How do we manage chronic pain?

Best Practice and Research: Clinical Rheumatology

Volumn 14, Issue 4, 2000, Pages 797-811

  Schaible, Hans Georg ^a   Vanegas, Horacio ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

Inflammation; Neuropeptides; Neurotransmitters

Indexed keywords

ADENOSINE RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BRADYKININ ANTAGONIST; CALCITONIN GENE RELATED PEPTIDE DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CANNABINOID; CAPSAICIN; CLONIDINE; CYCLOOXYGENASE 2 INHIBITOR; KETAMINE; LOCAL ANESTHETIC AGENT; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROKININ 1 RECEPTOR ANTAGONIST; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; SODIUM CHANNEL BLOCKING AGENT;

ANALGESIC ACTIVITY; CENTRAL NERVOUS SYSTEM FUNCTION; CHRONIC INFLAMMATION; CHRONIC PAIN; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; HUMAN; INJURY; NEUROANATOMY; NEUROPHARMACOLOGY; NEUROPHYSIOLOGY; NOCICEPTION; PERIPHERAL NERVOUS SYSTEM FUNCTION; PHYSIOTHERAPY; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; PSYCHOSOCIAL CARE; REVIEW; RHEUMATOID ARTHRITIS; SENSITIZATION; SOCIAL ASPECT;

EID: 0034532381     PISSN: 15216942     EISSN: None     Source Type: Journal    
DOI: 10.1053/berh.2000.0114     Document Type: Article

References (38)

1. One pair or many pains? A new look at pain mechanisms
2. The neurophysiology of pain
3. Multiple representations of pain in human cerebral cortex
4. The cortical representation of pain
5. Neurotransmitters in nociceptive modulatory circuits
6. Afferent and spinal mechanisms of joint pain
7. Nociception from skeletal muscle in relation to clinical muscle pain
8. Sensory afferent processing in multi-responsive DRG neurons
9. Signal transduction in nociceptive afferent neurons in inflammatory conditions
10. Evidence for a central component of post-injury pain hypersensitivity
11. Central hyperexcitability triggered by noxious inputs
12. Effects of antagonists to high-threshold calcium channels upon spinal mechanisms of pain, hyperalgesia and allodynia
13. N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint
14. Modulation of spinal excitability: Cooperation between neurokinin and excitatory amino acid transmitters
15. On the role of tachykinins and calcitonin gene-related peptide in the spinal mechanisms of nociception and in the induction and maintenance of inflammation-evoked hyperexcitability in spinal cord neurons (with special reference to nociception in joints)
16. Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation
17. Prostanoids synthesised by cyclooxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability
18. The role of demographic and psychosocial factors in transition from acute to chronic pain
19. Prevention of chronicity
20. Cyclooxygenases 1 and 2
21. Dissociation between the antinociceptive and anti-inflammatory effects of nonsteroidal anti-inflammatory drugs. A survey of their analgesic efficacy
22. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
23. Spinal actions of non-steroidal anti-inflammatory drugs: Evidence for a central role of prostanoids in nociceptive processing
24. Interactions of sympathetic and primary afferent neurons following nerve injury and tissue trauma
25. Ions in the fire: Recent ion-channel research and approaches to pain therapy
26. Bradykinin and inflammatory pain
27. Peripheral morphine analgesia
28. The capsaicin receptor: A heat-activated ion channel in the pain pathway
29. Where and how do opioids act?
30. Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-induced secondary hyperalgesia in man: A double-blind, cross-over comparison with morphine and placebo
31. Spinal systems and pain processing: Development of novel analgesic drugs with mechanically defined models
32. Antinociception induced by systemic or PAG-microinjected lysine-acetylsalicylate in rats. Effects on tail flick-related activity of medullary off- and on-cells
33. An analgesia circuit activated by cannabinoids
34. Antidepressants in the management of chronic pain syndromes
35. The neurobiology of placebo analgesia: From endogenous opioids to cholecystokinin