Vasodilator effects of adrenomedullin on small pulmonary arteries and veins in anaesthetized cats

British Journal of Pharmacology

Volumn 121, Issue 4, 1997, Pages 679-686

  Shirai, Mikiyasu ^a   Shimouchi, Akito ^a   Ikeda, Soichiro ^b   Ninomiya, Ishio ^c   Sunagawa, Kenji ^a   Kangawa, Kenji ^a   Matsuo, Hisayuki ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

^c HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Adrenomedullin; Calcitonin gene related peptide; CGRP8 37; Hexamethonium bromide; Hypoxic pulmonary vasoconstriction; Pulmonary vasodilatation; Small pulmonary vessels; Vascular internal diameter

Indexed keywords

ADRENOMEDULLIN; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ARTERY DILATATION; ARTICLE; BLOOD VESSEL TONE; CAT; HYPOXIA; INTRAARTERIAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY VEIN; VEIN DILATATION;

ADRENOMEDULLIN; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CATS; PEPTIDES; PULMONARY ARTERY; PULMONARY VEINS; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; VASOCONSTRICTION; VASODILATION; VASODILATOR AGENTS;

EID: 0030979851     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701178     Document Type: Article

References (38)

1. ANDERSSON, S.E. (1989). Effects of intravenous calcitonin gene-related peptide (CGRP) on local blood flow in the cat. Acta Physiol. Scand., 137, 259-270.
2. BEVAN, J.A. & LAHER, I. (1991). Pressure and flow-dependent vascular tone. FASEB J., 5, 2267-2273.
3. BORGSTROM, P , GRANDE, P.-O. & LINDBOM, L. (1981). Responses of single arterioles in vivo in cat skeletal muscle to change in arterial pressure applied at different rates. Acta Physiol. Scand., 113, 207-212.
4. DEWITT, B.J., CHENG, D.Y., CAMINITI, G.N., NOSSAMAN, B.D., COY, D.H., MUROHY, W.A. & KADOWITZ, P.J. (1994). Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the pulmonary vascular bed of the cat. Eur. J. Pharmacol., 257, 303-306.
5. 1 receptors. Life Sci., 56, PL19-25.
6. ELHAWARY, A.M., POON, J. & PANG, C.C.Y. (1995). Effects of calcitonin gene-related peptide receptor antagonists on renal actions of adrenomedullin. Br. J. Pharmacol., 115, 1133-1140.
7. GARDINER, S.M., KEMP, P.A., MARCH, J.E. & BENNETT, T. (1995). Regional haemodynamic effects of human and rat adrenomedullin in conscious rats. Br. J. Pharmacol., 114, 584-591.
8. 13 52 with calcitonin gene-related peptide receptors in the microvasculature of the rat and hamster. Br. J. Pharmacol., 114, 592-597.
9. HAO, Q., CHANG, J.-K., CHARAVI, H., FORTENBERRY, Y., HYMAN, A. & LIPPTON, H. (1994). An adrenomedullin (ADM) fragment retains the systemic vasodilator activity of human ADM. Life Sci., 54, PL265-270.
10. HAYNES, J.M. & COOPER, M.E. (1995). Adrenomedullin and calcitonin gene-related peptide in the rat isolated kidney and in the anaesthetized rat: in vitro and in vivo effects. Eur. J. Pharmacol., 280, 91-94.
11. HEATON, J., LIN, B., CHANG, J.-K., STEINBERG, S., HYMAN, A. & LIPPTON, H. (1995). Pulmonary vasodilation to adrenomedullin: a novel peptide in humans. Am. J. Physiol., 268, H2211-H2215.
12. ISHIMITSU, T., NISHIKIMI, T., SAITO, Y., KITAMURA, K., ETO, T., KANGAWA, K., MATSUO, H., OMAE, T. & MATSUOKA, H. (1994). Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure. J. Clin. Invest., 94, 2158-2161.
13. ISHIZAKA, Y., ISHIZAKA, Y., TANAKA, M , KITAMURA, K., KANGAWA. K., MINAMINO, N., MATSUO, H. & ETO, T. (1994). Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells. Biochem. Biophys. Res. Commun., 200, 642-646.
14. KAPAS, S., CATT, K.J. & CLARK, A.J.L. (1995). Cloning and expression of cDNA encoding a rat adrenomedullin receptor. J. Biol. Chem., 270, 25344-25347.
15. KITAMURA, K., ICHIKI, Y., TANAKA, M., KAWAMOTO, M., EMURA, J., SAKAKIBARA, S., KANGAWA, K., MATSUO, H. & ETO, T. (1994). Immunoreactive adrenomedullin in human plasma. FEBS Lett., 341, 288-290.
16. KITAMURA, K., KANGAWA, K., KAWAMOTO, M., ICHIKI, Y., NAKAMURA, S., MATSUO, H. & ETO, T. (1993a). Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophys. Res. Commun., 192, 553-560.
17. KITAMURA, K., SAKATA, J., KANGAWA, K., KOJIMA, M., MATSUO, H. & ETO, T. (1993b). Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. Biochem. Biophys. Res. Commun., 194, 720-725.
18. KOLLER, A. & KALEY, G. (1990). Endothelium regulates skeletal muscle microcirculation by a blood flow velocity-sensing mechanism. Am. J. Physiol., 258, H916-H920.
19. KONTOS, H.A., WEI, E.P., NAVARI, R.M., LEVASSEUR, J.E., ROSENBLUM, W.I. & PATTERSON, J.L. JR. (1978). Responses of cerebral arteries and arterioles to acute hypotension and hypertension. Am. J. Physiol., 234, H371-H383.
20. LIPPTON, H., CHANG, J.-K., HAO, Q., SUMMER, W. & HYMAN, A.L. (1994). Adrenomedullin dilates the pulmonary vascular bed in vivo. J. Appl. Physiol., 76, 2154-2156.
21. MARSHALL, B.E. (1990). Hypoxic pulmonary vasoconstriction. Acta Physiol. Scand., 34 (Suppl. 94), 37-41.
22. NISHIKIMI, T., KITAMURA, K., SAITO, Y., SHIMADA, K., ISHIMITU, T., TAKAMIYA, M., KANGAWA, K., MATSUO, H., ETO, T., OMAE, T. & MATSUOKA, H. (1994). Clinical studies on the sites of production and clearance of circulating adrenomedullin in human subjects. Hypertension, 24, 600-604.
23. NUKI, C, KAWASAKI, H., KITAMURA, K., TAKENAGA, M., KANGAWA, K., ETO, T. & WADA, A. (1993). Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds. Biochem. Biophys. Res. Commun., 196, 245-251.
24. OWJI, A.A., SMITH, D.M., COPPOCK, H.A., MORGAN, D.G.A., BHOGAL, R., GHATEI, M.A. & BLOOM, S.R. (1995). An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat. Endocrinology, 136, 2127-2134.
25. PERREAULT, T. & GUTKOWSKA, J. (1995). Role of atrial natriuretic factor in lung physiology and pathology. Am. J. Respir. Crit. Care Med., 151, 226-242.
26. RICHARDS, A.M., NICHOLLS, M.G., LEWIS, L. & LAINCHBURY, J.G. (1996). Adrenomedullin. Clin. Sci., 91, 3-16.
27. SADA, K., SHIRAI, M. & NINOMIYA, I. (1985). X-ray TV system for measuring microcirculation in small pulmonary vessels. J. Appl. Physiol., 59, 1013-1018.
28. SHIMOKUBO, T., SAKATA, J., KITAMURA, K., KANGAWA, K., MATSUO, H. & ETO, T. (1995). Augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension. Life Sci., 51, 1771-1779.
29. SHIRAI, M., NINOMIYA, I. & SHINDO, T. (1993). Selective and tone-dependent vasodilation of arterial segment in rabbit and feline pulmonary microcirculation in response to ANP. Jpn. J. Physiol., 43, 485-499.
30. SHIRAI, M., SHIMOUCHI, A. & NINOMIYA, I. (1996). Microfocus X-ray television system for measuring internal diameter of arterioles and medium-sized arteries running into organ parenchyma (Abstract). Jpn. J. Physiol., 46(suppl.), S46.
31. SHIRAI, M., SHINDO, T. & NINOMIYA, I. (1994a). β-Adrenergic mechanisms attenuate hypoxic pulmonary vasoconstriction during systemic hypoxia in cats. Am. J. Physiol., 266, H1777-H1785.
32. SHARAI, M., SHINDO, T , SHIMOUCHI, A. & NINOMIYA, I. (1994b). Diameter and flow velocity changes of feline small pulmonary vessels in response to sympathetic nerve stimulation. Pflügers Arch., 429, 267-273.
33. SMIESKO, V., LANG, D.J. & JOHNSON, P.C. (1989). Dilator response of rat mesenteric arcading arterioles to increased blood flow velocity. Am. J. Physiol., 257, H1958-H1965.
34. SOBIN, S., INTAGLIETTA, S.M., FRASHER, W.G. & TREMER, H.M. (1966). The geometry of the pulmonary microcirculation. Angiology, 17, 24-30.
35. WALLENSTEIN, S., ZUCKER, C.L. & FLEISS, J.L. (1980). Some statistical methods useful in circulation research. Circ. Res., 47, 2-9.
36. WEIR, E.K. & ARCHER, S. (1995). The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J., 9, 183-189.
37. YOSHIBAYASHI, M., KITAMURA, K , SAITO, Y, KANGAWA, K., MATSUO, H., MATSUOKA, H., ETO, T. & KAMIYA, T. (1994). Elevated plasma levels of adrenomedullin, a novel hypotensive peptide, in pulmonary hypertension. Circulation, 90, 1-308.
38. ZHAO, L., BROWN, L.A., OWJI, A.A., NUNEZ, D.J.R., SMITH, D.M., GHATEI, M.A., BLOOM, S.R. & WILKINS, M.R. (1996). Adrenomedullin activity in chronically hypoxic rat lungs. Am. J. Physiol., 271, H622-H629.