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Volumn 37, Issue 10, 2007, Pages 774-782

Effects of free fatty acids on carbohydrate metabolism and insulin signalling in perfused rat liver

Author keywords

Fasting state; Free fatty acids; Insulin signalling; Lactate; Liver

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; LACTIC ACID; THYROXINE;

EID: 34748832900     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2007.01858.x     Document Type: Article
Times cited : (22)

References (47)
  • 1
    • 13444306673 scopus 로고    scopus 로고
    • Adipotoxicity and the insulin resistance syndrome
    • Anderwald C, Roden M. Adipotoxicity and the insulin resistance syndrome. Pediatr Endocrinol Rev 2004 1 : 310 9.
    • (2004) Pediatr Endocrinol Rev , vol.1 , pp. 310-9
    • Anderwald, C.1    Roden, M.2
  • 2
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997 46 : 3 10.
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 3
    • 3042841952 scopus 로고    scopus 로고
    • How free fatty acids inhibit glucose utilization in human skeletal muscle
    • Roden M. How free fatty acids inhibit glucose utilization in human skeletal muscle. News Physiol Sci 2004 19 : 92 6.
    • (2004) News Physiol Sci , vol.19 , pp. 92-6
    • Roden, M.1
  • 4
    • 0036788388 scopus 로고    scopus 로고
    • Effects of insulin treatment in type 2 diabetic patients on intracellular lipid content in liver and skeletal muscles
    • Anderwald C, Bernroider E, Krššák M, Stingl H, Brehm A, Bischof MG et al. Effects of insulin treatment in type 2 diabetic patients on intracellular lipid content in liver and skeletal muscles. Diabetes 2002 51 : 3025 32.
    • (2002) Diabetes , vol.51 , pp. 3025-32
    • Anderwald, C.1    Bernroider, E.2    Krššák, M.3    Stingl, H.4    Brehm, A.5    Bischof, M.G.6
  • 6
    • 0021691098 scopus 로고
    • Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects
    • Bogardus C, Lillioja S, Howard BV, Reaven G, Mott D. Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. J Clin Invest 1984 74 : 1238 46.
    • (1984) J Clin Invest , vol.74 , pp. 1238-46
    • Bogardus, C.1    Lillioja, S.2    Howard, B.V.3    Reaven, G.4    Mott, D.5
  • 7
    • 0034072554 scopus 로고    scopus 로고
    • Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans
    • Roden M, Stingl H, Chandramouli V, Schumann WC, Hofer A, Landau BR et al. Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes 2000 49 : 701 7.
    • (2000) Diabetes , vol.49 , pp. 701-7
    • Roden, M.1    Stingl, H.2    Chandramouli, V.3    Schumann, W.C.4    Hofer, A.5    Landau, B.R.6
  • 10
    • 85047683106 scopus 로고    scopus 로고
    • Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2
    • Anderwald C, Müller G, Koca G, Fürnsinn C, Waldhäusl W, Roden M. Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2. Mol Endocrinol 2002 16 : 1612 28.
    • (2002) Mol Endocrinol , vol.16 , pp. 1612-28
    • Anderwald, C.1    Müller, G.2    Koca, G.3    Fürnsinn, C.4    Waldhäusl, W.5    Roden, M.6
  • 11
    • 0033379840 scopus 로고    scopus 로고
    • Effect of high-altitude acclimation on NEFA turnover and lipid utilization during exercise in rats
    • McClelland GB, Hochachka PW, Weber JM. Effect of high-altitude acclimation on NEFA turnover and lipid utilization during exercise in rats. Am J Physiol 1999 277 : 1095 102.
    • (1999) Am J Physiol , vol.277 , pp. 1095-102
    • McClelland, G.B.1    Hochachka, P.W.2    Weber, J.M.3
  • 13
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70, S6 kinase pathway. a negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • Tremblay F, Marette A. Amino acid and insulin signaling via the mTOR/p70, S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 2001 276 : 38052 60.
    • (2001) J Biol Chem , vol.276 , pp. 38052-60
    • Tremblay, F.1    Marette, A.2
  • 14
    • 0036674293 scopus 로고    scopus 로고
    • Inhibition of glucose production and stimulation of bile flow by R (+) -alpha-lipoic acid enantiomer in rat liver
    • Anderwald C, Koca G, Fürnsinn C, Waldhäusl W, Roden M. Inhibition of glucose production and stimulation of bile flow by R (+) -alpha-lipoic acid enantiomer in rat liver. Liver 2002 22 : 355 61.
    • (2002) Liver , vol.22 , pp. 355-61
    • Anderwald, C.1    Koca, G.2    Fürnsinn, C.3    Waldhäusl, W.4    Roden, M.5
  • 15
    • 10644246130 scopus 로고    scopus 로고
    • In vivo and in vitro evidence for a hepatic modulation of the leptin signal in rats
    • Brabant G, Nave H, Horn R, Anderwald C, Muller G, Roden M. In vivo and in vitro evidence for a hepatic modulation of the leptin signal in rats. Eur J Clin Invest 2004 34 : 831 7.
    • (2004) Eur J Clin Invest , vol.34 , pp. 831-7
    • Brabant, G.1    Nave, H.2    Horn, R.3    Anderwald, C.4    Muller, G.5    Roden, M.6
  • 17
    • 24144446404 scopus 로고    scopus 로고
    • Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
    • Tremblay F, Krebs M, Dombrowski L, Brehm A, Bernroider E, Roth E et al. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 2005 54 : 2674 84.
    • (2005) Diabetes , vol.54 , pp. 2674-84
    • Tremblay, F.1    Krebs, M.2    Dombrowski, L.3    Brehm, A.4    Bernroider, E.5    Roth, E.6
  • 18
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004 431 : 200 5.
    • (2004) Nature , vol.431 , pp. 200-5
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3    Picard, F.4    Joaquin, M.5    Sticker, M.6
  • 19
    • 0014198445 scopus 로고
    • Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats
    • Exton JH, Park CR. Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats. J Biol Chem 1967 242 : 2622 36.
    • (1967) J Biol Chem , vol.242 , pp. 2622-36
    • Exton, J.H.1    Park, C.R.2
  • 20
    • 0013923479 scopus 로고
    • Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver
    • Williamson JR, Kreisberg RA, Felts PW. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc Natl Acad Sci U S A 1966 56 : 247 54.
    • (1966) Proc Natl Acad Sci U S a , vol.56 , pp. 247-54
    • Williamson, J.R.1    Kreisberg, R.A.2    Felts, P.W.3
  • 21
    • 0015845504 scopus 로고
    • Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man
    • Wise JK, Hendler R, Felig P. Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man. J Clin Invest 1973 52 : 2774 82.
    • (1973) J Clin Invest , vol.52 , pp. 2774-82
    • Wise, J.K.1    Hendler, R.2    Felig, P.3
  • 22
    • 0026005773 scopus 로고
    • In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans
    • Clore JN, Glickman PS, Nestler JE, Blackard WG. In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans. Am J Physiol 1991 261 : E425 9.
    • (1991) Am J Physiol , vol.261
    • Clore, J.N.1    Glickman, P.S.2    Nestler, J.E.3    Blackard, W.G.4
  • 24
    • 0035082482 scopus 로고    scopus 로고
    • Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes
    • Boden G, Chen X, Capulong E, Mozzoli M. Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 2001 50 : 810 6.
    • (2001) Diabetes , vol.50 , pp. 810-6
    • Boden, G.1    Chen, X.2    Capulong, E.3    Mozzoli, M.4
  • 25
    • 0025079179 scopus 로고
    • Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration
    • Jenssen T, Nurjhan N, Consoli A, Gerich JE. Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration. J Clin Invest 1990 86 : 489 97.
    • (1990) J Clin Invest , vol.86 , pp. 489-97
    • Jenssen, T.1    Nurjhan, N.2    Consoli, A.3    Gerich, J.E.4
  • 26
    • 1242340302 scopus 로고    scopus 로고
    • The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
    • Halestrap AP, Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 2004 447 : 619 28.
    • (2004) Pflugers Arch , vol.447 , pp. 619-28
    • Halestrap, A.P.1    Meredith, D.2
  • 28
    • 0031683950 scopus 로고    scopus 로고
    • Hyperpolarization of the cell membrane of mouse hepatocytes by lactate, pyruvate, and fructose is due to Ca2+-dependent activation of K+ channels and of the Na+/K+-ATPase
    • Lutz TA, Wild S, Boutellier S, Sutter D, Volkert M, Scharrer E. Hyperpolarization of the cell membrane of mouse hepatocytes by lactate, pyruvate, and fructose is due to Ca2+-dependent activation of K+ channels and of the Na+/K+-ATPase. Biochim Biophys Acta 1998 1372 : 359 69.
    • (1998) Biochim Biophys Acta , vol.1372 , pp. 359-69
    • Lutz, T.A.1    Wild, S.2    Boutellier, S.3    Sutter, D.4    Volkert, M.5    Scharrer, E.6
  • 29
  • 30
    • 0028936422 scopus 로고
    • Tracing hepatic gluconeogenesis relative to citric acid cycle activity in vitro and in vivo. Comparisons in the use of [3-13C] lactate, [2-13C] acetate, and alpha-keto [3-13C] isocaproate
    • Beylot M, Soloviev MV, David F, Landau BR, Brunengraber H. Tracing hepatic gluconeogenesis relative to citric acid cycle activity in vitro and in vivo. Comparisons in the use of [3-13C] lactate, [2-13C] acetate, and alpha-keto [3-13C] isocaproate. J Biol Chem 1995 270 : 1509 14.
    • (1995) J Biol Chem , vol.270 , pp. 1509-14
    • Beylot, M.1    Soloviev, M.V.2    David, F.3    Landau, B.R.4    Brunengraber, H.5
  • 31
    • 0033754945 scopus 로고    scopus 로고
    • Effects of short-term leptin exposure on triglyceride deposition in rat liver
    • Roden M, Anderwald C, Fürnsinn C, Waldhäusl W, Lohninger A. Effects of short-term leptin exposure on triglyceride deposition in rat liver. Hepatology 2000 32 : 1045 9.
    • (2000) Hepatology , vol.32 , pp. 1045-9
    • Roden, M.1    Anderwald, C.2    Fürnsinn, C.3    Waldhäusl, W.4    Lohninger, A.5
  • 32
    • 0035434118 scopus 로고    scopus 로고
    • Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism
    • Edgerton DS, Cardin S, Emshwiller M, Neal D, Chandramouli V, Schumann WC et al. Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes 2001 50 : 1872 82.
    • (2001) Diabetes , vol.50 , pp. 1872-82
    • Edgerton, D.S.1    Cardin, S.2    Emshwiller, M.3    Neal, D.4    Chandramouli, V.5    Schumann, W.C.6
  • 33
    • 0036086520 scopus 로고    scopus 로고
    • Activation of liver G-6-Pase in response to insulin-induced hypoglycemia or epinephrine infusion in the rat
    • Bady I, Zitoun C, Guignot L, Mithieux G. Activation of liver G-6-Pase in response to insulin-induced hypoglycemia or epinephrine infusion in the rat. Am J Physiol Endocrinol Metab 2002 282 : E905 10.
    • (2002) Am J Physiol Endocrinol Metab , vol.282
    • Bady, I.1    Zitoun, C.2    Guignot, L.3    Mithieux, G.4
  • 34
    • 0025215824 scopus 로고
    • Insulin down-regulates insulin receptor number and up-regulates insulin receptor affinity in cells expressing a tyrosine kinase-defective insulin receptor
    • Sbraccia P, Wong KY, Brunetti A, Rafaeloff R, Trischitta V, Hawley DM et al. Insulin down-regulates insulin receptor number and up-regulates insulin receptor affinity in cells expressing a tyrosine kinase-defective insulin receptor. J Biol Chem 1990 265 : 4902 7.
    • (1990) J Biol Chem , vol.265 , pp. 4902-7
    • Sbraccia, P.1    Wong, K.Y.2    Brunetti, A.3    Rafaeloff, R.4    Trischitta, V.5    Hawley, D.M.6
  • 35
    • 0030911521 scopus 로고    scopus 로고
    • Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells
    • Ogihara T, Shin BC, Anai M, Katagiri H, Inukai K, Funaki M et al. Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells. J Biol Chem 1997 272 : 12868 73.
    • (1997) J Biol Chem , vol.272 , pp. 12868-73
    • Ogihara, T.1    Shin, B.C.2    Anai, M.3    Katagiri, H.4    Inukai, K.5    Funaki, M.6
  • 36
    • 33745107554 scopus 로고    scopus 로고
    • Mechanisms of disease: Hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance
    • Roden M. Mechanisms of disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance. Nat Clin Pract Endocrinol Metab 2006 2 : 335 48.
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , pp. 335-48
    • Roden, M.1
  • 37
    • 2642561229 scopus 로고    scopus 로고
    • Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB
    • Weigert C, Brodbeck K, Staiger H, Kausch C, Machicao F, Haring HU et al. Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB. J Biol Chem 2004 279 : 23942 52.
    • (2004) J Biol Chem , vol.279 , pp. 23942-52
    • Weigert, C.1    Brodbeck, K.2    Staiger, H.3    Kausch, C.4    MacHicao, F.5    Haring, H.U.6
  • 38
    • 0035156817 scopus 로고    scopus 로고
    • Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function
    • Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY. Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Diabetes 2001 50 : 69 76.
    • (2001) Diabetes , vol.50 , pp. 69-76
    • Maedler, K.1    Spinas, G.A.2    Dyntar, D.3    Moritz, W.4    Kaiser, N.5    Donath, M.Y.6
  • 39
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer C, Craig DL, Biden TJ. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 1999 274 : 24202 10.
    • (1999) J Biol Chem , vol.274 , pp. 24202-10
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 40
    • 14644435061 scopus 로고    scopus 로고
    • Differential utilization of saturated palmitate and unsaturated oleate: Evidence from cultured myotubes
    • Gaster M, Rustan AC, Beck-Nielsen H. Differential utilization of saturated palmitate and unsaturated oleate: evidence from cultured myotubes. Diabetes 2005 54 : 648 56.
    • (2005) Diabetes , vol.54 , pp. 648-56
    • Gaster, M.1    Rustan, A.C.2    Beck-Nielsen, H.3
  • 41
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002 277 : 50230 6.
    • (2002) J Biol Chem , vol.277 , pp. 50230-6
    • Yu, C.1    Chen, Y.2    Cline, G.W.3    Zhang, D.4    Zong, H.5    Wang, Y.6
  • 42
    • 17744383753 scopus 로고    scopus 로고
    • Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans
    • Krebs M, Krššák M, Nowotny P, Weghuber D, Gruber S, Mlynarik V et al. Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans. J Clin Endocrinol Metab 2001 86 : 2153 60.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2153-60
    • Krebs, M.1    Krššák, M.2    Nowotny, P.3    Weghuber, D.4    Gruber, S.5    Mlynarik, V.6
  • 43
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden G, Chen X, Ruiz J, White JV, Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 1994 93 : 2438 46.
    • (1994) J Clin Invest , vol.93 , pp. 2438-46
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 44
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 1999 103 : 253 9.
    • (1999) J Clin Invest , vol.103 , pp. 253-9
    • Dresner, A.1    Laurent, D.2    Marcucci, M.3    Griffin, M.E.4    Dufour, S.5    Cline, G.W.6
  • 47
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004 279 : 32345 53.
    • (2004) J Biol Chem , vol.279 , pp. 32345-53
    • Samuel, V.T.1    Liu, Z.X.2    Qu, X.3    Elder, B.D.4    Bilz, S.5    Befroy, D.6


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