Suppression of NF-κB-mediated β-defensin gene expression in the mammalian airway by the Bordetella type III secretion system

Cellular Microbiology

Volumn 7, Issue 4, 2005, Pages 489-497

  Legarda, Diana ^a,b,d   Klein Patel, Marcia E ^a,b   Yim, Sunghan ^a   Yuk, Ming H ^c   Diamond, Gill ^a  

^a RUTGERS SCHOOL OF DENTAL MEDICINE   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; BETA DEFENSIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; TOLL LIKE RECEPTOR 4; CELL SURFACE RECEPTOR; MEMBRANE PROTEIN; TOLL LIKE RECEPTOR; TRACHEAL ANTIMICROBIAL PEPTIDE, BOVINE;

AIRWAY; ANIMAL CELL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL IMMUNITY; BACTERIAL VIRULENCE; BORDETELLA BRONCHISEPTICA; CELL CULTURE; CELL NUCLEUS; CONTROLLED STUDY; COW; GENE ACTIVATION; GENE EXPRESSION; GENE TRANSLOCATION; GRAM NEGATIVE BACTERIUM; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; INNATE IMMUNITY; MAMMAL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRACHEA MUCOSA; WILD TYPE; ANIMAL; CATTLE; CYTOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROBIOLOGY; PATHOGENICITY; TRACHEA; UPREGULATION;

BACTERIA (MICROORGANISMS); BORDETELLA; BORDETELLA BRONCHISEPTICA; BOVINAE; MAMMALIA; NEGIBACTERIA;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; BORDETELLA BRONCHISEPTICA; CATTLE; CELLS, CULTURED; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; MEMBRANE GLYCOPROTEINS; NF-KAPPA B; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TRACHEA; UP-REGULATION;

EID: 15944372598     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2004.00473.x     Document Type: Article

References (31)

1. Becker, M.N., Diamond, G., Verghese, M.W., and Randell, S.H. (2000) CD14-dependent lipopolysaccharide-incluced beta-defensin-2 expression in human tracheobronchial epithelium. J Biol Chem 275: 29731-29736.
2. Beuscher, H.U., Rodel, F., Forsberg, A., and Rollinghoff, M. (1995) Bacterial evasion of host immune defense: Yersinia enterocolitica encodes a suppressor for tumor necrosis factor alpha expression. Infect Immun 63: 1270-1277.
3. Boland, A., and Cornelis, G.R. (1998) Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during Yersinia infection. Infect Immun 66: 1878-1884.
4. Cotter, P.A., and Miller, J.F. (1994) BvgAS-mediated signal transduction: analysis of phase-locked regulatory mutants of Bordetella bronchiseptica in a rabbit model. Infect Immun 62: 3381-3390.
5. Cotter, P.A., and Miller, J.F. (1997) A mutation in the Bordetella bronchiseptica bvgS gene results in reduced virulence and increased resistance to starvation, and identifies a new class of Bvg-regulated antigens. Mol Microbiol 24: 671-685.
6. Diamond, G., and Bevins, C.L. (1998) Beta-defensins: endogenous antibiotics of the innate host defense response. Clin Immunol Immunop 88: 221-225.
7. Diamond, G., Zasloff, M., Eck, H., Brasseur, M., Maloy, W.L., and Bevins, C.L. (1991) Tracheal antimicrobial peptide, a novel cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci USA 88: 3952-3956.
8. Diamond, G., Jones, D.E., and Bevins, C.L. (1993) Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene. Proc Natl Acad Sci USA 90: 4596-4600.
9. Diamond, G., Russell, J.P., and Bevins, C.L. (1996) Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc Natl Acad Sci USA 93: 5156-5160.
10. Diamond, G., Legarda, D., and Ryan, L.K. (2000a) The innate immune response of the respiratory epithelium. Immunol Rev 173: 27-38.
11. Diamond, G., Kaiser, V., Rhodes, J., Russell, J.P., and Bevins, C.L. (2000b) Transcriptional regulation of β-defensin gene expression in tracheal epithelial cells. Infect Immun 68: 113-119.
12. Galan, J.E., and Collmer, A. (1999) Type III secretion machines: bacterial devices for protein delivery into host cells. Science 284: 1322-1328.
13. Jackson, L.A., Cherry, J.D., Wang, S.P., and Grayston, J.T. (2000) Frequency of serological evidence of Bordetella infections and mixed infections with other respiratory pathogens in university students with cough illnesses. Clin Infect Dis 31: 3-6.
14. Li, J.-D., Feng, W., Gallup, M., Kim, J.-H., Gum, J., Kim, Y., and Basbaum, C. (1998) Activation of NF-kB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa induced mucin overproduction in epithelial cells. Proc Natl Acad Sci USA 95: 5718-5723.
15. Lien, E., Means, T.K., Heine, H., Yoshimura, A., Kusumoto, S., Fukase, K, et al. (2000) Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest 105: 497-504.
16. Martinez de Tejada, G., Miller, J.F., and Cotter, P.A. (1996) Comparative analysis of the virulence control systems of Bordetella pertussis and Bordetella bronchiseptica. Mol Microbiol 22: 895-908.
17. Neish, A.S., Gewirtz, A.T., Zeng, H., Young, AX, Hobert, M.E., Karmali, V, et al. (2000) Prokaryotic regulation of epithelial responses by inhibition of ikappaB-alpha ubiquitination. Science 289: 1560-1563.
18. O'Neil, D.A., Porter, E.M., Elewaut, D., Anderson, G.M., Eckmann, L., Ganz, T., and Kagnoff, M.F. (1999) Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 163: 6718-6724.
19. Orth, K., Palmer, L.E., Bao, Z.Q., Stewart, S., Rudolph, A.E., Bliska, J.B., and Dixon, J.E. (1999) Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector. Science 285: 1920-1923.
20. Orth, K., Xu, Z., Mudgett, M.B., Bao, Z.Q., Palmer, L.E., Bliska, J.B, et al. (2000) Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease. Science 290: 1594-1597.
21. Palmer, L.E., Pancetti, A.R., Greenberg, S., and Bliska, J.B. (1999) YbpJ of Yersinia spp. is sufficient to cause downregulation of multiple mitogen-activated protein kinases in eukaryotic cells. Infect Immun 67: 708-716.
22. Ruckdeschel, K., Machold, J., Roggenkamp, A., Schubert,S., Pierre, J., Zumbihl, R, et al. (1997) Yersinia enterocolitica promotes deactivation of macrophage mitogen-activated protein kinases extracellular signal-regulated kinase-1/2, p38, and c-Jun NH2-terminal kinase. Correlation with its inhibitory effect on tumor necrosis factor-alpha production. J Biol Chem 272: 15920-15927.
23. Russell, J.P., Diamond, G., Tarver, A.P., Scanlin, T.F., and Bevins, C.L. (1996) Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect Immun 64: 1565-1568.
24. Ryan, L.K., Rhodes, J., Bhat, M., and Diamond, G. (1998) Expression of beta-defensin genes in bovine alveolar macrophages. Infect Immun 66: 878-881.
25. Schesser, K., Spiik, A.K., Dukuzumuremyi, J.M., Neurath, M.F., Pettersson, S., and Wolf-Watz, H. (1998) The yopJ locus is required for Yersinia-mediated inhibition of NF-kappaB activation and cytokine expression: YopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity. Mol Microbiol 28: 1067-1079.
26. Skinner, J.A., Reissinger, A., Shen, H., and Yuk, M.H. (2004) Bordetella type III secretion and adenylate cyclase toxin synergize to drive dendritic cells into a semimature state. J Immunol 173: 1934-1940.
27. Tsutsumi-Ishii, Y., and Nagaoka, I. (2002) NF-kappaB-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysaccharide stimulation. J Leukoc Biol 71: 154-162.
28. Wu, R., Nolan, E., and Turner, C. (1985a) Expression of tracheal differentiated functions in serum-free hormone-supplemented medium. J Cell Physiol 125: 167-181.
29. Wu, R., Yankaskas, J., Cheng, E., Knowles, M.R., and Boucher, R. (1985b) Growth and differentiation of human nasal epithelial cells in culture. Am Rev Respir Dis 132: 311-320.
30. Yuk, M.H., Harvill, E.T., and Miller, J.F. (1998) The BvgAS virulence control system regulates type III secretion in Bordetella bronchiseptica. Mol Microbiol 28: 945-959.
31. Yuk, M.H., Harvill, E.T., Cotter, P.A., and Miller, J.F. (2000) Modulation of host immune responses, induction of apoptosis and inhibition of NF-kappaB activation by the Bordetella type III secretion system. Mol Microbiol 35: 991-1004.