-
1
-
-
0032718352
-
Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice
-
Fuss IJ, Marth T, Neurath MF, Pearlstein GF, Jain A, Strober W. Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice. Gastroenterology 1999; 117: 1078-1088
-
(1999)
Gastroenterology
, vol.117
, pp. 1078-1088
-
-
Fuss, I.J.1
Marth, T.2
Neurath, M.F.3
Pearlstein, G.F.4
Jain, A.5
Strober, W.6
-
2
-
-
8344284998
-
Anti-interleukin-12 antibody for active Crohn's disease
-
Mannon P, Fuss IJ, Mayer L, Elson CO, Sandborn WJ, Present D, Dolin B, Goodman N, Groden C, Hornung RL, Quezado M, Yang Z, Neurath MF, Salfeld J, Veldman GM, Schwertschlag U, Strober W. Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med 2004; 351: 2069-2079
-
(2004)
N Engl J Med
, vol.351
, pp. 2069-2079
-
-
Mannon, P.1
Fuss, I.J.2
Mayer, L.3
Elson, C.O.4
Sandborn, W.J.5
Present, D.6
Dolin, B.7
Goodman, N.8
Groden, C.9
Hornung, R.L.10
Quezado, M.11
Yang, Z.12
Neurath, M.F.13
Salfeld, J.14
Veldman, G.M.15
Schwertschlag, U.16
Strober, W.17
-
3
-
-
0032432066
-
Acquired resistance but not innate resistance to Mycobacterium bovis bacillus Calmette-Guerin is compromised by interleukin-12 ablation
-
Thompson-Snipes L, Skamene E, Radzioch D. Acquired resistance but not innate resistance to Mycobacterium bovis bacillus Calmette-Guerin is compromised by interleukin-12 ablation. Infect Immun 1998; 66: 5268-5274
-
(1998)
Infect Immun
, vol.66
, pp. 5268-5274
-
-
Thompson-Snipes, L.1
Skamene, E.2
Radzioch, D.3
-
4
-
-
24944529247
-
TNF-blocking agents and tuberculosis: New drugs illuminate an old topic
-
Keane J. TNF-blocking agents and tuberculosis: new drugs illuminate an old topic. Rheumatology (Oxford) 2005; 44: 714-720
-
(2005)
Rheumatology (Oxford)
, vol.44
, pp. 714-720
-
-
Keane, J.1
-
5
-
-
33845903050
-
Aggravation of intestinal inflammation by depletion/ deficiency of gammadelta T cells in different types of IBD animal models
-
Kuhl AA, Pawlowski NN, Grollich K, Loddenkemper C, Zeitz M, Hoffmann JC. Aggravation of intestinal inflammation by depletion/ deficiency of gammadelta T cells in different types of IBD animal models. J Leukoc Biol 2007; 81: 168-175
-
(2007)
J Leukoc Biol
, vol.81
, pp. 168-175
-
-
Kuhl, A.A.1
Pawlowski, N.N.2
Grollich, K.3
Loddenkemper, C.4
Zeitz, M.5
Hoffmann, J.C.6
-
6
-
-
0035106502
-
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease
-
Kosiewicz MM, Nast CC, Krishnan A, Rivera-Nieves J, Moskaluk CA, Matsumoto S, Kozaiwa K, Cominelli F. Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J Clin Invest 2001; 107: 695-702
-
(2001)
J Clin Invest
, vol.107
, pp. 695-702
-
-
Kosiewicz, M.M.1
Nast, C.C.2
Krishnan, A.3
Rivera-Nieves, J.4
Moskaluk, C.A.5
Matsumoto, S.6
Kozaiwa, K.7
Cominelli, F.8
-
7
-
-
0034658617
-
IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii
-
Suzuki Y, Sher A, Yap G, Park D, Neyer LE, Liesenfeld O, Fort M, Kang H, Gufwoli E. IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii. J Immunol 2000; 164: 5375-5382
-
(2000)
J Immunol
, vol.164
, pp. 5375-5382
-
-
Suzuki, Y.1
Sher, A.2
Yap, G.3
Park, D.4
Neyer, L.E.5
Liesenfeld, O.6
Fort, M.7
Kang, H.8
Gufwoli, E.9
-
8
-
-
0029841124
-
Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii
-
Liesenfeld O, Kosek J, Remington JS, Suzuki Y. Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii. J Exp Med 1996; 184: 597-607
-
(1996)
J Exp Med
, vol.184
, pp. 597-607
-
-
Liesenfeld, O.1
Kosek, J.2
Remington, J.S.3
Suzuki, Y.4
-
9
-
-
0033030226
-
TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii
-
Liesenfeld O, Kang H, Park D, Nguyen TA, Parkhe CV, Watanabe H, Abo T, Sher A, Remington JS, Suzuki Y. TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii. Parasite Immunol 1999; 21: 365-376
-
(1999)
Parasite Immunol
, vol.21
, pp. 365-376
-
-
Liesenfeld, O.1
Kang, H.2
Park, D.3
Nguyen, T.A.4
Parkhe, C.V.5
Watanabe, H.6
Abo, T.7
Sher, A.8
Remington, J.S.9
Suzuki, Y.10
-
10
-
-
0037083246
-
Oral infection of C57BL/6 mice with Toxoplasma gondii: A new model of inflammatory bowel disease?
-
Liesenfeld O. Oral infection of C57BL/6 mice with Toxoplasma gondii: a new model of inflammatory bowel disease? J Infect Dis 2002; 185 Suppl 1: S96-S101
-
(2002)
J Infect Dis
, vol.185
, Issue.SUPPL. 1
-
-
Liesenfeld, O.1
-
11
-
-
9244250314
-
Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control
-
Vossenkamper A, Struck D, Alvarado-Esquivel C, Went T, Takeda K, Akira S, Pfeffer K, Alber G, Lochner M, Forster I, Liesenfeld O. Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control. Eur J Immunol 2004; 34: 3197-3207
-
(2004)
Eur J Immunol
, vol.34
, pp. 3197-3207
-
-
Vossenkamper, A.1
Struck, D.2
Alvarado-Esquivel, C.3
Went, T.4
Takeda, K.5
Akira, S.6
Pfeffer, K.7
Alber, G.8
Lochner, M.9
Forster, I.10
Liesenfeld, O.11
-
12
-
-
3242805827
-
IL-23 provides a limited mechanism of reilstance to acute toxoplasmosis in the absence of IL-12
-
Lieberman LA, Cardillo F, Owyang AM, Rennick DM, Cua DJ, Kastelein RA, Hunter CA. IL-23 provides a limited mechanism of reilstance to acute toxoplasmosis in the absence of IL-12. J Immunol 2004; 173: 1887-1893
-
(2004)
J Immunol
, vol.173
, pp. 1887-1893
-
-
Lieberman, L.A.1
Cardillo, F.2
Owyang, A.M.3
Rennick, D.M.4
Cua, D.J.5
Kastelein, R.A.6
Hunter, C.A.7
-
13
-
-
0037340388
-
The nature of molecular recognition by T cells
-
Davis SJ, Ikemizu S, Evans EJ, Fugger L, Bakker TR, van der Merwe PA. The nature of molecular recognition by T cells. Nat Immunol 2003; 4: 217-224
-
(2003)
Nat Immunol
, vol.4
, pp. 217-224
-
-
Davis, S.J.1
Ikemizu, S.2
Evans, E.J.3
Fugger, L.4
Bakker, T.R.5
van der Merwe, P.A.6
-
14
-
-
0036604984
-
Formation and function of the immunological synapse
-
van der Merwe PA. Formation and function of the immunological synapse. Curr Opin Immunol 2002; 14: 293-298
-
(2002)
Curr Opin Immunol
, vol.14
, pp. 293-298
-
-
van der Merwe, P.A.1
-
15
-
-
0042971650
-
Molecular interactions mediating T cell antigen recognition
-
van der Merwe PA, Davis SJ. Molecular interactions mediating T cell antigen recognition. Annu Rev Immunol 2003; 21: 659-684
-
(2003)
Annu Rev Immunol
, vol.21
, pp. 659-684
-
-
van der Merwe, P.A.1
Davis, S.J.2
-
16
-
-
0025027664
-
Differential responsiveness to CD3-Ti vs. CD2-dependent activation of human intestinal T lymphocytes
-
Pirzer UC, Schurmann G, Post S, Betzler M, Meuer SC. Differential responsiveness to CD3-Ti vs. CD2-dependent activation of human intestinal T lymphocytes. Eur J Immunol 1990; 20: 2339-2342
-
(1990)
Eur J Immunol
, vol.20
, pp. 2339-2342
-
-
Pirzer, U.C.1
Schurmann, G.2
Post, S.3
Betzler, M.4
Meuer, S.C.5
-
17
-
-
0023845341
-
Mucosal T cells provide helper function but do not proliferate when stimulated by specific antigen in lymphogranuloma venereum proctitis in nonhuman primates
-
Zeitz M, Quinn TC, Graeff AS, James SP. Mucosal T cells provide helper function but do not proliferate when stimulated by specific antigen in lymphogranuloma venereum proctitis in nonhuman primates. Gastroenterology 1988; 94: 353-366
-
(1988)
Gastroenterology
, vol.94
, pp. 353-366
-
-
Zeitz, M.1
Quinn, T.C.2
Graeff, A.S.3
James, S.P.4
-
18
-
-
0026478567
-
Development and function of T cells in mice with a disrupted CD2 gene
-
Killeen N, Stuart SG, Littman DR. Development and function of T cells in mice with a disrupted CD2 gene. EMBO J 1992; 11: 4329-4336
-
(1992)
EMBO J
, vol.11
, pp. 4329-4336
-
-
Killeen, N.1
Stuart, S.G.2
Littman, D.R.3
-
19
-
-
0027376261
-
CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus
-
Evans CF, Rall GF, Killeen N, Littman D, Oldstone MB. CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus. J Immunol 1993; 151: 6259-6264
-
(1993)
J Immunol
, vol.151
, pp. 6259-6264
-
-
Evans, C.F.1
Rall, G.F.2
Killeen, N.3
Littman, D.4
Oldstone, M.B.5
-
20
-
-
0031059288
-
CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells
-
Teh SJ, Killeen N, Tarakhovsky A, Littman DR, Teh HS. CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells. Blood 1997; 89: 1308-1318
-
(1997)
Blood
, vol.89
, pp. 1308-1318
-
-
Teh, S.J.1
Killeen, N.2
Tarakhovsky, A.3
Littman, D.R.4
Teh, H.S.5
-
21
-
-
0043125619
-
T cell costimulatory molecule function determines susceptibility to infection with Pneumocystis carinii in mice
-
Beck JM, Blackmon MB, Rose CM, Kimzey SL, Preston AM, Green JM. T cell costimulatory molecule function determines susceptibility to infection with Pneumocystis carinii in mice. J Immunol 2003; 171: 1969-1977
-
(2003)
J Immunol
, vol.171
, pp. 1969-1977
-
-
Beck, J.M.1
Blackmon, M.B.2
Rose, C.M.3
Kimzey, S.L.4
Preston, A.M.5
Green, J.M.6
-
22
-
-
27144440483
-
Alpha CD 2 mAb treatment safely attenuates adoptive transfer colitis
-
Pawlowski NN, Kakirman H, Kuhl AA, Liesenfeld O, Groffich K, Loddenkemper C, Zeitz M, Hoffmann JC. Alpha CD 2 mAb treatment safely attenuates adoptive transfer colitis. Lab Invest 2005; 85: 1013-1023
-
(2005)
Lab Invest
, vol.85
, pp. 1013-1023
-
-
Pawlowski, N.N.1
Kakirman, H.2
Kuhl, A.A.3
Liesenfeld, O.4
Groffich, K.5
Loddenkemper, C.6
Zeitz, M.7
Hoffmann, J.C.8
-
23
-
-
0028241835
-
Antibody against interleukin-6 reduces inflammation and numbers of cysts in brains of mice with toxoplasmic encephalitis
-
Suzuki Y, Yang Q, Conley FK, Abrams JS, Remington JS. Antibody against interleukin-6 reduces inflammation and numbers of cysts in brains of mice with toxoplasmic encephalitis. Infect Immun 1994; 62: 2773-2778
-
(1994)
Infect Immun
, vol.62
, pp. 2773-2778
-
-
Suzuki, Y.1
Yang, Q.2
Conley, F.K.3
Abrams, J.S.4
Remington, J.S.5
-
24
-
-
0034795561
-
Neutralization of interleukin-18 reduces severity in murine colitis and intestinal EFN-gamma and TNF-alpha production
-
Siegmund B, Fantuzzi G, Rieder F, Gamboni-Robertson F, Lehr HA, Hartmann G, Dinarello CA, Endres S, Eigler A. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal EFN-gamma and TNF-alpha production. Am J Physiol Regul Integr Camp Physiol 2001; 281: R1264-R1273
-
(2001)
Am J Physiol Regul Integr Camp Physiol
, vol.281
-
-
Siegmund, B.1
Fantuzzi, G.2
Rieder, F.3
Gamboni-Robertson, F.4
Lehr, H.A.5
Hartmann, G.6
Dinarello, C.A.7
Endres, S.8
Eigler, A.9
-
25
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
26
-
-
33845428754
-
Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii
-
Heimesaat MM, Bereswill S, Fischer A, Fuchs D, Struck D, Niebergall J, Jahn HK, Dunay IR, Moter A, Gescher DM, Schumann RR, Gobel UB, Liesenfeld O. Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii. J Immunol 2006; 177: 8785-8795
-
(2006)
J Immunol
, vol.177
, pp. 8785-8795
-
-
Heimesaat, M.M.1
Bereswill, S.2
Fischer, A.3
Fuchs, D.4
Struck, D.5
Niebergall, J.6
Jahn, H.K.7
Dunay, I.R.8
Moter, A.9
Gescher, D.M.10
Schumann, R.R.11
Gobel, U.B.12
Liesenfeld, O.13
-
27
-
-
0019440343
-
Toxoplasma gondii infection of the central nervous system. Use of the peroxidase-antiperoxidase method to demonstrate toxoplasma in formalin fixed, paraffin embedded tissue sections
-
Conley FK, Jenkins KA, Remington JS. Toxoplasma gondii infection of the central nervous system. Use of the peroxidase-antiperoxidase method to demonstrate toxoplasma in formalin fixed, paraffin embedded tissue sections. Hum Pathol 1981; 12: 690-698
-
(1981)
Hum Pathol
, vol.12
, pp. 690-698
-
-
Conley, F.K.1
Jenkins, K.A.2
Remington, J.S.3
-
28
-
-
0029959459
-
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
-
Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, Kuhn R, Muller W, Trinchieri G, Sher A. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol 1996; 157: 798-805
-
(1996)
J Immunol
, vol.157
, pp. 798-805
-
-
Gazzinelli, R.T.1
Wysocka, M.2
Hieny, S.3
Scharton-Kersten, T.4
Cheever, A.5
Kuhn, R.6
Muller, W.7
Trinchieri, G.8
Sher, A.9
-
29
-
-
0030970867
-
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii
-
Scharton-Kersten TM, Yap G, Magram J, Sher A. Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J Exp Med 1997; 185: 1261-1273
-
(1997)
J Exp Med
, vol.185
, pp. 1261-1273
-
-
Scharton-Kersten, T.M.1
Yap, G.2
Magram, J.3
Sher, A.4
-
31
-
-
0024438401
-
Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice
-
Suzuki Y, Conley FK, Remington JS. Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice. J Immunol 1989; 143: 2045-2050
-
(1989)
J Immunol
, vol.143
, pp. 2045-2050
-
-
Suzuki, Y.1
Conley, F.K.2
Remington, J.S.3
-
32
-
-
0023895411
-
Interferon-gamma: The major mediator of resistance against Toxoplasma gondii
-
Suzuki Y, Orellana MA, Schreiber RD, Remington JS. Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science 1988; 240: 516-518
-
(1988)
Science
, vol.240
, pp. 516-518
-
-
Suzuki, Y.1
Orellana, M.A.2
Schreiber, R.D.3
Remington, J.S.4
-
33
-
-
0028036859
-
Enhancement of intracellular replication of Toxoplasma gondii by IL-6. Interactions with IFN-gamma and TNF-alpha
-
Beaman MH, Hunter CA, Remington JS. Enhancement of intracellular replication of Toxoplasma gondii by IL-6. Interactions with IFN-gamma and TNF-alpha. J Immunol 1994; 153: 4583-4587
-
(1994)
J Immunol
, vol.153
, pp. 4583-4587
-
-
Beaman, M.H.1
Hunter, C.A.2
Remington, J.S.3
-
34
-
-
0030914438
-
Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice
-
Suzuki Y, Rard S, Liesenfeld O, Kojima T, Lim S, Nguyen TA, Dalrymple SA, Murray R, Remington JS. Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice. Infect Immun 1997; 65: 2339-2345
-
(1997)
Infect Immun
, vol.65
, pp. 2339-2345
-
-
Suzuki, Y.1
Rard, S.2
Liesenfeld, O.3
Kojima, T.4
Lim, S.5
Nguyen, T.A.6
Dalrymple, S.A.7
Murray, R.8
Remington, J.S.9
-
35
-
-
0027476561
-
Mucosal and systemic cellular immune responses induced by Toxoplasma gondii antigens in cyst orally infected mice
-
Chardes T, Velge-Roussel F, Mevelec P, Mevelec MN, Buzoni-Gatel D, Bout D. Mucosal and systemic cellular immune responses induced by Toxoplasma gondii antigens in cyst orally infected mice. Immunology 1993; 78: 421-429
-
(1993)
Immunology
, vol.78
, pp. 421-429
-
-
Chardes, T.1
Velge-Roussel, F.2
Mevelec, P.3
Mevelec, M.N.4
Buzoni-Gatel, D.5
Bout, D.6
-
36
-
-
34347271355
-
Exacerbation of murine ileitis by toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli
-
Heimesaat MM, Fischer A, Jahn HK, Niebergall J, Freudenberg M, Blaut M, Liesenfeld O, Schumann RR, Göbel UB, Bereswill S. Exacerbation of murine ileitis by toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli. Gut 2007; 56: 941-948
-
(2007)
Gut
, vol.56
, pp. 941-948
-
-
Heimesaat, M.M.1
Fischer, A.2
Jahn, H.K.3
Niebergall, J.4
Freudenberg, M.5
Blaut, M.6
Liesenfeld, O.7
Schumann, R.R.8
Göbel, U.B.9
Bereswill, S.10
-
37
-
-
0033571386
-
CD2 sets quantitative thresholds in T cell activation
-
Bachmann MF, Barner M, Kopf M. CD2 sets quantitative thresholds in T cell activation. J Exp Med 1999; 190: 1383-1392
-
(1999)
J Exp Med
, vol.190
, pp. 1383-1392
-
-
Bachmann, M.F.1
Barner, M.2
Kopf, M.3
-
38
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in crohn disease and experimental colitis in vivo
-
Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, Wirtz S, Schutz M, Bartsch B, Holtmann M, Becker C, Strand D, Czaja J, Schlaak JF, Lehr HA, Autschbach F, Schurmann G, Nishimoto N, Yoshizaki K, Ito H, Kishimoto T, Galle PR, Rose-John S, Neurath MF. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med 2000; 6: 583-588
-
(2000)
Nat Med
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Mullberg, J.4
Jostock, T.5
Wirtz, S.6
Schutz, M.7
Bartsch, B.8
Holtmann, M.9
Becker, C.10
Strand, D.11
Czaja, J.12
Schlaak, J.F.13
Lehr, H.A.14
Autschbach, F.15
Schurmann, G.16
Nishimoto, N.17
Yoshizaki, K.18
Ito, H.19
Kishimoto, T.20
Galle, P.R.21
Rose-John, S.22
Neurath, M.F.23
more..
-
39
-
-
0034193039
-
IL-6 is required for the development of Th1 cell-mediated murine colitis
-
Yamamoto M, Yoshizaki K, Kishimoto T, Ito H. IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol 2000; 164: 4878-4882
-
(2000)
J Immunol
, vol.164
, pp. 4878-4882
-
-
Yamamoto, M.1
Yoshizaki, K.2
Kishimoto, T.3
Ito, H.4
-
40
-
-
11144358366
-
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
-
discussion 947
-
Ito H, Takazoe M, Fukuda Y, Hibi T, Kusugami K, Andoh A, Matsumoto T, Yamamura T, Azuma J, Nishimoto N, Yoshizaki K, Shimoyama T, Kishimoto T. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 2004; 126: 989-996; discussion 947
-
(2004)
Gastroenterology
, vol.126
, pp. 989-996
-
-
Ito, H.1
Takazoe, M.2
Fukuda, Y.3
Hibi, T.4
Kusugami, K.5
Andoh, A.6
Matsumoto, T.7
Yamamura, T.8
Azuma, J.9
Nishimoto, N.10
Yoshizaki, K.11
Shimoyama, T.12
Kishimoto, T.13
-
41
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B, Kleinschek MA, Owyang A, Mattson J, Blumenschein W, Murphy E, Sathe M, Cua DJ, Kastelein RA, Rennick D. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 2006; 116: 1310-1316
-
(2006)
J Clin Invest
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
Cheung, J.2
Scheerens, H.3
Poulet, F.4
McClanahan, T.5
McKenzie, B.6
Kleinschek, M.A.7
Owyang, A.8
Mattson, J.9
Blumenschein, W.10
Murphy, E.11
Sathe, M.12
Cua, D.J.13
Kastelein, R.A.14
Rennick, D.15
-
42
-
-
27544490377
-
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6: 1123-1132
-
(2005)
Nat Immunol
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
Hatton, R.D.2
Mangan, P.R.3
Turner, H.4
Murphy, T.L.5
Murphy, K.M.6
Weaver, C.T.7
-
43
-
-
33744984785
-
Th17: An effector CD4 T cell lineage with regulatory T cell ties
-
Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006; 24: 677-688
-
(2006)
Immunity
, vol.24
, pp. 677-688
-
-
Weaver, C.T.1
Harrington, L.E.2
Mangan, P.R.3
Gavrieli, M.4
Murphy, K.M.5
-
44
-
-
33846456970
-
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
-
Hirota K, Hashimoto M, Yoshitomi H, Tanaka S, Nomura T, Yamaguchi T, Iwakura Y, Sakaguchi N, Sakaguchi S. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med 2007; 204: 41-47
-
(2007)
J Exp Med
, vol.204
, pp. 41-47
-
-
Hirota, K.1
Hashimoto, M.2
Yoshitomi, H.3
Tanaka, S.4
Nomura, T.5
Yamaguchi, T.6
Iwakura, Y.7
Sakaguchi, N.8
Sakaguchi, S.9
-
45
-
-
0038054271
-
Evidence for the critical role of interleukin-12 but not interferon-gamma in the pathogenesis of experimental colitis in mice
-
Tozawa K, Hanai H, Sugimoto K, Baba S, Sugimura H, Aoshi T, Uchijima M, Nagata T, Koide Y. Evidence for the critical role of interleukin-12 but not interferon-gamma in the pathogenesis of experimental colitis in mice. J Gastroenterol Hepatol 2003; 18: 578-587
-
(2003)
J Gastroenterol Hepatol
, vol.18
, pp. 578-587
-
-
Tozawa, K.1
Hanai, H.2
Sugimoto, K.3
Baba, S.4
Sugimura, H.5
Aoshi, T.6
Uchijima, M.7
Nagata, T.8
Koide, Y.9
-
46
-
-
0034033440
-
Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient mice
-
Camoglio L, te Velde AA, de Boer A, ten Kate FJ, Kopf M, van Deventer SJ. Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient mice. Eur J Immunol 2000; 30: 1486-1495
-
(2000)
Eur J Immunol
, vol.30
, pp. 1486-1495
-
-
Camoglio, L.1
te Velde, A.A.2
de Boer, A.3
ten Kate, F.J.4
Kopf, M.5
van Deventer, S.J.6
-
47
-
-
0032530697
-
IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice
-
Davidson NJ, Hudak SA, Lesley RE, Menon S, Leach MW, Rennick DM. IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. Immunol 1998; 161: 3143-3149
-
(1998)
Immunol
, vol.161
, pp. 3143-3149
-
-
Davidson, N.J.1
Hudak, S.A.2
Lesley, R.E.3
Menon, S.4
Leach, M.W.5
Rennick, D.M.6
-
48
-
-
0028519015
-
Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
-
Powrie F, Leach MW, Mauze S, Menon S, Caddle LB, Coffman RL. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994; 1: 553-562
-
(1994)
Immunity
, vol.1
, pp. 553-562
-
-
Powrie, F.1
Leach, M.W.2
Mauze, S.3
Menon, S.4
Caddle, L.B.5
Coffman, R.L.6
-
49
-
-
0036467452
-
CD2 facilitates differentiation of CD4 Th cells without affecting Th1/Th2 polarization
-
Sasada T, Yang H, Reinherz EL. CD2 facilitates differentiation of CD4 Th cells without affecting Th1/Th2 polarization. J Immunol 2002; 168: 1113-1122
-
(2002)
J Immunol
, vol.168
, pp. 1113-1122
-
-
Sasada, T.1
Yang, H.2
Reinherz, E.L.3
-
50
-
-
0037154745
-
Immunology. The immunological synapse--a multitasking system
-
van Der Merwe PA, Davis SJ. Immunology. The immunological synapse--a multitasking system. Science 2002; 295: 1479-1480
-
(2002)
Science
, vol.295
, pp. 1479-1480
-
-
van Der Merwe, P.A.1
Davis, S.J.2
-
51
-
-
0035846326
-
Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
-
Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, Schwieterman WD, Siegel JN, Braun MM. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 2001; 345: 1098-1104
-
(2001)
N Engl J Med
, vol.345
, pp. 1098-1104
-
-
Keane, J.1
Gershon, S.2
Wise, R.P.3
Mirabile-Levens, E.4
Kasznica, J.5
Schwieterman, W.D.6
Siegel, J.N.7
Braun, M.M.8
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