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Volumn 27, Issue 4, 2007, Pages 327-338

Death receptor-mediated liver injury

Author keywords

Caspase inhibition; Fibrosis; Lipoapotosis

Indexed keywords

ALDEHYDE DEHYDROGENASE; BH3 PROTEIN; CASPASE 10; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CATHEPSIN B; COLLAGEN TYPE 1; CYTOKERATIN; CYTOKERATIN 18; DEATH RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL; PROTEIN BID; PROTEIN MCL 1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR RECEPTOR 1; UBIQUITIN PROTEIN LIGASE E3; UNINDEXED DRUG;

EID: 35948933964     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-991510     Document Type: Article
Times cited : (54)

References (111)
  • 1
    • 0036708291 scopus 로고    scopus 로고
    • Death receptor-mediated apoptosis and the liver
    • Yoon JH, Gores GJ. Death receptor-mediated apoptosis and the liver. J Hepatol 2002;37:400-410
    • (2002) J Hepatol , vol.37 , pp. 400-410
    • Yoon, J.H.1    Gores, G.J.2
  • 2
    • 0035034541 scopus 로고    scopus 로고
    • Apoptosis and liver diseases: Recent concepts of mechanism and significance
    • Ockner RK. Apoptosis and liver diseases: recent concepts of mechanism and significance. J Gastroenterol Hepatol 2001;16:248-260
    • (2001) J Gastroenterol Hepatol , vol.16 , pp. 248-260
    • Ockner, R.K.1
  • 3
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata S. Apoptosis by death factor. Cell 1997;88:355-365
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 4
    • 1242336980 scopus 로고    scopus 로고
    • Apoptosis: The nexus of liver injury and fibrosis
    • Canbay A, Friedman S, Gores GJ. Apoptosis: the nexus of liver injury and fibrosis. Hepatology 2004;39:273-278
    • (2004) Hepatology , vol.39 , pp. 273-278
    • Canbay, A.1    Friedman, S.2    Gores, G.J.3
  • 5
    • 0031092634 scopus 로고    scopus 로고
    • Lethal effect of recombinant human Fas ligand in mice pretreated with Propionibacterium acnes
    • Tanaka M, Suda T, Yatomi T, et al. Lethal effect of recombinant human Fas ligand in mice pretreated with Propionibacterium acnes. J Immunol 1997;158:2303-2309
    • (1997) J Immunol , vol.158 , pp. 2303-2309
    • Tanaka, M.1    Suda, T.2    Yatomi, T.3
  • 6
    • 0033735804 scopus 로고    scopus 로고
    • Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: Evidence for a postmitochondrial processing of caspase-8
    • Bajt ML, Lawson JA, Vonderfecht SL, et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci 2000;58:109-117
    • (2000) Toxicol Sci , vol.58 , pp. 109-117
    • Bajt, M.L.1    Lawson, J.A.2    Vonderfecht, S.L.3
  • 7
    • 5944233768 scopus 로고    scopus 로고
    • Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    • Holler N, Zaru R, Micheau O, et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 2000;1:489-495
    • (2000) Nat Immunol , vol.1 , pp. 489-495
    • Holler, N.1    Zaru, R.2    Micheau, O.3
  • 8
    • 0038610713 scopus 로고    scopus 로고
    • Caspase 8 small interfering RNA prevents acute liver failure in mice
    • Zender L, Hutker S, Liedtke C, et al. Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc Natl Acad Sci USA 2003;100:7797-7802
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7797-7802
    • Zender, L.1    Hutker, S.2    Liedtke, C.3
  • 9
    • 0032124903 scopus 로고    scopus 로고
    • Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
    • Chen J, Nagayama T, Jin K, et al. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 1998;18:4914-4928
    • (1998) J Neurosci , vol.18 , pp. 4914-4928
    • Chen, J.1    Nagayama, T.2    Jin, K.3
  • 10
    • 0030462463 scopus 로고    scopus 로고
    • BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway
    • Strobel T, Swanson L, Korsmeyer S, et al. BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc Natl Acad Sci USA 1996;93:14094-14099
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14094-14099
    • Strobel, T.1    Swanson, L.2    Korsmeyer, S.3
  • 11
    • 3042687605 scopus 로고    scopus 로고
    • Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die
    • Ekert PG, Read SH, Silke J, et al. Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. J Cell Biol 2004;165:835-842
    • (2004) J Cell Biol , vol.165 , pp. 835-842
    • Ekert, P.G.1    Read, S.H.2    Silke, J.3
  • 12
    • 0028856130 scopus 로고
    • Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver
    • Adachi M, Suematsu S, Kondo T, et al. Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat Genet 1995;11:294-300
    • (1995) Nat Genet , vol.11 , pp. 294-300
    • Adachi, M.1    Suematsu, S.2    Kondo, T.3
  • 13
    • 0027297663 scopus 로고
    • Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
    • Pfeffer K, Matsuyama T, Kundig TM, et al. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 1993;73:457-467
    • (1993) Cell , vol.73 , pp. 457-467
    • Pfeffer, K.1    Matsuyama, T.2    Kundig, T.M.3
  • 14
    • 11844305926 scopus 로고    scopus 로고
    • Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice
    • Yue HH, Diehl GE, Winoto A. Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice. Cell Death Differ 2005;12:94-97
    • (2005) Cell Death Differ , vol.12 , pp. 94-97
    • Yue, H.H.1    Diehl, G.E.2    Winoto, A.3
  • 15
    • 10744224746 scopus 로고    scopus 로고
    • HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice
    • Wang Y, Cui F, Lv Y, et al. HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice. Hepatology 2004;39:318-324
    • (2004) Hepatology , vol.39 , pp. 318-324
    • Wang, Y.1    Cui, F.2    Lv, Y.3
  • 16
    • 0037152184 scopus 로고    scopus 로고
    • Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-fas ligand antibody therapy
    • Nakamoto Y, Kaneko S, Fan H, et al. Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-fas ligand antibody therapy. J Exp Med 2002;196:1105-1111
    • (2002) J Exp Med , vol.196 , pp. 1105-1111
    • Nakamoto, Y.1    Kaneko, S.2    Fan, H.3
  • 17
    • 33846850424 scopus 로고    scopus 로고
    • Inflammatory tales of liver cancer
    • Hoffmann A, Xia Y, Verma IM. Inflammatory tales of liver cancer. Cancer Cell 2007;11:99-101
    • (2007) Cancer Cell , vol.11 , pp. 99-101
    • Hoffmann, A.1    Xia, Y.2    Verma, I.M.3
  • 18
    • 35948958492 scopus 로고    scopus 로고
    • The Fas/FasL signaling pathway
    • Dufour J-F, Clavien P-A, eds, Berlin, Heidelberg: Springer-Verlag;
    • Guicciardi ME, Gores GJ. The Fas/FasL signaling pathway. In: Dufour J-F, Clavien P-A, eds. Signaling Pathways in Liver Diseases. Berlin, Heidelberg: Springer-Verlag; 2005:129-138
    • (2005) Signaling Pathways in Liver Diseases , pp. 129-138
    • Guicciardi, M.E.1    Gores, G.J.2
  • 19
    • 0037276437 scopus 로고    scopus 로고
    • The CD95(APO-1/Fas) Dros Inf ServC and beyond
    • Peter ME, Krammer PH. The CD95(APO-1/Fas) Dros Inf ServC and beyond. Cell Death Differ 2003;10:26-35
    • (2003) Cell Death Differ , vol.10 , pp. 26-35
    • Peter, M.E.1    Krammer, P.H.2
  • 20
    • 0028883850 scopus 로고
    • Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (Dros Inf ServC) with the receptor
    • Kischkel FC, Hellbardt S, Behrmann I, et al. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (Dros Inf ServC) with the receptor. EMBO J 1995;14:5579-5588
    • (1995) EMBO J , vol.14 , pp. 5579-5588
    • Kischkel, F.C.1    Hellbardt, S.2    Behrmann, I.3
  • 21
    • 0029965280 scopus 로고    scopus 로고
    • FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
    • Chinnaiyan AM, Tepper CG, Seldin MF, et al. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 1996;271:4961-4965
    • (1996) J Biol Chem , vol.271 , pp. 4961-4965
    • Chinnaiyan, A.M.1    Tepper, C.G.2    Seldin, M.F.3
  • 22
    • 0032536771 scopus 로고    scopus 로고
    • Two CD95 (APO-1/Fas) signaling pathways
    • Scaffidi C, Fulda S, Srinivasan A, et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J 1998;17:1675-1687
    • (1998) EMBO J , vol.17 , pp. 1675-1687
    • Scaffidi, C.1    Fulda, S.2    Srinivasan, A.3
  • 24
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
    • Wei MC, Zong WX, Cheng EH, et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001;292:727-730
    • (2001) Science , vol.292 , pp. 727-730
    • Wei, M.C.1    Zong, W.X.2    Cheng, E.H.3
  • 25
    • 27544446991 scopus 로고    scopus 로고
    • Willis SN, Adams JM. Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 2005;17:617-625
    • Willis SN, Adams JM. Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 2005;17:617-625
  • 26
    • 0030861210 scopus 로고    scopus 로고
    • Hepatocytes in the bile duct-ligated rat express Bcl-2
    • Kurosawa H, Que FG, Roberts LR, et al. Hepatocytes in the bile duct-ligated rat express Bcl-2. Am J Physiol 1997;272(6 Pt 1):G1587-G1593
    • (1997) Am J Physiol , vol.272 , Issue.6 PART 1
    • Kurosawa, H.1    Que, F.G.2    Roberts, L.R.3
  • 27
    • 0030996170 scopus 로고    scopus 로고
    • Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene
    • Tzung SP, Fausto N, Hockenbery DM. Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am J Pathol 1997;150:1985-1995
    • (1997) Am J Pathol , vol.150 , pp. 1985-1995
    • Tzung, S.P.1    Fausto, N.2    Hockenbery, D.M.3
  • 28
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li H, Zhu H, Xu CJ, et al. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998;94:491-501
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3
  • 29
    • 0037178881 scopus 로고    scopus 로고
    • Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis
    • Li S, Zhao Y, He X, et al. Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J Biol Chem 2002;277:26912-26920
    • (2002) J Biol Chem , vol.277 , pp. 26912-26920
    • Li, S.1    Zhao, Y.2    He, X.3
  • 30
    • 13344285339 scopus 로고
    • Identification and characterization of a new member of the TNF family that induces apoptosis
    • Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995;3:673-682
    • (1995) Immunity , vol.3 , pp. 673-682
    • Wiley, S.R.1    Schooley, K.2    Smolak, P.J.3
  • 31
    • 0037418619 scopus 로고    scopus 로고
    • TRAIL-induced signalling and apoptosis
    • MacFarlane M. TRAIL-induced signalling and apoptosis. Toxicol Lett 2003;139:89-97
    • (2003) Toxicol Lett , vol.139 , pp. 89-97
    • MacFarlane, M.1
  • 32
    • 16644372319 scopus 로고    scopus 로고
    • Following a TRAIL: Update on a ligand and its five receptors
    • Kimberley FC, Screaton GR. Following a TRAIL: update on a ligand and its five receptors. Cell Res 2004;14:359-372
    • (2004) Cell Res , vol.14 , pp. 359-372
    • Kimberley, F.C.1    Screaton, G.R.2
  • 33
    • 0001203366 scopus 로고    scopus 로고
    • Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor
    • Wu GS, Burns TF, Zhan Y, et al. Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res 1999;59:2770-2775
    • (1999) Cancer Res , vol.59 , pp. 2770-2775
    • Wu, G.S.1    Burns, T.F.2    Zhan, Y.3
  • 34
    • 33750292822 scopus 로고    scopus 로고
    • The murine TRAIL receptor signals caspase-independent cell death through ceramide
    • Thon L, Mathieu S, Kabelitz D, et al. The murine TRAIL receptor signals caspase-independent cell death through ceramide. Exp Cell Res 2006;312:3808-3821
    • (2006) Exp Cell Res , vol.312 , pp. 3808-3821
    • Thon, L.1    Mathieu, S.2    Kabelitz, D.3
  • 35
    • 33745056174 scopus 로고    scopus 로고
    • Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor
    • van der Sloot AM, Tur V, Szegezdi E, et al. Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor. Proc Natl Acad Sci USA 2006;103:8634-8639
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8634-8639
    • van der Sloot, A.M.1    Tur, V.2    Szegezdi, E.3
  • 36
    • 0032713075 scopus 로고    scopus 로고
    • Safety and antitumor activity of recombinant soluble Apo2 ligand
    • Ashkenazi A, Pai RC, Fong S, et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 1999;104:155-162
    • (1999) J Clin Invest , vol.104 , pp. 155-162
    • Ashkenazi, A.1    Pai, R.C.2    Fong, S.3
  • 37
    • 0032929520 scopus 로고    scopus 로고
    • Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    • Walczak H, Miller RE, Ariail K, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999;5:157-163
    • (1999) Nat Med , vol.5 , pp. 157-163
    • Walczak, H.1    Miller, R.E.2    Ariail, K.3
  • 38
    • 33845727452 scopus 로고    scopus 로고
    • TRAIL mediates apoptosis in cancerous but not normal primary cultured cells of the human reproductive tract
    • Sadarangani A, Kato S, Espinoza N, et al. TRAIL mediates apoptosis in cancerous but not normal primary cultured cells of the human reproductive tract. Apoptosis 2007;12:73-85
    • (2007) Apoptosis , vol.12 , pp. 73-85
    • Sadarangani, A.1    Kato, S.2    Espinoza, N.3
  • 39
    • 9144234147 scopus 로고    scopus 로고
    • TRAIL and its receptors as targets for cancer therapy
    • Yagita H, Takeda K, Hayakawa Y, et al. TRAIL and its receptors as targets for cancer therapy. Cancer Sci 2004;95:777-783
    • (2004) Cancer Sci , vol.95 , pp. 777-783
    • Yagita, H.1    Takeda, K.2    Hayakawa, Y.3
  • 40
    • 0042329166 scopus 로고    scopus 로고
    • Hepatitis B virus enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity by increasing TRAIL-R1/death receptor 4 expression
    • Janssen HL, Higuchi H, Abdulkarim A, et al. Hepatitis B virus enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity by increasing TRAIL-R1/death receptor 4 expression. J Hepatol 2003;39:414-420
    • (2003) J Hepatol , vol.39 , pp. 414-420
    • Janssen, H.L.1    Higuchi, H.2    Abdulkarim, A.3
  • 41
    • 0035914341 scopus 로고    scopus 로고
    • The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis
    • Higuchi H, Bronk SF, Takikawa Y, et al. The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis. J Biol Chem 2001;276:38610-38618
    • (2001) J Biol Chem , vol.276 , pp. 38610-38618
    • Higuchi, H.1    Bronk, S.F.2    Takikawa, Y.3
  • 43
    • 16644383355 scopus 로고    scopus 로고
    • Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury
    • Ding WX, Yin XM. Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury. J Cell Mol Med 2004;8:445-454
    • (2004) J Cell Mol Med , vol.8 , pp. 445-454
    • Ding, W.X.1    Yin, X.M.2
  • 44
    • 33645799492 scopus 로고    scopus 로고
    • Mechanisms of liver injury. I. TNF-alpha-induced liver injury: Role of IKK, JNK, and ROS pathways
    • Schwabe RF, Brenner DA. Mechanisms of liver injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 2006;290:G583-G589
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Schwabe, R.F.1    Brenner, D.A.2
  • 45
    • 0041853690 scopus 로고    scopus 로고
    • Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    • Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003;114:181-190
    • (2003) Cell , vol.114 , pp. 181-190
    • Micheau, O.1    Tschopp, J.2
  • 46
    • 33749076455 scopus 로고    scopus 로고
    • Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes
    • Wullaert A, Heyninck K, Beyaert R. Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes. Biochem Pharmacol 2006;72:1090-1101
    • (2006) Biochem Pharmacol , vol.72 , pp. 1090-1101
    • Wullaert, A.1    Heyninck, K.2    Beyaert, R.3
  • 47
    • 33846154622 scopus 로고    scopus 로고
    • Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury
    • Chen X, Ding WX, Ni HM, et al. Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury. Mol Cell Biol 2007;27:541-553
    • (2007) Mol Cell Biol , vol.27 , pp. 541-553
    • Chen, X.1    Ding, W.X.2    Ni, H.M.3
  • 48
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • Kamata H, Honda S, Maeda S, et al. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005;120:649-661
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3
  • 49
    • 0033756474 scopus 로고    scopus 로고
    • Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
    • Guicciardi ME, Deussing J, Miyoshi H, et al. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest 2000;106:1127-1137
    • (2000) J Clin Invest , vol.106 , pp. 1127-1137
    • Guicciardi, M.E.1    Deussing, J.2    Miyoshi, H.3
  • 53
    • 22344435528 scopus 로고    scopus 로고
    • Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis
    • Guicciardi ME, Bronk SF, Werneburg NW, et al. Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis. Gastroenterology 2005;129:269-284
    • (2005) Gastroenterology , vol.129 , pp. 269-284
    • Guicciardi, M.E.1    Bronk, S.F.2    Werneburg, N.W.3
  • 54
    • 12344303157 scopus 로고    scopus 로고
    • Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury
    • Baskin-Bey ES, Canbay A, Bronk SF, et al. Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2005;288:G396-G402
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Baskin-Bey, E.S.1    Canbay, A.2    Bronk, S.F.3
  • 55
    • 0142151769 scopus 로고    scopus 로고
    • Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression
    • Canbay A, Feldstein AE, Higuchi H, et al. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology 2003;38:1188-1198
    • (2003) Hepatology , vol.38 , pp. 1188-1198
    • Canbay, A.1    Feldstein, A.E.2    Higuchi, H.3
  • 56
    • 33746268090 scopus 로고    scopus 로고
    • Alcohol and the liver
    • Reuben A. Alcohol and the liver. Curr Opin Gastroenterol 2006;22:263-271
    • (2006) Curr Opin Gastroenterol , vol.22 , pp. 263-271
    • Reuben, A.1
  • 58
    • 0035111054 scopus 로고    scopus 로고
    • Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis
    • Natori S, Rust C, Stadheim LM, et al. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J Hepatol 2001;34:248-253
    • (2001) J Hepatol , vol.34 , pp. 248-253
    • Natori, S.1    Rust, C.2    Stadheim, L.M.3
  • 59
    • 4544335155 scopus 로고    scopus 로고
    • Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients
    • Ribeiro PS, Cortez-Pinto H, Sola S, et al. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol 2004;99:1708-1717
    • (2004) Am J Gastroenterol , vol.99 , pp. 1708-1717
    • Ribeiro, P.S.1    Cortez-Pinto, H.2    Sola, S.3
  • 60
    • 0035408265 scopus 로고    scopus 로고
    • Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway
    • Zhou Z, Sun X, Kang YJ. Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway. Am J Pathol 2001;159:329-338
    • (2001) Am J Pathol , vol.159 , pp. 329-338
    • Zhou, Z.1    Sun, X.2    Kang, Y.J.3
  • 61
    • 0032986039 scopus 로고    scopus 로고
    • Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide
    • Deaciuc IV, Fortunato F, D'Souza NB, et al. Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide. Alcohol Clin Exp Res 1999;23:349-356
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 349-356
    • Deaciuc, I.V.1    Fortunato, F.2    D'Souza, N.B.3
  • 62
    • 18344389339 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress and CD95 ligand: A dual mechanism for hepatocyte apoptosis in chronic alcoholism
    • Minana JB, Gomez-Cambronero L, Lloret A, et al. Mitochondrial oxidative stress and CD95 ligand: a dual mechanism for hepatocyte apoptosis in chronic alcoholism. Hepatology 2002;35:1205-1214
    • (2002) Hepatology , vol.35 , pp. 1205-1214
    • Minana, J.B.1    Gomez-Cambronero, L.2    Lloret, A.3
  • 63
    • 29344441053 scopus 로고    scopus 로고
    • Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis
    • Ramalho RM, Cortez-Pinto H, Castro RE, et al. Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis. Eur J Gastroenterol Hepatol 2006;18:21-29
    • (2006) Eur J Gastroenterol Hepatol , vol.18 , pp. 21-29
    • Ramalho, R.M.1    Cortez-Pinto, H.2    Castro, R.E.3
  • 64
    • 0025363385 scopus 로고
    • Increased plasma tumor necrosis factor in severe alcoholic hepatitis
    • Bird GL, Sheron N, Goka AK, et al. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med 1990;112:917-920
    • (1990) Ann Intern Med , vol.112 , pp. 917-920
    • Bird, G.L.1    Sheron, N.2    Goka, A.K.3
  • 65
    • 0032835529 scopus 로고    scopus 로고
    • Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice
    • Yin M, Wheeler MD, Kono H, et al. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology 1999;117:942-952
    • (1999) Gastroenterology , vol.117 , pp. 942-952
    • Yin, M.1    Wheeler, M.D.2    Kono, H.3
  • 66
    • 0030716183 scopus 로고    scopus 로고
    • Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat
    • Iimuro Y, Gallucci RM, Luster MI, et al. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 1997;26:1530-1537
    • (1997) Hepatology , vol.26 , pp. 1530-1537
    • Iimuro, Y.1    Gallucci, R.M.2    Luster, M.I.3
  • 67
    • 0036784414 scopus 로고    scopus 로고
    • Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: A randomized controlled pilot study
    • Spahr L, Rubbia-Brandt L, Frossard JL, et al. Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study. J Hepatol 2002;37:448-455
    • (2002) J Hepatol , vol.37 , pp. 448-455
    • Spahr, L.1    Rubbia-Brandt, L.2    Frossard, J.L.3
  • 68
    • 28844459409 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: From cell biology to clinical practice
    • Cortez-Pinto H, de Moura MC, Day CP. Non-alcoholic steatohepatitis: from cell biology to clinical practice. J Hepatol 2006;44:197-208
    • (2006) J Hepatol , vol.44 , pp. 197-208
    • Cortez-Pinto, H.1    de Moura, M.C.2    Day, C.P.3
  • 69
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998;114:842-845
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 70
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A, Zein NN, Yerian LM, et al. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006;44:27-33
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3
  • 71
    • 0034755341 scopus 로고    scopus 로고
    • Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis
    • Nehra V, Angulo P, Buchman AL, et al. Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. Dig Dis Sci 2001;46:2347-2352
    • (2001) Dig Dis Sci , vol.46 , pp. 2347-2352
    • Nehra, V.1    Angulo, P.2    Buchman, A.L.3
  • 72
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • Malhi H, Bronk SF, Werneburg NW, et al. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem 2006;281:12093-12101
    • (2006) J Biol Chem , vol.281 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3
  • 73
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein AE, Canbay A, Angulo P, et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003;125:437-443
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3
  • 74
    • 0035196704 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress
    • Robertson G, Leclercq I, Farrell GC. Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress. Am J Physiol Gastrointest Liver Physiol 2001;281:G1135-G1139
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281
    • Robertson, G.1    Leclercq, I.2    Farrell, G.C.3
  • 75
    • 3042824524 scopus 로고    scopus 로고
    • Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    • Feldstein AE, Werneburg NW, Canbay A, et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004;40:185-194
    • (2004) Hepatology , vol.40 , pp. 185-194
    • Feldstein, A.E.1    Werneburg, N.W.2    Canbay, A.3
  • 76
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • Li Z, Yang S, Lin H, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003;37:343-350
    • (2003) Hepatology , vol.37 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3
  • 77
    • 0141427999 scopus 로고    scopus 로고
    • Kountouras J, Zavos C, Chatzopoulos D. Apoptosis in hepatitis C. J Viral Hepat 2003;10:335-342
    • Kountouras J, Zavos C, Chatzopoulos D. Apoptosis in hepatitis C. J Viral Hepat 2003;10:335-342
  • 78
    • 0028153997 scopus 로고
    • Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis
    • Gonzalez-Amaro R, Garcia-Monzon C, Garcia-Buey L, et al. Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis. J Exp Med 1994;179:841-848
    • (1994) J Exp Med , vol.179 , pp. 841-848
    • Gonzalez-Amaro, R.1    Garcia-Monzon, C.2    Garcia-Buey, L.3
  • 79
    • 33751535476 scopus 로고    scopus 로고
    • Blockade of TRAIL pathway ameliorates HBV-induced hepatocyte apoptosis in an acute hepatitis model
    • Liu YG, Liu SX, Liang XH, et al. Blockade of TRAIL pathway ameliorates HBV-induced hepatocyte apoptosis in an acute hepatitis model. Biochem Biophys Res Commun 2007;352:329-334
    • (2007) Biochem Biophys Res Commun , vol.352 , pp. 329-334
    • Liu, Y.G.1    Liu, S.X.2    Liang, X.H.3
  • 80
    • 0030067167 scopus 로고    scopus 로고
    • Hepatitis B virus transgenic mice: Models of viral immunobiology and pathogenesis
    • Chisari FV. Hepatitis B virus transgenic mice: models of viral immunobiology and pathogenesis. Curr Top Microbiol Immunol 1996;206:149-173
    • (1996) Curr Top Microbiol Immunol , vol.206 , pp. 149-173
    • Chisari, F.V.1
  • 81
    • 1642367212 scopus 로고    scopus 로고
    • Expression of FasL and perforin/granzyme B mRNA in chronic hepatitis B virus infection
    • Lee JY, Chae DW, Kim SM, et al. Expression of FasL and perforin/granzyme B mRNA in chronic hepatitis B virus infection. J Viral Hepat 2004;11:130-135
    • (2004) J Viral Hepat , vol.11 , pp. 130-135
    • Lee, J.Y.1    Chae, D.W.2    Kim, S.M.3
  • 82
    • 0030027743 scopus 로고    scopus 로고
    • Fas antigen expression in liver tissues of patients with chronic hepatitis B
    • Mochizuki K, Hayashi N, Hiramatsu N, et al. Fas antigen expression in liver tissues of patients with chronic hepatitis B. J Hepatol 1996;24:1-7
    • (1996) J Hepatol , vol.24 , pp. 1-7
    • Mochizuki, K.1    Hayashi, N.2    Hiramatsu, N.3
  • 83
    • 2142758645 scopus 로고    scopus 로고
    • Variations in the serum concentrations of soluble Fas and soluble Fas ligand in Vietnamese patients infected with hepatitis B virus
    • Song le H, Binh VQ, Duy DN, et al. Variations in the serum concentrations of soluble Fas and soluble Fas ligand in Vietnamese patients infected with hepatitis B virus. J Med Virol 2004;73:244-249
    • (2004) J Med Virol , vol.73 , pp. 244-249
    • Song le, H.1    Binh, V.Q.2    Duy, D.N.3
  • 84
    • 0029997619 scopus 로고    scopus 로고
    • Activation of the tumor necrosis factor-alpha system in the liver in chronic hepatitis B virus infection
    • Fang JW, Shen WW, Meager A, et al. Activation of the tumor necrosis factor-alpha system in the liver in chronic hepatitis B virus infection. Am J Gastroenterol 1996;91:748-753
    • (1996) Am J Gastroenterol , vol.91 , pp. 748-753
    • Fang, J.W.1    Shen, W.W.2    Meager, A.3
  • 85
    • 0028955999 scopus 로고
    • Tumor necrosis factor receptors in patients with chronic hepatitis B virus infection
    • Marinos G, Naoumov NV, Rossol S, et al. Tumor necrosis factor receptors in patients with chronic hepatitis B virus infection. Gastroenterology 1995;108:1453-1463
    • (1995) Gastroenterology , vol.108 , pp. 1453-1463
    • Marinos, G.1    Naoumov, N.V.2    Rossol, S.3
  • 86
    • 0030787584 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha
    • Su F, Schneider RJ. Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha. Proc Natl Acad Sci USA 1997;94:8744-8749
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8744-8749
    • Su, F.1    Schneider, R.J.2
  • 87
    • 0037268529 scopus 로고    scopus 로고
    • Involvement of TRAIL and its receptors in viral hepatitis
    • Mundt B, Kuhnel F, Zender L, et al. Involvement of TRAIL and its receptors in viral hepatitis. FASEB J 2003;17:94-96
    • (2003) FASEB J , vol.17 , pp. 94-96
    • Mundt, B.1    Kuhnel, F.2    Zender, L.3
  • 88
    • 0035179965 scopus 로고    scopus 로고
    • Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta
    • Sato K, Hida S, Takayanagi H, et al. Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta. Eur J Immunol 2001;31:3138-3146
    • (2001) Eur J Immunol , vol.31 , pp. 3138-3146
    • Sato, K.1    Hida, S.2    Takayanagi, H.3
  • 89
    • 0035137696 scopus 로고    scopus 로고
    • Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
    • Takeda K, Hayakawa Y, Smyth MJ, et al. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med 2001;7:94-100
    • (2001) Nat Med , vol.7 , pp. 94-100
    • Takeda, K.1    Hayakawa, Y.2    Smyth, M.J.3
  • 90
    • 0036899204 scopus 로고    scopus 로고
    • Detection of soluble TRAIL in HBV infected patients and its clinical implications
    • Han LH, Sun WS, Ma CH, et al. Detection of soluble TRAIL in HBV infected patients and its clinical implications. World J Gastroenterol 2002;8:1077-1080
    • (2002) World J Gastroenterol , vol.8 , pp. 1077-1080
    • Han, L.H.1    Sun, W.S.2    Ma, C.H.3
  • 91
    • 33845920091 scopus 로고    scopus 로고
    • Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax
    • Liang X, Liu Y, Zhang Q, et al. Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax. J Immunol 2007;178:503-510
    • (2007) J Immunol , vol.178 , pp. 503-510
    • Liang, X.1    Liu, Y.2    Zhang, Q.3
  • 92
    • 0030955346 scopus 로고    scopus 로고
    • Epidemiology of hepatitis C
    • Alter MJ. Epidemiology of hepatitis C. Hepatology 1997;26(3 suppl 1):62S-65S
    • (1997) Hepatology , vol.26 , Issue.3 SUPPL. 1
    • Alter, M.J.1
  • 93
    • 0037274212 scopus 로고    scopus 로고
    • Bantel H, Schulze-Osthoff K. Apoptosis in hepatitis C virus infection. Cell Death Differ 2003;10(suppl 1):S48-S58
    • Bantel H, Schulze-Osthoff K. Apoptosis in hepatitis C virus infection. Cell Death Differ 2003;10(suppl 1):S48-S58
  • 94
    • 0028200655 scopus 로고
    • Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C
    • Hiramatsu N, Hayashi N, Katayama K, et al. Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C. Hepatology 1994;19:1354-1359
    • (1994) Hepatology , vol.19 , pp. 1354-1359
    • Hiramatsu, N.1    Hayashi, N.2    Katayama, K.3
  • 95
    • 7044220856 scopus 로고    scopus 로고
    • Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury
    • Bantel H, Lugering A, Heidemann J, et al. Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology 2004;40:1078-1087
    • (2004) Hepatology , vol.40 , pp. 1078-1087
    • Bantel, H.1    Lugering, A.2    Heidemann, J.3
  • 96
    • 0031957325 scopus 로고    scopus 로고
    • Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis
    • Zhu N, Khoshnan A, Schneider R, et al. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J Virol 1998;72:3691-3697
    • (1998) J Virol , vol.72 , pp. 3691-3697
    • Zhu, N.1    Khoshnan, A.2    Schneider, R.3
  • 97
    • 0033892895 scopus 로고    scopus 로고
    • Significance of soluble TNF receptor-I in acute-type fulminant hepatitis
    • Tokushige K, Yamaguchi N, Ikeda I, et al. Significance of soluble TNF receptor-I in acute-type fulminant hepatitis. Am J Gastroenterol 2000;95:2040-2046
    • (2000) Am J Gastroenterol , vol.95 , pp. 2040-2046
    • Tokushige, K.1    Yamaguchi, N.2    Ikeda, I.3
  • 98
    • 13544269612 scopus 로고    scopus 로고
    • Hepatitis C virus core protein modulates TRAIL-mediated apoptosis by enhancing Bid cleavage and activation of mitochondria apoptosis signaling pathway
    • Chou AH, Tsai HF, Wu YY, et al. Hepatitis C virus core protein modulates TRAIL-mediated apoptosis by enhancing Bid cleavage and activation of mitochondria apoptosis signaling pathway. J Immunol 2005;174:2160-2166
    • (2005) J Immunol , vol.174 , pp. 2160-2166
    • Chou, A.H.1    Tsai, H.F.2    Wu, Y.Y.3
  • 99
    • 0035853773 scopus 로고    scopus 로고
    • Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteins
    • Machida K, Tsukiyama-Kohara K, Seike E, et al. Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteins. J Biol Chem 2001;276:12140-12146
    • (2001) J Biol Chem , vol.276 , pp. 12140-12146
    • Machida, K.1    Tsukiyama-Kohara, K.2    Seike, E.3
  • 100
    • 33646166625 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein
    • Saito K, Meyer K, Warner R, et al. Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein. J Virol 2006;80:4372-4379
    • (2006) J Virol , vol.80 , pp. 4372-4379
    • Saito, K.1    Meyer, K.2    Warner, R.3
  • 101
    • 12444253844 scopus 로고    scopus 로고
    • Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers
    • Hsu EC, Hsi B, Hirota-Tsuchihara M, et al. Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers. Nat Biotechnol 2003;21:519-525
    • (2003) Nat Biotechnol , vol.21 , pp. 519-525
    • Hsu, E.C.1    Hsi, B.2    Hirota-Tsuchihara, M.3
  • 102
    • 3242728426 scopus 로고    scopus 로고
    • Oral IDN-6556, an anti-apoptotic caspase inhibitor, lowers aminotransferases in HCV patients
    • Schiff ER, Pockros P, Schiffman ML, et al. Oral IDN-6556, an anti-apoptotic caspase inhibitor, lowers aminotransferases in HCV patients. J Hepatol 2004;40(suppl 1):24
    • (2004) J Hepatol , vol.40 , Issue.SUPPL. 1 , pp. 24
    • Schiff, E.R.1    Pockros, P.2    Schiffman, M.L.3
  • 103
    • 1342329725 scopus 로고    scopus 로고
    • The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse
    • Canbay A, Feldstein A, Baskin-Bey E, et al. The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J Pharmacol Exp Ther 2004;308:1191-1196
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 1191-1196
    • Canbay, A.1    Feldstein, A.2    Baskin-Bey, E.3
  • 104
    • 0038476330 scopus 로고    scopus 로고
    • Apoptotic body engulfment by a human stellate cell line is profibrogenic
    • Canbay A, Taimr P, Torok N, et al. Apoptotic body engulfment by a human stellate cell line is profibrogenic. Lab Invest 2003;83:655-663
    • (2003) Lab Invest , vol.83 , pp. 655-663
    • Canbay, A.1    Taimr, P.2    Torok, N.3
  • 105
    • 0042744006 scopus 로고    scopus 로고
    • Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
    • Canbay A, Guicciardi ME, Higuchi H, et al. Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J Clin Invest 2003;112:152-159
    • (2003) J Clin Invest , vol.112 , pp. 152-159
    • Canbay, A.1    Guicciardi, M.E.2    Higuchi, H.3
  • 106
    • 33644548700 scopus 로고    scopus 로고
    • Proteasome inhibition induces hepatic stellate cell apoptosis
    • Anan A, Baskin-Bey ES, Bronk SF, et al. Proteasome inhibition induces hepatic stellate cell apoptosis. Hepatology 2006;43:335-344
    • (2006) Hepatology , vol.43 , pp. 335-344
    • Anan, A.1    Baskin-Bey, E.S.2    Bronk, S.F.3
  • 107
    • 0034830886 scopus 로고    scopus 로고
    • Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats
    • Wright MC, Issa R, Smart DE, et al. Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. Gastroenterology 2001;121:685-698
    • (2001) Gastroenterology , vol.121 , pp. 685-698
    • Wright, M.C.1    Issa, R.2    Smart, D.E.3
  • 108
    • 0032841856 scopus 로고    scopus 로고
    • Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins
    • Elsharkawy AM, Wright MC, Hay RT, et al. Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins. Hepatology 1999;30:761-769
    • (1999) Hepatology , vol.30 , pp. 761-769
    • Elsharkawy, A.M.1    Wright, M.C.2    Hay, R.T.3
  • 109
    • 0037219276 scopus 로고    scopus 로고
    • Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis
    • Taimr P, Higuchi H, Kocova E, et al. Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology 2003;37:87-95
    • (2003) Hepatology , vol.37 , pp. 87-95
    • Taimr, P.1    Higuchi, H.2    Kocova, E.3
  • 110
    • 0036724910 scopus 로고    scopus 로고
    • Caspase 9-dependent killing of hepatic stellate cells by activated Kupffer cells
    • Fischer R, Carters A, Reinehr R, et al. Caspase 9-dependent killing of hepatic stellate cells by activated Kupffer cells. Gastroenterology 2002;123:845-861
    • (2002) Gastroenterology , vol.123 , pp. 845-861
    • Fischer, R.1    Carters, A.2    Reinehr, R.3
  • 111
    • 33845644601 scopus 로고    scopus 로고
    • STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity
    • Jeong WI, Park O, Radaeva S, et al. STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Hepatology 2006;44:1441-1451
    • (2006) Hepatology , vol.44 , pp. 1441-1451
    • Jeong, W.I.1    Park, O.2    Radaeva, S.3


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