Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells

Xenobiotica

Volumn 33, Issue 7, 2003, Pages 703-716

  Swales, K ^a   Plant, N ^a   Ayrton, A ^b   Hood, S ^b   Gibson, G ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANE RECEPTOR; CYTOCHROME P450 3A; CYTOCHROME P450 3A23; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; GLUCOCORTICOID RECEPTOR ALPHA; MESSENGER RNA; NUCLEAR FACTOR 4ALPHA; PREGNANE X RECEPTOR; RETINOID X RECEPTOR; STEROID RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL CELL; ARTICLE; CELL STRAIN; CELL STRAIN FAO; CELL STRAIN H4IIEC3; CELL STRAIN HEPG2; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HEPATOMA CELL; HOST CELL; HUMAN; HUMAN CELL; HYPOTHESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPECIES DIFFERENCE; TRANSCRIPTION INITIATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOCHROME P-450 CYP3A; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIVER NEOPLASMS; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RIFAMPIN; SPECIES SPECIFICITY; TISSUE DISTRIBUTION; TRANSCRIPTION FACTORS;

ANIMALIA; APOGON BRACHYGRAMMUS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0041529817     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/0049825031000121626     Document Type: Article

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