메뉴 건너뛰기




Volumn 98, Issue 5, 2007, Pages 944-951

Adrenomedullin and endothelial barrier function

Author keywords

Adrenomedullin; Endothelium; Inflammation; Permeability; Sepsis

Indexed keywords

ADRENOMEDULLIN; CALCITONIN RECEPTOR LIKE RECEPTOR; CYCLIC AMP; PROCOAGULANT; PROTEIN ZO1; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; RECEPTOR ACTIVITY MODIFYING PROTEIN 3;

EID: 36049023200     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH07-02-0128     Document Type: Article
Times cited : (97)

References (151)
  • 1
    • 33645553318 scopus 로고    scopus 로고
    • Endothelial tight junctions: Permeable barriers of the vessel wall
    • Bazzoni G. Endothelial tight junctions: permeable barriers of the vessel wall. Thromb Haemost 2006; 95: 36-42.
    • (2006) Thromb Haemost , vol.95 , pp. 36-42
    • Bazzoni, G.1
  • 2
    • 0034168402 scopus 로고    scopus 로고
    • Microvascular dysfunction in sepsis
    • Lush CW, Kvietys PR. Microvascular dysfunction in sepsis. Microcirculation 2000; 7: 83-101.
    • (2000) Microcirculation , vol.7 , pp. 83-101
    • Lush, C.W.1    Kvietys, P.R.2
  • 3
    • 33644839612 scopus 로고    scopus 로고
    • Signaling mechanisms regulating endothelial permeability
    • Mehta D, Malik AB. Signaling mechanisms regulating endothelial permeability. Physiol Rev 2006; 86: 279-367.
    • (2006) Physiol Rev , vol.86 , pp. 279-367
    • Mehta, D.1    Malik, A.B.2
  • 4
    • 0042845698 scopus 로고    scopus 로고
    • Targets for pharmacological intervention of endothelial hyperpermeability and barrier function
    • Nieuw Amerongen GP, van Hinsbergh VW. Targets for pharmacological intervention of endothelial hyperpermeability and barrier function. Vascul Pharmacol 2002; 39: 257-272.
    • (2002) Vascul Pharmacol , vol.39 , pp. 257-272
    • Nieuw Amerongen, G.P.1    van Hinsbergh, V.W.2
  • 6
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348: 138-150.
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 7
    • 0034123126 scopus 로고    scopus 로고
    • Endothelium function in sepsis
    • Volk T, Kox WJ. Endothelium function in sepsis. Inflamm Res 2000; 49: 185-198.
    • (2000) Inflamm Res , vol.49 , pp. 185-198
    • Volk, T.1    Kox, W.J.2
  • 8
    • 0037247739 scopus 로고    scopus 로고
    • Interaction of pathogens with the endothelium
    • Hippenstiel S, Suttorp, N. Interaction of pathogens with the endothelium. Thromb Haemost 2003; 89: 18-24.
    • (2003) Thromb Haemost , vol.89 , pp. 18-24
    • Hippenstiel, S.1    Suttorp, N.2
  • 9
    • 15244341423 scopus 로고    scopus 로고
    • Epithelial barrier dysfunction: A unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level
    • Fink MP, Delude RL. Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit Care Clin 2005; 21: 177-196.
    • (2005) Crit Care Clin , vol.21 , pp. 177-196
    • Fink, M.P.1    Delude, R.L.2
  • 10
    • 33750514400 scopus 로고    scopus 로고
    • Mechanisms of acute lung injury/acute respiratory distress syndrome
    • Suratt BT, Parsons PE. Mechanisms of acute lung injury/acute respiratory distress syndrome. Clin Chest Med 2006; 27: 579-589.
    • (2006) Clin Chest Med , vol.27 , pp. 579-589
    • Suratt, B.T.1    Parsons, P.E.2
  • 11
    • 4644293107 scopus 로고    scopus 로고
    • Pulmonary endothelium in acute lung injury: From basic science to the critically ill
    • Orfanos SE, Mavrommati I, Korovesi I, et al. Pulmonary endothelium in acute lung injury: from basic science to the critically ill. Intensive Care Med 2004; 30: 1702-1714.
    • (2004) Intensive Care Med , vol.30 , pp. 1702-1714
    • Orfanos, S.E.1    Mavrommati, I.2    Korovesi, I.3
  • 12
    • 0037764069 scopus 로고    scopus 로고
    • Fluid therapy in sepsis with capillary leakage
    • Marx G. Fluid therapy in sepsis with capillary leakage. Eur J Anaesthesiol 2003; 20: 429-442.
    • (2003) Eur J Anaesthesiol , vol.20 , pp. 429-442
    • Marx, G.1
  • 13
    • 0036316548 scopus 로고    scopus 로고
    • Blood-brain barrier breakdown in septic encephalopathy and brain tumours
    • Davies DC. Blood-brain barrier breakdown in septic encephalopathy and brain tumours. J Anat 2002; 200: 639-646.
    • (2002) J Anat , vol.200 , pp. 639-646
    • Davies, D.C.1
  • 14
    • 0033962411 scopus 로고    scopus 로고
    • Inflammatory mediators and modulation of blood-brain barrier permeability
    • Abbott NJ. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol Neurobiol 2000; 20: 131-147.
    • (2000) Cell Mol Neurobiol , vol.20 , pp. 131-147
    • Abbott, N.J.1
  • 15
    • 0030958851 scopus 로고    scopus 로고
    • Endothelial permeability for macromolecules. Mechanistic aspects of pathophysiological modulation
    • van Hinsbergh WM. Endothelial permeability for macromolecules. Mechanistic aspects of pathophysiological modulation. Arterioscler Thromb Vasc Biol 1997; 17: 1018-1023.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 1018-1023
    • van Hinsbergh, W.M.1
  • 16
    • 3042590902 scopus 로고    scopus 로고
    • Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis
    • Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev 2004; 84: 869-901.
    • (2004) Physiol Rev , vol.84 , pp. 869-901
    • Bazzoni, G.1    Dejana, E.2
  • 17
    • 0030751655 scopus 로고    scopus 로고
    • Occludin as a possible determinant of tight junction permeability in endothelial cells
    • Hirase T, Staddon JM, Saitou M, et al. Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci 1997; 110: 1603-1613.
    • (1997) J Cell Sci , vol.110 , pp. 1603-1613
    • Hirase, T.1    Staddon, J.M.2    Saitou, M.3
  • 18
    • 33751546663 scopus 로고    scopus 로고
    • Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts
    • Orlova VV, Economopoulou M, Lupu F, et al. Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts. J Exp Med 2006; 203: 2703-2714.
    • (2006) J Exp Med , vol.203 , pp. 2703-2714
    • Orlova, V.V.1    Economopoulou, M.2    Lupu, F.3
  • 19
    • 0036319020 scopus 로고    scopus 로고
    • Intracellular signalling involved in modulating human endothelial barrier function
    • van Hinsbergh VW, van Amerongen GP. Intracellular signalling involved in modulating human endothelial barrier function. J Anat 2002; 200: 549-560.
    • (2002) J Anat , vol.200 , pp. 549-560
    • van Hinsbergh, V.W.1    van Amerongen, G.P.2
  • 20
    • 0042344708 scopus 로고    scopus 로고
    • Protein kinase signaling in the modulation of microvascular permeability
    • Yuan SY. Protein kinase signaling in the modulation of microvascular permeability. Vascul Pharmacol 2002; 39: 213-223.
    • (2002) Vascul Pharmacol , vol.39 , pp. 213-223
    • Yuan, S.Y.1
  • 21
    • 0036357937 scopus 로고    scopus 로고
    • Molecular mechanisms of thrombin-induced endothelial cell permeability
    • Bogatcheva NV, Garcia JG, Verin AD. Molecular mechanisms of thrombin-induced endothelial cell permeability. Biochemistry (Mosc) 2002; 67: 75-84.
    • (2002) Biochemistry (Mosc) , vol.67 , pp. 75-84
    • Bogatcheva, N.V.1    Garcia, J.G.2    Verin, A.D.3
  • 22
    • 0035093056 scopus 로고    scopus 로고
    • Cytoskeletal effects of rho-like small guanine nucleotide-binding proteins in the vascular system
    • Nieuw Amerongen GP, van Hinsbergh VW. Cytoskeletal effects of rho-like small guanine nucleotide-binding proteins in the vascular system. Arterioscler Thromb Vasc Biol 2001; 21: 300-311.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 300-311
    • Nieuw Amerongen, G.P.1    van Hinsbergh, V.W.2
  • 23
    • 0029803695 scopus 로고    scopus 로고
    • Regulation of thrombin-mediated endothelial cell contraction and permeability
    • Garcia JG, Verin AD, Schaphorst KL. Regulation of thrombin-mediated endothelial cell contraction and permeability. Semin Thromb Hemost 1996; 22: 309-315.
    • (1996) Semin Thromb Hemost , vol.22 , pp. 309-315
    • Garcia, J.G.1    Verin, A.D.2    Schaphorst, K.L.3
  • 24
    • 0022549594 scopus 로고
    • Contractile elements in the regulation of macromolecular permeability
    • Miller FN, Sims DE. Contractile elements in the regulation of macromolecular permeability. Fed Proc 1986; 45: 84-88.
    • (1986) Fed Proc , vol.45 , pp. 84-88
    • Miller, F.N.1    Sims, D.E.2
  • 25
    • 33847029590 scopus 로고    scopus 로고
    • Involvement of microtubules, p38 and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction
    • Bogatcheva NV, Adyshev D, Mambetsariev B, et al. Involvement of microtubules, p38 and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 2006; 292: L487-499.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.292
    • Bogatcheva, N.V.1    Adyshev, D.2    Mambetsariev, B.3
  • 26
    • 21844450693 scopus 로고    scopus 로고
    • Involvement of microtabules and Rho pathway in TGF-betal-induced lung vascular barrier dysfunction
    • Birukova AA, Birukov KG, Adyshev D, et al. Involvement of microtabules and Rho pathway in TGF-betal-induced lung vascular barrier dysfunction. J Cell Physiol 2005; 204: 934-947.
    • (2005) J Cell Physiol , vol.204 , pp. 934-947
    • Birukova, A.A.1    Birukov, K.G.2    Adyshev, D.3
  • 28
    • 10044270843 scopus 로고    scopus 로고
    • Novel role of microtubules in thrombin-induced endothelial barrier dysfunction
    • Birukova AA, Birukov KG, Gmurova K, et al. Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J 2004; 18: 1879-1990.
    • (2004) FASEB J , vol.18 , pp. 1879-1990
    • Birukova, A.A.1    Birukov, K.G.2    Gmurova, K.3
  • 29
    • 4444247919 scopus 로고    scopus 로고
    • Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: Role of Rho-dependent mechanisms
    • Birukova AA, Smurova K, Birukov KG, et al. Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol 2004; 201: 55-70.
    • (2004) J Cell Physiol , vol.201 , pp. 55-70
    • Birukova, A.A.1    Smurova, K.2    Birukov, K.G.3
  • 30
    • 0038746767 scopus 로고    scopus 로고
    • The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability
    • Petrache I, Birukova A, Ramirez SI, et al. The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability. Am J Respir Cell Mol Biol 2003; 28: 574-581.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 574-581
    • Petrache, I.1    Birukova, A.2    Ramirez, S.I.3
  • 31
    • 0033982988 scopus 로고    scopus 로고
    • Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes
    • Katz J, Sambandam V, Wu JH, et al. Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes. Infect Immun 2000; 68: 1441-1449.
    • (2000) Infect Immun , vol.68 , pp. 1441-1449
    • Katz, J.1    Sambandam, V.2    Wu, J.H.3
  • 32
    • 0036120364 scopus 로고    scopus 로고
    • Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains
    • Katz J, Yang QB, Zhang P, et al. Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains. Infect Immun 2002; 70: 2512-2518.
    • (2002) Infect Immun , vol.70 , pp. 2512-2518
    • Katz, J.1    Yang, Q.B.2    Zhang, P.3
  • 33
    • 0031854869 scopus 로고    scopus 로고
    • Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins
    • Carden D, Xiao F, Moak C, et al. Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol 1998; 275: H385-H392.
    • (1998) Am J Physiol , vol.275
    • Carden, D.1    Xiao, F.2    Moak, C.3
  • 34
    • 0027748995 scopus 로고
    • Human neutrophil elastase increases permeability of cultured pulmonary endothelial cell monolayers
    • Suttorp, N, Nolte A, Wilke A, et al. Human neutrophil elastase increases permeability of cultured pulmonary endothelial cell monolayers. Int J Microcirc Clin Exp 1993; 13: 187-203.
    • (1993) Int J Microcirc Clin Exp , vol.13 , pp. 187-203
    • Suttorp, N.1    Nolte, A.2    Wilke, A.3
  • 35
    • 29144466638 scopus 로고    scopus 로고
    • Adrenomedullin treatment abolishes ileal mucosal hypoperfusion induced by Staphylococcus aureus alpha-toxin-an intravital microscopic study on an isolated rat ileum
    • Brell B, Hippenstiel S, David I, et al. Adrenomedullin treatment abolishes ileal mucosal hypoperfusion induced by Staphylococcus aureus alpha-toxin-an intravital microscopic study on an isolated rat ileum. Crit Care Med 2005; 33: 2810-2816.
    • (2005) Crit Care Med , vol.33 , pp. 2810-2816
    • Brell, B.1    Hippenstiel, S.2    David, I.3
  • 36
    • 0024996889 scopus 로고
    • Staphylococcal alpha-toxin-induced vascular leakage in isolated perfused rabbit lungs
    • Seeger W, Birkemeyer RG, Ermert L, et al. Staphylococcal alpha-toxin-induced vascular leakage in isolated perfused rabbit lungs. Lab Invest 1990; 63: 341-349.
    • (1990) Lab Invest , vol.63 , pp. 341-349
    • Seeger, W.1    Birkemeyer, R.G.2    Ermert, L.3
  • 37
    • 0024403003 scopus 로고
    • Effects of bacterial toxins and calcium-ionophores on endothelial permeability in vitro
    • Suttorp N, Hessz T, Fuchs T, et al. Effects of bacterial toxins and calcium-ionophores on endothelial permeability in vitro. Prog Clin Biol Res 1989; 308: 127-131.
    • (1989) Prog Clin Biol Res , vol.308 , pp. 127-131
    • Suttorp, N.1    Hessz, T.2    Fuchs, T.3
  • 38
    • 0023807110 scopus 로고
    • Bacterial exotoxins and endothelial permeability for water and albumin in vitro
    • Suttorp N, Hessz T, Seeger W, et al. Bacterial exotoxins and endothelial permeability for water and albumin in vitro. Am J Physiol 1988; 255: C368-C376.
    • (1988) Am J Physiol , vol.255
    • Suttorp, N.1    Hessz, T.2    Seeger, W.3
  • 39
    • 0037019988 scopus 로고    scopus 로고
    • Adrenomedullin reduces endothelial hyperpermeability
    • Hippenstiel S, Witzenrath M, Schmeck B, et al. Adrenomedullin reduces endothelial hyperpermeability. Circ Res 2002; 91: 618-625.
    • (2002) Circ Res , vol.91 , pp. 618-625
    • Hippenstiel, S.1    Witzenrath, M.2    Schmeck, B.3
  • 40
    • 0029874897 scopus 로고    scopus 로고
    • Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability
    • Suttorp N, Hippenstiel S, Fuhrmann M, et al. Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability. Am J Physiol 1996; 270: C778-C785.
    • (1996) Am J Physiol , vol.270
    • Suttorp, N.1    Hippenstiel, S.2    Fuhrmann, M.3
  • 41
    • 0024376790 scopus 로고
    • Escherichia coli hemolysin causes thromboxane-mediated hypertension and vascular leakage in rabbit lungs
    • Seeger W, Walter H, Neuhof H, et al. Escherichia coli hemolysin causes thromboxane-mediated hypertension and vascular leakage in rabbit lungs. Prog Clin Biol Res 1989; 308: 67-72.
    • (1989) Prog Clin Biol Res , vol.308 , pp. 67-72
    • Seeger, W.1    Walter, H.2    Neuhof, H.3
  • 42
    • 0029126956 scopus 로고
    • Hydrogen peroxide-induced increase in lung endothelial and epithelial permeability-effect of adenylate cyclase stimulation and phosphodiesterase inhibition
    • Seeger W, Hansen T, Rossig R, et al. Hydrogen peroxide-induced increase in lung endothelial and epithelial permeability-effect of adenylate cyclase stimulation and phosphodiesterase inhibition. Microvasc Res 1995; 50: 1-17.
    • (1995) Microvasc Res , vol.50 , pp. 1-17
    • Seeger, W.1    Hansen, T.2    Rossig, R.3
  • 43
    • 0027195164 scopus 로고
    • Role of phosphodiesterases in the regulation of endothelial permeability in vitro
    • Suttorp N, Weber U, Welsch T, et al. Role of phosphodiesterases in the regulation of endothelial permeability in vitro. J Clin Invest 1993; 91: 1421-1428.
    • (1993) J Clin Invest , vol.91 , pp. 1421-1428
    • Suttorp, N.1    Weber, U.2    Welsch, T.3
  • 44
    • 20944438000 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: Role in endothelial hyperpermeability
    • Seybold J, Thomas D, Witzenrath M, et al. Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability. Blood 2005; 105: 3569-3576.
    • (2005) Blood , vol.105 , pp. 3569-3576
    • Seybold, J.1    Thomas, D.2    Witzenrath, M.3
  • 45
    • 0027197671 scopus 로고
    • Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
    • Kitamura K, Kangawa K, Kawamoto M, et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993; 192: 553-560.
    • (1993) Biochem Biophys Res Commun , vol.192 , pp. 553-560
    • Kitamura, K.1    Kangawa, K.2    Kawamoto, M.3
  • 46
    • 0036266044 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
    • Poyner DR, Sexton PM, Marshall I, et al. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 2002; 54: 233-246.
    • (2002) Pharmacol Rev , vol.54 , pp. 233-246
    • Poyner, D.R.1    Sexton, P.M.2    Marshall, I.3
  • 47
    • 0036443430 scopus 로고    scopus 로고
    • Cell and molecular biology of the multifunctional peptide, adrenomedullin
    • Lopez J, Martinez A. Cell and molecular biology of the multifunctional peptide, adrenomedullin. Int Rev Cytol 2002; 221: 1-92.
    • (2002) Int Rev Cytol , vol.221 , pp. 1-92
    • Lopez, J.1    Martinez, A.2
  • 48
    • 1942485274 scopus 로고    scopus 로고
    • Adrenomedullin - what do we know 10 years since its discovery?
    • Beltowski J, Jamroz A. Adrenomedullin - what do we know 10 years since its discovery? Pol J Pharmacol 2004; 56: 5-27.
    • (2004) Pol J Pharmacol , vol.56 , pp. 5-27
    • Beltowski, J.1    Jamroz, A.2
  • 49
    • 0034723350 scopus 로고    scopus 로고
    • Adrenomedullin: Potential in physiology and pathophysiology
    • Jougasaki M, Burnett JC, Jr. Adrenomedullin: potential in physiology and pathophysiology. Life Sci 2000; 66: 855-872.
    • (2000) Life Sci , vol.66 , pp. 855-872
    • Jougasaki, M.1    Burnett Jr., J.C.2
  • 50
    • 15744387321 scopus 로고    scopus 로고
    • Adrenomedullin and its related peptide
    • Shimosawa T, Fujita T. Adrenomedullin and its related peptide. Endocr J 2005; 52: 1-10.
    • (2005) Endocr J , vol.52 , pp. 1-10
    • Shimosawa, T.1    Fujita, T.2
  • 51
    • 0027982529 scopus 로고
    • Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide (PAMP)
    • Kitamura K, Kangawa K, Ishiyama Y, et al. Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide (PAMP). FEB S Lett 1994; 351: 35-37.
    • (1994) FEB S Lett , vol.351 , pp. 35-37
    • Kitamura, K.1    Kangawa, K.2    Ishiyama, Y.3
  • 52
    • 0036127418 scopus 로고    scopus 로고
    • Adrenomedullin and PAMP: Discovery, structures, and cardiovascular functions
    • Kitamura K, Kangawa K, Eto T. Adrenomedullin and PAMP: discovery, structures, and cardiovascular functions. Microsc Res Tech 2002; 57: 3-13.
    • (2002) Microsc Res Tech , vol.57 , pp. 3-13
    • Kitamura, K.1    Kangawa, K.2    Eto, T.3
  • 53
    • 0034887742 scopus 로고    scopus 로고
    • Alternative splicing of the proadrenomedullin gene results in differential expression of gene products
    • Martinez A, Hodge DL, Garayoa M, et al. Alternative splicing of the proadrenomedullin gene results in differential expression of gene products. J Mol Endocrinol 2001; 27: 31-41.
    • (2001) J Mol Endocrinol , vol.27 , pp. 31-41
    • Martinez, A.1    Hodge, D.L.2    Garayoa, M.3
  • 54
    • 0031897476 scopus 로고    scopus 로고
    • Proadrenomedullin-derived peptides
    • Samson WK. Proadrenomedullin-derived peptides. Front Neuroendocrinol 1998; 19: 100-127.
    • (1998) Front Neuroendocrinol , vol.19 , pp. 100-127
    • Samson, W.K.1
  • 55
    • 4444356533 scopus 로고    scopus 로고
    • Identification of an Adrenomedullin precursor fragment in plasma of sepsis patients
    • Struck J, Tao C, Morgenthaler NG, et al. Identification of an Adrenomedullin precursor fragment in plasma of sepsis patients. Peptides 2004; 25: 1369-1372.
    • (2004) Peptides , vol.25 , pp. 1369-1372
    • Struck, J.1    Tao, C.2    Morgenthaler, N.G.3
  • 56
    • 0030060354 scopus 로고    scopus 로고
    • Vasopressor activities of N-terminal fragments of adrenomedullin in anesthetized rat
    • Watanabe TX, Itahara Y, Inui T, et al. Vasopressor activities of N-terminal fragments of adrenomedullin in anesthetized rat. Biochem Biophys Res Commun 1996; 219: 59-63.
    • (1996) Biochem Biophys Res Commun , vol.219 , pp. 59-63
    • Watanabe, T.X.1    Itahara, Y.2    Inui, T.3
  • 57
    • 33750849230 scopus 로고    scopus 로고
    • Analysis of responses to adrenomedullin-(13-52) in the pulmonary vascular bed of rats
    • Gumusel B, Hao Q, Hyman AL, et al. Analysis of responses to adrenomedullin-(13-52) in the pulmonary vascular bed of rats. Am J Physiol 1998; 274: H1255-H1263.
    • (1998) Am J Physiol , vol.274
    • Gumusel, B.1    Hao, Q.2    Hyman, A.L.3
  • 58
    • 0028116160 scopus 로고
    • Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells
    • Eguchi S, Hirata Y, Iwasaki H, et al. Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. Endocrinology 1994; 135: 2454-2458.
    • (1994) Endocrinology , vol.135 , pp. 2454-2458
    • Eguchi, S.1    Hirata, Y.2    Iwasaki, H.3
  • 59
    • 18344417422 scopus 로고    scopus 로고
    • Adrenomedullin amidation enzyme activities in hypertensive patients
    • Shimosawa T, Kanozawa K, Nagasawa R, et al. Adrenomedullin amidation enzyme activities in hypertensive patients. Hypertens Res 2000; 23: 167-171.
    • (2000) Hypertens Res , vol.23 , pp. 167-171
    • Shimosawa, T.1    Kanozawa, K.2    Nagasawa, R.3
  • 60
    • 0033591323 scopus 로고    scopus 로고
    • Secretion and clearance of the mature form of adrenomedullin in humans
    • Hirayama N, Kitamura K, Imamura T, et al. Secretion and clearance of the mature form of adrenomedullin in humans. Life Sci 1999; 64: 2505-2509.
    • (1999) Life Sci , vol.64 , pp. 2505-2509
    • Hirayama, N.1    Kitamura, K.2    Imamura, T.3
  • 61
    • 0032539746 scopus 로고    scopus 로고
    • The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma
    • Kitamura K, Kato J, Kawamoto M, et al. The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma. Biochem Biophys Res Commun 1998; 244: 551-555.
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 551-555
    • Kitamura, K.1    Kato, J.2    Kawamoto, M.3
  • 62
    • 0031768318 scopus 로고    scopus 로고
    • Regulation of adrenomedullin production in rat endothelial cells
    • Isumi Y, Shoji H, Sugo S, et al. Regulation of adrenomedullin production in rat endothelial cells. Endocrinology 1998; 139: 838-846.
    • (1998) Endocrinology , vol.139 , pp. 838-846
    • Isumi, Y.1    Shoji, H.2    Sugo, S.3
  • 63
    • 0035688323 scopus 로고    scopus 로고
    • Regulation of adrenomedullin secretion from cultured cells
    • Tomoda Y, Isumi Y, Katafuchi T, et al. Regulation of adrenomedullin secretion from cultured cells. Peptides 2001; 22: 1783-1794.
    • (2001) Peptides , vol.22 , pp. 1783-1794
    • Tomoda, Y.1    Isumi, Y.2    Katafuchi, T.3
  • 64
    • 0031663474 scopus 로고    scopus 로고
    • Induction of adrenomedullin mRNA and protein by lipopolysaccharide and paclitaxel (Taxol) in murine macrophages
    • Zaks-Zilberman M, Salkowski CA, Elsasser T, et al. Induction of adrenomedullin mRNA and protein by lipopolysaccharide and paclitaxel (Taxol) in murine macrophages. Infect Immun 1998; 66: 4669-4675.
    • (1998) Infect Immun , vol.66 , pp. 4669-4675
    • Zaks-Zilberman, M.1    Salkowski, C.A.2    Elsasser, T.3
  • 65
    • 0032997463 scopus 로고    scopus 로고
    • Adrenomedullin is upregulated in the heart and aorta during the early and late stages of sepsis
    • Zhou M, Chaudry IH, Wang P. Adrenomedullin is upregulated in the heart and aorta during the early and late stages of sepsis. Biochim Biophys Acta 1999; 1453: 273-283.
    • (1999) Biochim Biophys Acta , vol.1453 , pp. 273-283
    • Zhou, M.1    Chaudry, I.H.2    Wang, P.3
  • 66
    • 0034885177 scopus 로고    scopus 로고
    • The small intestine is an important source of adrenomedullin release during polymicrobial sepsis
    • Zhou M, Chaudry IH, Wang P. The small intestine is an important source of adrenomedullin release during polymicrobial sepsis. Am J Phygiol Regul Integr Comp Physiol 2001; 281: R654-R660.
    • (2001) Am J Phygiol Regul Integr Comp Physiol , vol.281
    • Zhou, M.1    Chaudry, I.H.2    Wang, P.3
  • 67
    • 34249781266 scopus 로고    scopus 로고
    • Gene silencing of human RAMP2 mediated by short-interfering RNA
    • Albertin G, Ruggero M, Guidolin D, et al. Gene silencing of human RAMP2 mediated by short-interfering RNA. Int J Mol Med 2006; 18: 531-535.
    • (2006) Int J Mol Med , vol.18 , pp. 531-535
    • Albertin, G.1    Ruggero, M.2    Guidolin, D.3
  • 68
    • 0033279612 scopus 로고    scopus 로고
    • A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1
    • Buhlmann N, Leuthauser K, Muff R, et al. A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1. Endocrinology 1999; 140: 2883-2890.
    • (1999) Endocrinology , vol.140 , pp. 2883-2890
    • Buhlmann, N.1    Leuthauser, K.2    Muff, R.3
  • 69
    • 8744300052 scopus 로고    scopus 로고
    • Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin
    • Conner AC, Simms J, Hay DL, et al. Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin. Biochem Soc Trans 2004; 32: 843-846.
    • (2004) Biochem Soc Trans , vol.32 , pp. 843-846
    • Conner, A.C.1    Simms, J.2    Hay, D.L.3
  • 70
    • 33645230587 scopus 로고    scopus 로고
    • Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene
    • Dackor RT, Fritz-Six K, Dunworth WP, et al. Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Mol Cell Biol 2006; 26: 2511-2518.
    • (2006) Mol Cell Biol , vol.26 , pp. 2511-2518
    • Dackor, R.T.1    Fritz-Six, K.2    Dunworth, W.P.3
  • 71
    • 0036290263 scopus 로고    scopus 로고
    • The adrenomedullin receptor acts as clearance receptor in pulmonary circulation
    • Dschietzig T, Azad HA, Asswad L, et al. The adrenomedullin receptor acts as clearance receptor in pulmonary circulation. Biochem Biophys Res Commun 2002; 294: 315-318.
    • (2002) Biochem Biophys Res Commun , vol.294 , pp. 315-318
    • Dschietzig, T.1    Azad, H.A.2    Asswad, L.3
  • 72
    • 34247850802 scopus 로고    scopus 로고
    • Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling
    • Gibbons C, Dackor R, Dunworth W, et al. Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling. Mol Endocrinol 2006; 21: 783-796.
    • (2006) Mol Endocrinol , vol.21 , pp. 783-796
    • Gibbons, C.1    Dackor, R.2    Dunworth, W.3
  • 73
    • 4143149538 scopus 로고    scopus 로고
    • The calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS blocks CGRP and adrenomedullin vasoactive responses in the microvasculature
    • Grant AD, Tam CW, Lazar Z, et al. The calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS blocks CGRP and adrenomedullin vasoactive responses in the microvasculature. Br J Pharmacol 2004; 142: 1091-1098.
    • (2004) Br J Pharmacol , vol.142 , pp. 1091-1098
    • Grant, A.D.1    Tam, C.W.2    Lazar, Z.3
  • 74
    • 12244290339 scopus 로고    scopus 로고
    • Desensitisation of adrenomedullin and CGRP receptors
    • Hay DL, Poyner DR, Smith DM. Desensitisation of adrenomedullin and CGRP receptors. Regul Pept 2003; 112: 139-145.
    • (2003) Regul Pept , vol.112 , pp. 139-145
    • Hay, D.L.1    Poyner, D.R.2    Smith, D.M.3
  • 75
    • 0033041026 scopus 로고    scopus 로고
    • The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells
    • Kamitani S, Asakawa M, Shimekake Y, et al. The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. FEBS Lett 1999; 448: 111-114.
    • (1999) FEBS Lett , vol.448 , pp. 111-114
    • Kamitani, S.1    Asakawa, M.2    Shimekake, Y.3
  • 76
    • 33645223704 scopus 로고    scopus 로고
    • Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothelial cells and induce its desensitisation by different mechanisms
    • Nikitenko LL, Blucher N, Fox SB, et al. Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothelial cells and induce its desensitisation by different mechanisms. J Cell Sci 2006; 119: 910-922.
    • (2006) J Cell Sci , vol.119 , pp. 910-922
    • Nikitenko, L.L.1    Blucher, N.2    Fox, S.B.3
  • 77
    • 0036670622 scopus 로고    scopus 로고
    • Adrenomedullin: Receptor and signal transduction
    • Smith DM, Coppock HA, Withers DJ, et al. Adrenomedullin: receptor and signal transduction. Biochem Soc Trans 2002; 30: 432-437.
    • (2002) Biochem Soc Trans , vol.30 , pp. 432-437
    • Smith, D.M.1    Coppock, H.A.2    Withers, D.J.3
  • 78
    • 33644853220 scopus 로고    scopus 로고
    • Enhanced vascular responses to adrenomedullin in mice over-expressing receptor-activity-modifying protein 2
    • Tam CW, Husmann K, Clark NC, et al. Enhanced vascular responses to adrenomedullin in mice over-expressing receptor-activity-modifying protein 2. Circ Res 2006; 98: 262-270.
    • (2006) Circ Res , vol.98 , pp. 262-270
    • Tam, C.W.1    Husmann, K.2    Clark, N.C.3
  • 79
    • 0029796938 scopus 로고    scopus 로고
    • Adrenomedullin acts via stimulation of cyclic AMP and not via calcium signalling in vascular cells in culture
    • Barker S, Kapas S, Corder R, et al. Adrenomedullin acts via stimulation of cyclic AMP and not via calcium signalling in vascular cells in culture. J Hum Hypertens 1996; 10: 421-423.
    • (1996) J Hum Hypertens , vol.10 , pp. 421-423
    • Barker, S.1    Kapas, S.2    Corder, R.3
  • 80
    • 6344237420 scopus 로고    scopus 로고
    • Adrenomedullin receptors: Pharmacological features and possible pathophysiological roles
    • Kuwasako K, Cao YN, Nagoshi Y, et al. Adrenomedullin receptors: pharmacological features and possible pathophysiological roles. Peptides 2004; 25: 2003-2012.
    • (2004) Peptides , vol.25 , pp. 2003-2012
    • Kuwasako, K.1    Cao, Y.N.2    Nagoshi, Y.3
  • 81
    • 0028922340 scopus 로고
    • Adrenomedullin stimulates two signal transduction pathways, cAMP accumulation and Ca2+ mobilization, in bovine aortic endothelial cells
    • Shimekake Y, Nagata K, Ohta S, et al. Adrenomedullin stimulates two signal transduction pathways, cAMP accumulation and Ca2+ mobilization, in bovine aortic endothelial cells. J Biol Chem 1995; 270: 4412-4417.
    • (1995) J Biol Chem , vol.270 , pp. 4412-4417
    • Shimekake, Y.1    Nagata, K.2    Ohta, S.3
  • 82
    • 33747395381 scopus 로고    scopus 로고
    • Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors
    • Yurugi-Kobayashi T, Itoh H, Schroeder T, et al. Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors. Arterioscler Thromb Vasc Biol 2006; 26: 1977-1984.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1977-1984
    • Yurugi-Kobayashi, T.1    Itoh, H.2    Schroeder, T.3
  • 83
    • 33748449302 scopus 로고    scopus 로고
    • Intermedin (adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytes
    • Dong F, Taylor MM, Samson WY, et al. Intermedin (adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytes. J Appl Physiol 2006; 101: 778-784.
    • (2006) J Appl Physiol , vol.101 , pp. 778-784
    • Dong, F.1    Taylor, M.M.2    Samson, W.Y.3
  • 84
    • 0345689352 scopus 로고    scopus 로고
    • Adrenomedullin increases AP-1 expression in rat mesangial cells via activation of protein kinase-A and p38 MAPK
    • Parameswaran N, Hall CS, McCabe LR, etal. Adrenomedullin increases AP-1 expression in rat mesangial cells via activation of protein kinase-A and p38 MAPK. Cell Physiol Biochem 2003; 13: 367-374.
    • (2003) Cell Physiol Biochem , vol.13 , pp. 367-374
    • Parameswaran, N.1    Hall, C.S.2    McCabe, L.R.3
  • 85
    • 33646423011 scopus 로고    scopus 로고
    • Adrenomedullin in the rostral ventrolateral medulla inhibits baroreflex control of heart rate: A role for protein kinase A
    • Xu Y, Krukoff TL. Adrenomedullin in the rostral ventrolateral medulla inhibits baroreflex control of heart rate: a role for protein kinase A. Br J Pharmacol 2006; 148: 70-77.
    • (2006) Br J Pharmacol , vol.148 , pp. 70-77
    • Xu, Y.1    Krukoff, T.L.2
  • 86
    • 34147118416 scopus 로고    scopus 로고
    • Adrenomedullin inhibits angiotensin II-induced oxidative stress via Csk-mediated inhibition of Src activity
    • Liu J, Shimosawa T, Matsui H, et al. Adrenomedullin inhibits angiotensin II-induced oxidative stress via Csk-mediated inhibition of Src activity. Am J Physiol Heart Circ Physiol 2007; 292: H1714-1721.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Liu, J.1    Shimosawa, T.2    Matsui, H.3
  • 87
    • 2642529116 scopus 로고    scopus 로고
    • Angiogenic role of adrenomedullin through activation of Akt, mitogen-activated protein kinase, and focal adhesion kinase in endothelial cells
    • Kim W, Moon SO, Sung MJ, et al. Angiogenic role of adrenomedullin through activation of Akt, mitogen-activated protein kinase, and focal adhesion kinase in endothelial cells. FASEB J 2003; 17: 1937-1939.
    • (2003) FASEB J , vol.17 , pp. 1937-1939
    • Kim, W.1    Moon, S.O.2    Sung, M.J.3
  • 88
    • 0038018585 scopus 로고    scopus 로고
    • Adrenomedullin provokes endothelial Akt activation and promotes vascular regeneration both in vitro and in vivo
    • Miyashita K, Itoh H, Sawada N, et al. Adrenomedullin provokes endothelial Akt activation and promotes vascular regeneration both in vitro and in vivo. FEBS Lett 2003; 544: 86-92.
    • (2003) FEBS Lett , vol.544 , pp. 86-92
    • Miyashita, K.1    Itoh, H.2    Sawada, N.3
  • 89
    • 0035816724 scopus 로고    scopus 로고
    • Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase/Akt-dependent pathway in rat aorta
    • Nishimatsu H, Suzuki E, Nagata D, et al. Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase/Akt-dependent pathway in rat aorta. Circ Res 2001; 89: 63-70.
    • (2001) Circ Res , vol.89 , pp. 63-70
    • Nishimatsu, H.1    Suzuki, E.2    Nagata, D.3
  • 90
    • 9144253125 scopus 로고    scopus 로고
    • Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway
    • Okumura H, Nagaya N, Itoh T, et al. Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway. Circulation 2004; 109: 242-248.
    • (2004) Circulation , vol.109 , pp. 242-248
    • Okumura, H.1    Nagaya, N.2    Itoh, T.3
  • 91
    • 0033959726 scopus 로고    scopus 로고
    • Adrenomedullin decreases extracellular signal-regulated kinase activity through an increase in protein phosphatase-2A activity in mesangial cells
    • Parameswaran N, Nambi P, Hall CS, et al. Adrenomedullin decreases extracellular signal-regulated kinase activity through an increase in protein phosphatase-2A activity in mesangial cells. Eur J Pharmacol 2000; 388: 133-138.
    • (2000) Eur J Pharmacol , vol.388 , pp. 133-138
    • Parameswaran, N.1    Nambi, P.2    Hall, C.S.3
  • 93
    • 0034453838 scopus 로고    scopus 로고
    • Adrenomedullin, a multifunctional regulatory peptide
    • Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev 2000; 21: 138-167.
    • (2000) Endocr Rev , vol.21 , pp. 138-167
    • Hinson, J.P.1    Kapas, S.2    Smith, D.M.3
  • 94
    • 33644789977 scopus 로고    scopus 로고
    • Adrenomedullin: A protective factor for blood vessels
    • Kato J, Tsuruda T, Kita T, et al. Adrenomedullin: a protective factor for blood vessels. Arterioscler Thromb Vasc Biol 2005; 25: 2480-2487.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2480-2487
    • Kato, J.1    Tsuruda, T.2    Kita, T.3
  • 96
    • 30644461078 scopus 로고    scopus 로고
    • Adrenomedullin and tumour angiogenesis
    • Nikitenko LL, Fox SB, Kehoe S, et al. Adrenomedullin and tumour angiogenesis. Br J Cancer 2006; 94: 1-7.
    • (2006) Br J Cancer , vol.94 , pp. 1-7
    • Nikitenko, L.L.1    Fox, S.B.2    Kehoe, S.3
  • 97
    • 0033029032 scopus 로고    scopus 로고
    • Adrenomedullin and the control of fluid and electrolyte homeostasis
    • Samson WK. Adrenomedullin and the control of fluid and electrolyte homeostasis. Annu Rev Physiol 1999; 61: 363-389.
    • (1999) Annu Rev Physiol , vol.61 , pp. 363-389
    • Samson, W.K.1
  • 98
    • 0033645481 scopus 로고    scopus 로고
    • Adrenomedullin in the treatment of pulmonary hypertension
    • Vijay P. Adrenomedullin in the treatment of pulmonary hypertension. Heart 2000; 84: 575-576.
    • (2000) Heart , vol.84 , pp. 575-576
    • Vijay, P.1
  • 99
    • 0032196511 scopus 로고    scopus 로고
    • Adrenomedullin in sepsis and septic shock
    • Wang P. Adrenomedullin in sepsis and septic shock. Shock 1998; 10: 383-384.
    • (1998) Shock , vol.10 , pp. 383-384
    • Wang, P.1
  • 100
    • 0035685847 scopus 로고    scopus 로고
    • Andrenomedullin and cardiovascular responses in sepsis
    • Wang P. Andrenomedullin and cardiovascular responses in sepsis. Peptides 2001; 22: 1835-1840.
    • (2001) Peptides , vol.22 , pp. 1835-1840
    • Wang, P.1
  • 101
    • 33645395054 scopus 로고    scopus 로고
    • Mechanisms of adrenomedullin antimicrobial action
    • Allaker RP, Grosvenor PW, McAnerney DC, et al. Mechanisms of adrenomedullin antimicrobial action. Peptides 2005; 27: 661-666.
    • (2005) Peptides , vol.27 , pp. 661-666
    • Allaker, R.P.1    Grosvenor, P.W.2    McAnerney, D.C.3
  • 102
    • 33748852946 scopus 로고    scopus 로고
    • The central role of adrenomedullin in host defense
    • Zudaire E, Portal-Nunez S, Cuttitta F. The central role of adrenomedullin in host defense. J Leukoc Biol 2006; 80: 237-244.
    • (2006) J Leukoc Biol , vol.80 , pp. 237-244
    • Zudaire, E.1    Portal-Nunez, S.2    Cuttitta, F.3
  • 103
    • 0029887956 scopus 로고    scopus 로고
    • Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis
    • Hirata Y, Mitaka C, Sato K, et al. Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab 1996; 81: 1449-1453.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1449-1453
    • Hirata, Y.1    Mitaka, C.2    Sato, K.3
  • 104
    • 0030965779 scopus 로고    scopus 로고
    • Increased plasma concentrations of adrenomedullin correlate with relaxation of vascular tone in patients with septic shock
    • Nishio K, Akai Y, Murao Y, et al. Increased plasma concentrations of adrenomedullin correlate with relaxation of vascular tone in patients with septic shock. Crit Care Med 1997; 25: 953-957.
    • (1997) Crit Care Med , vol.25 , pp. 953-957
    • Nishio, K.1    Akai, Y.2    Murao, Y.3
  • 105
    • 0032766206 scopus 로고    scopus 로고
    • Increased plasma levels of adrenomedullin in patients with systemic inflammatory response syndrome
    • Ueda S, Nishio K, Minamino N, et al. Increased plasma levels of adrenomedullin in patients with systemic inflammatory response syndrome. Am J Respir Crit Care Med 1999; 160: 132-136.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 132-136
    • Ueda, S.1    Nishio, K.2    Minamino, N.3
  • 106
    • 34248330207 scopus 로고    scopus 로고
    • Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]
    • Christ-Crain M, Morgenthaler NG, Stolz D, et al. Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397], Crit Care 2006; 10: R96.
    • (2006) Crit Care , vol.10
    • Christ-Crain, M.1    Morgenthaler, N.G.2    Stolz, D.3
  • 107
    • 0032134917 scopus 로고    scopus 로고
    • Up-regulation of a novel potent vasodilatory peptide adrenomedullin during polymicrobial sepsis
    • Wang P, Zhou M, Ba ZF, et al. Up-regulation of a novel potent vasodilatory peptide adrenomedullin during polymicrobial sepsis. Shock 1998; 10: 118-122.
    • (1998) Shock , vol.10 , pp. 118-122
    • Wang, P.1    Zhou, M.2    Ba, Z.F.3
  • 108
    • 33644975207 scopus 로고    scopus 로고
    • Differential induction of adrenomedullin, interleukins and tumour necrosis factor-alpha by lipopolysaccharide in rat tissues in vivo
    • Li YY, Wong LY, Cheung BM, et al. Differential induction of adrenomedullin, interleukins and tumour necrosis factor-alpha by lipopolysaccharide in rat tissues in vivo. Clin Exp Pharmacol Physiol 2005; 32: 1110-1118.
    • (2005) Clin Exp Pharmacol Physiol , vol.32 , pp. 1110-1118
    • Li, Y.Y.1    Wong, L.Y.2    Cheung, B.M.3
  • 109
    • 2942597581 scopus 로고    scopus 로고
    • Increased adrenomedullin expression in lungs in endotoxaemia
    • Cheung BM, Hwang IS, Li CY, et al. Increased adrenomedullin expression in lungs in endotoxaemia. J Endocrinol 2004; 181: 339-345.
    • (2004) J Endocrinol , vol.181 , pp. 339-345
    • Cheung, B.M.1    Hwang, I.S.2    Li, C.Y.3
  • 110
    • 0035163227 scopus 로고    scopus 로고
    • Biosynthesis and secretion of adrenomedullin and proadrenomedullin N-terminal 20 peptide in a rat model of endotoxin shock
    • Matsui E, Kitamura K, Yoshida M, et al. Biosynthesis and secretion of adrenomedullin and proadrenomedullin N-terminal 20 peptide in a rat model of endotoxin shock. Hypertens Res 2001; 24: 543-549.
    • (2001) Hypertens Res , vol.24 , pp. 543-549
    • Matsui, E.1    Kitamura, K.2    Yoshida, M.3
  • 111
    • 13644270251 scopus 로고    scopus 로고
    • Adrenomedullin expression in a rat model of acute lung injury induced by hypoxia and LPS
    • Agotreta J, Zulueta JJ, Montuenga LM, et al. Adrenomedullin expression in a rat model of acute lung injury induced by hypoxia and LPS. Am J Physiol Lung Cell Mol Physiol 2005; 288: L536-L545.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288
    • Agotreta, J.1    Zulueta, J.J.2    Montuenga, L.M.3
  • 112
    • 0035895276 scopus 로고    scopus 로고
    • Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional adrenomedullin gene
    • Caron KM, Smithies O. Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional adrenomedullin gene. Proc Natl Acad Sci U S A 2001; 98: 615-619.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 615-619
    • Caron, K.M.1    Smithies, O.2
  • 113
    • 27744573043 scopus 로고    scopus 로고
    • Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse
    • Czyzyk TA, Ning Y, Hsu MS, et al. Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse. Dev Biol 2005; 287: 301-313.
    • (2005) Dev Biol , vol.287 , pp. 301-313
    • Czyzyk, T.A.1    Ning, Y.2    Hsu, M.S.3
  • 114
    • 17044440501 scopus 로고    scopus 로고
    • Adrenomedullin reduces Staphylococcus aureus alpha-toxin-induced rat ileum microcirculatory damage
    • Brell B, Temmesfeld-Wollbruck B, Altzschner I, et al. Adrenomedullin reduces Staphylococcus aureus alpha-toxin-induced rat ileum microcirculatory damage. Crit Care Med 2005; 33: 819-826.
    • (2005) Crit Care Med , vol.33 , pp. 819-826
    • Brell, B.1    Temmesfeld-Wollbruck, B.2    Altzschner, I.3
  • 115
    • 33745237414 scopus 로고    scopus 로고
    • Perturbation of endothelial junction proteins by Staphylococcus aureus alpha-toxin: Inhibition of endothelial gap formation by adrenomedullin
    • Hocke AC, Temmesfeld-Wollbrueck B, Schmeck B, et al. Perturbation of endothelial junction proteins by Staphylococcus aureus alpha-toxin: inhibition of endothelial gap formation by adrenomedullin. Histochem Cell Biol 2006; 126: 305-316.
    • (2006) Histochem Cell Biol , vol.126 , pp. 305-316
    • Hocke, A.C.1    Temmesfeld-Wollbrueck, B.2    Schmeck, B.3
  • 116
    • 0035930469 scopus 로고    scopus 로고
    • Adrenomedullin regulates blood-brain barrier ftinctions in vitro
    • Kis B, Deli MA, Kobayashi H, et al. Adrenomedullin regulates blood-brain barrier ftinctions in vitro. Neuroreport 2001; 12: 4139-4142.
    • (2001) Neuroreport , vol.12 , pp. 4139-4142
    • Kis, B.1    Deli, M.A.2    Kobayashi, H.3
  • 117
    • 1442303755 scopus 로고    scopus 로고
    • Chronic adrenomedullin treatment improves blood-brain barrier function but has no effects on expression of tight junction proteins
    • Kis B, Snipes JA, Deli MA, et al. Chronic adrenomedullin treatment improves blood-brain barrier function but has no effects on expression of tight junction proteins. Acta Neurochir Suppl 2003; 86: 565-568.
    • (2003) Acta Neurochir Suppl , vol.86 , pp. 565-568
    • Kis, B.1    Snipes, J.A.2    Deli, M.A.3
  • 118
    • 0032741011 scopus 로고    scopus 로고
    • Adrenomedullin inhibits ovalbumin-induced bronchoconstriction and airway microvascular leakage in guinea-pigs
    • Ohbayashi H, Suito H, Yoshida N, et al. Adrenomedullin inhibits ovalbumin-induced bronchoconstriction and airway microvascular leakage in guinea-pigs. Eur Respir J 1999; 14: 1076-1081.
    • (1999) Eur Respir J , vol.14 , pp. 1076-1081
    • Ohbayashi, H.1    Suito, H.2    Yoshida, N.3
  • 119
    • 3042703994 scopus 로고    scopus 로고
    • The assessment of vasoactive properties of CGRP and adrenomedullin in the microvasculature: A study using in vivo and in vitro assays in the mouse
    • Tam C, Brain SD. The assessment of vasoactive properties of CGRP and adrenomedullin in the microvasculature: a study using in vivo and in vitro assays in the mouse. J Mol Neurosci 2004; 22: 117-124.
    • (2004) J Mol Neurosci , vol.22 , pp. 117-124
    • Tam, C.1    Brain, S.D.2
  • 120
    • 33745090582 scopus 로고    scopus 로고
    • Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5
    • Honda M, Nakagawa S, Hayashi K, et al. Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5. Cell Mol Neurobiol 2006; 26: 109-118.
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 109-118
    • Honda, M.1    Nakagawa, S.2    Hayashi, K.3
  • 121
    • 0029979610 scopus 로고    scopus 로고
    • Hyperpermeability of pulmonary endothelial monolayer: Protective role of phosphodiesterase isoenzymes 3 and 4
    • Suttorp N, Ehrciser P, Hippenstiel S, et al. Hyperpermeability of pulmonary endothelial monolayer: protective role of phosphodiesterase isoenzymes 3 and 4. Lung 1996; 174: 181-194.
    • (1996) Lung , vol.174 , pp. 181-194
    • Suttorp, N.1    Ehrciser, P.2    Hippenstiel, S.3
  • 122
    • 0032562258 scopus 로고    scopus 로고
    • Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide
    • Szokodi I, Kinnunen P, Tavi P, et al. Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide. Circulation 1998; 97: 1062-1070.
    • (1998) Circulation , vol.97 , pp. 1062-1070
    • Szokodi, I.1    Kinnunen, P.2    Tavi, P.3
  • 123
    • 33751241720 scopus 로고    scopus 로고
    • Epac proteins: Multi-purpose cAMP targets
    • Bos JL. Epac proteins: multi-purpose cAMP targets. Trends Biochem Sci 2006; 31: 680-686.
    • (2006) Trends Biochem Sci , vol.31 , pp. 680-686
    • Bos, J.L.1
  • 124
    • 14944377651 scopus 로고    scopus 로고
    • Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase
    • Cullere X, Shaw SK, Andersson L, et al. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood 2005; 105: 1950-1955.
    • (2005) Blood , vol.105 , pp. 1950-1955
    • Cullere, X.1    Shaw, S.K.2    Andersson, L.3
  • 125
    • 11144305139 scopus 로고    scopus 로고
    • Cyclic AW potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway
    • Fukuhara S, Sakurai A, Sano H, et al. Cyclic AW potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol 2005; 25: 136-146.
    • (2005) Mol Cell Biol , vol.25 , pp. 136-146
    • Fukuhara, S.1    Sakurai, A.2    Sano, H.3
  • 126
    • 28044439151 scopus 로고    scopus 로고
    • Effect of adrenomedullin on adrenergic vasoconstriction in mesenteric resistance arteries of the rat
    • Akiyama S, Hatanaka Y, Hobara N, et al. Effect of adrenomedullin on adrenergic vasoconstriction in mesenteric resistance arteries of the rat. J Pharmacol Sci 2005; 99: 264-271.
    • (2005) J Pharmacol Sci , vol.99 , pp. 264-271
    • Akiyama, S.1    Hatanaka, Y.2    Hobara, N.3
  • 127
    • 0034674021 scopus 로고    scopus 로고
    • Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature
    • Shindo T, Kurihara H, Maemura K, et al. Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature. Circulation 2000; 101: 2309-2316.
    • (2000) Circulation , vol.101 , pp. 2309-2316
    • Shindo, T.1    Kurihara, H.2    Maemura, K.3
  • 128
    • 0035899895 scopus 로고    scopus 로고
    • Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene
    • Shindo T, Kurihara Y, Nishimatsu H, et al. Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Circulation 2001; 104: 1964-1971.
    • (2001) Circulation , vol.104 , pp. 1964-1971
    • Shindo, T.1    Kurihara, Y.2    Nishimatsu, H.3
  • 129
    • 0030979851 scopus 로고    scopus 로고
    • Vasodilator effects of adrenomedullin on small pulmonary arteries and veins in anaesthetized cats
    • Shirai M, Shimouchi A, Ikeda S, et al. Vasodilator effects of adrenomedullin on small pulmonary arteries and veins in anaesthetized cats. Br J Pharmacol 1997; 121: 679-686.
    • (1997) Br J Pharmacol , vol.121 , pp. 679-686
    • Shirai, M.1    Shimouchi, A.2    Ikeda, S.3
  • 130
    • 26044448572 scopus 로고    scopus 로고
    • Adrenomedullin causes coronary vasodilation in humans: Effects of inhibition of nitric oxide synthesis
    • Ueda K, Teragawa H, Kimura M, et al. Adrenomedullin causes coronary vasodilation in humans: effects of inhibition of nitric oxide synthesis. J Cardiovasc Pharmacol 2005; 46: 534-539.
    • (2005) J Cardiovasc Pharmacol , vol.46 , pp. 534-539
    • Ueda, K.1    Teragawa, H.2    Kimura, M.3
  • 131
    • 33947544431 scopus 로고    scopus 로고
    • Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock
    • Temmesfeld-Wollbruck B, Brell B, David I, et al. Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock. Intensive Care Med 2007; 33: 703-710.
    • (2007) Intensive Care Med , vol.33 , pp. 703-710
    • Temmesfeld-Wollbruck, B.1    Brell, B.2    David, I.3
  • 132
    • 33646759327 scopus 로고    scopus 로고
    • Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response
    • Gonzalez-Rey E, Chorny A, Varela N, et al. Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response. Am J Pathol 2006; 168: 1921-1930.
    • (2006) Am J Pathol , vol.168 , pp. 1921-1930
    • Gonzalez-Rey, E.1    Chorny, A.2    Varela, N.3
  • 133
    • 0036830201 scopus 로고    scopus 로고
    • Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: Role of adrenomedullin and adrenomedullin binding protein-1
    • Yang S, Zhou M, Chaudry IH, et al. Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: role of adrenomedullin and adrenomedullin binding protein-1. Ann Surg 2002; 236: 625-633.
    • (2002) Ann Surg , vol.236 , pp. 625-633
    • Yang, S.1    Zhou, M.2    Chaudry, I.H.3
  • 134
    • 0036884978 scopus 로고    scopus 로고
    • Mechanisms of the beneficial effect of adrenomedullin and adrenomedullin-binding protein-1 in sepsis: Down-regulation of proinflammatory cytokines
    • Yang S, Zhou M, Fowler DE, et al. Mechanisms of the beneficial effect of adrenomedullin and adrenomedullin-binding protein-1 in sepsis: down-regulation of proinflammatory cytokines. Crit Care Med 2002; 30: 2729-2735.
    • (2002) Crit Care Med , vol.30 , pp. 2729-2735
    • Yang, S.1    Zhou, M.2    Fowler, D.E.3
  • 135
    • 13444265866 scopus 로고    scopus 로고
    • Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage
    • Cui X, Wu R, Zhou M, et al. Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage. Crit Care Med 2005; 33: 391-398.
    • (2005) Crit Care Med , vol.33 , pp. 391-398
    • Cui, X.1    Wu, R.2    Zhou, M.3
  • 136
    • 3242664327 scopus 로고    scopus 로고
    • Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis
    • Zhou M, Simms HH, Wang P. Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis. Ann Surg 2004; 240: 321-330.
    • (2004) Ann Surg , vol.240 , pp. 321-330
    • Zhou, M.1    Simms, H.H.2    Wang, P.3
  • 137
    • 0034728767 scopus 로고    scopus 로고
    • Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis
    • Ono Y, Okano I, Kojima M, et al. Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Biochem Biophys Res Commun 2000; 271: 197-202.
    • (2000) Biochem Biophys Res Commun , vol.271 , pp. 197-202
    • Ono, Y.1    Okano, I.2    Kojima, M.3
  • 138
    • 0034213969 scopus 로고    scopus 로고
    • Mechanism of the beneficial effects of pentoxifylline during sepsis: Maintenance of adrenomedullin responsiveness and downregulation of proinflammatory cytokines
    • Koo DJ, Yoe P, Cioffi WG, et al. Mechanism of the beneficial effects of pentoxifylline during sepsis: maintenance of adrenomedullin responsiveness and downregulation of proinflammatory cytokines. J Surg Res 2000; 91: 70-76.
    • (2000) J Surg Res , vol.91 , pp. 70-76
    • Koo, D.J.1    Yoe, P.2    Cioffi, W.G.3
  • 139
    • 0035747129 scopus 로고    scopus 로고
    • The role of adrenomedullin in producing differential hemodynamic, responses during sepsis
    • Koo DJ, Zhou M, Chaudry IH, et al. The role of adrenomedullin in producing differential hemodynamic, responses during sepsis. J Surg Res 2001; 95: 207-218.
    • (2001) J Surg Res , vol.95 , pp. 207-218
    • Koo, D.J.1    Zhou, M.2    Chaudry, I.H.3
  • 140
    • 0032775468 scopus 로고    scopus 로고
    • Reduction in vascular responsiveness to adrenomedullin during sepsis
    • Wang P, Yoo P, Zhou M, et al. Reduction in vascular responsiveness to adrenomedullin during sepsis. J Surg Res 1999; 85: 59-65.
    • (1999) J Surg Res , vol.85 , pp. 59-65
    • Wang, P.1    Yoo, P.2    Zhou, M.3
  • 141
    • 0036128895 scopus 로고    scopus 로고
    • Identification, characterization, and physiological actions of factor H as an adrenomedullin binding protein present in human plasma
    • Pio R, Elsasser TH, Martinez A, et al. Identification, characterization, and physiological actions of factor H as an adrenomedullin binding protein present in human plasma. Microsc Res Tech 2002; 57: 23-27.
    • (2002) Microsc Res Tech , vol.57 , pp. 23-27
    • Pio, R.1    Elsasser, T.H.2    Martinez, A.3
  • 142
    • 0035853722 scopus 로고    scopus 로고
    • Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners
    • Pio R, Martinez A, Unsworth EJ, et al. Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners. J iel Chem 2001; 276: 12292-12300.
    • (2001) J iel Chem , vol.276 , pp. 12292-12300
    • Pio, R.1    Martinez, A.2    Unsworth, E.J.3
  • 143
    • 0036724151 scopus 로고    scopus 로고
    • Adrenomedullin binding protein-1 modulates vascular responsiveness to adrenomedullin in late sepsis
    • Zhou M, Ba ZF, Chaudry IH, et al. Adrenomedullin binding protein-1 modulates vascular responsiveness to adrenomedullin in late sepsis. Am J Physiol Regul Integr Comp, Physiol 2002; 283: R553-R560.
    • (2002) Am J Physiol Regul Integr Comp, Physiol , vol.283
    • Zhou, M.1    Ba, Z.F.2    Chaudry, I.H.3
  • 144
    • 33750603467 scopus 로고    scopus 로고
    • Adrenomedullin binding protein-1 is downregulated during polymicrobial sepsis in the rat
    • Cui Y, Ji Y, Wu R, et al. Adrenomedullin binding protein-1 is downregulated during polymicrobial sepsis in the rat. Int J Mol Med 2006; 17: 925-929.
    • (2006) Int J Mol Med , vol.17 , pp. 925-929
    • Cui, Y.1    Ji, Y.2    Wu, R.3
  • 145
    • 21444456794 scopus 로고    scopus 로고
    • Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: The central role of adrenomedullin binding protein-1
    • Wu R, Cui X, Dong W, et al. Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1. Ann Surg 2005; 242: 115-123.
    • (2005) Ann Surg , vol.242 , pp. 115-123
    • Wu, R.1    Cui, X.2    Dong, W.3
  • 146
    • 3042597423 scopus 로고    scopus 로고
    • Vascular actions of calcitonin gene-related peptide and adrenomedullin
    • Brain SD, Grant AD. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev 2004; 84: 903-934.
    • (2004) Physiol Rev , vol.84 , pp. 903-934
    • Brain, S.D.1    Grant, A.D.2
  • 147
    • 0033536569 scopus 로고    scopus 로고
    • Comparison of vasodilator potency of adrenomedulling and proadrenomedullin N-terminal 20 peptide in human
    • Nakamura M, Yoshida H, Hiramori K. Comparison of vasodilator potency of adrenomedulling and proadrenomedullin N-terminal 20 peptide in human. Life Sci 1999; 65: 2151-2156.
    • (1999) Life Sci , vol.65 , pp. 2151-2156
    • Nakamura, M.1    Yoshida, H.2    Hiramori, K.3
  • 148
    • 0035685215 scopus 로고    scopus 로고
    • A review of the biological properties and clinical implications of adrenomedullin and proadrenomedullin N-terminal 20 peptide (PAMP), hypotensive and vasodilating peptides
    • Eto T. A review of the biological properties and clinical implications of adrenomedullin and proadrenomedullin N-terminal 20 peptide (PAMP), hypotensive and vasodilating peptides. Peptides 2001; 22: 1693-1711.
    • (2001) Peptides , vol.22 , pp. 1693-1711
    • Eto, T.1
  • 149
    • 0031587560 scopus 로고    scopus 로고
    • Proadrenomedullin N-terminal 20-peptide (PAMP) receptors and signal transduction. in the rat adrenal gland
    • Hinson JP, Hagi-Pavli E, Thomson LM, et al. Proadrenomedullin N-terminal 20-peptide (PAMP) receptors and signal transduction. in the rat adrenal gland. Life Sci 1998; 62: 439-443.
    • (1998) Life Sci , vol.62 , pp. 439-443
    • Hinson, J.P.1    Hagi-Pavli, E.2    Thomson, L.M.3
  • 150
    • 0030011287 scopus 로고    scopus 로고
    • Specific binding sites for proadrenomedullin N-terminal 20 peptide (PAMP) in the rat
    • Iwasaki H, Hirata Y, Iwashina M, et al. Specific binding sites for proadrenomedullin N-terminal 20 peptide (PAMP) in the rat. Endocrinology 1996; 137: 3045-3050.
    • (1996) Endocrinology , vol.137 , pp. 3045-3050
    • Iwasaki, H.1    Hirata, Y.2    Iwashina, M.3
  • 151
    • 0037967789 scopus 로고    scopus 로고
    • Roles of different peptide fragments derived from proadrenomedullin in the regulation of vascular tone in isolated rat aorta
    • Li J, Ren Y, Deng X, et al. Roles of different peptide fragments derived from proadrenomedullin in the regulation of vascular tone in isolated rat aorta. Peptides 2003; 24: 563-568.
    • (2003) Peptides , vol.24 , pp. 563-568
    • Li, J.1    Ren, Y.2    Deng, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.