Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 23, 2006, Pages 8634-8639

  Van Der Sloot, Almer M ^a   Tur, Vicente ^b   Szegezdi, Eva ^c   Mullally, Margaret M ^a,d   Cool, Robbert H ^a   Samali, Afshin ^c   Serrano, Luis ^b   Quax, Wim J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apoptosis inducing ligand 2; Biopharmaceutical; Computational protein design; Death receptor; Receptor selectivity

Indexed keywords

DEATH RECEPTOR 4; DEATH RECEPTOR 5; OSTEOPROTEGERIN; OSTEOPROTEGERIN RECEPTOR; RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

ALGORITHM; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CROSS LINKING; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; COMPUTATIONAL BIOLOGY; HUMANS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; SURFACE PLASMON RESONANCE; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33745056174     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510187103     Document Type: Article

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