TNF-α, nitric oxide and IFN-γ are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii

Parasite Immunology

Volumn 21, Issue 7, 1999, Pages 365-376

  Liesenfeld, Oliver ^a,b   Kang, Hoil ^a,b   Park, Daniel ^a   Nguyen, Thu A ^a   Parkhe, Chandan V ^a   Watanabe, Hisami ^c   Abo, Toru ^c   Sher, Alan ^d   Remington, Jack S ^a,b   Suzuki, Yasuhiro ^a,b  

^a PALO ALTO MEDICAL FOUNDATION   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NIIGATA UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Genetic susceptibility; Interferon ; Intestine; Necrosis; Nitric oxide; Toxoplasma gondii; Tumour necrosis factor

Indexed keywords

AMINOGUANIDINE; CD4 ANTIGEN; GAMMA INTERFERON; MONOCLONAL ANTIBODY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; INTESTINE NECROSIS; INTRAPERITONEAL DRUG ADMINISTRATION; LAMINA PROPRIA; MONONUCLEAR CELL; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ADMINISTRATION, ORAL; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; GENETIC PREDISPOSITION TO DISEASE; ILEUM; INTERFERON TYPE II; INTESTINAL DISEASES, PARASITIC; MICE; MICE, INBRED C57BL; NECROSIS; NITRIC OXIDE; POLYMERASE CHAIN REACTION; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; PROTOZOA; TOXOPLASMA GONDII;

EID: 0033030226     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1999.00237.x     Document Type: Article

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