 [4 (IMIDAZOL 2 YLAMINO) 4 OXOBUTYL]ISOXAZOLIN 3 YLCARBONYL]AMINOPROPIONIC ACID TRIFLUOROACETATE; FIBRINOGEN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; DRUG EFFECT; DRUG POTENCY; HUMAN; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION;

BETA-ALANINE; CELL ADHESION; CELL MOVEMENT; CHEMOTAXIS; GUANIDINES; HUMANS; HYPERPLASIA; ISOXAZOLES; KIDNEY; PLATELET AGGREGATION; RECEPTORS, VITRONECTIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VITRONECTIN;

EID: 0034642555     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9900321     Document Type: Article

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