Adrenomedullin reduces endothelial hyperpermeability

Circulation Research

Volumn 91, Issue 7, 2002, Pages 618-625

  Hippenstiel, Stefan ^a   Witzenrath, Martin ^a   Schmeck, Bernd ^a   Hocke, Andreas ^a   Krisp, Mathias ^a   Krüll, Matthias ^a   Seybold, Joachim ^a   Seeger, Werner ^c   Rascher, Wolfgang ^b   Schütte, Hartwig ^c   Suttorp, Norbert ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Adrenomedullin; Cultured endothelial cells; Endothelial barrier dysfunction; Endothelial permeability

Indexed keywords

ADRENOMEDULLIN; CALCIUM ION; CYCLIC AMP; CYCLIC AMP PHOSPHODIESTERASE; CYCLIC GMP; HEMOLYSIN; HYDROGEN PEROXIDE; MYOSIN LIGHT CHAIN; PHOSPHODIESTERASE; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IV; THROMBIN; UNCLASSIFIED DRUG;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ESCHERICHIA COLI; HUMAN; HUMAN CELL; INFLAMMATION; ISOLATED LUNG; LUNG EDEMA; LUNG PERFUSION; MICROFILAMENT; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; RABBIT; SEPSIS; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ADRENOMEDULLIN; ANIMALS; CALCIUM; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CYCLIC AMP; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; HYDROGEN PEROXIDE; LUNG; MICROFILAMENTS; MYOSIN LIGHT CHAINS; PEPTIDES; PHOSPHORYLATION; PULMONARY EDEMA; RABBITS; SWINE;

EID: 0037019988     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000036603.61868.F9     Document Type: Article

References (41)

1. Fein AM, Calalang-Colucci MG. Acute lung injury and acute respiratory distress syndrome in sepsis and septic shock. Crit Care Clin. 2000;16:289-317.
2. Stevens T, Garcia JG, Shasby DM, Bhattacharya J, Malik AB. Mechanisms regulating endothelial cell barrier function. Am J Physiol. 2000;279:L419-L422.
3. Borbiev T, Verin AD, Shi S, Liu F, Garcia JG. Regulation of endothelial cell barrier function by calcium/calmodulin-dependent protein kinase II. Am J Physiol. 2001;280:L983-L990.
4. Carbajal JM, Gratrix ML, Yu CH, Schaeffer RC Jr. ROCK mediates thrombin's endothelial barrier dysfunction. Am J Physiol. 2000;279:C195-C204.
5. Nieuw Amerongen GP, van Delft S, Vermeer MA, Collard JG, van Hinsbergh VW. Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases. Circ Res. 2000;87:335-340.
6. Tinsley JH, De Lanerolle P, Wilson E, Ma W, Yuan SY. Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability. Am J Physiol. 2000;279:C1285-C1289.
7. Siflinger-Birnboim A, Goligorsky MS, Del Vecchio PJ, Malik AB. Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability. Lab Invest. 1992;67:24-30.
8. Suttorp N, Weber U, Welsch T, Schudt C. Role of phosphodiesterases in the regulation of endothelial permeability in vitro. J Clin Invest. 1993;91:1421-1428.
9. Suttorp N, Hippenstiel S, Fuhrmann M, Krüll M, Podzuweit T. Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability. Am J Physiol. 1996;270:C778-C785.
10. Suttorp N, Ehreiser P, Hippenstiel S. Fuhrmann M, Krüll M, Tenor H, Schudt C. Hyperpermeability of pulmonary endothelial monolayer: protective role of phosphodiesterase isoenzymes 3 and 4. Lung. 1996;174:181-194.
11. Garcia JG, Verin AD, Schaphorst KL. Regulation of thrombin-mediated endothelial cell contraction and permeability. Semin Thromb Hemost. 1996;22:309-315.
12. Suttorp N, Floer B, Schnittler H, Seeger W, Bhakdi S. Effects of Escherichia coli hemolysin on endothelial cell function. Infect Immun. 1990;58:3796-3801.
13. Suttorp, N, Fuhrmann M, Tannert-Otto S, Grimminger F, Bhadki S. Pore-forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells. J Exp Med. 1993;178:337-341.
14. Lum H, Jaffe HA, Schulz IT, Masood A, RayChaudhury A. Green RD. Expression of PKA inhibitor (PKI) gene abolishes cAMP-mediated protection to endothelial barrier dysfunction. Am J Physiol. 1999;277:C580-C588.
15. Hirata Y, Mitaka C, Sato K, Nagura T, Tsunoda Y, Amaha K, Marumo F. Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab. 1996;81:1449-1453.
16. Nikitenko LL, Smith DM, Hague S, Wilson CR, Bicknell R, Rees MC. Adrenomedullin and the microvasculature. Trends Pharmacol Sci. 2002;23:101-103.
17. Ueda S, Nishio K, Minamino N, Kubo A, Akai Y, Kangawa K, Matsuo H, Fujimura Y, Yoshioka A, Masui K, Doi N, Murao Y, Miyamoto S. Increased plasma levels of adrenomedullin in patients with systemic inflammatory response syndrome. Am J Respir Crit Care Med. 1999;160:132-136.
18. Wang P, Zhou M, Ba ZF, Cioffi WG, Chaudry IH. Up-regulation of a novel potent vasodilatory peptide adrenomedullin during polymicrobial sepsis. Shock. 1998;10:118-122.
19. Wang P. Adrenomedullin in sepsis and septic shock. Shock. 1998;10:383-384.
20. Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev. 2000;21:138-167.
21. Samson WK. Adrenomedullin and the control of fluid and electrolyte homeostasis. Annu Rev Physiol. 1999;61:363-389.
22. Ishimitsu T, Miyata A, Matsuoka H, Kangawa K. Transcriptional regulation of human adrenomedullin gene in vascular endothelial cells. Biochem Biophys Res Commun. 1998;243:463-470.
23. Buhlmann N, Leuthauser K, Muff R, Fischer JA, Born W. A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMPI. Endocrinology. 1999;140:2883-2890.
24. Barker S, Kapas S, Corder R, Clark AJ. Adrenomedullin acts via stimulation of cyclic AMP and not via calcium signalling in vascular cells in culture. J Hum Hypertens. 1996;10:421-423.
25. 2+ mobilization, in bovine aortic endothelial cells. J Biol Chem. 1995;270:4412-4417.
26. Shindo T, Kurihara H, Maemura K, Kurihara Y, Kuwaki T, Izumida T, Minamino N, Ju KH, Morita H, Oh-hashi Y, Kumada M, Kangawa K, Nagai R, Yazaki Y. Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature. Circulation. 2000;101:2309-2316.
27. Caron KM, Smithies O. Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional adrenomedullin gene. Proc Natl Acad Sci U S A. 2001;98:615-619.
28. Hippenstiel S, Soeth S, Kellas B, Fuhrmann O, Seybold J, Krüll M, Eichel-Streiber C, Goebeler M, Ludwig S, Suttorp N. Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells. Blood. 2000;95:3044-3051.
29. Krüll M, Dold C, Hippenstiel S, Rosseau S, Lohmeyer J, Suttorp N. Escherichia coli hemolysin and Staphylococcus aureus α-toxin potently induce neutrophil adhesion to cultured human endothelial cells. J Immunol. 1996;157:4133-4140.
30. Feth F, Rascher W, Michel MC. G-protein coupling and signalling of Y1-like neuropeptide Y receptors in SK-N-MC cells. Naunyn Schmiedebergs Arch Pharmacol. 1991;344:1-7.
31. Hippenstiel S, Krüll M, Ikemann A, Risau W, Clauss M, Suttorp N. VEGF induces hyperpermeability by a direct action on endothelial cells. Am J Physiol. 1998;274:L678-L684.
32. 2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985;260:3440-3450.
33. Seeger W, Walmrath D, Grimminger F, Rosseau S, Schütte H, Kramer HJ, Ermert L, Kiss L. Adult respiratory distress syndrome: model systems using isolated perfused rabbit lungs. Methods Enzymol. 1994;233:549-584.
34. Seeger W, Hansen T, Rössig R, Schmehl T, Schütte H, Kramer HJ, Walmrath D, Weissmann N, Grimminger F, Suttorp N. Hydrogen peroxide-induced increase in lung endothelial and epithelial permeability: effect of adenylate cyclase stimulation and phosphodiesterase inhibition. Microvasc Res. 1995;50:1-17.
35. Nishio K, Akai Y, Murao Y, Doi N, Ueda S, Tabuse H, Miyamoto S, Dohi K, Minamino N, Shoji H, Kitamura K, Kangawa K, Matsuo H. Increased plasma concentrations of adrenomedullin correlate with relaxation of vascular tone in patients with septic shock. Crit Care Med. 1997;25:953-957.
36. Vijay P. Adrenomedullin in the treatment of pulmonary hypertension. Heart. 2000;84:575-576.
37. Garcia JG, Verin AD, Schaphorst K, Siddiqui R, Patterson CE, Csortos C, Natarajan V. Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60(src). Am J Physiol. 1999;276:L989-L998.
38. Essler M, Staddon JM, Weber PC, Aepfelbacher M. Cyclic AMP blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signaling. J Immunol. 2000;164:6543-6549.
39. Comerford KM, Lawrence DW, Synnestvedt K, Levi BP, Colgan SP. Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability. FASEB J. 2002;16:583-585.
40. Patterson CE, Davis HW, Schaphorst KL, Garcia JG. Mechanisms of cholera toxin prevention of thrombin- and PMA-induced endothelial cell barrier dysfunction. Microvasc Res. 1994;48:212-235.
41. Ono Y, Okano I, Kojima M, Okada K, Kangawa K. Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Biochem Biophys Res Commun. 2000;271:197-202.