Comparison of blood-brain barrier permeability in mice and rats using in situ brain perfusion technique

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 279, Issue 3 48-3, 2000, Pages

  Murakami, Hideyasu ^a   Takanaga, Hitomi ^a   Matsuo, Hirotami ^a   Ohtani, Hisakazu ^a   Sawada, Yasufumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Carotid perfusion pressure; Cerebral perfusion fluid flow; Contribution of systemic blood to total flow; Permeability coefficient surface area product; Vascular volume

Indexed keywords

ACID; AMINO ACID; BASE; DRUG; SUGAR ACID;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CAPILLARY PERMEABILITY; CAROTID ARTERY; DRUG TRANSPORT; FLOW; MALE; MEASUREMENT; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; RAT; SYSTEMIC CIRCULATION; TECHNIQUE; TRANSPORT KINETICS;

EID: 0033827023     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.279.3.h1022     Document Type: Article

References (30)

1. Blood-endothelial cell and blood-brain barrier transport of L-proline, α-aminoisobutyric acid, and L-alanine
2. Restrictive transport of a lipid-soluble peptide (cyclosporin) through the blood-brain barrier
3. In vivo glycerol metabolism in the pregnant rat
4. The blood-brain barrier, a dynamic regulatory interface
5. Comparison of lipid-mediated blood-brain-barrier penetrability in neonates and adults
6. Role of P-glycoprotein in the blood-brain transport of colchicine and vinblastine
7. Studies with alkylating esters-IV: The metabolism of propane-1,3-dimethanesulphonate and its relevance to the mode of action of myleran
8. Drug transfer across the blood-brain barrier
9. 14C-glycerol in the intact rat
10. Opening of the blood-brain barrier by acute elevation of intracarotid pressure
11. Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier
12. P-glycoprotein mediates the efflux of quinidine across the blood-brain barrier
13. Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
14. Contribution of P-glycoprotein to bunitrolol efflux across blood-brain barrier
15. P-glycoprotein-mediated transport of itraconazole across the blood-brain barrier
16. 3H-nicotine
17. Brain uptake of radiolabeled amino acid, amine, hexoses after arterial injection
18. Transport of metabolic substrates through the blood-brain barrier
19. Downregulation of blood-brain barrier glucose transporter in experimental diabetes
20. Quantitative aspects of reversible osmotic opening of the blood-brain barrier
21. Drug entry into the brain
22. In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier
23. Kinetic analysis of cerebrovascular transport based on indicator diffusion technique
24. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
25. Absence of the mdr 1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
26. Efflux transport of tolbutamide across the blood-brain barrier
27. An in situ brain perfusion technique to study cerebrovascular transport in the rat
28. Functional involvement of P-glycoprotein in blood-brain barrier
29. A pharmacokinetic analysis program (MULTI) for microcomputer