메뉴 건너뛰기




Volumn 66, Issue 10, 1998, Pages 4669-4675

Induction of adrenomedullin mRNA and protein by lipopolysaccharide and paclitaxel (Taxol) in murine macrophages

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; BACTERIUM LIPOPOLYSACCHARIDE; MESSENGER RNA; PACLITAXEL;

EID: 0031663474     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.10.4669-4675.1998     Document Type: Article
Times cited : (48)

References (50)
  • 1
    • 0028957549 scopus 로고
    • Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome, A randomized, controlled, double-blind, multicenter clinical trial
    • TNF-alpha MAb Sepsis Studs Group
    • Abraham, E., R. Wunderfnk, H. Silverman, T. M. Perl, S. Nasraway, H. Levy, R. Bone, R. P. Wenzel, R. Balk, and R. Allred. 1995. Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome, A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Studs Group. JAMA 273:934-941.
    • (1995) JAMA , vol.273 , pp. 934-941
    • Abraham, E.1    Wunderfnk, R.2    Silverman, H.3    Perl, T.M.4    Nasraway, S.5    Levy, H.6    Bone, R.7    Wenzel, R.P.8    Balk, R.9    Allred, R.10
  • 2
    • 0025317052 scopus 로고
    • Potential antitumor agents. 60. Relationships between structure and in vivo colon 38 activity for 5-suhstituted 9-oxoxanthene-4-acetic acids
    • Atwell. G. J., G. W. Rewcastle, B. C. Baguley, and W. A. Denny. 1990. Potential antitumor agents. 60. Relationships between structure and in vivo colon 38 activity for 5-suhstituted 9-oxoxanthene-4-acetic acids. J. Med. Chem. 33:1375-1379.
    • (1990) J. Med. Chem. , vol.33 , pp. 1375-1379
    • Atwell, G.J.1    Rewcastle, G.W.2    Baguley, B.C.3    Denny, W.A.4
  • 3
    • 0028924980 scopus 로고
    • Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2. and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages
    • Barber, S. A., M. J. Fultz, C. A. Salkowski, and S. N. Vogel. 1995. Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2. and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages. Infect. Immun. 63:601-608.
    • (1995) Infect. Immun. , vol.63 , pp. 601-608
    • Barber, S.A.1    Fultz, M.J.2    Salkowski, C.A.3    Vogel, S.N.4
  • 4
    • 0026686641 scopus 로고
    • Taxol. a microtubule-stabilizing antineoplustic agent, induces expression of tumor necrosis factor alpha and interleukin-1 in macrophages
    • Bogdan, C., and A. Ding. 1442. Taxol. a microtubule-stabilizing antineoplustic agent, induces expression of tumor necrosis factor alpha and interleukin-1 in macrophages. J. Leukocyte Biol. 52:119-121.
    • (1442) J. Leukocyte Biol. , vol.52 , pp. 119-121
    • Bogdan, C.1    Ding, A.2
  • 5
    • 0025912129 scopus 로고
    • A critical evaluation of new agents for the treatment of sepsis
    • Bone, R. C. 1991. A critical evaluation of new agents for the treatment of sepsis. JAMA 266:1686-1691.
    • (1991) JAMA , vol.266 , pp. 1686-1691
    • Bone, R.C.1
  • 6
    • 0031037913 scopus 로고    scopus 로고
    • Characterization of a mutant cell line that docs not activate NF-kB in response to multiple stimuli
    • Courtois, G., S. T. Whiteside, C. H. Sibley, and A. Israel. 1997. Characterization of a mutant cell line that docs not activate NF-kB in response to multiple stimuli. Mol. Cell. Biol. 17:1441-1449.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1441-1449
    • Courtois, G.1    Whiteside, S.T.2    Sibley, C.H.3    Israel, A.4
  • 7
    • 0027400726 scopus 로고
    • Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    • Dalton. D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 259:1739-1742.
    • (1993) Science , vol.259 , pp. 1739-1742
    • Dalton, D.K.1    Pitts-Meek, S.2    Keshav, S.3    Figari, I.S.4    Bradley, A.5    Stewart, T.A.6
  • 8
    • 0025319864 scopus 로고
    • Shared actions of endotoxin and taxol on TNF receptors and TNF release
    • Ding, A. H., F. Porteu, E. Sanchez, and C. F. Nathan. 1490. Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science 248:370-372.
    • (1490) Science , vol.248 , pp. 370-372
    • Ding, A.H.1    Porteu, F.2    Sanchez, E.3    Nathan, C.F.4
  • 9
    • 0027366571 scopus 로고
    • Induction of IFN-gamma in macrophages by lipopolysaecharide
    • Fultz, M. J., S. A. Barber, C. W. Dieffenhach, and S. N. Vogel. 1993. Induction of IFN-gamma in macrophages by lipopolysaecharide. Int. Immunol. 5:1383-1392.
    • (1993) Int. Immunol. , vol.5 , pp. 1383-1392
    • Fultz, M.J.1    Barber, S.A.2    Dieffenhach, C.W.3    Vogel, S.N.4
  • 10
    • 0029941031 scopus 로고    scopus 로고
    • Oxidized LDL potentiates LPS- Induced transcription of the chemokine KC gene
    • Hamilton, T. A., and J. A. Major. 1996. Oxidized LDL potentiates LPS- induced transcription of the chemokine KC gene. J. Leukocyte Biol. 59:940-947.
    • (1996) J. Leukocyte Biol. , vol.59 , pp. 940-947
    • Hamilton, T.A.1    Major, J.A.2
  • 12
    • 0023597809 scopus 로고
    • Lipid A-associated proteins provide an alternate "second signal" in the activation of recombinant interferon-gamma-primed. C3H/HeJ macrophages to a fully tumoricidal state
    • Hogan, M. M., and S. N. Vogel. 1987. Lipid A-associated proteins provide an alternate "second signal" in the activation of recombinant interferon-gamma-primed. C3H/HeJ macrophages to a fully tumoricidal state. J. Immunol. 139:3697-3702.
    • (1987) J. Immunol. , vol.139 , pp. 3697-3702
    • Hogan, M.M.1    Vogel, S.N.2
  • 13
    • 0024208939 scopus 로고
    • d) macrophages requires the presence of lipid A-associated proteins
    • d) macrophages requires the presence of lipid A-associated proteins. J. Immunol. 141:4196-4202.
    • (1988) J. Immunol. , vol.141 , pp. 4196-4202
    • Hogan, M.M.1    Vogel, S.N.2
  • 14
    • 0003633755 scopus 로고
    • National Research Council DHEW publication no. (NIH) 85-23. Institute of Laboratory Resources. Washington, D.C.
    • 13a. Institute of Laboratory Animal Resources. 1985. Guide for the care and use of laboratory animals. National Research Council DHEW publication no. (NIH) 85-23. Institute of Laboratory Resources. Washington, D.C.
    • (1985) Guide for the Care and use of Laboratory Animals
  • 15
  • 17
    • 0030941175 scopus 로고    scopus 로고
    • Secretory leukocyte protease inhibitor: A macrophage product induced by and antagonistic to bacterial lipopolysaccharide
    • Jin, F.-Y., C. Nathan, D. Radzioch, and A. Ding. 1997. Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide. Cell 88:417-426.
    • (1997) Cell , vol.88 , pp. 417-426
    • Jin, F.-Y.1    Nathan, C.2    Radzioch, D.3    Ding, A.4
  • 21
    • 0027181496 scopus 로고
    • Cloning and characterization of cDNA encoding a precursor for human adrenomedullin
    • (Er-ratum. 202:643, 1994.)
    • Kitamura, K., J. Sakata, K. Kangawa, M. Kojima, H. Matsuo, and T. Eto. 1993. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. Biochem. Biophys. Res. Commun. 194:720-725. (Er-ratum. 202:643, 1994.)
    • (1993) Biochem. Biophys. Res. Commun. , vol.194 , pp. 720-725
    • Kitamura, K.1    Sakata, J.2    Kangawa, K.3    Kojima, M.4    Matsuo, H.5    Eto, T.6
  • 22
    • 0028026944 scopus 로고
    • Taxoplasrna gondii soluble antigen induces a subset of lipopolysaccharide-inducible genes and tyrosine phosphoproteins in peritoneal macrophages
    • LI, Z. Y., C. L. Manthey, P. Y. Perera, A. Sher, and S. N. Vogel. 1994. Taxoplasrna gondii soluble antigen induces a subset of lipopolysaccharide-inducible genes and tyrosine phosphoproteins in peritoneal macrophages. Infect. Immun. 62:3434-3440.
    • (1994) Infect. Immun. , vol.62 , pp. 3434-3440
    • Li, Z.Y.1    Manthey, C.L.2    Perera, P.Y.3    Sher, A.4    Vogel, S.N.5
  • 23
    • 0026670898 scopus 로고
    • Taxol increases steady-state levels of lipopolysacchwride-inducible genes and protein-tyrosine phosphorylation in murine macrophages
    • Manthey, C. L., M. E. Brandes, P. Y. Perera, and S. N. Vogel. 1992. Taxol increases steady-state levels of lipopolysacchwride-inducible genes and protein-tyrosine phosphorylation in murine macrophages. J. Immunol. 149:2459-2465.
    • (1992) J. Immunol. , vol.149 , pp. 2459-2465
    • Manthey, C.L.1    Brandes, M.E.2    Perera, P.Y.3    Vogel, S.N.4
  • 25
    • 0028324655 scopus 로고
    • Taxol provides a second signal for murine macrophage tumoricidal activity
    • Manthey, C. L., P. Y. Perera, C. A. Salkowski, and S. N. Vogel. 1994. Taxol provides a second signal for murine macrophage tumoricidal activity. J. Immunol. 152:825-831.
    • (1994) J. Immunol. , vol.152 , pp. 825-831
    • Manthey, C.L.1    Perera, P.Y.2    Salkowski, C.A.3    Vogel, S.N.4
  • 26
    • 0026505172 scopus 로고
    • The role of cytokines in host responses to endotoxin
    • Manthey, C. L., and S. N. Vogel. 1992. The role of cytokines in host responses to endotoxin. Rev, Med. Microbiol. 3:72-79.
    • (1992) Rev, Med. Microbiol. , vol.3 , pp. 72-79
    • Manthey, C.L.1    Vogel, S.N.2
  • 27
    • 0030670077 scopus 로고    scopus 로고
    • Expression of adrenomedullin and its receptor in normal and malignant human skin: A potential pluripotent role in the integument
    • Martinez, A., T. H. Elsasser, C. Muro-Cacho, T. W. Moody, M. J. Miller, C. J. Maori, and F. Cuttitta. 1997. Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument. Endocrinology 138:5597-5604.
    • (1997) Endocrinology , vol.138 , pp. 5597-5604
    • Martinez, A.1    Elsasser, T.H.2    Muro-Cacho, C.3    Moody, T.W.4    Miller, M.J.5    Maori, C.J.6    Cuttitta, F.7
  • 29
    • 0014122519 scopus 로고
    • Chemical, physical, biological properties of a lipopolysaccharide from Escherichia coli K-235
    • McIntire, F. C., H. W. Sievert, G. H. Barlow, R. A. Finley, and A. Y. Lee. 1967. Chemical, physical, biological properties of a lipopolysaccharide from Escherichia coli K-235. Biochemistry 6:2363-2372.
    • (1967) Biochemistry , vol.6 , pp. 2363-2372
    • McIntire, F.C.1    Sievert, H.W.2    Barlow, G.H.3    Finley, R.A.4    Lee, A.Y.5
  • 30
    • 0029834198 scopus 로고    scopus 로고
    • Adrenomedullin expression in human tumor cell lines. Its potential role as an autocrine growth factor
    • Miller, M. J., A. Martinez, E. J. Unsworth, C. J. Thiele, T. W. Moody, T. Elsasser, and F. Cuttitta. 1996. Adrenomedullin expression in human tumor cell lines. Its potential role as an autocrine growth factor. J. Biol. Chem. 271:23345-23351.
    • (1996) J. Biol. Chem. , vol.271 , pp. 23345-23351
    • Miller, M.J.1    Martinez, A.2    Unsworth, E.J.3    Thiele, C.J.4    Moody, T.W.5    Elsasser, T.6    Cuttitta, F.7
  • 31
    • 0028144708 scopus 로고
    • Inhibition of nitric oxide synthesis is detrimental during endotoxemia
    • Minnard, E. A., J. Shou, H. Naama, A. Cech, H. Gallagher, and J. M. Daly. 1994. Inhibition of nitric oxide synthesis is detrimental during endotoxemia. Arch. Surg. 129:142-147.
    • (1994) Arch. Surg. , vol.129 , pp. 142-147
    • Minnard, E.A.1    Shou, J.2    Naama, H.3    Cech, A.4    Gallagher, H.5    Daly, J.M.6
  • 32
    • 0016861416 scopus 로고
    • Fractions of lipopolysaccharide from Escherichia coli O111:B4 prepared by two extraction procedures
    • Morrison, D. C., and L. Leive. 1975. Fractions of lipopolysaccharide from Escherichia coli O111:B4 prepared by two extraction procedures. J. Biol. Chem. 250:2911-2919.
    • (1975) J. Biol. Chem. , vol.250 , pp. 2911-2919
    • Morrison, D.C.1    Leive, L.2
  • 33
    • 0025225333 scopus 로고
    • Interleukin-1 receptor antagonist reduces mortality from endotoxin shock
    • Ohlsson, K., P. Bjork, M. Bergenfeldt, R. Hageman, and R. C. Thompson. 1990. Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature 348:550-552.
    • (1990) Nature , vol.348 , pp. 550-552
    • Ohlsson, K.1    Bjork, P.2    Bergenfeldt, M.3    Hageman, R.4    Thompson, R.C.5
  • 34
    • 0023607880 scopus 로고
    • Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: Heart rate as an early predictor of prognosis
    • Parker, M. M., J. H. Shelhamer, C. Natanson, D. W. Alling, and J. E. Parrillo. 1987. Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: heart rate as an early predictor of prognosis. Crit. Care Med. 15:923-929.
    • (1987) Crit. Care Med. , vol.15 , pp. 923-929
    • Parker, M.M.1    Shelhamer, J.H.2    Natanson, C.3    Alling, D.W.4    Parrillo, J.E.5
  • 35
    • 0027920980 scopus 로고
    • Pathogenetic mechanisms of septic shock
    • Parrillo, J. E. 1993. Pathogenetic mechanisms of septic shock. N. Engl. J. Med. 328:1471-1477.
    • (1993) N. Engl. J. Med. , vol.328 , pp. 1471-1477
    • Parrillo, J.E.1
  • 36
    • 0028063124 scopus 로고
    • Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid in primary murine macrophages. Dissection of signaling pathways leading to gene induction and tyrosine phosphorylation
    • Perera, P.-Y., S. A. Barber, L. M. Ching, and S. N. Vogel. 1994. Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid in primary murine macrophages. Dissection of signaling pathways leading to gene induction and tyrosine phosphorylation. J. Immunol. 153:4684-1693.
    • (1994) J. Immunol. , vol.153 , pp. 4684-11693
    • Perera, P.-Y.1    Barber, S.A.2    Ching, L.M.3    Vogel, S.N.4
  • 37
    • 0030021823 scopus 로고    scopus 로고
    • Paclitaxel (Taxol)-induced NF-KB translocation in murine macrophages
    • Perera, P.-Y., N. Qureshi, and S. N. Vogel. 1996. Paclitaxel (Taxol)-induced NF-KB translocation in murine macrophages. Infect. Immun. 64:878-884.
    • (1996) Infect. Immun. , vol.64 , pp. 878-884
    • Perera, P.-Y.1    Qureshi, N.2    Vogel, S.N.3
  • 38
    • 0024605005 scopus 로고
    • Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo
    • Rewcastle, G. W., G. J. Atwell, B. C. Baguley, S. B. Calveley, and W. A. Denny. 1989. Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo. J. Med. Chem. 32:793-799.
    • (1989) J. Med. Chem. , vol.32 , pp. 793-799
    • Rewcastle, G.W.1    Atwell, G.J.2    Baguley, B.C.3    Calveley, S.B.4    Denny, W.A.5
  • 40
    • 0031567894 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo: The roles of macrophages, endogenous IFN-gamma, and TNF receptor-1-mediated signaling
    • Salkowski, C. A., G. Detore, R. McNally, N. van Rooijen, and S. N. Vogel. 1997. Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo: the roles of macrophages, endogenous IFN-gamma, and TNF receptor-1-mediated signaling. J. Immunol. 158:905-912.
    • (1997) J. Immunol. , vol.158 , pp. 905-912
    • Salkowski, C.A.1    Detore, G.2    McNally, R.3    Van Rooijen, N.4    Vogel, S.N.5
  • 41
    • 0029076291 scopus 로고
    • Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection
    • Salkowski, C. A., R. Neta, T. A. Wynn, G. Strassmann, N. van Rooijen, and S. N. Vogel. 1995. Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. J. Immunol. 155:3168-3179.
    • (1995) J. Immunol. , vol.155 , pp. 3168-3179
    • Salkowski, C.A.1    Neta, R.2    Wynn, T.A.3    Strassmann, G.4    Van Rooijen, N.5    Vogel, S.N.6
  • 42
    • 0028804125 scopus 로고
    • Endotoxin markedly elevates plasma concentration and gene transcription of adrenomedullin in rat
    • Shoji, H., N. Minamino, K. Kangawa, and H. Matsuo. 1995. Endotoxin markedly elevates plasma concentration and gene transcription of adrenomedullin in rat. Biochem. Biophys. Res. Commun. 215:531-537.
    • (1995) Biochem. Biophys. Res. Commun. , vol.215 , pp. 531-537
    • Shoji, H.1    Minamino, N.2    Kangawa, K.3    Matsuo, H.4
  • 43
    • 0003520060 scopus 로고    scopus 로고
    • Up-regulation of rat adrenomedullin gene expression by endotoxin: Relation to nitric oxide synthesis
    • So, S., Y. Hattori, K. Kasai, S. Shimoda, and S. S. Gross. 1996. Up-regulation of rat adrenomedullin gene expression by endotoxin: relation to nitric oxide synthesis. Life Sci. 58:L309-L315.
    • (1996) Life Sci. , vol.58
    • So, S.1    Hattori, Y.2    Kasai, K.3    Shimoda, S.4    Gross, S.S.5
  • 45
    • 0028954392 scopus 로고
    • Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells
    • Sugo, S., N. Minamino, H. Shoji, K. Kangawa, K. Kitamura, T. Eto, and H. Matsuo. 1995. Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 207:25-32.
    • (1995) Biochem. Biophys. Res. Commun. , vol.207 , pp. 25-32
    • Sugo, S.1    Minamino, N.2    Shoji, H.3    Kangawa, K.4    Kitamura, K.5    Eto, T.6    Matsuo, H.7
  • 46
    • 0002171415 scopus 로고
    • The Lps gene: Insights into the genetic and molecular basis of LPS responsiveness and macrophage differentiation
    • B. Beutler (ed.). Raven Press, New York, N.Y.
    • Vogel, S. N. 1992. The Lps gene: insights into the genetic and molecular basis of LPS responsiveness and macrophage differentiation, p. 485-513. In B. Beutler (ed.). Tumor necrosis factors: the molecules and their emerging role in medicine. Raven Press, New York, N.Y.
    • (1992) Tumor Necrosis Factors: The Molecules and Their Emerging Role in Medicine , pp. 485-513
    • Vogel, S.N.1
  • 48
    • 0029886747 scopus 로고    scopus 로고
    • Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/ interferon-gamma
    • Zhang, X., V. E. Laubach, E. W. Alley, K. A. Edwards, P. A. Sherman, S. W. Russell, and W. J. Murphy. 1996. Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/ interferon-gamma. J. Leukocyte Biol. 59:575-585.
    • (1996) J. Leukocyte Biol. , vol.59 , pp. 575-585
    • Zhang, X.1    Laubach, V.E.2    Alley, E.W.3    Edwards, K.A.4    Sherman, P.A.5    Russell, S.W.6    Murphy, W.J.7
  • 49
    • 0032556955 scopus 로고    scopus 로고
    • PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a nonestrogenic mechanism in the human endometrium
    • Zhao, Y., S. Hague, S. Manek, L. Zhang, R. Bicknell, and M. C. Rees. 1998. PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a nonestrogenic mechanism in the human endometrium. Oncogene 16:409-415.
    • (1998) Oncogene , vol.16 , pp. 409-415
    • Zhao, Y.1    Hague, S.2    Manek, S.3    Zhang, L.4    Bicknell, R.5    Rees, M.C.6
  • 50
    • 0026016470 scopus 로고
    • Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial
    • The HA-1A Sepsis Study Group
    • Ziegler, E. J., C. J. J. Fisher, C. L. Sprung, R. C. Straube, J. C. Sadoff, G. E. Foulke, C. H. Wortel, M. P. Fink, R. P. Dellinger, and N. N. Teng. 1991. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group. N. Engl. J. Med. 324:429-436.
    • (1991) N. Engl. J. Med. , vol.324 , pp. 429-436
    • Ziegler, E.J.1    Fisher, C.J.J.2    Sprung, C.L.3    Straube, R.C.4    Sadoff, J.C.5    Foulke, G.E.6    Wortel, C.H.7    Fink, M.P.8    Dellinger, R.P.9    Teng, N.N.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.