Induction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species

Diabetologia

Volumn 41, Issue 3, 1998, Pages 249-256

  Du, X L ^b,c   Sui, G Z ^a   Stockklauser Farber K ^c   Weiss J ^c   Zink, S ^c   Schwippert, B ^c   Wu, Q X ^b   Tschope D ^c   Rosen P ^c,d  

^a QINGDAO UNIVERSITY   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

Apoptosis; Endothelial cells; Proinsulin; Umbilical vein

Indexed keywords

PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; 3' O METHYLGUANOSINE; 3'-O-METHYLGUANOSINE; DNA FRAGMENT; DRUG DERIVATIVE; GLUCOSE; GUANOSINE; PROINSULIN; SUPEROXIDE DISMUTASE;

APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; HYPERGLYCEMIA; PATHOGENESIS; PRIORITY JOURNAL; UMBILICAL VEIN; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

APOPTOSIS; CELLS, CULTURED; DNA FRAGMENTATION; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GLUCOSE; GUANOSINE; HUMANS; PROINSULIN; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; UMBILICAL VEINS;

EID: 0031594539     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050900     Document Type: Article

References (36)

1. Lorenzi M, Cagliero E (1991) Pathobiology of endothelial and other vascular cells in diabetes mellitus. Diabetes 40: 653-659
2. Cohen RA (1993) Dysfunction of vascular endothelium in diabetes mellitus. Circulation 87 [Suppl 5]: 67-76
3. Rösen P, Ballhausen Th, Bloch W, Addicks K (1995) Endothelial relaxation is disturbed in the diabetic rat by oxidative stress: the influence of tocopherol as antioxidant. Diabetologia, 38: 1157-1168
4. Nordt TK, Schneider DJ, Sobel BE (1994) Augmentation of the synthesis of plasminogen activator inhibitor type-1 by a precursor of insulin. Circulation 89: 321-330
5. Rodriguez-Villar C, Conget I, Casamitjama R, Vidal J, Manzanares JM, Gomis R (1997) High proinsulin levels in late pre-IDDM stage. Diabetes Res Clin Pract 37: 145-148
6. Haffner SM, Stern MP, Mittinen H (1995) High proinsulin and specific insulin are both associated with a parental history of diabetes in non-diabetic Mexican-American subjects. Diabetes 44: 1156-1160
7. Sanke T, Nanjo K (1994) Review for clinical molecular genetics of mutant insulin. Nippon Rinsho 52: 2550-2555
8. Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257
9. Baumgartner-Parzer SM, Wagner L, Pettermann M, Grillari J, Gessl A, Waldhäusl (1995) High-glucose-triggered apoptosis in cultured endothelial cells. Diabetes 44: 1323-1327
10. Munn DH, Beall AC, Song D, Wrenn RW, Throckmorton DC (1995) Activation-induced apoptosis in human macrophages: developmental regulation of a novel cell-death pathway by macrophage-colony-stimulating factor and interferon-gamma. J Exp Med 181: 127-136
11. Hannun YA, Obeid LM (1995) Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci 20: 73-77
12. Messmer UK, Lapetina EG, Brune B (1995) Nitric oxide-induced apoptosis in RAW-254.7 macrophages is antagonised by protein-kinase-A-activating compounds. Mol Pharm 47: 757-765
13. Jacobson MD, Burne JF, King MP, Miyashita T, Reed JC, Raff MC (1993) Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 361: 365-369
14. Jarvis WD, Turner AJ, Povirk LF, Traylor RS, Grant S (1994) Induction of apototic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res 54: 1707-1714
15. Zhu WH, Loh TT (1996) Differential effects of phorbol ester on apoptosis in HL-60 promyelocytic leukemia cells. Biochem Pharmacol 51: 1229-1236
16. Powis G, Gasdaska JR, Baker A (1997) Redox signaling and the control of cell growth and death. In: Sies H (ed) Antioxidants in disease: mechanisms and therapy. Academic Press, New York, pp 329-359
17. Hunt JV, Smith CT, Wolff SP (1990) Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes 39:1420-1424
18. Lyons TJ (1991) Oxidised low density lipoproteins: a role in the pathogenesis of atherosclerosis in diabetes? Diabet Med 8: 411-419
19. Jaffe FA, Hoyer LW, Nachman RL (1973) Synthesis of antihemophilic factor antigen by cultures human endothelial cells. J Clin Invest 52: 2757-2764
20. Fabio RC (1994) Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J Cell Biol 127:537-546
21. Martin SJ, Green DR, Cotter TG (1994) Dicing with death: dissecting the components of the apoptosis mechanisms. TIBS 19: 26-30
22. Philgreen M, Thomas J, Marvel J (1996) Comparison of two cell death detection methods: in situ nick translation and TUNEL. Boehringer Information 99: 13-14
23. Polunovsky VA, Wendt CH, Ingbar DH, Peterson MS, Bittermann PB (1994) Induction of apoptosis by TNFα: modulation by inhibitors of protein synthesis. Exp Cell Res 214: 584-594
24. Lorenzi M, Cagliero E, Toledo S (1985) Glucose toxicity for human endothelial cells in culture. Delayed replication, disturbed cell cycle and accelerated death. Diabetes 34: 621-627
25. Lorenzi M, Montisano DF, Toledo S, Barrieux A (1986) High glucose induces DNA damage in cultured human endothelial cells. J Clin Invest 77: 322-325
26. Lorenzi M, Nordberg JA, Toledo S (1987) High glucose prolongs cell-cycle traversal of cultured human endothelial cells. Diabetes 36: 1261-1267
27. Inoguchi T, Xia P, Kunisaki M, Higashi S, King GL (1994) Preferential elevation of protein kinase C isoform II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility of glycaemic control by islet cell transplantation. Proc Natl Acad Sci (USA) 89: 11059-11063
28. Lee TS, MacGregor LC, Fluharty SJ, King GL (1989) Differential regulation of protein kinase C and (Na, K)-adenosine triphosphate activities by elevated glucose levels in retinal capillary endothelial cells. J Clin Invest 83: 90-94
29. 2+/EDRF signaling are due to generation of superoxide anions. Diabetes 45: 1386-1395
30. Giardino I, Edelstein D, Brownlee M (1996) Bcl-2 expression or antioxidants prevent the hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells. J Clin Invest 97: 1422-1428
31. Yan SD, Schmidt AM, Anderson GM et al. (1994) Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem 269: 9889-9897
32. Tesfamariam B (1994) Free radicals in diabetic endothelial cell dysfunction. Free Radic Biol Med 16: 383-391
33. Sellins KS, Cohen JJ (1987) Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. J Immunol 139:3199-3206
34. Wyllie AH (1980) Glucocorticoid-induced thymocytes apoptosis is associated with endogenous endonuclease activation. Nature 284: 555-556
35. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J 12: 2005-2015
36. Higgins KA, Perez JR, Coleman TA et al. (1993) Antisense inhibition of the p65 subunit of NF-κB blocks tumorgenicity and causes tumor regression. Proc Natl Acad Sci USA 90: 9901-9905