Biodegradable cross-linked starch/protein microcapsules containing proteinase inhibitor for oral protein administration

International Journal of Pharmaceutics

Volumn 189, Issue 2, 1999, Pages 171-178

  Larionova, N V ^a   Ponchel, G ^b   Duchene D ^b   Larionova, N I ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b Pharmacotech Biopharm UMR C   (France)

Author keywords

Aprotinin; Biodegradable microcapsules; Oral protein drug delivery; Proteinase inhibitor; Starch microcapsules

Indexed keywords

ALCOHOL; AMYLASE; APROTININ; BENZOYLARGININE 4 NITROANILIDE; BOVINE SERUM ALBUMIN; CHLOROFORM; CYCLOHEXANE; ESTERASE; PANCREATIN; POLYOXYETHYLENE SORBITAN TRIOLEATE; POLYSORBATE; POLYSORBATE 85; PROTEIN; PROTEINASE INHIBITOR; REAGENT; SORBITAN OLEATE; STARCH; SURFACTANT; TEREPHTHALOYL CHLORIDE; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADATION; CONTROLLED STUDY; CROSS LINKING; DEGRADATION; DRUG FORMULATION; DRUG RELEASE; FEASIBILITY STUDY; MICROCAPSULE; MORPHOLOGY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

ADMINISTRATION, ORAL; ANIMALS; APROTININ; BIODEGRADATION, ENVIRONMENTAL; BUFFERS; CAPSULES; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; HYDROGEN-ION CONCENTRATION; MECHANICS; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; PHTHALIC ACIDS; PROTEASE INHIBITORS; PROTEINS; SERUM ALBUMIN, BOVINE; STARCH; TIME FACTORS; TRYPSIN;

EID: 0032841191     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00249-5     Document Type: Article

References (31)

1. Berezin, I.V., Antonov, V.K., Martinek, K. (Eds.), 1976. Immobilized Enzymes v.2. Moscow University Press, Moscow, pp. 5-17.
2. Bernkop-Schnürch A. The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J. Control. Release. 52:1998;1-16.
3. Bernkop-Schnürch A. Polymer/inhibitor conjugates, a promising strategy to overcome the enzymatic barrier to perorally administered (poly)peptide drugs? S.T.P. Pharma Sci. 9:1999;83-92.
4. Bernkop-Schnürch A., Scerbe-Saiko A. Synthesis and in vitro evaluation of chitosan-EDTA-protease inhibitor conjugates which might be useful in oral delivery of peptides and proteins. Pharm. Res. 15:1998;263-269.
5. Bernkop-Schnürch A., Krauland A., Valenta C. Development and in vitro evaluation of a drug delivery system based on chitosan-EDTA BBI conjugate. J. Drug Targeting. 6:1998;207-214.
6. Brøndsted H., Andersen C., Hovgaard L. Crosslinked dextran. A new capsule material for colon targeting of drugs. J. Control. Release. 53:1998;7-13.
7. Davis S.S., Hardy J.G., Fara J.W. The transit of pharmaceutic dosage forms through the small intestine. Gut. 27:1986;886-892.
8. Duchêne D., Ponchel G. Colonic administration, development of drug delivery systems, contribution of bioadhesion. S.T.P. Pharma Sci. 3:1993;277-285.
9. Esposito E., Cortesi R., Bortolotti F., Menegatti E., Nastruzzi C. Production and characterization of biodegradable microparticles for the controlled delivery of proteinase inhibitors. Int. J. Pharm. 129:1996;263-273.
10. Fernández-Hervás M.J., Fell J.T. Pectin/chitosan mixtures as coatings for colon-specific drug delivery: an in vitro evaluation. Int. J. Pharm. 169:1998;115-119.
11. Friend D.R. Glycoside prodrugs: novel pharmacotherapy for colonic diseases. S.T.P. Pharma Sci. 5:1995;70-76.
12. Kakade M.L., Simons N., Liener I.E. An evaluation of natural vs. synthetic substrate for measuring the antitrypsin activity of soybean samples. Cereal. Chem. 46:1969;518-526.
13. Kakoulides E.P., Smart J.D., Tsibouklis J. Azo-cross-linked poly(acrylic acid) for colonic delivery and adhesion specificity: in vitro degradation and preliminary ex vivo bioadhesion studies. J. Control. Release. 54:1998;95-109.
14. Kalala W., Kinget R., Van den Mooter G., Samyn C. Colonic drug-targeting: in vitro release of ibuprofen from capsules coated with poly(ether-ester) azopolymers. Int. J. Pharm. 139:1996;187-195.
15. Langguth P., Bohner V., Heizmann J., Merkle H.P., Wolffram S., Amidon G.L., Yamashita S. The challenge of proteolytic enzymes in intestinal peptide delivery. Int. J. Pharm. 46:1997;39-57.
16. Larionova N.I., Kazanskaya N.F., Sakharov I.Y. Soluble high-molecular weight derivatives of the pancreatic trypsin inhibitor associated with dextran. Biochemistry (Moscow). 42:1977;1237-1243.
17. Larionova, N.V., Moroz, N.A., Larionova, N.I., Hamdi, G., Dumistracel, I., Duchêne, D., Ponchel, G., 1997. Encapsulation of basic pancreatic trypsin inhibitor (BTPI) in starch microcapsules. Proc. Symposium: Particulate Systems, From Formulation to Production, Istanbul, pp. 91-92.
18. Larionova, N., Ponchel, G., Duchêne, D., 1998. Release of aprotinin and a model protein from cross-linked starch microcapsules. Proc. 2nd World Meeting Pharmaceutics Biopharmaceutics and Pharmaceutical Technology, Paris, pp. 541-542.
19. Larionova N.I., Moroz N.A., Tyurina O.P. Molecular design, characterization and pharmacological activity of conjugates of protein proteinase inhibitors. S.T.P. Pharma Sci. 9:1999;67-82.
20. Larvin M., Mayer A.D., McMahon M.J., Müller-Esterl W., Fritz H. Intra-peritoneal aprotinin therapy for acute pancreatitis. Biol. Chem. Hoppe-Seyler. 369(Suppl.):1988;149-152.
21. Levy M.C., Andry M.C. Microparticles prepared through interfacial cross-linking of starch derivatives. Int. J. Pharm. 62:1990;27-35.
22. Levy M.C., Andry M.C. Mixed-walled microcapsules made of cross-linked proteins and polysaccharides: preparation and properties. J. Microencapsulation. 8:1991;335-347.
23. Levy M.C., Lefebvre S., Rahmouni M., Andry M.C., Manfait M. Fourier transform infrared spectroscopic studies of human serum albumin microcapsules prepared by interfacial cross-linking with terephthaloyl chloride: influence of polycondensation pH on spectra and relation with microcapsule morphology and size. J. Pharm. Sci. 80:1991;578-584.
24. Lorenzo-Lamosa M.L., Remuñán-López C., Vila-Jato J.L., Alonso M.J. Design of microencapsulated chitosan microspheres for colonic drug delivery. J. Control. Release. 52:1998;109-118.
25. Lowry O.H., Rosenbrough N.J., Farrand A.L., Randall R.J. Protein measurement with folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
26. Milojevic S., Newton J.M., Cummings J.H., Gibson G.R., Bothman R.L., Ring S.G., Allwood M.C., Stockham M. Amylose, the new perspective in oral drug delivery to the human large intestine. S.T.P. Pharma Sci. 5:1995;47-53.
27. Robert S., Wagner B.K., Boulanger M., Richer M. Aprotinin. Ann. Pharmacother. 30:1996;372-380.
28. Rubinstein A., Gliko-Kabir I. Synthesis and swelling-dependent enzymatic degradation of borax-modified guar gum for colonic delivery purposes. S.T.P. Pharma Sci. 5:1995;41-46.
29. Tiourina, O., Hamdi, G., Larionova, N., Duchêne, D., Ponchel, G., 1998. Preparation and characterization of polymethacryloyl starch microspheres loaded with basic pancreatic trypsin inhibitor. Proc. 2nd World Meeting Pharmaceutics Biopharmaceutics and Pharmaceutical Technology, Paris, pp. 539-540.
30. Watts P.J., Illum L. Colonic drug delivery. Drug Dev. Ind. Pharm. 23:1997;893-913.
31. Yamamoto A., Taniguchi T., Rikyuu K., Tsuji T., Fujita T., Murakami M., Muranishi S. Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm. Res. 11:1994;1496-1500.