Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 parasite control

European Journal of Immunology

Volumn 34, Issue 11, 2004, Pages 3197-3207

  Vossenkämper, Anna ^a   Struck, Daniela ^a   Alvarado Esquivel, Cosme ^a,f   Went, Tobias ^a   Takeda, Kioyshi ^b   Akira, Shizuo ^b   Pfeffer, Klaus ^c   Alber, Gottfried ^d   Lochner, Matthias ^e   Förster, Irmgard ^e   Liesenfeld, Oliver ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b OSAKA UNIVERSITY   (Japan)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f Laboratorio de Investigación Biomédica   (Mexico)

Author keywords

Cytokines; Inflammation; Mucosa; Parasitic infections (protozoan); T cells

Indexed keywords

CYTOKINE ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 12 ANTIBODY; INTERLEUKIN 18; INTERLEUKIN 2; NEUTRALIZING ANTIBODY; PROTEIN P35; PROTEIN P40;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIVISION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEATH; FEMALE; HEPATITIS; HOST RESISTANCE; IMMUNOPATHOLOGY; INTESTINE NECROSIS; MOUSE; MOUTH INFECTION; NONHUMAN; PARASITE CONTROL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SMALL INTESTINE DISEASE; TH1 CELL; TOXOPLASMA GONDII; TOXOPLASMOSIS; WILD TYPE;

ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN; FEMALE; HISTOCYTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P35; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-18; INTESTINE, SMALL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; PROTEIN SUBUNITS; SPECIFIC PATHOGEN-FREE ORGANISMS; SPLEEN; TOXOPLASMA; TOXOPLASMOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 9244250314     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200424993     Document Type: Article

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