Thymic involution implications for self-tolerance

Methods in Molecular Biology

Volumn 380, Issue , 2007, Pages 377-390

  Hakim, Frances T ^a   Gress, Ronald E ^a  

^a NONE

Author keywords

Immune reconstitution; Involution; Regulatory T cells; Thymopoiesis

Indexed keywords

ANIMAL; ARTICLE; CYTOLOGY; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; PATHOLOGY; PHYSIOLOGY; REGULATORY T LYMPHOCYTE; THYMUS;

ANIMALS; HUMANS; SELF TOLERANCE; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND;

EID: 36549069125     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1385/1-59745-395-1:377     Document Type: Article

References (57)

1. Wing, K., Ekmark, A., Karlsson, H., Rudin, A., and Suri-Payer, E. (2002) Characterization of human CD25+ CD4+ T cells in thymus, cord and adult blood. Immunol. 106, 190-199.
2. Wing, K., Larsson, P., Sandstrom, K., Lundin, S. B., Suri-Payer, E., and Rudin, A. (2005) CD4+ CD25+ FOXP3+ regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses. Immunol. 115, 516-525.
3. Anderson, M. S., Venanzi, E. S., Chen, Z., Berzins, S .P., Benoist, C., and Mathis, D. (2005) The cellular mechanism of Aire control of T cell tolerance. Immunity 23, 227-239.
4. Sakaguchi, S. (2005) Naturally arising Foxp3-expressing CD25(+)CD4(+) regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6, 345-352.
5. Shen, S., Ding, Y., Tadokoro, C. E., et al. (2005) Control of homeostatic proliferation by regulatory T cells. J Clin. Invest. 115, 3517-3526.
6. King, C., Ilic, A., Koelsch, K., and Sarvetnick, N. (2004) Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 117, 265-277.
7. Mackali, C. L., Fleisher, T. A., Brown, M. R., et al. (1995) Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N. Engl. J. Med. 332, 143-149.
8. McCune, J. M., Loftus, R., Schmidt, D. K., et al. (1998) High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J. Clin. Invest. 101, 2301-2308.
9. Hakim, F T., Memon, S. A., Cepeda, R., et al. (2005) Age-dependent incidence, time course, and consequences of thymic renewal in adults. J Clin. Invest. 115, 930-939.
10. Haynes, B. F., Marke, M. L., Sempowski, G. D., Patel, D. D., and Hale, L. P. (2000) The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu. Rev. Immunol. 18, 529-560.
11. Brelinska, R. (2003) Thymic epithelial cells in age-dependent involution. Microscopy Res. Technique 62, 488-500.
12. Shiraishi, J., Utsuyama, M., Seki, S., et al. (2003) Essential microenvironment for thymopoiesis is preserved in human adult and aged thymus. Clin. Dev. Immunol. 10, 53-59.
13. Mackali, C. L., Punt, J. A., Morgan, P., Farr, A. G., and Gress, R. E. (1998) Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution. Eur. J. Immunol. 28, 1886-1893.
14. Douek, D. C. and Koup, R. A. (2000) Evidence for thymic function in the elderly. Vaccine 18, 1638-1641.
15. Jamieson, B. D., Douek, D. C., Killian, S., et al. (1999) Generation of functional thymocytes in the human adult. Immunity 10, 569-575.
16. Douek, D. C., McFarland, R. D., Keiser, P. H., et al. (1998) Changes in thymic function with age and during the treatment of HIV infection. Nature 396, 690-695.
17. Dion, M. L., Poulin, J. F., Bordi, R., et al. (2004) HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation. Immunity 21, 757-768.
18. Schwab, R., Szabo, P., Manavalan, J. S., et al. (1997) Expanded CD4+ and CD8+ T cell clones in elderly humans. J Immunol. 158, 4493-4499.
19. Ouyang, Q., Wagner, W. M., Walter, S., et al. (2003) An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant EpsteinBarr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Mech. Ageing Dev. 124, 477-485.
20. Ouyang, Q., Wagner, W. M., Wikby, A., et al. (2003) Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J. Clin. Immunol. 23, 247-257.
21. Maèkali, C. L., Bare, C. V., Granger, L. A., Sharrow, S. O., Titus, J. A., and Gress, R. E. (1996) Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J. Immunol. 156, 4609-4616.
22. Goldrath, A. W., Bogatzki, L. Y., and Bevan, M. J. (2000) Naïve T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J Exp. Med. 192, 557-564.
23. Tough, D. F and Sprent, J. (1994) Turnover of naïve- and memory-phenotype T cells. J Exp. Med. 179, 1127-1135.
24. Geginat, J., Lanzavecchia, A., and Sallusto, F (2003) Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. Blood 101, 4260-4266.
25. Geginat, J., Sallusto, F., and Lanzavecchia, A. (2001) Cytokine-driven proliferation and differentiation of human naïve, central memory, and effector memory CD4(+) T cells. J Exp. Med. 194, 1711-1719.
26. Fry, T. J. and Mackall, C. L. (2005) The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J. Immunol. 174, 6571-6576.
27. Beyer, M., Kochanek, M., Giese, T., et al. (2006) In vivo peripheral expansion of naive CD4+CD25high FOXP3+ regulatory T cells in patients with multiple myeloma. Blood 107, 3940-3949.
28. Seddiki, N., Santner-Nanan, B., Tangye, S. G., et al. (2006) Persistence of naïve CD45RA+ regulatory T cells in adult life. Blood 107, 2830-2838.
29. Beyer, M., Kochanek, M., Darabi, K., et al. (2005) Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood 106, 2018-2025.
30. Walker, M. R., Kasprowicz, D. J., Gersuk, V. H., et al. (2003) Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J Clin. Invest. 112, 1437-1443.
31. Gregg, R., Smith, C. M., Clark, F. J., et al. (2005) The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age. Clin. Exp. Immunol. 140, 540-546.
32. Tsaknaridis, L., Spencer, L., Culbertson, N., et al. (2003) Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity. J. Neurosci. Res. 74, 296-308.
33. French, R. A., Broussard, S. R., Meier, W. A., et al. (2002) Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution. Endocrinol. 143, 690-699.
34. Vigano, A., Saresella, M., Trabattoni, D., et al. (2004) Growth hormone in T-lymphocyte thymic and postthymic development: a study in HIV-infected children. J Pediatr. 145, 542-548.
35. Napolitano, L. A., Lo, J. C., Gotway, M. B., et al. (2002) Increased thymic mass and circulating naïve CD4 T cells in HIV-I-infected adults treated with growth hormone. Aids 16, 1103-1111.
36. Leposavic, G., Obradovic, S., Kosec, D., Pejcic-Karapetrovic, B., and VidicDankovic, B. (2001) In vivo modulation of the distribution of thymocyte subsets by female sex steroid hormones. Int. Immunopharmacol. 1, 1-12.
37. Greenstein, B. D., Fitzpatrick, F. T., Adcock, I. M., Kendall, M. D., and Wheeler, M. J. (1986) Reappearance of the thymus in old rats after orchidectomy: inhibition of regeneration by testosterone. J. Endocrinol. 110, 417-422.
38. Windmill, K. F and Lee, V. W. (1998) Effects of castration on the lymphocytes of the thymus, spleen and lymph nodes. Tissue Cell 30, 104-111.
39. Sutherland, J. S., Goldberg, G. L., Hammett, M. V., et al. (2005) Activation of thymic regeneration in mice and humans following androgen blockade. J Immunol. 175, 2741-2753.
40. Peschon, J. J., Morrissey, P. J., Grabstein, K. H., et al. (1994) Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180, 1955-1960.
41. Phillips, J. A., Brondstetter, T. I., English, C. A., Lee, H. E., Virts, E. L., and Thoman, M. L. (2004) IL-7 gene therapy in aging restores early thymopoiesis without reversing involution. J. Immunol. 173, 4867-4874.
42. Andrew, D. and Aspinall, R. (2002) Age-associated thymic atrophy is linked to a decline in IL-7 production. Exp. Gerontol. 37, 455-463.
43. Ortman, C. L., Dittmar, K. A., Witte, P. L., and Le, P. T (2002) Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments. Int. Immunol. 14, 813-822.
44. Sempowski, G. D., Hale, L. P., Sundy, J. S., et al. (2000) Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J. Immunol. 164, 2180-2187.
45. Talvensarri, K., Clave, E., Douay, C., et al. (2002) A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation. Blood 99, 1458-1464.
46. Sharp, A., Kukulansky, T., and Globerson, A. (1990) In vitro analysis of agerelated-changes in the developmental potential of bone-marrow thymocyte progenitors. Eur. J. Immunol. 20, 2541-2546.
47. Hirokawa, K., Kubo, S., Utsuyama, M., Kurashima, C., and Sado, T (1986) Agerelated change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice. Cell. Immunol. 100, 443-451.
48. Min, H., Montecino-Rodriguez, E., and Dorshkind, K. (2004) Reduction in the developmental potential of intrathymic T cell progenitors with age. J. Immunol. 173, 245-250.
49. Foss, D. L., Donskoy, E., and Goldschneider, I. (2001) The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice. J Exp. Med. 193, 365-374.
50. Prockop, S. E. and Petrie, H. T (2004) Regulation of thymus size by competition for stromal niches among early T cell progenitors. J. Immunol. 173, 1604-1611.
51. Almeida, A. R., Borghans, J. A., and Freitas, A. A. (2001) T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J. Exp. Med. 194, 591-599.
52. Douek, D. C., Vescio, R. A., Betts, M. R., et al. (2000) Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet 355, 1875-1881.
53. Kolte, L., Strandberg, C., Dreves, A. M., et al. (2002) Thymic involvement in immune recovery during antiretroviral treatment of HIV infection in adults; comparison of CT and sonographic findings. Scand. J. Infect. Dis. 34, 668-672.
54. Dumont-Girard, F., Roux, E., van Lier, R. A., et al. (1998) Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants. Blood 92, 4464-4471.
55. Hakim, F. T., Cepeda, R., Kaimei, S., et al. (1997) Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood 90, 3789-3798.
56. Muraro, P. A., Douek, D. C., Packer, A., et al. (2005) Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. J. Exp. Med. 201, 805-816.
57. Zhang, H., Chua, K. S., Guimond, M., et al. (2005) Lymphopenia and interleukin2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. Nat. Med. 11, 1238-1243.