Peripheral inflammatory hyperalgesia modulates morphine delivery to the brain: A role for P-glycoprotein

Journal of Neurochemistry

Volumn 102, Issue 5, 2007, Pages 1677-1690

  Seelbach, Melissa J ^a   Brooks, Tracy A ^a   Egleton, Richard D ^a   Davis, Thomas P ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

carrageenan; Blood brain barrier; Efflux; Hyperalgesia; Morphine; Pgp

Indexed keywords

CARRAGEENAN; CYCLOSPORIN A; GLYCOPROTEIN P; MORPHINE; MORPHINE SULFATE; OPIATE; TRITIUM;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN BLOOD VESSEL; BRAIN PERFUSION; CONTROLLED STUDY; DRUG UPTAKE; ENDOTHELIUM; FEMALE; HYPERALGESIA; IN VIVO STUDY; INFLAMMATION; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; REGULATORY MECHANISM; SINGLE DRUG DOSE; WESTERN BLOTTING;

ANIMALS; BEHAVIOR, ANIMAL; BIOLOGICAL TRANSPORT; BRAIN; CARRAGEENAN; CYCLOSPORINE; ENDOTHELIUM; ENZYME INHIBITORS; FEMALE; FUNCTIONAL LATERALITY; HYPERALGESIA; MICROCIRCULATION; MORPHINE; NARCOTICS; NEUTROPHIL INFILTRATION; P-GLYCOPROTEIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

ANIMALIA;

EID: 34547902120     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04644.x     Document Type: Article

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