-
1
-
-
14844351853
-
Genetics of type 2 diabetes mellitus: Status and perspectives
-
Hansen LPedersen O: Genetics of type 2 diabetes mellitus: status and perspectives. Diabetes Obes Metab 2005; 7: 122-135
-
(2005)
Diabetes Obes Metab
, vol.7
, pp. 122-135
-
-
Hansen LPedersen, O.1
-
2
-
-
0037300945
-
High prevalence of undiagnosed diabetes mellitus in Southern Germany: Target populations for efficient screening. The KORA survey 2000
-
Rathmann W, Haastert B, Icks A, Lowel H, Meisinger C, Holle R, Giani G: High prevalence of undiagnosed diabetes mellitus in Southern Germany: target populations for efficient screening. The KORA survey 2000. Diabetologia 2003; 46: 182-189
-
(2003)
Diabetologia
, vol.46
, pp. 182-189
-
-
Rathmann, W.1
Haastert, B.2
Icks, A.3
Lowel, H.4
Meisinger, C.5
Holle, R.6
Giani, G.7
-
3
-
-
32544451924
-
-
Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38: 320-323
-
Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38: 320-323
-
-
-
-
4
-
-
33746075560
-
TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
-
Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D: TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 2006; 355: 241-250
-
(2006)
N Engl J Med
, vol.355
, pp. 241-250
-
-
Florez, J.C.1
Jablonski, K.A.2
Bayley, N.3
Pollin, T.I.4
de Bakker, P.I.5
Shuldiner, A.R.6
Knowler, W.C.7
Nathan, D.M.8
Altshuler, D.9
-
5
-
-
33746082818
-
Genetic variants and common diseases - better late than never
-
O'Rahilly S, Wareham NJ: Genetic variants and common diseases - better late than never. N Engl J Med 2006; 355: 306-308
-
(2006)
N Engl J Med
, vol.355
, pp. 306-308
-
-
O'Rahilly, S.1
Wareham, N.J.2
-
7
-
-
0037093315
-
T-cell factors: Turn-ons and turn-offs
-
Hurlstone AClevers H: T-cell factors: turn-ons and turn-offs. EMBO J 2002; 21: 2303-2311
-
(2002)
EMBO J
, vol.21
, pp. 2303-2311
-
-
Hurlstone AClevers, H.1
-
8
-
-
33644813850
-
Regulation of Wnt signaling by protein-protein interaction and post-translational modifications
-
Kikuchi A, Kishida S, Yamamoto H: Regulation of Wnt signaling by protein-protein interaction and post-translational modifications. Exp Mol Med 2006; 38: 1-10
-
(2006)
Exp Mol Med
, vol.38
, pp. 1-10
-
-
Kikuchi, A.1
Kishida, S.2
Yamamoto, H.3
-
9
-
-
33645717329
-
-
Kiessling A, Ehrhart-Bornstein M: Transcription factor 7-like 2 (TCFL2) - a novel factor involved in pathogenesis of type 2 diabetes. Comment on: Grant et al., Nature Genetics 2006, Published online 15 January 2006. Horm Metab Res 2006; 38: 137-138
-
Kiessling A, Ehrhart-Bornstein M: Transcription factor 7-like 2 (TCFL2) - a novel factor involved in pathogenesis of type 2 diabetes. Comment on: Grant et al., Nature Genetics 2006, Published online 15 January 2006. Horm Metab Res 2006; 38: 137-138
-
-
-
-
10
-
-
23844467739
-
KORA - a research platform for population based health research
-
Holle R, Happich M, Lowel H, Wichmann HE: KORA - a research platform for population based health research. Gesundheitswesen 2005; 67 (Suppl 1): S19-S25
-
(2005)
Gesundheitswesen
, vol.67
, Issue.SUPPL. 1
-
-
Holle, R.1
Happich, M.2
Lowel, H.3
Wichmann, H.E.4
-
11
-
-
23844464069
-
Type 2 diabetes mellitus in Augsburg - an epidemiological overview
-
Meisinger C, Doring A, Heier M, Thorand B, Lowel H: Type 2 diabetes mellitus in Augsburg - an epidemiological overview. Gesundheitswesen 2005; 67 (Suppl 1): S103-S109
-
(2005)
Gesundheitswesen
, vol.67
, Issue.SUPPL. 1
-
-
Meisinger, C.1
Doring, A.2
Heier, M.3
Thorand, B.4
Lowel, H.5
-
12
-
-
23844472247
-
KORA-gen-resource for population genetics, controls and a broad spectrum of disease phenotypes
-
Wichmann HE, Gieger C, Illig T: KORA-gen-resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen 2005; 67 (Suppl 1): S26-S30
-
(2005)
Gesundheitswesen
, vol.67
, Issue.SUPPL. 1
-
-
Wichmann, H.E.1
Gieger, C.2
Illig, T.3
-
14
-
-
33747139333
-
IL-6 promoter polymorphisms and quantitative traits related to the metabolic syndrome in KORA S4
-
Grallert H, Huth C, Kolz M, Meisinger C, Herder C, Strassburger K, Giani G, Wichmann HE, Adamski J, Illig T, Rathmann W: IL-6 promoter polymorphisms and quantitative traits related to the metabolic syndrome in KORA S4. Exp Gerontol 2006; 41: 737-745
-
(2006)
Exp Gerontol
, vol.41
, pp. 737-745
-
-
Grallert, H.1
Huth, C.2
Kolz, M.3
Meisinger, C.4
Herder, C.5
Strassburger, K.6
Giani, G.7
Wichmann, H.E.8
Adamski, J.9
Illig, T.10
Rathmann, W.11
-
15
-
-
0035897696
-
Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)
-
Executive Summary of The Third Report of The National Cholesterol Education Program NCEP
-
Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-2497
-
(2001)
JAMA
, vol.285
, pp. 2486-2497
-
-
-
16
-
-
33646378160
-
Prevalence of the metabolic syndrome in the elderly population according to IDF, WHO, and NCEP definitions and associations with C-reactive protein: The KORA Survey 2000
-
Rathmann W, Haastert B, Icks A, Giani G, Holle R, Koenig W, Lowel H, Meisinger C: Prevalence of the metabolic syndrome in the elderly population according to IDF, WHO, and NCEP definitions and associations with C-reactive protein: the KORA Survey 2000. Diabetes Care 2006; 29: 461
-
(2006)
Diabetes Care
, vol.29
, pp. 461
-
-
Rathmann, W.1
Haastert, B.2
Icks, A.3
Giani, G.4
Holle, R.5
Koenig, W.6
Lowel, H.7
Meisinger, C.8
-
17
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
-
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
Naylor, B.A.4
Treacher, D.F.5
Turner, R.C.6
-
18
-
-
4444266092
-
Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults
-
Weidinger S, Klopp N, Wagenpfeil S, Rummler L, Schedel M, Kabesch M, Schafer T, Darsow U, Jakob T, Behrendt H, Wichmann HE, Ring J, Illig T: Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. J Med Genet 2004; 41: 658-663
-
(2004)
J Med Genet
, vol.41
, pp. 658-663
-
-
Weidinger, S.1
Klopp, N.2
Wagenpfeil, S.3
Rummler, L.4
Schedel, M.5
Kabesch, M.6
Schafer, T.7
Darsow, U.8
Jakob, T.9
Behrendt, H.10
Wichmann, H.E.11
Ring, J.12
Illig, T.13
-
19
-
-
33750196383
-
SNP-based analysis of genetic substructure in the German population
-
Steffens M, Lamina C, Illig T, Bettecken T, Vogler R, Entz P, Suk EK, Toliat MR, Klopp N, Caliebe A, Konig IR, Kohler K, Ludemann J, Lacava AD, Fimmers R, Lichtner P, Ziegler A, Wolf A, Krawczak M, Nurnberg P, Hampe J, Schreiber S, Meitinger T, Wichmann HE, Roeder K, Wienker TF, Baur MP: SNP-based analysis of genetic substructure in the German population. Hum Hered 2006; 62: 20-29
-
(2006)
Hum Hered
, vol.62
, pp. 20-29
-
-
Steffens, M.1
Lamina, C.2
Illig, T.3
Bettecken, T.4
Vogler, R.5
Entz, P.6
Suk, E.K.7
Toliat, M.R.8
Klopp, N.9
Caliebe, A.10
Konig, I.R.11
Kohler, K.12
Ludemann, J.13
Lacava, A.D.14
Fimmers, R.15
Lichtner, P.16
Ziegler, A.17
Wolf, A.18
Krawczak, M.19
Nurnberg, P.20
Hampe, J.21
Schreiber, S.22
Meitinger, T.23
Wichmann, H.E.24
Roeder, K.25
Wienker, T.F.26
Baur, M.P.27
more..
-
20
-
-
33745075360
-
Retinol-binding protein 4, insulin resistance, and type 2 diabetes
-
Polonsky KS: Retinol-binding protein 4, insulin resistance, and type 2 diabetes. N Engl J Med 2006; 354: 2596-2598
-
(2006)
N Engl J Med
, vol.354
, pp. 2596-2598
-
-
KS, P.1
-
21
-
-
33750889376
-
Transcription factor TCF7L2 genetic study in the French population: Expression in human beta-cells and adipose tissue and strong association with type 2 diabetes
-
Cauchi S, Meyre D, Dina C, Choquet H, Samson C, Gallina S, Balkau B, Charpentier G, Pattou F, Stetsyuk V, Scharfmann R, Staels B, Fruhbeck G, Froguel P: Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 2006; 55: 2903-2908
-
(2006)
Diabetes
, vol.55
, pp. 2903-2908
-
-
Cauchi, S.1
Meyre, D.2
Dina, C.3
Choquet, H.4
Samson, C.5
Gallina, S.6
Balkau, B.7
Charpentier, G.8
Pattou, F.9
Stetsyuk, V.10
Scharfmann, R.11
Staels, B.12
Fruhbeck, G.13
Froguel, P.14
-
22
-
-
33750584981
-
Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: Replication and evidence for a role in both insulin secretion and insulin resistance
-
Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD, Mitchell BD, Shuldiner AR: Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 2006; 55: 2654-2659
-
(2006)
Diabetes
, vol.55
, pp. 2654-2659
-
-
Damcott, C.M.1
Pollin, T.I.2
Reinhart, L.J.3
Ott, S.H.4
Shen, H.5
Silver, K.D.6
Mitchell, B.D.7
Shuldiner, A.R.8
-
23
-
-
33750602980
-
Association analysis of 6736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk
-
Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M, Wiltshire S, Hattersley AT, McCarthy MI: Association analysis of 6736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 2006; 55: 2640-2644
-
(2006)
Diabetes
, vol.55
, pp. 2640-2644
-
-
Groves, C.J.1
Zeggini, E.2
Minton, J.3
Frayling, T.M.4
Weedon, M.N.5
Rayner, N.W.6
Hitman, G.A.7
Walker, M.8
Wiltshire, S.9
Hattersley, A.T.10
McCarthy, M.I.11
-
24
-
-
33751369509
-
Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women
-
in press
-
Humphries SE, Gable D, Cooper JA, Ireland H, Stephens JW, Hurel SJ, Li KW, Palmen J, Miller MA, Cappuccio FP, Elkeles R, Godsland I, Miller GJ, Talmud PJ: Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women. J Mol Med 2006, in press
-
(2006)
J Mol Med
-
-
Humphries, S.E.1
Gable, D.2
Cooper, J.A.3
Ireland, H.4
Stephens, J.W.5
Hurel, S.J.6
Li, K.W.7
Palmen, J.8
Miller, M.A.9
Cappuccio, F.P.10
Elkeles, R.11
Godsland, I.12
Miller, G.J.13
Talmud, P.J.14
-
25
-
-
33750892139
-
Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
-
Saxena R, Gianniny L, Burtt NP, Lyssenko V, Giuducci C, Sjogren M, Florez JC, Almgren P, Isomaa B, Orho-Melander M, Lindblad U, Daly MJ, Tuomi T, Hirschhorn JN, Ardlie KG, Groop LC, Altshuler D: Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes 2006; 55: 2890-2895
-
(2006)
Diabetes
, vol.55
, pp. 2890-2895
-
-
Saxena, R.1
Gianniny, L.2
Burtt, N.P.3
Lyssenko, V.4
Giuducci, C.5
Sjogren, M.6
Florez, J.C.7
Almgren, P.8
Isomaa, B.9
Orho-Melander, M.10
Lindblad, U.11
Daly, M.J.12
Tuomi, T.13
Hirschhorn, J.N.14
Ardlie, K.G.15
Groop, L.C.16
Altshuler, D.17
-
26
-
-
33750587754
-
Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample
-
Scott LJ, Bonnycastle LL, Willer CJ, Sprau AG, Jackson AU, Narisu N, Duren WL, Chines PS, Stringham HM, Erdos MR, Valle TT, Tuomilehto J, Bergman RN, Mohlke KL, Collins FS, Boehnke M: Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes 2006; 55: 2649-2653
-
(2006)
Diabetes
, vol.55
, pp. 2649-2653
-
-
Scott, L.J.1
Bonnycastle, L.L.2
Willer, C.J.3
Sprau, A.G.4
Jackson, A.U.5
Narisu, N.6
Duren, W.L.7
Chines, P.S.8
Stringham, H.M.9
Erdos, M.R.10
Valle, T.T.11
Tuomilehto, J.12
Bergman, R.N.13
Mohlke, K.L.14
Collins, F.S.15
Boehnke, M.16
-
27
-
-
33845202747
-
Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort
-
Oct. 10; Epub ahead of print
-
Vliet-Ostaptchouk JV, Shiri-Sverdlov R, Zhernakova A, Strengman E, van Haeften TW, Hofker MH, Wijmenga C: Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort. Diabetologia 2006, Oct. 10; Epub ahead of print
-
(2006)
Diabetologia
-
-
Vliet-Ostaptchouk, J.V.1
Shiri-Sverdlov, R.2
Zhernakova, A.3
Strengman, E.4
van Haeften, T.W.5
Hofker, M.H.6
Wijmenga, C.7
-
28
-
-
33750594321
-
Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men
-
Zhang C, Qi L, Hunter DJ, Meigs JB, Manson JE, van Dam RM, Hu FB: Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men.. Diabetes 2006; 55: 2645-2648
-
(2006)
Diabetes
, vol.55
, pp. 2645-2648
-
-
Zhang, C.1
Qi, L.2
Hunter, D.J.3
Meigs, J.B.4
Manson, J.E.5
van Dam, R.M.6
Hu, F.B.7
-
29
-
-
33644876824
-
Wagenknecht LE, Haffner SM: Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis Study
-
Hanley AJ, Karter AJ, Williams K, Festa A, D'Agostino RB, Jr., Wagenknecht LE, Haffner SM: Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis Study. Circulation 2005; 112: 3713-3721
-
(2005)
Circulation
, vol.112
, pp. 3713-3721
-
-
Hanley, A.J.1
Karter, A.J.2
Williams, K.3
Festa, A.4
RB Jr., D.5
-
30
-
-
1542347695
-
Convergence of Wnt, beta-catenin, and cadherin pathways
-
Nelson WJ, Nusse R: Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004; 303: 1483-1487
-
(2004)
Science
, vol.303
, pp. 1483-1487
-
-
Nelson, W.J.1
Nusse, R.2
-
31
-
-
12544254474
-
TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta
-
Yi F, Brubaker PL, Jin T: TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J Biol Chem 2005; 280: 1457-1464
-
(2005)
J Biol Chem
, vol.280
, pp. 1457-1464
-
-
Yi, F.1
Brubaker, P.L.2
Jin, T.3
|