The genomic context of natural killer receptor extended gene families

Immunological Reviews

Volumn 181, Issue , 2001, Pages 20-38

  Trowsdale, John ^a   Barten, Roland ^a   Haude, Anja ^a   Andrew Stewart, C ^a   Beck, Stephan ^b   Wilson, Michael J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN RECEPTOR; LECTIN RECEPTOR; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; CHROMOSOME 12P; CHROMOSOME 19Q; EXON; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MULTIGENE FAMILY; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR GENE; REVIEW;

ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 19; EVOLUTION, MOLECULAR; GENOME, HUMAN; HUMANS; KILLER CELLS, NATURAL; LEUKOCYTES; LIGANDS; MICE; MINISATELLITE REPEATS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; POLYMORPHISM, GENETIC; RECEPTORS, IMMUNOLOGIC; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 0034895149     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2001.1810102.x     Document Type: Review

References (141)

1. Regulation of immune responses through inhibitory receptors
2. Specificity, function and development of NK cells
3. NK cell receptors
4. On guard-activating NK receptors
5. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells
6. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes
7. Human NK cell receptors involved in MHC class I recognition are disulphide-linked heterodimers of CD94 and NKG2 subunits
8. Natural killer cell receptors specific for major histocompatibility complex class I molecules
9. Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts
10. Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C
11. Role of immunoreceptor tyrosine-base activation motif in signal transduction from antigen and Fc receptor
12. DAP12: A key accessory protein for relaying signals by natural killer cell receptors
13. DAP12 and KAP10 (DAP10)-novel transmembrane adapter proteins of the CD3zeta family
14. The NKC and regulation of natural killer cell mediated immunity
15. A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors
16. Extensive gene duplications and a large inversion characterise the human leukocyte receptor cluster
17. Organisation of the leukocyte receptor cluster (LRC) on human chromosome 19q13.4
18. Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis
19. NK cells, MHC class I antigens and missing self
20. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
21. A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells
22. Complete sequence and gene map of a human major histocompatibility complex (MHC)
23. Plasticity in the organization and sequences of human KIR/ILT gene families
24. Divergent and convergent evolution of NK-cell receptors
25. The murine homologue of human NKp46, a triggering receptor involved in the induction of natural cytotoxity
26. Paired immunoglobulin-like receptors of activating and inhibitory types
27. Paired Ig-like receptor homologs in birds and mammals share a common ancestor with mammalian Fc receptors
28. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcαR and the natural killer receptors
29. Sialic acid binding receptors (siglecs) expressed by macrophages
30. The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expresion in normal and malignant tissues
31. Association of DAP12 with activating CD94/NKG2C NK cell receptors
32. KAP10, a novel adapter protein genetically linked to DAP12 but with unique signalling properties
33. A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes
34. Human diversity in killer cell inhibitory receptor genes
35. Genomic organization of a human killer cell inhibitory receptor gene
36. Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor
37. The NACHT family - A new group of predicted NTPases implicated in apoptosis and MHC transcription activation
38. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
39. Genomics of the major histocompatibility complex: Haplotypes, duplication, retroviruses and disease
40. Arrangement of the ILT gene duster: A common null allele of the ILT6 gene results from a 6.7 kbp deletion
41. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes
42. The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1
43. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors
44. Map of the human MHC
45. The human MHC lessons from the DNA sequence
46. A common inhibitory receptor for MHC class I molecules in human lymphoid and myelomonocytic cells
47. Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism
48. Repeat instability ar human minisatellites arising from meiotic recombination
49. High-resolution mapping of crossovers in human sperm defines a minisatellite-associated recombination hotspot
50. A fundamental division in the Alu family of repeated sequences
51. Reconstruction and analysis of human Alu genes
52. Prototypic sequences for human repetitive DNA
53. A new subfamily of recently retroposed Alu repeats
54. Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes
55. Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene
56. Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation
57. The human natural killer gene complex (NKC) is located on chromosome 12p13.1-p13.2
58. The activation antigen CD69
59. Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors
60. Regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, the predicted region of the human natural killer cell gene complex
61. Expression and function of NKRP1A molecule on human monocytes and dendritic cells
62. The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile
63. Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: Molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis
64. Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells
65. Structure of the gene coding for the human early lymphocyte activation antigen CD69: A C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors
66. Sequence analysis of a 62 kbp region overlapping the human KLRC duster of genes
67. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex
68. Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function
69. Divergent functions of lectin-like receptors on NK cells
70. The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells
71. Localization of five new Ly49 genes, including three closely related to Ly49c
72. The Ly-49 family: Genes, proteins and recognition of class I MHC
73. A 2-Mb YAC contig and physical map of the natural kiler gene complex on mouse chromosome 6
74. Recognition of the class Ib molecule Qa-1 (b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells
75. Evolution by the birth-and-death process in multigene families of the vertebrate immune system
76. The rise and fall of great class I genes
77. Effect of gene conversion on polymorphic patterns ar major histocompatibility complex loci
78. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes
79. Genetic control of natural killing and in vivo tumor elimination by the Chok locus
80. The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing
81. Genetic mappmg of Cmv1 in the region of mouse chromosome 6 encoding the NK gene complex associated loci Ly49 and musNKR-P1
82. Innate resistance to lethal mousepox is genetically linked to the NK gene complex on chromosome 6 and correlates with early restriction of virus replication by cells with an NK phenotype
83. The Cmv1 host resistance locus is closely linked to the Ly49 multigene family within the natural killer cell gene complex on mouse chromosome 6
84. High-resolution linkage map in the proximity of the host resistance locus Cmv1
85. Differential pathogenesis of lethal mousepox in congenic DBA/2 mice implicates natural killer cell receptor NKR-P1 in necrotizing hepatitis and the fifth component of complement in recruitment of circulating leukocytes to spleen
86. Localization on a physical map of the NKC-linked Cmv1 locus between Ly49b and the Prp gene duster on mouse chromosome 6
87. Assessment of Cmv1 candidates by genetic mapping and in vivo antibody depletion of NK cell subsets
88. Biology of animal lectins
89. The lectin-like NK cell receptor Ly-49A recognizes a carbohydrate-independent epitope on its MHC class I ligand
90. Major histocompatibility complex class I-dependent cell binding to isolated Ly-49A: Evidence for high-avidity interaction
91. Recognition of class I major histocompatibility complex molecules by Ly-49: Specificities and domain interactions
92. b
93. Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis
94. HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A
95. HLA-E binds to natural killer cell receptors
96. Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain
97. Identification of a human member of the Ly-49 multigene family
98. The human Ly-49L gene
99. An Fc receptor structurally related to MHC class I antigens
100. The human gene encoding the heavy chain of the MHC class I-like Fc receptor
101. The structure and evolution of FcRN
102. The chromosomal duplication model of the major histocompatibility complex
103. DC-SIGN, a related gene, DC-SIGNR and CD23 form a cluster on 19p13
104. The chicken B locus is a minimal essential MHC
105. Relationships among the genes encoding MHC molecules and the specific antigen receptors
106. BTN genes form a cluster of polymorphic orphan cell surface receptors in the extended MHC
107. The phylogenetic origin of antigen-specific receptors
108. Kissing cousins exchange CLIP
109. The structure of MHC class II: A role for dimer of dimers
110. Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand
111. The human natural killer cell immune synapse
112. Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors
113. LIRs/ILTs/MIRs, inhibitory and stimulatory Ig-superfamily receptors expressed in myeloid and lymphoid cells
114. Defence by diversity
115. MHC evolution: A long term investment in defense
116. Immunology. Some savage cuts in defence
117. HLA and HIV-1: Heterozygote advantage and B*35-Cw*04 disadvantage
118. Association of malaria parasite population structure, HLA, and immunological antagonism
119. Fcα/μR: Single member or first born in the family?
120. Complete sequence and gene map of a human major histocompatibility complex (MHC)
121. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
122. NKp44, a triggering receptor involved in tumour cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily
123. Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
124. Soluble forms of the novel MHC class I-related molecules, ULBP1 and ULBP2, bind to and functionally activate NK cells
125. FDFO3, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells
126. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells
127. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor
128. A family of proteins that inhibit signalling through tyrosine kinase receptors
129. The novel receptors that mediate the entry of herpes simplex viruses and animal alpha herpesviruses into cells
130. CD79a: A novel marker for B-cell neoplasms in routinely processed tissue samples
131. Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex
132. Genes encoding human killer-cell Ig-like receptors with D1 and D2 extracellular domains all contain untranslated pseudoexons encoding a third Ig-like domain
133. KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains
134. Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1
135. TRANSFAC: An integrated system for gene expression regulation
136. Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene
137. Structure of the human CD94 C-type lectin gene
138. Genomic structure, chromosome location and alternative splicing of the human NKG2-A gene