Genotyping of Toll-like receptor 4, myeloid differentiation factor 2 and CD-14 in the horse: An investigation into the influence of genetic polymorphisms on the LPS induced TNF-α response in equine whole blood

Veterinary Immunology and Immunopathology

Volumn 111, Issue 3-4, 2006, Pages 165-173

  Werners, A H ^a   Bull, S ^a   Vendrig, J C ^a   Smyth, T ^b   Bosch, R R ^a   Fink Gremmels, J ^a   Bryant, C E ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CD 14; Equine; LPS; MD 2; Polymorphism; TLR 4

Indexed keywords

CD14 ANTIGEN; COMPLEMENTARY DNA; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; MYELOID DIFFERENTIATION FACTOR 2; RECEPTOR PROTEIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PROTEIN MD 2; RNA;

ARTICLE; BLOOD; BLOOD ANALYSIS; BLOOD SAMPLING; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SEQUENCE; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; ANIMAL; ANIMAL DISEASE; CHEMISTRY; CYTOTOXICITY TEST; GENETICS; HORSE; IMMUNOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

EQUIDAE; EQUUS CABALLUS; MAMMALIA;

ANIMALS; ANTIGENS, CD14; CYTOTOXICITY TESTS, IMMUNOLOGIC; FEMALE; HORSES; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SEQUENCE ANALYSIS, DNA; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33745513799     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2005.12.003     Document Type: Article

References (38)

1. Agnese D.M., Calvano J.E., Hahm S.J., Coyle S.M., Corbett S.A., Calvano S.E., and Lowry S.F. Human toll-like receptor 4 mutations but not CD-14 polymorphisms are associated with an increased risk of Gram-negative infections. J. Infect. Dis. 186 (2002) 1522-1525
2. Arbour N.C., Lorenz E., Schutte B.C., Zabner J., Kline J.N., Jones M., Frees K., Watt J.L., and Schwartz D.A. TLR-4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25 (2000) 187-191
3. Baldini M., Carla Lohman I., Halonen M., Erickson R.P., Holt P.G., and Martinez F.D. A polymorphism* in the 5′ flanking region of the CD-14 gene is associated with circulating soluble CD-14 Levels and with total serum immunoglobulin E. Am. J. Respir. Cell Mol. Biol. 20 (1999) 976-983
4. Bertoni G., Kuhnert P., Peterhans E., and Pauli U. Improved bioassay for the detection of porcine tumor necrosis factor using a homologous cell line: PK(15). J. Immunol. Meth. 160 (1993) 267-271
5. Beutler B., and Poltorak A. Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response. Eur. Cytokine Netw. 11 (2000) 143-152
6. Coutinho A., Forni L., Melchers F., and Watanabe T. Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide. Eur. J. Immunol. 7 (1977) 325-328
7. Coutinho A., and Meo T. Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice. Immunogenetics (1978) 17-24
8. da Silva Correia J., and Ulevitch R.J. MD-2 and TLR-4 N-Linked glycosylations are important for a functional lipopolysaccharide receptor. J. Biol. Chem. 277 (2002) 1845-1854
9. Eilertsen K.E., Olsen J.O., Brox J., and B O.S. Association of the -159 C → T polymorphism in the CD-14 promoter with variations in serum lipoproteins in healthy subjects. Blood Coagul. Fibrinolysis 14 (2003) 663-670
10. Erridge C., Stewart J., and Poxton I.R. Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J. Exp. Med. 197 (2003) 1787-1791
11. Hamann L., Kumpf O., Muller M., Visintin A., Eckert J., Schlag P.M., and Schumann R.R. A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling. Genes Immunol. 5 (2004) 283-288
12. Kiechl S., Lorenz E., Reindl M., Wiedermann C.J., Oberhollenzer F., Bonora E., Willeit J., and Schwartz D.A. Toll-like receptor 4 polymorphisms and atherogenesis. N. Engl. J. Med. 347 (2002) 185-192
13. Klein W., Tromm A., Griga T., Fricke H., Folwaczny C., Hocke M., Eitner K., Marx M., Duerig N., and Epplen J.T. A polymorphism in the CD-14 gene is associated with Crohn disease. Scand. J. Gastroenterol. 37 (2002) 189-191
14. Lorenz E., Jones M., Wohlford-Lenane C., Meyer N., Frees K.L., Arbour N.C., and Schwartz D.A. Genes other than TLR-4 are involved in the response to inhaled LPS. Am. J. Physiol. Lung Cell Mol. Physiol. 281 (2001) L1106-L1114
15. Lorenz E., Mira J.P., Frees K.L., and Schwartz D.A. Relevance of mutations in the TLR-4 receptor in patients with Gram-negative septic shock. Arch. Intern. Med. 162 (2002) 1028-1032
16. Martin T.R., Mathison J.C., Tobias P.S., Leturcq D.J., Moriarty A.M., Maunder R.J., and Ulevitch R.J. Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs. J. Clin. Invest. 90 (1992) 2209-2219
17. Mathison J., Wolfson E., Steinemann S., Tobias P., and Ulevitch R. Lipopolysaccharide (LPS) recognition in macrophages. Participation of LPS-binding protein and CD-14 in LPS-induced adaptation in rabbit peritoneal exudate macrophages. J. Clin. Invest. 92 (1993) 2053-2059
18. Michel O., LeVan T.D., Stern D., Dentener M., Thorn J., Gnat D., Beijer M.L., Cochaux P., Holt P.G., Martinez F.D., and Rylander R. Systemic responsiveness to lipopolysaccharide and polymorphisms in the toll-like receptor 4 gene in human beings. J. Allergy Clin. Immunol. 112 (2003) 923-929
19. Morange P.E., Tiret L., Saut N., Luc G., Arveiler D., Ferrieres J., Amouyel P., Evans A., Ducimetiere P., Cambien F., and Juhan-Vague I. TLR-4/Asp299Gly, CD-14/C-260T, plasma levels of the soluble receptor CD-14 and the risk of coronary heart disease: The PRIME Study. Eur. J. Hum. Genet (2004)
20. O'Brien A.D., Rosenstreich D.L., Scher I., Campbell G.H., MacDermott R.P., and Formal S.B. Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J. Immunol. 124 (1980) 20-24
21. O'Neill L.A., and Dinarello C.A. The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunol. Today 21 (2000) 206-209
22. Okayama N., Fujimura K., Suehiro Y., Hamanaka Y., Fujiwara M., Matsubara T., Maekawa T., Hazama S., Oka M., Nohara H., Kayano K., Okita K., and Hinoda Y. Simple genotype analysis of the Asp299Gly polymorphism of the Toll-like receptor-4 gene that is associated with lipopolysaccharide hyporesponsiveness. J. Clin. Lab. Anal. 16 (2002) 56-58
23. Pauli U., Bertoni G., Duerr M., and Peterhans E. A bioassay for the detection of tumor necrosis factor from eight different species: evaluation of neutralization rates of a monoclonal antibody against human TNF-alpha. J. Immunol. Meth. 171 (1994) 263-265
24. Poltorak A., He X., Smirnova I., Liu M.-Y., Huffel C.V., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR-4 gene. Science 282 (1998) 2085-2088
25. Read R.C., Pullin J., Gregory S., Borrow R., Kaczmarski E.B., di Giovine F.S., Dower S.K., Cannings C., and Wilson A.G. A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease. J. Infect. Dis. 184 (2001) 640-642
26. Rosenstreich D.L., Vogel S.N., Jacques A.R., Wahl L.M., and Oppenheim J.J. Macrophage sensitivity to endotoxin: genetic control by a single codominant gene. J. Immunol. 121 (1978) 1664-1670
27. Schromm A.B., Lien E., Henneke P., Chow J.C., Yoshimura A., Heine H., Latz E., Monks B.G., Schwartz D.A., Miyake K., and Golenbock D.T. Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 Abolishes endotoxin-induced signaling. J. Exp. Med. 194 (2001) 79-88
28. Smirnova I., Poltorak A., Chan E.K., McBride C., and Beutler B. Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR-4). Genome Biol. 1 (2000) RESEARCH002
29. Sultzer B.M. Genetic control of leucocyte responses to endotoxin. Nature 219 (1968) 1253-1254
30. Takeuchi O., Takeda K., Hoshino K., Adachi O., Ogawa T., and Akira S. Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int. Immunol. 12 (2000) 113-117
31. Torok H.-P., Glas J., Tonenchi L., Mussack T., and Folwaczny C. Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis. Clin. Immunol. 112 (2004) 85-91
32. Unkelbach K., Gardemann A., Kostrzewa M., Philipp M., Tillmanns H., and Haberbosch W. A new promoter polymorphism in the gene of lipopolysaccharide receptor CD-14 is associated with expired myocardial infarction in patients with low atherosclerotic risk profile. Arterioscler. Thromb. Vasc. Biol. 19 (1999) 932-938
33. Villanueva de la Torre T., Bech-Serra J.J., Ruiz-Paz S., Baselga J., and Arribas J. Inactivating mutations block the tumor necrosis factor-alpha-converting enzyme in the early secretory pathway. Biochem. Biophys. Res. Commun. 314 (2004) 1028-1035
34. von Aulock S., Schroder N.W., Gueinzius K., Traub S., Hoffmann S., Graf K., Dimmeler S., Hartung T., Schumann R.R., and Hermann C. Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood. J. Infect. Dis. 188 (2003) 938-943
35. Woo J.G., Assa'ad A., Heizer A.B., Bernstein J.A., and Khurana Hershey G.K. The -159 C → T polymorphism of CD-14 is associated with nonatopic asthma and food allergy. J. Allergy Clin. Immunol. 112 (2003) 438-444
36. Yang H., Young D.W., Gusovsky F., and Chow J.C. Cellular events mediated by lipopolysaccharide-stimulated Toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1. J. Biol. Chem. 275 (2000) 20861-20866
37. Yang I.A., Holloway J.W., and Ye S. TLR-4 Asp299Gly polymorphism is not associated with coronary artery stenosis. Atherosclerosis 170 (2003) 187-190
38. Zheng S.L., Augustsson-Balter K., Chang B., Hedelin M., Li L., Adami H.-O., Bensen J., Li G., Johnasson J.-E., Turner A.R., Adams T.S., Meyers D.A., Isaacs W.B., Xu J., and Gronberg H. Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the Cancer Prostate in Sweden Study. Cancer Res. 64 (2004) 2918-2922