-
2
-
-
0030941820
-
Metabolic defects in lean nondiabetic offspring of NIDDM parents
-
Perseghin G, Ghosh S, Gerow K, Shulman GI. 1997 Metabolic defects in lean nondiabetic offspring of NIDDM parents. Diabetes. 46:1001-1009.
-
(1997)
Diabetes
, vol.46
, pp. 1001-1009
-
-
Perseghin, G.1
Ghosh, S.2
Gerow, K.3
Shulman, G.I.4
-
3
-
-
0031014830
-
Role of fatty acids in the pathogenesis of insulin resistance and IDDM
-
Boden G. 1996 Role of fatty acids in the pathogenesis of insulin resistance and IDDM. Diabetes. 45:3-10.
-
(1996)
Diabetes
, vol.45
, pp. 3-10
-
-
Boden, G.1
-
4
-
-
0024160877
-
Role of insulin resistance in human disease
-
Reaven GM. 1988 Role of insulin resistance in human disease. Diabetes. 37:1595-1607.
-
(1988)
Diabetes
, vol.37
, pp. 1595-1607
-
-
Reaven, G.M.1
-
5
-
-
0028342686
-
Mechanisms of fatty acid-induced inhibition of glucose uptake
-
Boden G, Chen X, Ruiz J, White JV, Rossetti L. 1994 Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest. 93:2438-2446.
-
(1994)
J Clin Invest
, vol.93
, pp. 2438-2446
-
-
Boden, G.1
Chen, X.2
Ruiz, J.3
White, J.V.4
Rossetti, L.5
-
6
-
-
0025775034
-
Effects of lipid on basal carbohydrate metabolism in normal men
-
Boden G, Jadali F. 1991 Effects of lipid on basal carbohydrate metabolism in normal men. Diabetes. 40:686-692.
-
(1991)
Diabetes
, vol.40
, pp. 686-692
-
-
Boden, G.1
Jadali, F.2
-
7
-
-
0032954778
-
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
-
Dresner A, Laurent D, Marcucci M, et al. 1999 Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest. 103:253-259.
-
(1999)
J Clin Invest
, vol.103
, pp. 253-259
-
-
Dresner, A.1
Laurent, D.2
Marcucci, M.3
-
8
-
-
0023706040
-
Artificial induction of intravascular lipolysis by lipid-heparin infusion leads to insulin resistance in man
-
Lee KU, Lee HK, Koh CS, Min HK. 1988 Artificial induction of intravascular lipolysis by lipid-heparin infusion leads to insulin resistance in man. Diabetologia. 31:285-290.
-
(1988)
Diabetologia
, vol.31
, pp. 285-290
-
-
Lee, K.U.1
Lee, H.K.2
Koh, C.S.3
Min, H.K.4
-
9
-
-
0033007561
-
Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans
-
Roden M, Krssak M, Stingl H, et al. 1999 Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans. Diabetes. 48:358-364.
-
(1999)
Diabetes
, vol.48
, pp. 358-364
-
-
Roden, M.1
Krssak, M.2
Stingl, H.3
-
10
-
-
0029948212
-
Mechanism of free fatty acid-induced insulin resistance in humans
-
Roden M, Price TB, Perseghin G, et al. 1996 Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. 97:2859-2865.
-
(1996)
J Clin Invest
, vol.97
, pp. 2859-2865
-
-
Roden, M.1
Price, T.B.2
Perseghin, G.3
-
11
-
-
0027475061
-
Contribution of muscle and liver to glucose-fatty acid cycle in humans
-
Saloranta C, Koivisto V, Widen E, et al. 1993 Contribution of muscle and liver to glucose-fatty acid cycle in humans. Am J Physiol. 264:E599-E605.
-
(1993)
Am J Physiol
, vol.264
-
-
Saloranta, C.1
Koivisto, V.2
Widen, E.3
-
12
-
-
0028207988
-
Glucose-fatty acid cycle operates in humans at the level of both whole body and skeletal muscle during low and high physiological plasma insulin concentrations
-
Vaag A, Handberg A, Skott P, Damsbo P, Richter EA, Beck-Nielsen H. 1994 Glucose-fatty acid cycle operates in humans at the level of both whole body and skeletal muscle during low and high physiological plasma insulin concentrations. Eur J Endocrinol. 130:70-79.
-
(1994)
Eur J Endocrinol
, vol.130
, pp. 70-79
-
-
Vaag, A.1
Handberg, A.2
Skott, P.3
Damsbo, P.4
Richter, E.A.5
Beck-Nielsen, H.6
-
13
-
-
0013844340
-
The glucose fatty acids cycle in obesity and maturity onset diabetes mellitus
-
Randle PJ, Garland PB, Newsholme EA, Hales CN. 1965 The glucose fatty acids cycle in obesity and maturity onset diabetes mellitus. Ann NY Acad Sci. 131:324-333.
-
(1965)
Ann NY Acad Sci
, vol.131
, pp. 324-333
-
-
Randle, P.J.1
Garland, P.B.2
Newsholme, E.A.3
Hales, C.N.4
-
14
-
-
50549202600
-
The glucose fatty-acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
-
Randle PJ, Hales CN, Garland PB, Newsholme EA. 1963 The glucose fatty- acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. I:785-789.
-
(1963)
Lancet
, vol.1
, pp. 785-789
-
-
Randle, P.J.1
Hales, C.N.2
Garland, P.B.3
Newsholme, E.A.4
-
15
-
-
0029962286
-
Plasma free fatty acids decrease insulin-stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats
-
Kim JK, Wi JK, Youn JH. 1996 Plasma free fatty acids decrease insulin- stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats. Diabetes. 45:446-453.
-
(1996)
Diabetes
, vol.45
, pp. 446-453
-
-
Kim, J.K.1
Wi, J.K.2
Youn, J.H.3
-
16
-
-
0030610804
-
In vivo NMR investigation of intramuscular glucose metabolism in conscious rats
-
Jucker BM, Rennings AJM, Cline GW, Shulman GI. 1997 In vivo NMR investigation of intramuscular glucose metabolism in conscious rats. J Biol Chem. 272:10464-10473.
-
(1997)
J Biol Chem
, vol.272
, pp. 10464-10473
-
-
Jucker, B.M.1
Rennings, A.J.M.2
Cline, G.W.3
Shulman, G.I.4
-
17
-
-
0031753812
-
Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis
-
Chalkley SM, Hettiarachi M, Chrisholm DJ, Kraegen EW. 1998 Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis. Metabolism. 47:1121-1126.
-
(1998)
Metabolism
, vol.47
, pp. 1121-1126
-
-
Chalkley, S.M.1
Hettiarachi, M.2
Chrisholm, D.J.3
Kraegen, E.W.4
-
18
-
-
0030720085
-
Tissue triglycerides, insulin resistance, and insulin production: Implication for hyperinsulinemia of obesity
-
Koyama K, Chen G, Lee Y, Unger RH. 1997 Tissue triglycerides, insulin resistance, and insulin production: implication for hyperinsulinemia of obesity. Am J Physiol. 273:E708-E713.
-
(1997)
Am J Physiol
, vol.273
-
-
Koyama, K.1
Chen, G.2
Lee, Y.3
Unger, R.H.4
-
19
-
-
0030969532
-
Skeletal muscle triglyceride levels are inversely related to insulin action
-
Pan DA, Lillioja S, Kriketos AD, et al. 1997 Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes. 46:983-988.
-
(1997)
Diabetes
, vol.46
, pp. 983-988
-
-
Pan, D.A.1
Lillioja, S.2
Kriketos, A.D.3
-
21
-
-
0030023775
-
The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans
-
Roden M, Perseghin G, Petersen KF, et al. 1996 The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. J Clin Invest. 97:642-648.
-
(1996)
J Clin Invest
, vol.97
, pp. 642-648
-
-
Roden, M.1
Perseghin, G.2
Petersen, K.F.3
-
22
-
-
0017227895
-
Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism
-
Gerich JE, Lorenzi M, Bier M, et al. 1976 Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. J Clin Invest. 57:875-884.
-
(1976)
J Clin Invest
, vol.57
, pp. 875-884
-
-
Gerich, J.E.1
Lorenzi, M.2
Bier, M.3
-
23
-
-
0027475912
-
Effect of hyperglycemia per se on glucose turnover rates in patients with insulin-dependent diabetes
-
Hother-Nielsen O, Vaag A, Skott P, Beck-Nielsen H. 1993 Effect of hyperglycemia per se on glucose turnover rates in patients with insulin-dependent diabetes. Metabolism. 42:86-93.
-
(1993)
Metabolism
, vol.42
, pp. 86-93
-
-
Hother-Nielsen, O.1
Vaag, A.2
Skott, P.3
Beck-Nielsen, H.4
-
25
-
-
0026611962
-
31P-Nuclear magnetic resonance measurements of muscle glucose-6-phosphate: Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in noninsulin-dependent diabetes mellitus
-
31P-Nuclear magnetic resonance measurements of muscle glucose-6-phosphate: evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in noninsulin-dependent diabetes mellitus. J Clin Invest. 89:1069-1075.
-
(1992)
J Clin Invest
, vol.89
, pp. 1069-1075
-
-
Rothman, D.L.1
Shulman, R.G.2
Shulman, G.I.3
-
26
-
-
0018696222
-
2+ on the Keq of the creating kinase reaction and other phosphate hydrolyses and phosphate transfer reactions
-
2+ on the Keq of the creating kinase reaction and other phosphate hydrolyses and phosphate transfer reactions. J Biol Chem. 254:6528-6537.
-
(1979)
J Biol Chem
, vol.254
, pp. 6528-6537
-
-
Lawson, J.W.R.1
Veech, R.L.2
-
27
-
-
0024493728
-
Localized high-resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivo
-
Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hanicke W, Sauter R. 1989 Localized high-resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo. Magn Reson Med. 9:79-93.
-
(1989)
Magn Reson Med
, vol.9
, pp. 79-93
-
-
Frahm, J.1
Bruhn, H.2
Gyngell, M.L.3
Merboldt, K.D.4
Hanicke, W.5
Sauter, R.6
-
28
-
-
0030946601
-
In vivo determination of intra-myocellular lipids in human muscle by means of localized H-1-MR-spectroscopy
-
Boesch C, Slotboom J, Hoppeler H, Kreis R. 1997 In vivo determination of intra-myocellular lipids in human muscle by means of localized H-1-MR-spectroscopy. Magn Reson Med. 37:484-493.
-
(1997)
Magn Reson Med
, vol.37
, pp. 484-493
-
-
Boesch, C.1
Slotboom, J.2
Hoppeler, H.3
Kreis, R.4
-
30
-
-
0027724430
-
Differential regulation of intracellular glucose metabolism by glucose and insulin in human muscle
-
Mandarino LJ, Consoli A, Jain A, Kelley DE. 1993 Differential regulation of intracellular glucose metabolism by glucose and insulin in human muscle. Am J Physiol. 265:E898-E905.
-
(1993)
Am J Physiol
, vol.265
-
-
Mandarino, L.J.1
Consoli, A.2
Jain, A.3
Kelley, D.E.4
-
31
-
-
0032568257
-
Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus
-
Inzucchi SE, Maggs MD, Spollett GR, et al. 1998 Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus. N Engl J Med. 338:867-872.
-
(1998)
N Engl J Med
, vol.338
, pp. 867-872
-
-
Inzucchi, S.E.1
Maggs, M.D.2
Spollett, G.R.3
-
33
-
-
0016739930
-
Modulation of fatty acid metabolism by glucagon in man
-
Schade DS, Eaton RP. 1975 Modulation of fatty acid metabolism by glucagon in man. Diabetes. 24:502-509.
-
(1975)
Diabetes
, vol.24
, pp. 502-509
-
-
Schade, D.S.1
Eaton, R.P.2
-
34
-
-
0027967411
-
Regulation of rat glucagon receptor expression
-
Yoo-Warren H, Willse AG, Hancock N, Hull J, McCaleb M, Livingston JN. 1994 Regulation of rat glucagon receptor expression. Biochim Biophys Res Commun. 205:347-353.
-
(1994)
Biochim Biophys Res Commun
, vol.205
, pp. 347-353
-
-
Yoo-Warren, H.1
Willse, A.G.2
Hancock, N.3
Hull, J.4
McCaleb, M.5
Livingston, J.N.6
-
35
-
-
0032945577
-
Whole body glucose metabolism
-
Zierler K. 1999 Whole body glucose metabolism. Am J Physiol. 276:E409-E426.
-
(1999)
Am J Physiol
, vol.276
-
-
Zierler, K.1
-
36
-
-
0031910907
-
Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans
-
Laurent D, Falk Petersen K, Russell RR, Cline GW, Shulman GI. 1998 Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans. Am J Physiol. 274:E130-E138.
-
(1998)
Am J Physiol
, vol.274
-
-
Laurent, D.1
Falk Petersen, K.2
Russell, R.R.3
Cline, G.W.4
Shulman, G.I.5
-
37
-
-
0026517191
-
Effect of increased free fatty acid supply on glucose metabolism and skeletal muscle glycogen synthase activity in normal man
-
Johnson AB, Argyraki M, Thow JC, Cooper BG, Fulcher G, Taylor R. 1992 Effect of increased free fatty acid supply on glucose metabolism and skeletal muscle glycogen synthase activity in normal man. Clin Sci. 82:219-226.
-
(1992)
Clin Sci
, vol.82
, pp. 219-226
-
-
Johnson, A.B.1
Argyraki, M.2
Thow, J.C.3
Cooper, B.G.4
Fulcher, G.5
Taylor, R.6
-
38
-
-
0026007729
-
Effect of increased plasma free fatty acid concentrations on muscle metabolism during exercise in men
-
Hargreaves M, Kiens B, Richter EA. 1991 Effect of increased plasma free fatty acid concentrations on muscle metabolism during exercise in men. J Appl Physiol. 70:194-201.
-
(1991)
J Appl Physiol
, vol.70
, pp. 194-201
-
-
Hargreaves, M.1
Kiens, B.2
Richter, E.A.3
-
39
-
-
0025376250
-
Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats
-
Rossetti L, Giaccari A. 1990 Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats. J Clin Invest. 85:1785-1792.
-
(1990)
J Clin Invest
, vol.85
, pp. 1785-1792
-
-
Rossetti, L.1
Giaccari, A.2
-
40
-
-
0024237258
-
Rates and tissue sites of noninsulin- and insulin-mediated glucose uptake in humans
-
Baron AD, Brechtel G, Wallace P, Edelman SV. 1988 Rates and tissue sites of noninsulin- and insulin-mediated glucose uptake in humans. Am J Physiol. 255:E769-E774.
-
(1988)
Am J Physiol
, vol.255
-
-
Baron, A.D.1
Brechtel, G.2
Wallace, P.3
Edelman, S.V.4
-
41
-
-
0018413776
-
Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man
-
Liljenquist JE, Mueller GL, Cherrington AD, Perry JM, Rabinowitz D. 1979 Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man. J Clin Endorinol Metab. 48:171-175.
-
(1979)
J Clin Endorinol Metab
, vol.48
, pp. 171-175
-
-
Liljenquist, J.E.1
Mueller, G.L.2
Cherrington, A.D.3
Perry, J.M.4
Rabinowitz, D.5
-
42
-
-
0018084372
-
Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones
-
Sacca L, Hendler R, Sherwin RS. 1978 Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones. J Clin Endorinol Metab. 47:1160-1163.
-
(1978)
J Clin Endorinol Metab
, vol.47
, pp. 1160-1163
-
-
Sacca, L.1
Hendler, R.2
Sherwin, R.S.3
-
43
-
-
0025735189
-
Hyperglycemia induces accumulation of glucose in human skeletal muscle
-
Katz A, Raz I, Spencer K, Rising R, Mott DM. 1991 Hyperglycemia induces accumulation of glucose in human skeletal muscle. Am J Physiol. 260:R698-R703.
-
(1991)
Am J Physiol
, vol.260
-
-
Katz, A.1
Raz, I.2
Spencer, K.3
Rising, R.4
Mott, D.M.5
-
44
-
-
0027395358
-
The relation between insulin sensitivity and the fatty-acid composition of skeletal muscle phospholipids
-
Borkman M, Storlien LH, Pan DA, Jenkins AB, Chrisholm DJ, Campbell LV. 1993 The relation between insulin sensitivity and the fatty-acid composition of skeletal muscle phospholipids. N Engl J Med. 328:238-244.
-
(1993)
N Engl J Med
, vol.328
, pp. 238-244
-
-
Borkman, M.1
Storlien, L.H.2
Pan, D.A.3
Jenkins, A.B.4
Chrisholm, D.J.5
Campbell, L.V.6
-
45
-
-
0031772874
-
Skeletal muscle phosphatidylcholine fatty acids and insulin sensitivity in normal humans
-
Clore JN, Li J, Gill R, et al. 1998 Skeletal muscle phosphatidylcholine fatty acids and insulin sensitivity in normal humans. Am J Physiol. 275:E665-E670.
-
(1998)
Am J Physiol
, vol.275
-
-
Clore, J.N.1
Li, J.2
Gill, R.3
-
47
-
-
0033595121
-
Implications for insulin resistance and diabetes mellitus
-
Shepherd PR, Kahn BB. 1999 Implications for insulin resistance and diabetes mellitus. N Engl J Med. 341:248-257.
-
(1999)
N Engl J Med
, vol.341
, pp. 248-257
-
-
Shepherd, P.R.1
Kahn, B.B.2
-
48
-
-
0030926433
-
Role of the glucosamine pathway in fat-induced insulin resistance
-
Hawkins M, Barzilai N, Liu R, Hu M, Chen W, Rosetti L. 1997 Role of the glucosamine pathway in fat-induced insulin resistance. J Clin Invest. 99:2173-2182.
-
(1997)
J Clin Invest
, vol.99
, pp. 2173-2182
-
-
Hawkins, M.1
Barzilai, N.2
Liu, R.3
Hu, M.4
Chen, W.5
Rosetti, L.6
-
49
-
-
0345086474
-
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade
-
Griffin ME, Marcucci MJ, Cline GW, et al. 1999 Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade. Diabetes. 48:1270-1274.
-
(1999)
Diabetes
, vol.48
, pp. 1270-1274
-
-
Griffin, M.E.1
Marcucci, M.J.2
Cline, G.W.3
-
51
-
-
0025007289
-
Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans
-
Bonadonna RC, Groop LC, Zych K, Shank M, DeFronzo RA. 1990 Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans. Am J Physiol. 259:E736-E750.
-
(1990)
Am J Physiol
, vol.259
-
-
Bonadonna, R.C.1
Groop, L.C.2
Zych, K.3
Shank, M.4
DeFronzo, R.A.5
-
52
-
-
0029991872
-
Glucose and insulin-induced inhibition of fatty acid oxidation: The glucose fatty acid cycle reversed
-
Sidossis LS, Wolfe RR. 1996 Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose fatty acid cycle reversed. Am J Physiol. 270:E733-E738.
-
(1996)
Am J Physiol
, vol.270
-
-
Sidossis, L.S.1
Wolfe, R.R.2
-
53
-
-
0024410912
-
Time dependence of the interaction between lipid and glucose in humans
-
Bonadonna RC, Zych K, Boni C, Ferrannini E, DeFronzo RA. 1989 Time dependence of the interaction between lipid and glucose in humans. Am J Physiol, 257:E49-E56.
-
(1989)
Am J Physiol
, vol.257
-
-
Bonadonna, R.C.1
Zych, K.2
Boni, C.3
Ferrannini, E.4
DeFronzo, R.A.5
-
54
-
-
0025835909
-
Effect of free fatty acids on glucose uptake and nonoxidative glycolysis across human forearm tissues in the basal state and during insulin stimulation
-
Yki-Järvinen H, Puhakainen I, Koivisto VA. 1991 Effect of free fatty acids on glucose uptake and nonoxidative glycolysis across human forearm tissues in the basal state and during insulin stimulation. J Clin Endocrinol Metab. 72:1268-1277.
-
(1991)
J Clin Endocrinol Metab
, vol.72
, pp. 1268-1277
-
-
Yki-Järvinen, H.1
Puhakainen, I.2
Koivisto, V.A.3
-
55
-
-
0033939992
-
Prevention of in vitro lipolysis by tetrahydrolipstatin
-
Krebs M, Stingl H, Nowotny P, et al. 2000 Prevention of in vitro lipolysis by tetrahydrolipstatin. Clin Chem. 46:950-954
-
(2000)
Clin Chem
, vol.46
, pp. 950-954
-
-
Krebs, M.1
Stingl, H.2
Nowotny, P.3
|