Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains

Infection and Immunity

Volumn 70, Issue 5, 2002, Pages 2512-2518

  Katz, Jannet ^a   Yang, Qiu Bo ^a   Zhang, Ping ^a   Potempa, Jan ^a   Travis, James ^a   Michalek, Suzanne M ^a   Balkovetz, Daniel F ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; GINGIPAIN; LEUPEPTIN; PROTEIN HRGPA; PROTEIN KGP; PROTEIN RGPB; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ARTICLE; BACTERIAL VIRULENCE; CELL JUNCTION; CONTROLLED STUDY; EPITHELIUM CELL; NONHUMAN; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN HYDROLYSIS;

ADHESINS, BACTERIAL; ANIMALS; CADHERINS; CATALYTIC DOMAIN; CELL LINE; CYSTEINE ENDOPEPTIDASES; DOGS; EPITHELIAL CELLS; HEMAGGLUTININS; HYDROLYSIS; PORPHYROMONAS GINGIVALIS;

EID: 0036120364     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.5.2512-2518.2002     Document Type: Article

References (50)

1. Analysis of the prtP gene encoding porphypain, a cysteine protease of Porphyromonas gingivalis
2. Fluorescence image analysis of the association between Porphyromonas gingivalis and gingival epithelial cells
3. Characterization of the Porphyromonas gingivalis antigen recognized by a monoclonal antibody which prevents colonization by this organism
4. Actinobacillus actinomycetemcomitans may utilize either actin-dependent or actin-independent mechanisms of invasion
5. Inactivation of tumor necrosis factor alpha by proteinases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis. Implications of immune evasion
6. Experimental Porphyromonas gingivalis infection in nonimmune athymic BALB/c mice
7. Characterization of an adherence and antigenic determinant of the Argl protease of Porphyromonas gingivalis which is present on multiple gene products
8. Molecular genetics and nomenclature of proteases of Porphyromonas gingivalis
9. Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis
10. Porphyrin-mediated binding to hemoglobin by the HA2 domain of cysteine proteinases (gingipains) and hemagglutinins from the periodontal pathogen Porphyromonas gingivalis
11. Interactions of Porphyromonas gingivalis with epithelial cells
12. The predominant cultivable microbiota of active and inactive periodontal lesions
13. Epithelial cell polarity affects susceptibility to Pseudomonas aeruginosa invasion and cytotoxicity
14. A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis
15. Role of gingipain R in the pathogenesis of Porphyromonas gingivalis-mediated periodontal disease
16. Inactivation of human serum bactericidal activity by a trypsin-like protease isolated from Porphyromonas gingivalis
17. The hemagglutinin gene A (hagA) of Porphyromonas gingivalis 381 contains four large, contiguous, direct repeats
18. Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis
19. Humoral response to Porphyromonas (Bacteroides) gingivalis in rats: Time course and T-cell dependence
20. Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes
21. Effect of host responses on the pathogenicity of strains of Porphyromonas gingivalis
22. The relationship between colonization and hemagglutination inhibiting and B cell epitopes of Porphyromonas gingivalis
23. Nature of periodontal diseases: Assessment and diagnosis
24. Proteases of Porphyromonas gingivalis: What don't they do?
25. Porphyromonas gingivalis invasion of gingival epithelial cells
26. Life below the gum line: Pathogenic mechanisms of Porphyromonas gingivalis
27. Revised sequence of the Porphyromonas gingivalis pryT cysteine protease/hemagglutinin gene: Homology with streptococcal pyrogenic exotoxin B/streptococcal proteinase
28. Antibodies to Bacteroides gingivalis in patients with treated and untreated periodontal disease
29. Immunoglobulin G response to subgingival gram-negative bacteria in human subjects
30. The Bacteroidesfragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells
31. Bacteroides-specific IgG and IgA subclass antibody-secreting cells isolated from chronically inflamed gingival tissues
32. Purification and properties of hemagglutinin from culture supernatant of Bacteroides gingivalis
33. MSCRAMM-mediated adherence of microorganisms to host tissues
34. Lysine- and arginine-specific proteinases from Porphyromonas gingivalis
35. Characterization of the binding activities of proteinase-adhesin complexes from Porphyromonas gingivalis
36. Role of bacterial proteinases in matrix destruction and modulation of host responses
37. Comparative properties of two cysteine proteinases (gingipains R), the products of two related but individual genes of Porphyromonas gingivalis
38. Porphyromonas gingivalis: A proteinase/gene accounting audit
39. Titration and mapping of the active site of cysteine proteinases from Porphyromonas gingivalis (gingipains) using peptidyl chloromethanes
40. Intragingival occurrence of Actinobacillus actinomycetemcomitans and Bacteroides gingivalis in active destructive periodontal lesions
41. Porphyromonas gingivalis invades oral epithelial cells in vitro
42. Porphyromonas gingivalis invades human pocket epithelium in vitro
43. Increased opsonization of a prtH-defective mutant of Porphyromonas gingivalis W83 is caused by reduced degradation of complement-derived opsonins
44. Biosynthesis of the cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby canine kidney epithelial cells
45. Requirements for invasion of epithelial cells by Actinobacillus actinomycetemcomitans
46. Characteristics of Bacteroides asaccharolyticus from dental plaques of beagle dogs
47. Bacteriology of human experimental gingivitis: Effect of plaque age
48. Bacterial proteins binding to the mammalian extracellular matrix
49. Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin
50. IL-8 degradation by Porphyromonas gingivalis proteases