Oral particulate delivery: Status and future trends

Advanced Drug Delivery Reviews

Volumn 34, Issue 2-3, 1998, Pages 339-350

  Chen, Hongming ^a   Langer, Robert ^b  

^a ASTRAZENECA   (United Kingdom)

^b USA   (United States)

Author keywords

Absorption efficiency; Gastrointestinal tract; Liposomes; M cells; Peyer's patches; Polymeric particles; Targeting

Indexed keywords

ABSORPTION; ADHESION; BIODEGRADATION; BIOPOLYMERS; CELLS; ENZYMES; LIPIDS; PARTICLES (PARTICULATE MATTER); PROTEINS;

ABSORPTION EFFICIENCY; LIPOSOMES; ORAL PARTICULATE DELIVERY; PEYERS PATCHES;

CONTROLLED DRUG DELIVERY;

GONADORELIN; LIPOSOME; MICROSPHERE; PEPTIDE; POLYMER; PROTEIN;

BIODEGRADATION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; ENCAPSULATION; HUMAN; INTESTINE ABSORPTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW;

EID: 0032403533     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(98)00047-7     Document Type: Review

References (57)

1. A.T. Florence, P.U. Jani, Particulate delivery: the challenge of the oral route, in: A. Rolland (Ed.), Pharmaceutical Particulate Carriers: Therapeutic Applications, Marcel Dekker: New York. 1993, pp. 65-107.
2. D.T. O'Hagan, Novel Delivery Systems for Oral Vaccines, Boca Raton, Florida: CRC Press, Inc., 1994.
3. Richards M.H., Gardner C.R. Effects of bile salts on the structural integrity of liposomes. Biochim. Biophys. Acta. 543:1978;508-522.
4. Deshmukh D.S., Bear W.D., Brockerhoff H. Can intact liposomes be absorbed in the gut? Life Sci. 28:1980;239-242.
5. D.T. O'Hagan, Microparticles as oral vaccines, in: D.T. O'Hagan (Ed.), Novel Delivery Systems for Oral Vaccines, CRC Press, Inc., Boca Raton, Florida, 1994, pp. 175-205.
6. Volkheimer G. Hematogenoue dissemination of ingested polyvinyl chloride particles. Ann. N.Y. Acad. Sci. 246:1975;164-171.
7. Sanders E., Ashworth C.T. A study of particulate intestinal absorption and hepatocellular uptake. Exp. Cell Res. 22:1961;137-145.
8. Hillery A., Jani P., Florence A. Comparative, quantitative study of lymphoid and non-lymphoid uptake of 60 nm polystyrene particles. J. Drug Targeting. 2:1994;151-156.
9. Hodges G., Carr E., Hazzard R., Carr K. Uptake and translocation of microparticles in small intestine. Morphology and quantitation of particle distribution. Dig. Dis. Sci. 40:1995;967-975.
10. Jani P.U., Florence A.T., McCarthy D.E. Further histological evidence of the gastrointestinal absorption of polystyrene nanospheres in the rat. Int. J. Pharm. 84:1992;245-252.
11. Florence A.T., Hillery A.M., Hussain N., Jani P.U. Nanoparticles as carriers for oral peptide absorption: studies on particle uptake and fate. J. Controlled Release. 36:1995;39-46.
12. Lefevre M.E., Vanderhoff J.W., Laissue J.A., Joel D.D. Accumulation of 2-mm latex particles in mouse Peyer's patches during chronic latex feeding. Experientia. 34:1978;120-122.
13. LeFevre M.E., Olivo R., Vanderhoff J.W., Joel D.D. Accumulation of Latex in Peyer's patches and its subsequent appearance in villi and mesenteric lymph nodes. Pro. Soc. Exp. Biol. Med. 159:1978;298-302.
14. Lefevre M.E., Joel D.D., Schidlovsky G. Retention of ingested latex particles in Peyer's patches of germfree and conventional mice. Pro. Soc. Exp. Biol. Med. 179:1985;522-528.
15. 7Be-Labeled carbon to weaning and aged mice. Pro. Soc. Exp. Biol. Med. 182:1986;112-119.
16. LeFevre M.E., Boccio A.M., Joel D.D. Intestinal uptake of fluorescent microspheres in young and aged mice. Pro. Soc. Exp. Biol. Med. 190:1989;23-27.
17. Volkheimer G. Persorption of particles: physiology and pharmacology. Adv. Pharmacol. Chemother. 14:1977;163-187.
18. Volkheimer G., Schulz F.H. The phenomenon of persorption. Digestion. 1:1968;213-218.
19. Pappo J., Ermak T.H. Uptake and translocation of fluorescent latex particles by rabbit Peyer's patch follicle epithelium: a quantitative model for M cell uptake. Clin. Exp. Immunol. 76:1989;144-148.
20. H. Chen, Polymerized Liposomes as Potential Oral Vaccine Delivery Vehicles, Department of Chemical Engineering Doctoral Thesis, M.I.T., Cambridge, 1997.
21. Eldridge J.H., Hammond C.J., Meulbroek J.A., Staas J.K., Gilley R.M., Tice T.R. Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administrated biodegradable microspheres target the Peyer's patches. J. Controlled Release. 11:1990;205-214.
22. Desai M.P., Labhasetwar V., Amidon G.L., Levy R.J. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 13(12):1996;1838-1845.
23. Challacombe S.J., Rahman D., O'Hagan D.T. Salivary, gut, vaginal and nasal antibody responses after oral immunization with biodegradable microparticles. Vaccine. 15(2):1997;169-175.
24. Damgé C., Michel C., Aprahamian M., Couvreur P. New approach for oral administration of insulin with polyalkycyanoacrylate nanocapsules as drug carrier. Diabetes. 37:1988;246-251.
25. Kreuter J. Peroral administration of nanoparticles. Adv. Drug Delivery Rev. 7:1991;71-86.
26. J. Kreuter, Nanoparticles as adjuvants for vaccines, in: M.F. Powell, M.J. Newman (Eds.), Vaccine Design. The Subunit and Adjuvant Approach, Plenum Press, New York, 1995, pp. 463-472.
27. Mathiowitz E., Jacob J.S., Jong Y.S., Carino G.P., Chickering D., Charturved P., Santos C.A., Vijayaraghavan K., Montogomery S., Bassett M., Morrell C. Biologically erodable microspheres as potential oral drug delivery systems. Nature. 386:1997;410-414.
28. J. Cleland, Design and production of single-immunization vaccines using polylactide polyglycolide microsphere systems, in: M.F. Powell, M.J. Newman (Eds.), Vaccine Design: The Subunit and Adjuvant Approach, Plenum Press, New York, 1995, pp. 439-462.
29. Santiago N., Milstein S., Rivera T., Garcia E., Zaidi T., Hong H., Bucher D. Oral Immunization of rats with proteinoid microspheres encapsulating influenza virus antigens. Pharm. Res. 10(8):1993;1243-1247.
30. T.L. Bowersock, Uptake of alginate microspheres by Peyer's patches. Proc. Int. Symp. Control. Rel. Bioact. Mater. 1994, pp. 839-840.
31. Artursson P., Martensson I.L., Sjoholm I. Biodegradable microspheres III. Some immunological properties of polyacryl starch microspheres. J. Pharm. Sci. 75:1986;697.
32. Schroder U., Stahl A. Crystallised dextran nanospheres with entrapped antigen and their use as adjuvants. J. Immunol. Methods. 70:1984;127.
33. N.K. Childers, S.M. Michalek, Liposomes, in: D.T. O'Hagan (Ed.), Novel Delivery Systems for Oral Vaccines, CRC Press, Inc., Boca Raton, Florida, 1994.
34. Okada J., Cohen S., Langer R. In vitro evaluation of polymerized liposomes as an oral drug delivery system. Pharm. Res. 12:1995;576-582.
35. Chen H., Torchilin V., Langer R. Polymerized liposomes as potential oral vaccine carriers: stability and bioavailability. J. Controlled Release. 42:1996;263-272.
36. Ohno H., Ogata Y., Tsuchida E. Gamma-ray polymerization of phospholipids having diene or triene groups as liposomes. J. Polym. Sci. Part A: Polym. Chem. 24:1986;2959-2969.
37. Ohno H., Ogata Y., Tsuchida E. Polymerization of liposomes composed of diene-containing lipids by UV and radical initiators: evidence for the different chemical environment of diene groups on 1- and 2-acyl chains. Macromolecules. 20:1987;929-933.
38. A.M. Mowat, K.J. Maloy, Immune stimulating complexes as vectors for oral immunization, in: D.T. O'Hagan (Ed.), Novel Delivery Systems for Oral Vaccines, CRC Press, Boca Raton, 1994, pp. 207-240.
39. Morein B. The ISCOM: an immunostimulating systems. Immunol. Lett. 25:1990;283-284.
40. Papahadjopoulos D., Vail W.J., Jacobson K., Poste G. Cochleate lipid cylinders: formation by fusion of unilamellar lipid vesicles. Biochim. Biophys. Acta. 394:1975;483-491.
41. R.J. Mannino, S. Gould-Fogerite, Lipid matrix-based vaccines for mucosal and systemic immunization, in: M.F. Powell, M.J. Newman (Eds.), Vaccine design: The Subunit and Adjuvant Approach, Plenum Press, New York, 1995, pp. 363-387.
42. Gould-Fogerite S., Kheiri M., Edghill-Smith Y., Wang Z., Feketeova E., Mannino R.J. Protein cochleates: unique subunit vaccines for mucosal and parental immunization. J. Cell. Biochem. S19A:1995;258-258.
43. Pappo J., Ermark T.H., Steger H.J. Monoclonal antibody-directed targeting of fluorescent polystyrene microsphere to Peyer's patch M cells. Immunology. 73:1991;277-280.
44. Pappo J. Generation and characterization of monoclonal antibodies recognizing follicle epithelial M cells in rabbit gut-associated lymphoid tissues. Cell. Immunol. 120:1989;31-41.
45. Chen H., Torchilin V., Langer R. Lectin-bearing polymerized liposomes as potential oral vaccine carriers. Pharm. Res. 13(9):1996;1378-1383.
46. Clark M.A., Jepson M.A., Simmons N.L., Booth T.A., Hirst B.H. Differential expression of lectin-binding sites defines mouse intestinal M-cells. J. Histochem. Cytochem. 41(11):1993;1679-1687.
47. Clark M.A., Jepson M.A., Simmons N.L., Hirst B.H. Differential surface characteristics of M cells from mouse intestinal Peyer's and caecal patches. Histochem. J. 26:1994;271-280.
48. Park H., Robinson J.R. Physico-chemical properties of water insoluble polymers important to mucin/epithelial adhesion. J. Controlled Release. 2:1985;47-57.
49. Smart J.D., Kellaway I.W., Worthington H.E.C. An in vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. J. Pharm. Pharmacol. 36:1984;295-299.
50. C.M. Lehr, A. Pusztai, The potential of bioadhesive lectins for the delivery of peptide and protein drugs to the gastrointestinal tract, in: A. Pusztai, S. Bardocz (Eds.), Lectins: Biomedical Perspectives, Taylor and Francis Ltd., London, 1995, pp. 117-140.
51. Lehr C.M., Bouwstra J.A., Kok W., De Boer A.G., Tukker J.J., Verhoef J.C., Breimer D.D., Junginger H. Effects of the mucoadhesive polymer polycarbophil on the intestinal absorption of a peptide drug in the rat. J. Pharm. Pharmacol. 44:1992;402-407.
52. Chickering D.E., Mathiowitz E. Bioadhesive microspheres: I. A novel electrobalance-based method to study adhesive interactions between individual microspheres and intestinal mucosa. J. Controlled Release. 34:1995;251-261.
53. Chickering D.E., Jacob J.S., Desai T.A., Harrison M., Harris W.P., Morrell C.N., Chaturvedi P., Mathiowitze E. Bioadhesive microspheres: III. An in vivo transit and bioavailability study of drug-loaded alginate and poly(fumaric-co-sebacic anhydride) microspheres. J. Controlled Release. 48:1997;35-48.
54. Damgé C., Michel C., Aprahamian M., Couvreur P., Devissaguet J.P. Nanocapsules as carriers for oral peptide delivery. J. Controlled Release. 13:1990;233-239.
55. Hillery A.M., Toth I., Florence A.T. Co-polymerised peptide particles II: Oral uptake of a novel co-polymeric nanoparticle delivery system for peptides. J. Controlled Release. 42:1996;65-73.
56. Challacombe S.J., Rahman D., Jeffery H., Davis S.S., O'Hagan D.T. Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen. Immunology. 76:1992;164-168.
57. O'Hagan D.T., McGee J.P., Boyle D.G., Li X.M., Potts B., Wang C.Y., Koff W.C. The preparation, characterization and pre-clinical evaluation of an orally administered HIV-1 vaccine, consisting of a branched peptide immunogen entrapped in controlled release microparticles. J. Controlled Release. 36:1995;75-84.