Intermedin (adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytes

Journal of Applied Physiology

Volumn 101, Issue 3, 2006, Pages 778-784

  Dong, Feng ^a   Taylor, Meghan M ^b   Samson, Willis K ^b   Ren, Jun ^a  

^a UNIVERSITY OF WYOMING   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac myocyte; Relengthening; Shortening

Indexed keywords

ADRENOMEDULLIN; CALCITONIN GENE RELATED PEPTIDE; CHELERYTHRINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; INTERMEDIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARDIOVASCULAR FUNCTION; CELL SHAPE; CELL SIZE; CONTROLLED STUDY; DOWN REGULATION; ELECTROSTIMULATION; FLUORESCENCE MICROSCOPY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE; HOMEOSTASIS; MOUSE; MYOTATIC REFLEX; NONHUMAN; PRIORITY JOURNAL; VELOCITY;

ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART VENTRICLES; MALE; MICE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NEUROPEPTIDES; PROTEIN KINASE C; SIGNAL TRANSDUCTION;

EID: 33748449302     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01631.2005     Document Type: Article

References (26)

1. Bell D and McDermott BJ. Calcitonin gene-related peptide stimulates a positive contractile response in rat ventricular cardiomyocytes. J Cardiovasc Pharmacol 23: 1011-1021, 1994.
2. Brain SD and Grant AD. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev 84: 903-934, 2004.
3. Duan J, Zhang HY, Adkins SD, Ren BH, Norby FL, Zhang X, Benoit JN, Epstein PN, and Ren J. Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA. Am J Physiol Endocrinol Metab 284: E366-E376, 2003.
4. Hahn HS, Marreez Y, Odley A, Sterbling A, Yussman MG, Hilty KC, Bodi I, Liggett SB, Schwartz A, and Dorn GW. Protein kinase C alpha negatively regulates systolic and diastolic function in pathological hypertrophy. Circ Res 93: 1111-1119, 2003.
5. Hay DL, Conner AC, Howitt SG, Smith DM, and Poyner DR. The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors. J Mol Neurosci 22: 105-113, 2004.
6. 2+ transients of mouse heart myocytes conditionally expressing PKC beta. Am J Physiol Cell Physiol 280: C1114-C1120, 2001.
7. 2+ release involved in positive inotropic effect mediated by CGRP in ventricular myocytes. Am J Physiol Regul Integr Comp Physiol 276: R259-R264, 1999.
8. Husmann K, Born W, Fischer JA, and Muff R. Three receptor-activity- modifying proteins define calcitonin gene-related peptide or adrenomedullin selectivity of the mouse calcitonin-like receptor in COS-7 cells. Biochem Pharmacol 66: 2107-2115, 2003.
9. Ihara T, Ikeda U, Tate Y, Ishibashi S, and Shimada K. Positive inotropic effects of adrenomedullin on rat papillary muscle. Eur J Pharmacol 390: 167-172, 2000.
10. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, and Foord SM. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393: 333-339, 1998.
11. Norby FL, Aberle NS, Kajstura J, Anversa P, and Ren J. Transgenic overexpression of insulin-like growth factor I prevents streptozotocin-induced cardiac contractile dysfunction and beta-adrenergic response in ventricular myocytes. J Endocrinol 180: 175-182, 2004.
12. Pan CS, Yang JH, Cai DY, Zhao J, Gerns H, Yang J, Chang JK, Tang CS, and Qi YF. Cardiovascular effects of newly discovered peptide intermedin/ adrenomedullin 2. Peptides 26: 1640-1646, 2005.
13. Ren J, Karpinski E, and Benishin CG. The actions of prostaglandin E2 on potassium currents in rat tail artery vascular smooth muscle cells: regulation by protein kinase A and protein kinase C. J Pharmacol Exp Ther 277: 394-402, 1996.
14. Roh J, Chang CL, Bhalla A, Klein C, and Hsu SY. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. J Biol Chem 279: 7264-7274, 2004.
15. 2+-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation. J Mol Cell Cardiol 31: 479-491, 1999.
16. Szokodi I, Kinnunen P, Tavi P, Weckstrom M, Toth M, and Ruskoaho H. Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide. Circulation 97: 1062-1070, 1998.
17. Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, and Miyano S. Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. FEBS Lett 556: 53-58, 2004.
18. Taylor MM, Bagley SL, and Samson WK. Intermedin/adrenomedullin-2 acts within central nervous system to elevate blood pressure and inhibit food and water intake. Am J Physiol Regul Integr Comp Physiol 288: R919-R927, 2005.
19. Taylor MM, Bagley SL, and Samson WK. Intermedin/adrenomedullin-2 inhibits growth hormone release from cultured, primary anterior pituitary cells. Endocrinology 147: 859-864, 2006.
20. Taylor MM and Samson WK. Adrenomedullin and the integrative physiology of fluid and electrolyte balance. Microsc Res Tech 57: 105-109, 2002.
21. Taylor MM and Samson WK. Stress hormone secretion is altered by central administration of intermedin/adrenomedullin-2. Brain Res 1045: 199-205, 2005.
22. Totsune K, Takahashi K, Mackenzie HS, Murakami O, Arihara Z, Sone M, Mouri T, Brenner BM, and Ito S. Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure. Clin Sci (Lond) 99: 541-546, 2000.
23. Watanuki S, Matsuda N, Sakuraya F, Jesmin S, and Hattori Y. Protein kinase C modulation of the regulation of sarcoplasmic reticular function by protein kinase A-mediated phospholamban phosphorylation in diabetic rats. Br J Pharmacol 141: 347-359, 2004.
24. Yang JH, Jia YX, Pan CS, Zhao J, Ouyang M, Yang J, Chang JK, Tang CS, and Qi YF. Effects of intermedin(1-53) on cardiac function and ischemia/reperfusion injury in isolated rat hearts. Biochem Biophys Res Commun 327: 713-719, 2005.
25. Yang JH, Qi YF, Jia YX, Pan CS, Zhao J, Yang J, Chang JK, and Tang CS. Protective effects of intermedin/adrenomedullin2 on ischemia/reperfusion injury in isolated rat hearts. Peptides 26: 501-507, 2005.
26. Zhao Y, Bell D, Smith LR, Zhao L, Devine AB, McHenry EM, Nicholls DP, and McDermott BJ. Differential expression of components of the cardiomyocyte adrenomedullin/intermedin receptor system following blood pressure reduction in nitric oxide-deficient hypertension. J Pharmacol Exp Ther 316: 1269-1281, 2006.