메뉴 건너뛰기




Volumn 11, Issue 6, 2004, Pages 497-503

Gene therapy progress and prospects: Cancer gene therapy using tumour suppressor genes

Author keywords

Cinical trial; p53; PTEN; Rb; Tumour suppressor gene

Indexed keywords

ADENOVIRUS VECTOR; AMINO ACID; ARF PROTEIN; CELL ADHESION MOLECULE; DOXORUBICIN; E1A PROTEIN; FLUOROURACIL; GEMCITABINE; INTERLEUKIN 24; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PLECTIN; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P107; PROTEIN P130; PROTEIN P14; PROTEIN P15; PROTEIN P16; PROTEIN P18; PROTEIN P21; PROTEIN P27; PROTEIN P53; RETINOBLASTOMA PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR SUPPRESSOR PROTEIN; UNINDEXED DRUG; VASCULOTROPIN; VINCRISTINE;

EID: 1842529509     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302238     Document Type: Review
Times cited : (96)

References (70)
  • 1
    • 0037142053 scopus 로고    scopus 로고
    • The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    • Rosenwald A et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 2002; 346: 1937-1947.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1937-1947
    • Rosenwald, A.1
  • 2
    • 0034954414 scopus 로고    scopus 로고
    • Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks
    • Khan J et al. Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nat Med 2001; 7: 673-679.
    • (2001) Nat. Med. , vol.7 , pp. 673-679
    • Khan, J.1
  • 3
    • 0036019371 scopus 로고    scopus 로고
    • A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer
    • Buller RE et al. A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer. Cancer Gene Ther 2002; 9: 553-566.
    • (2002) Cancer Gene Ther. , vol.9 , pp. 553-566
    • Buller, R.E.1
  • 4
    • 0035868848 scopus 로고    scopus 로고
    • Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: Results of a multicenter phase II study
    • Schuler M et al. Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: Results of a multicenter phase II study. J Clin Oncol 2001; 19: 1750-1758.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 1750-1758
    • Schuler, M.1
  • 5
    • 0037083558 scopus 로고    scopus 로고
    • Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation
    • Kuball J et al. Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation. J Clin Oncol 2002; 20: 957-965.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 957-965
    • Kuball, J.1
  • 6
    • 0038826049 scopus 로고    scopus 로고
    • Repeated intravesical instillations of an adenoviral vector in patients with locally advanced bladder cancer: A phase I study of p53 gene therapy
    • Pagliaro LC et al. Repeated intravesical instillations of an adenoviral vector in patients with locally advanced bladder cancer: A phase I study of p53 gene therapy. J Clin Oncol 2003; 21: 2247-2253.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2247-2253
    • Pagliaro, L.C.1
  • 7
    • 85047697641 scopus 로고    scopus 로고
    • Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: Biological and clinical results
    • Lang FF et al. Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: Biological and clinical results. J Clin Oncol 2003; 21: 2508-2518.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2508-2518
    • Lang, F.F.1
  • 8
    • 0037627875 scopus 로고    scopus 로고
    • Why did p53 gene therapy fail in ovarian cancer?
    • Zeimet AG, Marth C. Why did p53 gene therapy fail in ovarian cancer? Lancet Oncol 2003; 4: 415-422.
    • (2003) Lancet Oncol. , vol.4 , pp. 415-422
    • Zeimet, A.G.1    Marth, C.2
  • 9
    • 0034796867 scopus 로고    scopus 로고
    • Correlation of p53 mutations with resistance to platinum-based chemotherapy and shortened survival in ovarian cancer
    • Reles A et al. Correlation of p53 mutations with resistance to platinum-based chemotherapy and shortened survival in ovarian cancer. Clin Cancer Res 2001; 7: 2984-2997.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2984-2997
    • Reles, A.1
  • 10
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH, Lu X. Live or let die: The cell's response to p53. Nat Rev Cancer 2002; 2: 594-604.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 11
    • 0035823503 scopus 로고    scopus 로고
    • Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity
    • Wolf BB et al. Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity. J Biol Chem 2001; 276: 34244-34251.
    • (2001) J. Biol. Chem. , vol.276 , pp. 34244-34251
    • Wolf, B.B.1
  • 12
    • 0037022606 scopus 로고    scopus 로고
    • Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function
    • de Vries A et al. Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proc Natl Acad Sci USA 2002; 99: 2948-2953.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 2948-2953
    • de Vries, A.1
  • 13
    • 10744230945 scopus 로고    scopus 로고
    • p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
    • Bergamaschi D et al. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell 2003; 3: 387-402.
    • (2003) Cancer Cell , vol.3 , pp. 387-402
    • Bergamaschi, D.1
  • 14
    • 0035177690 scopus 로고    scopus 로고
    • Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: A phase I trial
    • Reid T et al. Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: A phase I trial, Gene Therapy 2001; 8: 1618-1626.
    • (2001) Gene Therapy , vol.8 , pp. 1618-1626
    • Reid, T.1
  • 15
    • 0038518576 scopus 로고    scopus 로고
    • Phase II trial of intravenous CI-1042 in patients with metastatic colorectal cancer
    • Hamid O et al. Phase II trial of intravenous CI-1042 in patients with metastatic colorectal cancer. J Clin Oncol 2003; 21: 1498-1504.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1498-1504
    • Hamid, O.1
  • 16
    • 0037087621 scopus 로고    scopus 로고
    • Phase I trial of intraperitoneal injection of the E1B-55-kDa-gene-deleted adenovirus ONYX-015 (dl1520) given on days 1 through 5 every 3 weeks in patients with recurrent/refractory epithelial ovarian cancer
    • Vasey PA et al. Phase I trial of intraperitoneal injection of the E1B-55-kDa-gene-deleted adenovirus ONYX-015 (dl1520) given on days 1 through 5 every 3 weeks in patients with recurrent/refractory epithelial ovarian cancer. J Clin Oncol 2002; 20: 1562-1569.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1562-1569
    • Vasey, P.A.1
  • 17
    • 0037314610 scopus 로고    scopus 로고
    • A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma
    • Hecht JR et al. A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma. Clin Cancer Res 2003; 9: 555-561.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 555-561
    • Hecht, J.R.1
  • 18
    • 0035076823 scopus 로고    scopus 로고
    • Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: A phase I trial
    • Mulvihill S et al. Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: A phase I trial. Gene Therapy 2001; 8: 308-315.
    • (2001) Gene Therapy , vol.8 , pp. 308-315
    • Mulvihill, S.1
  • 19
    • 0036828125 scopus 로고    scopus 로고
    • Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): Phase II viral, immunologic, and clinical endpoints
    • Reid T et al. Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): Phase II viral, immunologic, and clinical endpoints. Cancer Res 2002; 62: 6070-6079.
    • (2002) Cancer Res. , vol.62 , pp. 6070-6079
    • Reid, T.1
  • 20
    • 0035015925 scopus 로고    scopus 로고
    • Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway?
    • Dix BR et al. Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway? J Virol 2001; 75: 5443-5447.
    • (2001) J. Virol. , vol.75 , pp. 5443-5447
    • Dix, B.R.1
  • 21
    • 0033623250 scopus 로고    scopus 로고
    • Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015)
    • Ries SJ et al. Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015). Nat Med 2000; 6: 1128-1133.
    • (2000) Nat. Med. , vol.6 , pp. 1128-1133
    • Ries, S.J.1
  • 22
    • 0036891811 scopus 로고    scopus 로고
    • Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes
    • Edwards SJ et al. Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes. J Virol 2002; 76: 12483-12490.
    • (2002) J. Virol. , vol.76 , pp. 12483-12490
    • Edwards, S.J.1
  • 23
    • 0038756581 scopus 로고    scopus 로고
    • Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium
    • Flesken-Nikitin A et al. Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium. Cancer Res 2003; 63: 5459-3463.
    • (2003) Cancer Res. , vol.63 , pp. 3459-3463
    • Flesken-Nikitin, A.1
  • 24
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr CJ, McCormick F. The RB and p53 pathways in cancer. Cancer Cell 2002; 2: 103-112.
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 25
    • 0035204005 scopus 로고    scopus 로고
    • pRb-expressing adenovirus Ad5-Rb attenuates the p53-induced apoptosis in cervical cancer cell lines
    • Ip SM et al. pRb-expressing adenovirus Ad5-Rb attenuates the p53-induced apoptosis in cervical cancer cell lines. Eur J Cancer 2001; 37: 2475-2483.
    • (2001) Eur. J. Cancer , vol.37 , pp. 2475-2483
    • Ip, S.M.1
  • 26
    • 0037102276 scopus 로고    scopus 로고
    • The role of adenovirus-mediated retinoblastoma 94 in the treatment of head and neck cancer
    • Li D et al. The role of adenovirus-mediated retinoblastoma 94 in the treatment of head and neck cancer. Cancer Res 2002; 62: 4637-4644.
    • (2002) Cancer Res. , vol.62 , pp. 4637-4644
    • Li, D.1
  • 27
    • 0037442425 scopus 로고    scopus 로고
    • Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis and caspasedependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells
    • Zhang X et al. Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis and caspasedependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells. Cancer Res 2003; 63: 760-765.
    • (2003) Cancer Res. , vol.63 , pp. 760-765
    • Zhang, X.1
  • 28
    • 0035709610 scopus 로고    scopus 로고
    • Tissue-specific expression of an anti-proliferative hybrid transgene from the human smooth muscle alpha-actin promoter suppresses smooth muscle cell proliferation and neointima formation
    • Wills KN et al. Tissue-specific expression of an anti-proliferative hybrid transgene from the human smooth muscle alpha-actin promoter suppresses smooth muscle cell proliferation and neointima formation. Gene Therapy 2001; 8: 1847-1854.
    • (2001) Gene Therapy , vol.8 , pp. 1847-1854
    • Wills, K.N.1
  • 29
    • 0034650850 scopus 로고    scopus 로고
    • Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus- mediated gene transfer
    • Claudio PP et al. Mutations in the retinoblastoma-related gene RB2/p13O in lung tumors and suppression of tumor growth in vivo by retrovirus- mediated gene transfer. Cancer Res 2000; 60: 372-382.
    • (2000) Cancer Res. , vol.60 , pp. 372-382
    • Claudio, P.P.1
  • 30
    • 0033782862 scopus 로고    scopus 로고
    • An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy
    • Heise C et al. An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy. Nat Med 2000; 6: 1134-1139.
    • (2000) Nat. Med. , vol.6 , pp. 1134-1139
    • Heise, C.1
  • 31
    • 0034610723 scopus 로고    scopus 로고
    • A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo
    • Fueyo J et al. A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo. Oncogene 2000; 19: 2-12.
    • (2000) Oncogene , vol.19 , pp. 2-12
    • Fueyo, J.1
  • 32
    • 0036494383 scopus 로고    scopus 로고
    • Treatment of ovarian cancer with a tropism modified oncolytic adenovirus
    • Bauerschmitz GJ et al. Treatment of ovarian cancer with a tropism modified oncolytic adenovirus. Cancer Res 2002; 62: 1266-1270.
    • (2002) Cancer Res. , vol.62 , pp. 1266-1270
    • Bauerschmitz, G.J.1
  • 33
    • 0038288854 scopus 로고    scopus 로고
    • Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway
    • Fueyo J et al. Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway. J Natl Cancer Inst 2003; 95: 652-660.
    • (2003) J. Natl. Cancer Inst. , vol.95 , pp. 652-660
    • Fueyo, J.1
  • 34
    • 0037379880 scopus 로고    scopus 로고
    • An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathway-defective tumors: Dependence on E1A, the E2F-1 promoter, and viral replication for selectivity and efficacy
    • Jakubczak JL et al. An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathway-defective tumors: dependence on E1A, the E2F-1 promoter, and viral replication for selectivity and efficacy. Cancer Res 2003, 63: 1490-1499.
    • (2003) Cancer Res. , vol.63 , pp. 1490-1499
    • Jakubczak, J.L.1
  • 35
    • 19044386714 scopus 로고    scopus 로고
    • Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents
    • Johnson L et al. Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents. Cancer Cell 2002; 1: 325-337.
    • (2002) Cancer Cell , vol.1 , pp. 325-337
    • Johnson, L.1
  • 36
    • 0035956240 scopus 로고    scopus 로고
    • The role of adenovirus E4orf4 protein in viral replication and cell killing
    • Branton PE, Roopchand DE. The role of adenovirus E4orf4 protein in viral replication and cell killing. Oncogene 2001; 20: 7855-7865.
    • (2001) Oncogene , vol.20 , pp. 7855-7865
    • Branton, P.E.1    Roopchand, D.E.2
  • 37
    • 0042785967 scopus 로고    scopus 로고
    • Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo
    • Sharpless NE et al. Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo. Oncogene 2003; 22: 5055-5059.
    • (2003) Oncogene , vol.22 , pp. 5055-5059
    • Sharpless, N.E.1
  • 38
    • 0034905621 scopus 로고    scopus 로고
    • In vitro and in vivo adenovirus-mediated p53 and p16 tumor suppressor therapy in ovarian cancer
    • Modesitt SC et al. In vitro and in vivo adenovirus-mediated p53 and p16 tumor suppressor therapy in ovarian cancer. Clin Cancer Res 2001; 7: 1765-1772.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1765-1772
    • Modesitt, S.C.1
  • 39
    • 0035992313 scopus 로고    scopus 로고
    • Effects of adenovirus-mediated expression of p27Kip1, p21Waf1 and p161NK4A in cell lines derived from t(2;5) anaplastic large cell lymphoma and Hodgkin's disease
    • Turturro F et al. Effects of adenovirus-mediated expression of p27Kip1, p21Waf1 and p161NK4A in cell lines derived from t(2;5) anaplastic large cell lymphoma and Hodgkin's disease. Leukemia Lymphoma 2002; 43: 1323-1328.
    • (2002) Leukemia Lymphoma , vol.43 , pp. 1323-1328
    • Turturro, F.1
  • 40
    • 0036793067 scopus 로고    scopus 로고
    • Conditional expression of the tumor suppressor p16 in a heterotopic glioblastoma model results in loss of pRB expression
    • Simon M et al. Conditional expression of the tumor suppressor p16 in a heterotopic glioblastoma model results in loss of pRB expression. J Neurooncol 2002; 60: 1-12.
    • (2002) J. Neurooncol. , vol.60 , pp. 1-12
    • Simon, M.1
  • 41
    • 0035157892 scopus 로고    scopus 로고
    • Adenovirus-mediated p16 gene transfer changes the sensitivity to taxanes and Vinca alkaloids of human ovarian cancer cells
    • Kawakami Y et al. Adenovirus-mediated p16 gene transfer changes the sensitivity to taxanes and Vinca alkaloids of human ovarian cancer cells. Anticancer Res 2001; 21: 2537-2545.
    • (2001) Anticancer Res. , vol.21 , pp. 2537-2545
    • Kawakami, Y.1
  • 42
    • 85047698445 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression. of p14(ARF) induces p53 and Bax-independent apoptosis
    • Hemmati PG et al. Adenovirus-mediated overexpression. of p14(ARF) induces p53 and Bax-independent apoptosis. Oncogene 2002; 21: 3149-3161.
    • (2002) Oncogene , vol.21 , pp. 3149-3161
    • Hemmati, P.G.1
  • 43
    • 0037374474 scopus 로고    scopus 로고
    • Arf induces p53-dependent and -independent antiproliferative genes
    • Kuo ML et al. Arf induces p53-dependent and -independent antiproliferative genes. Cancer Res 2003; 63: 1046-1053.
    • (2003) Cancer Res. , vol.63 , pp. 1046-1053
    • Kuo, M.L.1
  • 44
    • 0036494469 scopus 로고    scopus 로고
    • Expression of p14ARF overcomes tumor resistance to p53
    • Lu W et al. Expression of p14ARF overcomes tumor resistance to p53. Cancer Res 2002; 62: 1305-4310.
    • (2002) Cancer Res. , vol.62 , pp. 1305-1310
    • Lu, W.1
  • 45
    • 0036789715 scopus 로고    scopus 로고
    • Growth suppression by a p14(ARF) exon 1beta adenovirus in human tumor cell lines of varying p53 and Rb status
    • Saadatmandi N et al. Growth suppression by a p14(ARF) exon 1beta adenovirus in human tumor cell lines of varying p53 and Rb status. Cancer Gene Ther 2002; 9: 830-839.
    • (2002) Cancer Gene Ther. , vol.9 , pp. 830-839
    • Saadatmandi, N.1
  • 46
    • 0036025370 scopus 로고    scopus 로고
    • Adenovirus-mediated p14ARF gene transfer cooperates with Ad5CMV-p53 to induce apoptosis in human cancer cells
    • Tango Y et al. Adenovirus-mediated p14ARF gene transfer cooperates with Ad5CMV-p53 to induce apoptosis in human cancer cells. Hum Gene Ther 2002; 13: 1373-1382.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 1373-1382
    • Tango, Y.1
  • 47
    • 0034685531 scopus 로고    scopus 로고
    • Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells
    • Yang CT et al. Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells. J Natl Cancer Inst 2000; 92: 636-641.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 636-641
    • Yang, C.T.1
  • 48
    • 0036385406 scopus 로고    scopus 로고
    • Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin
    • Deng X et al. Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin. Biochem Biophys Res Commun 2002; 296: 792-798.
    • (2002) Biochem. Biophys. Res. Commun. , vol.296 , pp. 792-798
    • Deng, X.1
  • 49
    • 85047700405 scopus 로고    scopus 로고
    • Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways
    • Weber HO et al. Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. Oncogene 2002; 21: 3207-3212.
    • (2002) Oncogene , vol.21 , pp. 3207-3212
    • Weber, H.O.1
  • 50
    • 0035279162 scopus 로고    scopus 로고
    • Human ARF binds E2F1 and inhibits its transcriptional activity
    • Eymin B et al. Human ARF binds E2F1 and inhibits its transcriptional activity. Oncogene 2001; 20: 1033-1041.
    • (2001) Oncogene , vol.20 , pp. 1033-1041
    • Eymin, B.1
  • 51
    • 0035958932 scopus 로고    scopus 로고
    • The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits HIF-1-mediated transcription
    • Fatyol K, Szalay AA. The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits HIF-1-mediated transcription. J Biol Chem 2001; 276: 28421-28429.
    • (2001) J. Biol. Chem. , vol.276 , pp. 28421-28429
    • Fatyol, K.1    Szalay, A.A.2
  • 52
    • 0035864758 scopus 로고    scopus 로고
    • Human ARF protein interacts with topoisomerase I and stimulates its activity
    • Karayan L et al. Human ARF protein interacts with topoisomerase I and stimulates its activity. Oncogene 2001; 20: 836-848.
    • (2001) Oncogene , vol.20 , pp. 836-848
    • Karayan, L.1
  • 53
    • 0037468575 scopus 로고    scopus 로고
    • p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice
    • Eymin B et al. p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice. Oncogene 2003; 22: 1822-1835.
    • (2003) Oncogene , vol.22 , pp. 1822-1835
    • Eymin, B.1
  • 54
    • 0038243115 scopus 로고    scopus 로고
    • Loss of PTEN promotes tumor development in malignant melanoma
    • Stahl JM et al. Loss of PTEN promotes tumor development in malignant melanoma. Cancer Res 2003; 63: 2881-2890.
    • (2003) Cancer Res. , vol.63 , pp. 2881-2890
    • Stahl, J.M.1
  • 55
    • 0036281498 scopus 로고    scopus 로고
    • The expanding role of PTEN in neoplasia: A molecule for all seasons?
    • Fernandez M, Eng C. The expanding role of PTEN in neoplasia: a molecule for all seasons? Clin Cancer Res 2002; 8: 1695-1698.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1695-1698
    • Fernandez, M.1    Eng, C.2
  • 56
    • 0035914390 scopus 로고    scopus 로고
    • PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression
    • Huang H et al. PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression. J Biol Chem 2001; 276: 38830-38836.
    • (2001) J. Biol. Chem. , vol.276 , pp. 38830-38836
    • Huang, H.1
  • 57
    • 0037050231 scopus 로고    scopus 로고
    • PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway
    • Yuan XJ, Whang YE. PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. Oncogene 2002; 21: 319-327.
    • (2002) Oncogene , vol.21 , pp. 319-327
    • Yuan, X.J.1    Whang, Y.E.2
  • 58
    • 0036278486 scopus 로고    scopus 로고
    • Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells
    • Davies MA et al. Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells. Clin Cancer Res 2002; 8: 1904-1914.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1904-1914
    • Davies, M.A.1
  • 59
    • 0042413371 scopus 로고    scopus 로고
    • In vivo gene therapy of human bladder cancer with PTEN suppresses tumor growth, downregulates phosphorylated Akt, and increases sensitivity to doxorubicin
    • Tanaka M, Grossman HB. In vivo gene therapy of human bladder cancer with PTEN suppresses tumor growth, downregulates phosphorylated Akt, and increases sensitivity to doxorubicin. Gene Therapy 2003; 10: 1636-1642.
    • (2003) Gene Therapy , vol.10 , pp. 1636-1642
    • Tanaka, M.1    Grossman, H.B.2
  • 60
    • 0037192768 scopus 로고    scopus 로고
    • PTEN modulates vascular endothelial growth factor-mediated signaling and angiogeluc effects
    • Huang J, Kontos CD. PTEN modulates vascular endothelial growth factor-mediated signaling and angiogeluc effects. J Biol Chem 2002; 277: 10760-10766.
    • (2002) J. Biol. Chem. , vol.277 , pp. 10760-10766
    • Huang, J.1    Kontos, C.D.2
  • 61
    • 0035836627 scopus 로고    scopus 로고
    • PTEN controls tumor-induced angiogenesis
    • Wen S et al. PTEN controls tumor-induced angiogenesis. Proc Natl Acad Sci USA 2001; 98: 4622-4627.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 4622-4627
    • Wen, S.1
  • 62
    • 0037699025 scopus 로고    scopus 로고
    • PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli
    • Abe T et al. PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli. Cancer Res 2003; 63: 2300-2305.
    • (2003) Cancer Res. , vol.63 , pp. 2300-2305
    • Abe, T.1
  • 63
    • 0035479966 scopus 로고    scopus 로고
    • Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas
    • Ekmekcioglu S et al. Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas. Int J Cancer 2001; 94: 54-59.
    • (2001) Int. J. Cancer , vol.94 , pp. 54-59
    • Ekmekcioglu, S.1
  • 64
    • 0034502591 scopus 로고    scopus 로고
    • Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro
    • Saeki T et al. Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro. Gene Ther 2000; 7: 2051-2057.
    • (2000) Gene Ther. , vol.7 , pp. 2051-2057
    • Saeki, T.1
  • 65
    • 0035317682 scopus 로고    scopus 로고
    • Melanoma differentiation associated gene-7 (mda-7): A novel anti-tumor gene for cancer gene therapy
    • Mhashilkar AM et al. Melanoma differentiation associated gene-7 (mda-7): A novel anti-tumor gene for cancer gene therapy. Mol Med 2001; 7: 271-282.
    • (2001) Mol. Med. , vol.7 , pp. 271-282
    • Mhashilkar, A.M.1
  • 66
    • 0037019174 scopus 로고    scopus 로고
    • Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo
    • Saeki T et al. Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo. Oncogene 2002; 21: 4558-4566.
    • (2002) Oncogene , vol.21 , pp. 4558-4566
    • Saeki, T.1
  • 67
    • 0037089491 scopus 로고    scopus 로고
    • Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR)
    • Pataer A et al. Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Cancer Res 2002; 62: 2239-2243.
    • (2002) Cancer Res. , vol.62 , pp. 2239-2243
    • Pataer, A.1
  • 68
    • 10744230205 scopus 로고    scopus 로고
    • MDA-7 negatively regulates the betacatenin and PI3K signaling pathways in breast and lung tumor cells
    • Mhashilkar AM et al. MDA-7 negatively regulates the betacatenin and PI3K signaling pathways in breast and lung tumor cells. Mol Ther 2003; 8: 207-219.
    • (2003) Mol. Ther. , vol.8 , pp. 207-219
    • Mhashilkar, A.M.1
  • 69
    • 0041513362 scopus 로고    scopus 로고
    • Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor
    • Ramesh R et al. Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor. Cancer Res 2003; 63: 5105-5113.
    • (2003) Cancer Res. , vol.63 , pp. 5105-5113
    • Ramesh, R.1
  • 70
    • 0038081144 scopus 로고    scopus 로고
    • OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer
    • Sellar GC et al. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. Nat Genet 2003; 34: 337-343.
    • (2003) Nat. Genet. , vol.34 , pp. 337-343
    • Sellar, G.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.