메뉴 건너뛰기




Volumn 39, Issue 1, 2007, Pages 46-52

Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys

Author keywords

Association study; Replication; SNP; TCF7L2; Type 2 diabetes

Indexed keywords

INSULIN; T CELL FACTOR 4; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG;

EID: 33947607216     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-957345     Document Type: Article
Times cited : (62)

References (31)
  • 1
    • 14844351853 scopus 로고    scopus 로고
    • Genetics of type 2 diabetes mellitus: Status and perspectives
    • Hansen LPedersen O: Genetics of type 2 diabetes mellitus: status and perspectives. Diabetes Obes Metab 2005; 7: 122-135
    • (2005) Diabetes Obes Metab , vol.7 , pp. 122-135
    • Hansen LPedersen, O.1
  • 2
    • 0037300945 scopus 로고    scopus 로고
    • High prevalence of undiagnosed diabetes mellitus in Southern Germany: Target populations for efficient screening. The KORA survey 2000
    • Rathmann W, Haastert B, Icks A, Lowel H, Meisinger C, Holle R, Giani G: High prevalence of undiagnosed diabetes mellitus in Southern Germany: target populations for efficient screening. The KORA survey 2000. Diabetologia 2003; 46: 182-189
    • (2003) Diabetologia , vol.46 , pp. 182-189
    • Rathmann, W.1    Haastert, B.2    Icks, A.3    Lowel, H.4    Meisinger, C.5    Holle, R.6    Giani, G.7
  • 3
    • 32544451924 scopus 로고    scopus 로고
    • Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38: 320-323
    • Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38: 320-323
  • 5
    • 33746082818 scopus 로고    scopus 로고
    • Genetic variants and common diseases - better late than never
    • O'Rahilly S, Wareham NJ: Genetic variants and common diseases - better late than never. N Engl J Med 2006; 355: 306-308
    • (2006) N Engl J Med , vol.355 , pp. 306-308
    • O'Rahilly, S.1    Wareham, N.J.2
  • 7
    • 0037093315 scopus 로고    scopus 로고
    • T-cell factors: Turn-ons and turn-offs
    • Hurlstone AClevers H: T-cell factors: turn-ons and turn-offs. EMBO J 2002; 21: 2303-2311
    • (2002) EMBO J , vol.21 , pp. 2303-2311
    • Hurlstone AClevers, H.1
  • 8
    • 33644813850 scopus 로고    scopus 로고
    • Regulation of Wnt signaling by protein-protein interaction and post-translational modifications
    • Kikuchi A, Kishida S, Yamamoto H: Regulation of Wnt signaling by protein-protein interaction and post-translational modifications. Exp Mol Med 2006; 38: 1-10
    • (2006) Exp Mol Med , vol.38 , pp. 1-10
    • Kikuchi, A.1    Kishida, S.2    Yamamoto, H.3
  • 9
    • 33645717329 scopus 로고    scopus 로고
    • Kiessling A, Ehrhart-Bornstein M: Transcription factor 7-like 2 (TCFL2) - a novel factor involved in pathogenesis of type 2 diabetes. Comment on: Grant et al., Nature Genetics 2006, Published online 15 January 2006. Horm Metab Res 2006; 38: 137-138
    • Kiessling A, Ehrhart-Bornstein M: Transcription factor 7-like 2 (TCFL2) - a novel factor involved in pathogenesis of type 2 diabetes. Comment on: Grant et al., Nature Genetics 2006, Published online 15 January 2006. Horm Metab Res 2006; 38: 137-138
  • 10
    • 23844467739 scopus 로고    scopus 로고
    • KORA - a research platform for population based health research
    • Holle R, Happich M, Lowel H, Wichmann HE: KORA - a research platform for population based health research. Gesundheitswesen 2005; 67 (Suppl 1): S19-S25
    • (2005) Gesundheitswesen , vol.67 , Issue.SUPPL. 1
    • Holle, R.1    Happich, M.2    Lowel, H.3    Wichmann, H.E.4
  • 11
    • 23844464069 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus in Augsburg - an epidemiological overview
    • Meisinger C, Doring A, Heier M, Thorand B, Lowel H: Type 2 diabetes mellitus in Augsburg - an epidemiological overview. Gesundheitswesen 2005; 67 (Suppl 1): S103-S109
    • (2005) Gesundheitswesen , vol.67 , Issue.SUPPL. 1
    • Meisinger, C.1    Doring, A.2    Heier, M.3    Thorand, B.4    Lowel, H.5
  • 12
    • 23844472247 scopus 로고    scopus 로고
    • KORA-gen-resource for population genetics, controls and a broad spectrum of disease phenotypes
    • Wichmann HE, Gieger C, Illig T: KORA-gen-resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen 2005; 67 (Suppl 1): S26-S30
    • (2005) Gesundheitswesen , vol.67 , Issue.SUPPL. 1
    • Wichmann, H.E.1    Gieger, C.2    Illig, T.3
  • 15
    • 0035897696 scopus 로고    scopus 로고
    • Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)
    • Executive Summary of The Third Report of The National Cholesterol Education Program NCEP
    • Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-2497
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 16
    • 33646378160 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome in the elderly population according to IDF, WHO, and NCEP definitions and associations with C-reactive protein: The KORA Survey 2000
    • Rathmann W, Haastert B, Icks A, Giani G, Holle R, Koenig W, Lowel H, Meisinger C: Prevalence of the metabolic syndrome in the elderly population according to IDF, WHO, and NCEP definitions and associations with C-reactive protein: the KORA Survey 2000. Diabetes Care 2006; 29: 461
    • (2006) Diabetes Care , vol.29 , pp. 461
    • Rathmann, W.1    Haastert, B.2    Icks, A.3    Giani, G.4    Holle, R.5    Koenig, W.6    Lowel, H.7    Meisinger, C.8
  • 17
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 20
    • 33745075360 scopus 로고    scopus 로고
    • Retinol-binding protein 4, insulin resistance, and type 2 diabetes
    • Polonsky KS: Retinol-binding protein 4, insulin resistance, and type 2 diabetes. N Engl J Med 2006; 354: 2596-2598
    • (2006) N Engl J Med , vol.354 , pp. 2596-2598
    • KS, P.1
  • 22
    • 33750584981 scopus 로고    scopus 로고
    • Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: Replication and evidence for a role in both insulin secretion and insulin resistance
    • Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD, Mitchell BD, Shuldiner AR: Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 2006; 55: 2654-2659
    • (2006) Diabetes , vol.55 , pp. 2654-2659
    • Damcott, C.M.1    Pollin, T.I.2    Reinhart, L.J.3    Ott, S.H.4    Shen, H.5    Silver, K.D.6    Mitchell, B.D.7    Shuldiner, A.R.8
  • 28
    • 33750594321 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men
    • Zhang C, Qi L, Hunter DJ, Meigs JB, Manson JE, van Dam RM, Hu FB: Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men.. Diabetes 2006; 55: 2645-2648
    • (2006) Diabetes , vol.55 , pp. 2645-2648
    • Zhang, C.1    Qi, L.2    Hunter, D.J.3    Meigs, J.B.4    Manson, J.E.5    van Dam, R.M.6    Hu, F.B.7
  • 29
    • 33644876824 scopus 로고    scopus 로고
    • Wagenknecht LE, Haffner SM: Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis Study
    • Hanley AJ, Karter AJ, Williams K, Festa A, D'Agostino RB, Jr., Wagenknecht LE, Haffner SM: Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis Study. Circulation 2005; 112: 3713-3721
    • (2005) Circulation , vol.112 , pp. 3713-3721
    • Hanley, A.J.1    Karter, A.J.2    Williams, K.3    Festa, A.4    RB Jr., D.5
  • 30
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-catenin, and cadherin pathways
    • Nelson WJ, Nusse R: Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004; 303: 1483-1487
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 31
    • 12544254474 scopus 로고    scopus 로고
    • TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta
    • Yi F, Brubaker PL, Jin T: TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J Biol Chem 2005; 280: 1457-1464
    • (2005) J Biol Chem , vol.280 , pp. 1457-1464
    • Yi, F.1    Brubaker, P.L.2    Jin, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.