Involvement of glycogen synthase kinase-3β in palmitate-induced human umbilical vein endothelial cell apoptosis

Journal of Vascular Research

Volumn 44, Issue 5, 2007, Pages 365-374

  Choi, Sung E ^a   Kang, Yup ^a   Jang, Hyun Ju ^a   Shin, Ha Chul ^a   Kim, Hyo Eun ^a   Kim, Hyo Soo ^b   Kim, Hae Jin ^a   Kim, Dae Jung ^a   Lee, Kwan Woo ^a  

^a Ajou University School of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

Apoptosis; GSK 3 ; HUVEC; Palmitate

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; FUMONISIN B1; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; PALMITIC ACID; SB 20358; SERINE; UNCLASSIFIED DRUG;

ADENOVIRUS; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; UMBILICAL VEIN; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANTHRACENES; APOPTOSIS; CASPASE 3; CELL CYCLE; CELLS, CULTURED; CYTOSOL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; FUMONISINS; GENETIC VECTORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMIDAZOLES; INDOLES; LITHIUM CHLORIDE; MALEIMIDES; MITOCHONDRIA; PALMITATES; PHOSPHORYLATION; PHOSPHOSERINE; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRIDINES; THIADIAZOLES; TRANSDUCTION, GENETIC; UMBILICAL VEINS;

EID: 34548160003     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000102321     Document Type: Article

References (48)

1. Winn RK, Harlan JM: The role of endothelial cell apoptosis in inflammatory and immune diseases. J Thromb Haemost 2005;3:1815-1824.
2. Stoneman VE, Bennett MR: Role of apoptosis in atherosclerosis and its therapeutic implications. Clin Sci (Lond) 2004;107:343-354.
3. Du XL, Sui GZ, Stockklauser-Farber K, Weiss J, Zink S, Schwippert B, Wu QX, Tschope D, Rosen P: Introduction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species. Diabetologia 1998;41:249-256.
4. Lizard G, Monier S, Cordelet C, Gesquiere L, Deckert V, Gueldry S, Lagrost L, Gambert P: Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7β -hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. Arterioscler Thromb Vasc Biol 1999;19:1190-1200.
5. Schmidt-Ott KM, Kagiyama S, Phillips MI: The multiple actions of angiotensin II in atherosclerosis. Regul Pept 2000;93:65-77.
6. Karsan A, Yee E, Harlan JM: Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1. J Biol Chem 1996;271:27201-27204.
7. Toborek M, Blanc EM, Kaiser S, Mattson MP, Hennig B: Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis, and apoptosis of cultured vascular endothelial cells. J Lipid Res 1997;38:2155-2167.
8. Yamagishi S, Okamoto T, Amano S, Inagaki Y, Koga K, Koga M, Choei H, Sasaki N, Kikuchi S, Takeuchi M, Makita Z: Palmitate-induced apoptosis of microvascular endothelial cells and pericytes. Mol Med 2002;8:179-184.
9. Artwohl M, Roden M, Waldhausl W, Freudenthaler A, Baumgartner-Parzer SM: Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells. FASEB J 2004;18:146-148.
10. Dersch K, Ichijo H, Bhakdi S, Husmann M: Fatty acids liberated from low-density lipoprotein trigger endothelial apoptosis via mitogen-activated protein kinases. Cell Death Differ 2005;12:1107-1114.
11. Hufnagel B, Dworak M, Soufi M, Mester Z, Zhu Y, Schaefer JR, Klumpp S, Krieglstein J: Unsaturated fatty acids isolated from human lipoproteins activate protein phosphatase type 2C beta and induce apoptosis in endothelial cells. Atherosclerosis 2005;180:245-254.
12. Staiger K, Staiger H, Weigert C, Haas C, Haring H-U: Saturated, but not unsaturated, fatty acids induced apoptosis of human coronary artery endothelial cells via nuclear factor- κB activation. Diabetes 2006;55:3121-3126.
13. Reaven GM, Hollenbeck C, Jeng CY, Wu MS, Chen YD: Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 1988;37:1020-1024.
14. Stins MF, Maxfield FR, Goldberg IJ: Polarized binding of lipoprotein lipase to endothelial cells. Implications for its physiological actions. Arterioscler Thromb 1992;12:1437-1446.
15. Doble BW, Woodgett JR: GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 2003;116:1175-1186.
16. Patel S, Doble B, Woodgett JR: Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword? Nat Rev Mol Cell Biol 2001;2:769-776.
17. Cohen P, Frame S: The renaissance of GSK3. Biochem Soc Trans 2004;32:803-808.
18. Watcharasit P, Bijur GN, Song L, Zhu J, Chen X, Jope RS: Glycogen synthase kinase-3β (GSK3β) binds to and promotes the actions of p53. J Biol Chem 2003;278:48872-48879.
19. Pap M, Cooper GM: Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3β signaling pathway. Mol Cell Biol 2002;22:578-586.
20. Hongisto V, Smeds N, Brecht S, Herdegen T, Courtney MJ, Coffey ET: Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3. Mol Cell Biol 2003;23:6027-6036.
21. Grimes CA, Jope RS: The multifaceted roles of glycogen synthase kinase 3β in cellular signaling. Prog Neurobiol 2001;65:391-426.
22. Chen S, Guttridge DC, You Z, Zhang Z, Fribley A, Mayo MW, Kitajewski J, Wang CY: Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol 2001;152:87-96.
23. Kim AJ, Shi Y, Austin RC, Werstuck GH: Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3. J Cell Sci 2005;118:89-99.
24. Linseman DA, Butts BD, Precht TA, Phelps RA, Le SS, Laessig TA, Bouchard RJ, Florez-McClure ML, Heidenreich KA: Glycogen synthase kinase-3β phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J Neurosci 2004;24:9993-10002.
25. Kim HS, Skurk C, Thomas SR, Bialik A, Suhara T, Kureishi Y, Birnbaum M, Keaney JF Jr, Walsh K: Regulation of angiogenesis by glycogen synthase kinase-3β. J Biol Chem 2002;277:41888-41896.
26. Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patane G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P: Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 2002;51:1437-1442.
27. Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr, Ory DS, Schaffer JE: Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci USA 2003;100:3077-3082.
28. de Vries JE, Vork MM, Roemen TH, de Jong YF, Cleutjens JP, van der Vusse GJ, van Bilsen M: Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes. J Lipid Res 1997;38:1384-1394.
29. Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, Ido Y: Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes 2005;54:1838-1845.
30. Hardy S, El-Assaad W, Przybytkowski E, Joly E, Prentki M, Langelier Y: Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin. J Biol Chem 2003;278:31861-31870.
31. Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY: Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 2003;52:726-733.
32. Kim HJ, Vosseler CA, Weber PC, Erl W: Docosahexaenoic acid induces apoptosis in proliferating human endothelial cells. J Cell Physiol 2005;204:881-888.
33. Mittendorfer B, Liem O, Patterson B, Miles J, Klein S: What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? Diabetes 2003;52:1641-1648.
34. Bajaj M, Suraamornkul S, Romanelli A, Cline G, Mandarino L, Shulman G, DeFronzo R: Effect of a saturated reduction in plasma free fatty acid concentration on intramuscular long-chain fatty acyl-CoA and insulin action in type 2 diabetic patients. Diabetes 2005;54:3148-3153.
35. Aoki M, Nata T, Morishita R, Matsushita H, Nakagami H, Yamamoto K, Yamazaki K, Nakabayashi M, Ogihara T, Kaneda Y: Endothelial apoptosis induced by oxidative stress through activation of NF-κB: antiapoptotic effect of antioxidant agents on endothelial cells. Hypertension 2001;38:48-55.
36. Warren MC, Bump EA, Medeiros D, Braunhut SJ: Oxidative stress-induced apoptosis of endothelial cells. Free Radic Biol Med 2000;29:537-547.
37. Shimabukuro M, Zhou YT, Levi M, Unger RH: Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 1998;95:2498-2502.
38. Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, Brendel MD, Bretzel RG, Haring HU, Kellerer M: Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Diabetes 2003;52:991-997.
39. Shimabukuro M, Wang MY, Zhou YT, Newgard CB, Unger RH: Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. Proc Natl Acad Sci USA 1998;95:9558-9561.
40. Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ: Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 2002;277:49676-49684.
41. Cousin SP, Hugl SR, Wrede CE, Kajio H, Myers MG Jr, Rhodes CJ: Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1. Endocrinology 2001;142:229-240.
42. Summers SA, Garza LA, Zhou H, Birnbaum MJ: Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol Cell Biol 1998;18:5457-5464.
43. Stratford S, DeWald DB, Summers SA: Ceramide dissociates 3′-phosphoinositide production from pleckstrin homology domain translocation. Biochem J 2001;354:359-368.
44. Cazzolli R, Carpenter L, Biden TJ, Schmitz-Peiffer C: A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. Diabetes 2001;50:2210-2218.
45. Zick Y: Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol 2001;11:437-441.
46. Shin SY, Chin BR, Lee YH, Kim JH: Involvement of glycogen synthase kinase-3β in hydrogen peroxide-induced suppression of Tcf/Lef-dependent transcriptional activity. Cell Signal 2006;18:601-607.
47. Brazil DP, Yang ZZ, Hemmings BA: Advances in protein kinase B signalling: AKT is on multiple fronts. Trends Biochem Sci 2004;29:233-242.
48. Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A: Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 2006;147:3398-3407.