Phosphorylation influences neurosteroid modulation of synaptic GABA A receptors in rat CA1 and dentate gyrus neurones

Neuropharmacology

Volumn 45, Issue 6, 2003, Pages 873-883

  Harney, Sarah C ^a   Frenguelli, Bruno G ^a   Lambert, Jeremy J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

GABAA receptors; Neurosteroid; Phosphorylation

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; ELTANOLONE; FLUNITRAZEPAM; NEUROSTEROID; PENTOBARBITAL; PROTEIN KINASE C;

ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DENTATE GYRUS; ELECTRIC CURRENT; ENZYME INHIBITION; EXPERIENCE; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PYRAMIDAL NERVE CELL; RAT; SYNAPTIC TRANSMISSION;

ANIMALS; DENTATE GYRUS; FEMALE; GABA MODULATORS; HIPPOCAMPUS; MALE; NEURONS; PENTOBARBITAL; PHOSPHORYLATION; PREGNANETRIOL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SYNAPSES;

EID: 0242536407     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(03)00251-X     Document Type: Article

References (49)

1. A, slow. J. Neurosci. 18:1998;1305-1317.
2. Barnard E.A., Skolnick P., Olsen R.W., Mohler H., Sieghart W., Biggio G., Braestrup C., Bateson A.N., Langer S.Z. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol. Rev. 50:1998;291-313.
3. A receptors. Neuropharmacology. 43:2002;651-661.
4. Brooks-Kayal A.R., Shumate M.D., Jin H., Rikhter T.Y., Kelly M.E., Coulter D.A. Gamma-aminobutyric acid A receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal development. J. Neurochem. 77:2001;1266-1278.
5. A receptors. Br. J. Pharmacol. 136:2002;965-974.
6. A receptor subunit expression. Neuron. 19:1997;1103-1114.
7. Cheng H.C., Kemp B.E., Pearson R.B., Smith A.J., Misconi L., Van Patten S.M., Walsh D.A. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J. Biol. Chem. 261:1986;989-992.
8. A IPSCs during development in rat hippocampal or cerebellar slices. J. Physiol. 521:1999;437-449.
9. Dale N., Pearson T., Frenguelli B.G. Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice. J. Physiol. 526:2000;143-155.
10. A receptor subunit. Nature. 385:1997;820-823.
11. A receptor channels. J. Neurophysiol. 71:1994;1318-1335.
12. Edwards F.A., Konnerth A., Sakmann B. Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: a patch-clamp study. J. Physiol. 430:1990;213-249.
13. Fancsik A., Linn D.M., Tasker J.G. Neurosteroid modulation of GABA IPSCs is phosphorylation dependent. J. Neurosci. 20:2000;3067-3075.
14. Gasior M., Carter R.B., Witkin J.M. Neuroactive steroids: potential therapeutic use in neurological and psychiatric disorders. Trends Pharmacol. Sci. 20:1999;107-112.
15. A receptors by benzodiazepines and barbiturates is autonomous of PKC activation. Neuropharmacology. 40:2001;327-333.
16. Hodge C.W., Raber J., McMahon T., Walter H., Sanchez-Perez A.M., Olive M.F., Mehmert K., Morrow A.L., Messing R.O. Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon. J. Clin. Invest. 110:2002;1003-1010.
17. House C., Kemp B.E. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science. 238:1987;1726-1728.
18. Kneussel M., Betz H. Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model. Trends Neurosci. 23:2000;429-435.
19. A receptors in supraoptic nucleus around parturition. J. Neurosci. 23:2003;788-797.
20. A receptors by endogenous and synthetic neuroactive steroids. Brain Res. Brain Res. Rev. 37:2001;68-80.
21. A receptor function. Trends Pharmacol. Sci. 16:1995;295-303.
22. A receptors. Brain Res. Mol. Brain Res. 52:1997;173-181.
23. A/benzodiazepine receptor heterogeneity: neurophysiological implications. Neuropharmacology. 34:1995;245-254.
24. Melcangi R.C., Magnaghi V., Galbiati M., Martini L. Formation and effects of neuroactive steroids in the central and peripheral nervous system. Int. Rev. Neurobiol. 46:2001;145-176.
25. Mellon S.H., Vaudry H. Biosynthesis of neurosteroids and regulation of their synthesis. Int. Rev. Neurobiol. 46:2001;33-78.
26. Mohler H., Fritschy J.M., Rudolph U. A new benzodiazepine pharmacology. J. Pharmacol. Exp. Ther. 300:2002;2-8.
27. Morrow A.L., VanDoren M.J., Penland S.N., Matthews D.B. The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brain Res. Brain Res. Rev. 37:2001;98-109.
28. Moss S.J., Smart T.G. Constructing inhibitory synapses. Nat. Rev. Neurosci. 2:2001;240-250.
29. A receptor currents in a rat model of chronic temporal lobe epilepsy. J. Physiol. 537:2001;453-465.
30. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 6:1992;2311-2322.
31. A responses in rat hippocampus. Neuron. 10:1993;189-200.
32. A receptor agonist muscimol. Neuropharmacology. 39:2000;440-448.
33. A receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience. 101:2000;815-850.
34. A receptor function by PKA and PKC in adult hippocampal neurons. J. Neurosci. 19:1999;674-683.
35. A receptor function. Neuropharmacology. 44:2003;49-55.
36. Reddy D.S. Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions? Trends Pharmacol. Sci. 24:2003;103-106.
37. Reddy D.S., Rogawski M.A. Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. J. Pharmacol. Exp. Ther. 294:2000;909-915.
38. Rupprecht R., di Michele F., Hermann B., Strohle A., Lancel M., Romeo E., Holsboer F. Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology. Brain Res. Brain Res. Rev. 37:2001;59-67.
39. Saxena N.C., Macdonald R.L. Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms. Mol. Pharmacol. 49:1996;567-579.
40. Sieghart W. Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. Pharmacol. Rev. 47:1995;181-234.
41. A receptors: protein phosphorylation. Mohler H. Pharmacology of GABA and Glycine Neurotransmission. 2001;195-225 Springer-Verlag, Berlin.
42. A receptor alpha4 subunit in association with increased anxiety. J. Neurosci. 18:1998;5275-5284.
43. Souroujon M.C., Mochly-Rosen D. Peptide modulators of protein-protein interactions in intracellular signaling. Nat. Biotechnol. 16:1998;919-924.
44. Uzunova V., Sheline Y., Davis J.M., Rasmusson A., Uzunov D.P., Costa E., Guidotti A. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc. Natl. Acad. Sci. USA. 95:1998;3239-3244.
45. A receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses. J. Neurosci. 23:2003;826-836.
46. A-mediated synaptic current by ethanol in hippocampal CA1 neurons: possible role of protein kinase C. J. Pharmacol. Exp. Ther. 268:1994;1388-1395.
47. A receptor subunit conferring atypical functional properties. J. Neurosci. 17:1997;5027-5037.
48. A receptors containing the delta subunit. J. Neurosci. 22:2002;1541-1549.
49. A receptors. J. Neurosci. 16:1996;6648-6656.