Evidence for a deep pore activation gate in small conductance Ca 2+-activated K+ channels

Journal of General Physiology

Volumn 130, Issue 6, 2007, Pages 601-610

  Bruening Wright, Andrew ^a   Lee, Wei Sheng ^a   Adelman, John P ^a   Maylie, James ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOETHYL METHANETHIOSULFONATE; BARIUM; CALCIUM ACTIVATED POTASSIUM CHANNEL; CYSTEINE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTROPHYSIOLOGY; NONHUMAN;

AMINO ACID SEQUENCE; ANIMALS; BARIUM; CADMIUM; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; DATA INTERPRETATION, STATISTICAL; DNA; ETHYL METHANESULFONATE; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POTASSIUM CHANNEL BLOCKERS; QUATERNARY AMMONIUM COMPOUNDS; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 36549082819     PISSN: 00221295     EISSN: 00221295     Source Type: Journal    
DOI: 10.1085/jgp.200709828     Document Type: Article

References (48)

1. Armstrong, C.M. 1971. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J. Gen. Physiol. 58:413-437.
2. Armstrong, C.M. 1974. Ionic pores, gates, and gating currents. Q. Rev. Biophys. 7:179-210.
3. Armstrong, C.M., and B. Hille. 1972. The inner quaternary ammonium ion receptor in potassium channels of the node of Ranvier. J. Gen. Physiol. 59:388-400.
4. Bond, C.T., J. Maylie, and J.P. Adelman. 2005. SK channels in excitability, pacemaking and synaptic integration. Curr. Opin. Neurobiol. 15:305-311.
5. + channels. J. Neurosci. 22:6499-6506.
6. Contreras, J.E., and M. Holmgren. 2006. Access of quaternary ammonium blockers to the internal pore of cyclic nucleotide-gated channels: implications for the location of the gate. J. Gen. Physiol. 127:481-494.
7. Cordero-Morales, J.F., L.G. Cuello, and E. Perozo. 2006a. Voltage-dependent gating at the KcsA selectivity filter. Nat. Struct. Mol. Biol. 13:319-322.
8. Cordero-Morales, J.F., L.G. Cuello, Y. Zhao, V. Jogini, D.M. Cortes, B. Roux, and E. Perozo. 2006b. Molecular determinants of gating at the potassium-channel selectivity filter. Nat. Struct. Mol. Biol. 13:311-318.
9. + channel. Neuron. 32:649-656.
10. + channel and its structural implications. Nature. 403:321-325.
11. + conduction and selectivity. Science. 280:69-77.
12. Fabiato, A., and F. Fabiato. 1979. Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J. Physiol. 75:463-505.
13. Flynn, G.E., and W.N. Zagotta. 2001. Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channels. Neuron. 30:689-698.
14. + channel. Biophys. J. 74:1808-1820.
15. + channels by calcium. J. Gen. Physiol. 111:565-581.
16. Ho, S.N., H.D. Hunt, R.M. Horton, J.K. Pullen, and L.R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene. 77:51-59.
17. + channel can be trapped in the open state by an intersubunit metal bridge. Neuron. 21:617-621.
18. + channels: evidence for a trap door mechanism of activation gating. J. Gen. Physiol. 109:527-535.
19. Jiang, Y., and R. MacKinnon. 2000. The barium site in a potassium channel by x-ray crystallography. J. Gen. Physiol. 115:269-272.
20. Jiang, Y., A. Lee, J. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002a. Crystal structure and mechanism of a calcium-gated potassium channel. Nature. 417:515-522.
21. Jiang, Y., A. Lee, J. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002b. The open pore conformation of potassium channels. Nature. 417:523-526.
22. 2+-activated potassium channels. J. Neurosci. 19:8830-8838.
23. Klein, H., L. Garneau, U. Banderali, M. Simoes, L. Parent, and R. Sauve. 2007. Structural determinants of the closed KCa3.1 channel pore in relation to channel gating: results from a substituted cysteine accessibility analysis. J. Gen. Physiol. 129:299-315.
24. Kohler, M., B. Hirschberg, C.T. Bond, J.M. Kinzie, N.V. Marrion, J. Maylie, and J.P. Adelman. 1996. Small-conductance, calcium-activated potassium channels from mammalian brain. Science. 273:1709-1714.
25. Kuo, A., J.M. Gulbis, J.F. Antcliff, T. Rahman, E.D. Lowe, J. Zimmer, J. Cuthbertson, F.M. Ashcroft, T. Ezaki, and D.A. Doyle. 2003. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science. 300:1922-1926.
26. Kuo, A., C. Domene, L.N. Johnson, D.A. Doyle, and C. Venien-Bryan. 2005. Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography. Structure. 13:1463-1472.
27. Liu, J., and S.A. Siegelbaum. 2000. Change of pore helix conformational state upon opening of cyclic nucleotide-gated channels. Neuron. 28:899-909.
28. + channel. Neuron. 19:175-184.
29. + channel. J. Gen. Physiol. 92:569-586.
30. Neyton, J., and C. Miller. 1988b. Potassium blocks barium permeation through a calcium-activated potassium channel. J. Gen. Physiol. 92:549-567.
31. +-channel activation gating. Science. 285:73-78.
32. + channels. Neuron. 37:953-962.
33. Proks, P., J.F. Antcliff, and F.M. Ashcroft. 2003. The ligand-sensitive gate of a potassium channel lies close to the selectivity filter. EMBO Rep. 4:70-75.
34. Rothberg, B.S., K.S. Shin, P.S. Phale, and G. Yellen. 2002. Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel. J. Gen. Physiol. 119:83-91.
35. 2+/calmodulin. Nature. 410:1120-1124.
36. Shin, K.S., B.S. Rothberg, and G. Yellen. 2001. Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate. J. Gen. Physiol. 117:91-101.
37. + channels rendered by intracellular divalent cation blockade. Biophys. J. 80:2207-2215.
38. + channel and its role in determining current-voltage relationship. Biophys. J. 83:2528-2538.
39. + channel. Neuron. 38:61-67.
40. + permeability. J. Gen. Physiol. 114:365-376.
41. Wilkens, C.M., and R.W. Aldrich. 2006. State-independent block of BK channels by an intracellular quaternary ammonium. J. Gen. Physiol. 128:347-364.
42. Xia, X.M., B. Fakler, A. Rivard, G. Wayman, T. Johnson-Pais, J.E. Keen, T. Ishii, B. Hirschberg, C.T. Bond, S. Lutsenko, et al. 1998. Mechanism of calcium gating in small-conductance calcium-activated potassium channels. Nature. 395:503-507.
43. 2+ channel. J. Gen. Physiol. 126:205-212.
44. Yellen, G. 2002. The voltage-gated potassium channels and their relatives. Nature. 419:35-42.
45. + channels; a molecular switch for electrical signaling. Neuron. 41:859-865.
46. Zheng, J., and F.J. Sigworth. 1997. Selectivity changes during activation of mutant Shaker potassium channels. J. Gen. Physiol. 110:101-117.
47. Zheng, J., and F.J. Sigworth. 1998. Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels. J. Gen. Physiol. 112:457-474.
48. + channel- Fab complex at 2.0 Å resolution. Nature. 414:43-48.