메뉴 건너뛰기




Volumn 6, Issue 3, 1998, Pages 207-214

Development and in vitro evaluation of a drug delivery system based on chitosan-EDTA BBI conjugate

Author keywords

Chymotrypsin; Drug delivery system; Elastase; Enzyme inhibition; Peroral administration of (poly)peptides; Trypsin

Indexed keywords

BOWMAN BIRK INHIBITOR; CHITOSAN; CHYMOTRYPSIN; EDETIC ACID; ELASTASE; INSULIN; MANNITOL; SERINE PROTEINASE; TRYPSIN;

EID: 0032411591     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869808997895     Document Type: Article
Times cited : (24)

References (25)
  • 1
    • 0023888769 scopus 로고
    • 2EDTA, and aprotinin on rectal, nasal, and buccal insulin delivery
    • 2EDTA, and aprotinin on rectal, nasal, and buccal insulin delivery. Pharm. Res., 5, 305-308.
    • (1988) Pharm. Res. , vol.5 , pp. 305-308
    • Aungst, B.J.1    Rogers, N.J.2
  • 2
    • 0030765867 scopus 로고    scopus 로고
    • Strategien zur peroralen Applikation von Peptid- Und Proteinwirkstoffen
    • Bernkop-Schnürch, A. (1997) Strategien zur peroralen Applikation von Peptid- und Proteinwirkstoffen. Sci. Pharm., 65, 61-81.
    • (1997) Sci. Pharm. , vol.65 , pp. 61-81
    • Bernkop-Schnürch, A.1
  • 3
    • 0032473473 scopus 로고    scopus 로고
    • The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins
    • in press
    • Bernkop-Schnürch, A. (1998) The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J. Control. Release, in press.
    • (1998) J. Control. Release
    • Bernkop-Schnürch, A.1
  • 4
    • 0031056746 scopus 로고    scopus 로고
    • Synthesis and evaluation of a modified mucoadhesive polymer protecting from α-chymotrypsinic degradation
    • Bernkop-Schnürch, A. and Apprich, I. (1997) Synthesis and evaluation of a modified mucoadhesive polymer protecting from α-chymotrypsinic degradation. Int. J. Pharm., 146, 247-254.
    • (1997) Int. J. Pharm. , vol.146 , pp. 247-254
    • Bernkop-Schnürch, A.1    Apprich, I.2
  • 5
    • 0030581134 scopus 로고    scopus 로고
    • Novel bioadhesive drug delivery system protecting (poly)peptides from gastric enzymatic degradation
    • Bernkop-Schnürch, A. and Dundalek, K. (1996) Novel bioadhesive drug delivery system protecting (poly)peptides from gastric enzymatic degradation. Int. J. Pharm., 138, 75-83.
    • (1996) Int. J. Pharm. , vol.138 , pp. 75-83
    • Bernkop-Schnürch, A.1    Dundalek, K.2
  • 6
    • 1842415952 scopus 로고    scopus 로고
    • Development and analysis of a polymer protecting from luminal enzymatic degradation caused by α-chymotrypsin
    • Bernkop-Schnürch, A. and Göckel, N.C. (1997) Development and analysis of a polymer protecting from luminal enzymatic degradation caused by α-chymotrypsin. Drug Dev. Ind. Pharm., 23, 733-740.
    • (1997) Drug Dev. Ind. Pharm. , vol.23 , pp. 733-740
    • Bernkop-Schnürch, A.1    Göckel, N.C.2
  • 7
    • 0032472305 scopus 로고    scopus 로고
    • Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: Synthesis and evaluation of different chitosan-EDTA conjugates
    • Bernkop-Schnürch, A. and Krajicek, M.E. (1998) Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan-EDTA conjugates. J. Control. Release, 50, 215-223.
    • (1998) J. Control. Release , vol.50 , pp. 215-223
    • Bernkop-Schnürch, A.1    Krajicek, M.E.2
  • 8
    • 0030900713 scopus 로고    scopus 로고
    • Development and in vitro evaluation of systems to protect peptide drugs from aminopeptidase N
    • Bernkop-Schnürch, A. and Marschütz, M. (1997) Development and in vitro evaluation of systems to protect peptide drugs from aminopeptidase N. Pharm. Res., 14, 181-185.
    • (1997) Pharm. Res. , vol.14 , pp. 181-185
    • Bernkop-Schnürch, A.1    Marschütz, M.2
  • 9
    • 0031901490 scopus 로고    scopus 로고
    • Intestinal peptide and protein delivery: Novel bioadhesive drug carrier-matrix shielding from enzymatic attack
    • in press
    • Bernkop-Schnürch, A. and Pasta, M. (1998) Intestinal peptide and protein delivery: novel bioadhesive drug carrier-matrix shielding from enzymatic attack. J. Pharm. Sci., in press.
    • (1998) J. Pharm. Sci.
    • Bernkop-Schnürch, A.1    Pasta, M.2
  • 10
    • 0031915514 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of chitosan-EDTA-protease-inhibitor conjugates which might be useful in oral delivery of peptides and proteins
    • Bernkop-Schnürch, A. and Scerbe-Saiko, A. (1998) Synthesis and in vitro evaluation of chitosan-EDTA-protease-inhibitor conjugates which might be useful in oral delivery of peptides and proteins. Pharm. Res., 15, 267-273.
    • (1998) Pharm. Res. , vol.15 , pp. 267-273
    • Bernkop-Schnürch, A.1    Scerbe-Saiko, A.2
  • 11
    • 0030813427 scopus 로고    scopus 로고
    • Development and in vitro evaluation of a drug delivery system protecting from trypsinic degradation
    • Bernkop-Schnürch, A., Bratengeyer, I. and Valenta, C. (1997a) Development and in vitro evaluation of a drug delivery system protecting from trypsinic degradation. Int. J. Pharm., 157, 17-25.
    • (1997) Int. J. Pharm. , vol.157 , pp. 17-25
    • Bernkop-Schnürch, A.1    Bratengeyer, I.2    Valenta, C.3
  • 12
    • 0030943636 scopus 로고    scopus 로고
    • Modified mucoadhesive polymers for the peroral administration of mainly elastase degradable therapeutic (poly)peptides
    • Bernkop-Schnürch, A., Schwarz, G.H. and Kratzel, M. (1997b) Modified mucoadhesive polymers for the peroral administration of mainly elastase degradable therapeutic (poly)peptides. J. Control. Release, 47, 113-121.
    • (1997) J. Control. Release , vol.47 , pp. 113-121
    • Bernkop-Schnürch, A.1    Schwarz, G.H.2    Kratzel, M.3
  • 13
    • 0030740816 scopus 로고    scopus 로고
    • Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase N
    • Bernkop-Schnürch, A., Paikl, Ch. and Valenta, C. (1997c) Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase N. Pharm. Res., 14, 917-922.
    • (1997) Pharm. Res. , vol.14 , pp. 917-922
    • Bernkop-Schnürch, A.1    Paikl, Ch.2    Valenta, C.3
  • 14
    • 0032516229 scopus 로고    scopus 로고
    • Basic studies on bioadhesive delivery systems for peptide and protein drugs
    • in press
    • Bernkop-Schnürch, A., Humenberger, C. and Valenta, C. (1998) Basic studies on bioadhesive delivery systems for peptide and protein drugs. Int. J. Pharm., in press.
    • (1998) Int. J. Pharm.
    • Bernkop-Schnürch, A.1    Humenberger, C.2    Valenta, C.3
  • 15
    • 0022017412 scopus 로고
    • The Bowman-Birk inhibitor
    • Birk, Y. (1985) The Bowman-Birk inhibitor. Int. J. Peptide Protein Res., 25, 113-131.
    • (1985) Int. J. Peptide Protein Res. , vol.25 , pp. 113-131
    • Birk, Y.1
  • 16
    • 0016175428 scopus 로고
    • Human liver aminopeptidase. Role of metal ions in mechanism of action
    • Garner, Ch.W. and Behal, F.J. (1974) Human liver aminopeptidase. Role of metal ions in mechanism of action. Biochemistry, 13, 3227-3233.
    • (1974) Biochemistry , vol.13 , pp. 3227-3233
    • Garner, Ch.W.1    Behal, F.J.2
  • 17
    • 0030839517 scopus 로고    scopus 로고
    • N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces - In vitro evaluation in intestinal epithelial cells (CACO-2)
    • Kotzé, A.F., Lueßen, H.L., Deleeuw, B.J., de Boer, B.G., Verhoef, J.C. and Junginger, E.H. (1997) N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces - in vitro evaluation in intestinal epithelial cells (CACO-2). Pharm. Res., 14, 1197-1202.
    • (1997) Pharm. Res. , vol.14 , pp. 1197-1202
    • Kotzé, A.F.1    Lueßen, H.L.2    Deleeuw, B.J.3    De Boer, B.G.4    Verhoef, J.C.5    Junginger, E.H.6
  • 18
    • 0028609750 scopus 로고
    • Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract
    • Lehr, C.-M. (1994) Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract. Crit. Rev. Ther. Drug. Car. Syst., 11, 119-160.
    • (1994) Crit. Rev. Ther. Drug. Car. Syst. , vol.11 , pp. 119-160
    • Lehr, C.-M.1
  • 19
    • 0028788346 scopus 로고
    • Mucoadhesive polymers in the peroral peptide drug delivery: II. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin
    • Lueßen, H.L., Verhoef, J.C., Borchard, G., Lehr, C.-M., de Boer, A.G. and Junginger, H.E. (1995) Mucoadhesive polymers in the peroral peptide drug delivery: II. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin. Pharm. Res., 12, 1293-1298.
    • (1995) Pharm. Res. , vol.12 , pp. 1293-1298
    • Lueßen, H.L.1    Verhoef, J.C.2    Borchard, G.3    Lehr, C.-M.4    De Boer, A.G.5    Junginger, H.E.6
  • 20
    • 17344382638 scopus 로고    scopus 로고
    • Mucoadhesive polymers in peroral peptide drug delivery. I. Influence of mucoadhesive excipients on the proteolytic activity of intestinal enzymes
    • Lueßen, H.L., de Leeuw, B.J., Pérard, D., Lehr, C.-M., de Boer, A.G., Verhoef, J.C. and Junginger, E.H. (1996) Mucoadhesive polymers in peroral peptide drug delivery. I. Influence of mucoadhesive excipients on the proteolytic activity of intestinal enzymes. Eur. J. Pharm. Sci., 4, 117-128.
    • (1996) Eur. J. Pharm. Sci. , vol.4 , pp. 117-128
    • Lueßen, H.L.1    De Leeuw, B.J.2    Pérard, D.3    Lehr, C.-M.4    De Boer, A.G.5    Verhoef, J.C.6    Junginger, E.H.7
  • 21
    • 0031018133 scopus 로고    scopus 로고
    • Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro
    • Lueßen, H.L., Rentel, C-O., Kotzé, A.F., Lehr, C.-M., de Boer, A.G., Verhoef, J.C. and Junginger, H.E. (1997) Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro. J. Control. Release, 45, 15-23.
    • (1997) J. Control. Release , vol.45 , pp. 15-23
    • Lueßen, H.L.1    Rentel, C.-O.2    Kotzé, A.F.3    Lehr, C.-M.4    De Boer, A.G.5    Verhoef, J.C.6    Junginger, H.E.7
  • 22
    • 0029968525 scopus 로고    scopus 로고
    • Proteinase inhibitors induce selective stimulation of human trypsin and chymotrypsin secretion
    • Reseland, J.E., Holm, H., Jacobsen, M.B., Jenssen, T.G. and Hanssen, L.E. (1996) Proteinase inhibitors induce selective stimulation of human trypsin and chymotrypsin secretion. Hum. Clin. Nutr., 126, 634-642.
    • (1996) Hum. Clin. Nutr. , vol.126 , pp. 634-642
    • Reseland, J.E.1    Holm, H.2    Jacobsen, M.B.3    Jenssen, T.G.4    Hanssen, L.E.5
  • 23
    • 0015501044 scopus 로고
    • Isolation and properties of complexes of the Bowman-Birk soybean inhibitor with trypsin and chymotrypsin
    • Seidl, D.S. and Liener, I.E. (1972) Isolation and properties of complexes of the Bowman-Birk soybean inhibitor with trypsin and chymotrypsin. J. Biol. Chem., 247, 3533-3538.
    • (1972) J. Biol. Chem. , vol.247 , pp. 3533-3538
    • Seidl, D.S.1    Liener, I.E.2
  • 24
    • 0031745232 scopus 로고    scopus 로고
    • Chitosan-EDTA conjugate: A novel polymer for topical used gels
    • Valenta, C., Christen, B. and Bernkop-Schnürch, A. (1998) Chitosan-EDTA conjugate: A novel polymer for topical used gels. J. Pharm. Pharmacol., 50, 445-452.
    • (1998) J. Pharm. Pharmacol. , vol.50 , pp. 445-452
    • Valenta, C.1    Christen, B.2    Bernkop-Schnürch, A.3
  • 25
    • 0028657017 scopus 로고
    • Enzymatic barriers for GI peptide and protein delivery
    • Woodley, J.F. (1994) Enzymatic barriers for GI peptide and protein delivery. Crit. Rev. Ther. Drug Car. Syst., 11, 61-95.
    • (1994) Crit. Rev. Ther. Drug Car. Syst. , vol.11 , pp. 61-95
    • Woodley, J.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.