-
1
-
-
0242656497
-
Death receptor-induced cell killing
-
Thorburn A (2004) Death receptor-induced cell killing. Cell Signal 16:139-144
-
(2004)
Cell Signal
, vol.16
, pp. 139-144
-
-
Thorburn, A.1
-
2
-
-
3342894130
-
Targeting death receptors in cancer with Apo2L/TRAIL
-
Kelley SK, Ashkenazi A (2004) Targeting death receptors in cancer with Apo2L/TRAIL. Curr Opin Pharmacol 4:333-339
-
(2004)
Curr Opin Pharmacol
, vol.4
, pp. 333-339
-
-
Kelley, S.K.1
Ashkenazi, A.2
-
3
-
-
33747839115
-
The complementary roles of the extrinsic and intrinsic apoptotic pathways in promoting the death of cancer cells
-
Mayes PA, El-Deiry WS (2006) The complementary roles of the extrinsic and intrinsic apoptotic pathways in promoting the death of cancer cells. Cancer J 12:247-249
-
(2006)
Cancer J
, vol.12
, pp. 247-249
-
-
Mayes, P.A.1
El-Deiry, W.S.2
-
4
-
-
13344285339
-
Identification and characterization of a new member of the TNF family that induces apoptosis
-
Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK et al (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3:673-682
-
(1995)
Immunity
, vol.3
, pp. 673-682
-
-
Wiley, S.R.1
Schooley, K.2
Smolak, P.J.3
Din, W.S.4
Huang, C.P.5
Nicholl, J.K.6
-
5
-
-
0032929520
-
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
-
Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M et al (1999) Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 5:157-163
-
(1999)
Nat Med
, vol.5
, pp. 157-163
-
-
Walczak, H.1
Miller, R.E.2
Ariail, K.3
Gliniak, B.4
Griffith, T.S.5
Kubin, M.6
-
6
-
-
0034630161
-
The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems
-
Walczak H, Krammer PH (2000) The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems. Exp Cell Res 256:58-66
-
(2000)
Exp Cell Res
, vol.256
, pp. 58-66
-
-
Walczak, H.1
Krammer, P.H.2
-
7
-
-
1442359848
-
The interplay between the Bcl-2 family and death receptor-mediated apoptosis
-
Sprick MR, Walczak H (2004) The interplay between the Bcl-2 family and death receptor-mediated apoptosis. Biochim Biophys Acta 1644:125-132
-
(2004)
Biochim Biophys Acta
, vol.1644
, pp. 125-132
-
-
Sprick, M.R.1
Walczak, H.2
-
8
-
-
3042822069
-
FLIP protein and TRAIL-induced apoptosis
-
Roth W, Reed JC (2004) FLIP protein and TRAIL-induced apoptosis. Vitam Horm 67:189-206
-
(2004)
Vitam Horm
, vol.67
, pp. 189-206
-
-
Roth, W.1
Reed, J.C.2
-
9
-
-
17644378775
-
C-FLIPR, a new regulator of death receptor-induced apoptosis
-
Golks A, Brenner D, Fritsch C, Krammer PH, Lavrik IN (2005) c-FLIPR, a new regulator of death receptor-induced apoptosis. J Biol Chem 280:14507-14513
-
(2005)
J Biol Chem
, vol.280
, pp. 14507-14513
-
-
Golks, A.1
Brenner, D.2
Fritsch, C.3
Krammer, P.H.4
Lavrik, I.N.5
-
10
-
-
0037067678
-
Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells
-
Xiao C, Yang BF, Asadi N, Beguinot F, Hao C (2002) Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells. J Biol Chem 277:25020-25025
-
(2002)
J Biol Chem
, vol.277
, pp. 25020-25025
-
-
Xiao, C.1
Yang, B.F.2
Asadi, N.3
Beguinot, F.4
Hao, C.5
-
11
-
-
33645210857
-
Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
-
Song JH, Bellail A, Tse MC, Yong VW, Hao C (2006) Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. J Neurosci 26:3299-3308
-
(2006)
J Neurosci
, vol.26
, pp. 3299-3308
-
-
Song, J.H.1
Bellail, A.2
Tse, M.C.3
Yong, V.W.4
Hao, C.5
-
12
-
-
22244464818
-
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
-
Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI et al (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19:1294-1305
-
(2005)
Genes Dev
, vol.19
, pp. 1294-1305
-
-
Willis, S.N.1
Chen, L.2
Dewson, G.3
Wei, A.4
Naik, E.5
Fletcher, J.I.6
-
13
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG et al (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17:393-403
-
(2005)
Mol Cell
, vol.17
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
Smith, B.J.4
Fletcher, J.I.5
Hinds, M.G.6
-
14
-
-
33751513394
-
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
-
Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ et al (2006) Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol 8:1348-1358
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1348-1358
-
-
Kim, H.1
Rafiuddin-Shah, M.2
Tu, H.C.3
Jeffers, J.R.4
Zambetti, G.P.5
Hsieh, J.J.6
-
15
-
-
21644463065
-
The inhibitor of apoptosis protein family and its antagonists in acute leukemias
-
Wrzesien-Kus A, Smolewski P, Sobczak-Pluta A, Wierzbowska A, Robak T (2004) The inhibitor of apoptosis protein family and its antagonists in acute leukemias. Apoptosis 9:705-715
-
(2004)
Apoptosis
, vol.9
, pp. 705-715
-
-
Wrzesien-Kus, A.1
Smolewski, P.2
Sobczak-Pluta, A.3
Wierzbowska, A.4
Robak, T.5
-
16
-
-
33748100542
-
The clinical trail of TRAIL
-
Duiker EW, Mom CH, de Jong S, Willemse PH, Gietema JA, van der Zee AG et al (2006) The clinical trail of TRAIL. Eur J Cancer 42:2233-2240
-
(2006)
Eur J Cancer
, vol.42
, pp. 2233-2240
-
-
Duiker, E.W.1
Mom, C.H.2
De Jong, S.3
Willemse, P.H.4
Gietema, J.A.5
Van Der Zee, A.G.6
-
17
-
-
14044278635
-
Tumor therapeutics by design: Targeting and activation of death receptors
-
Wajant H, Gerspach J, Pfizenmaier K (2005) Tumor therapeutics by design: targeting and activation of death receptors. Cytokine Growth Factor Rev 16:55-76
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 55-76
-
-
Wajant, H.1
Gerspach, J.2
Pfizenmaier, K.3
-
18
-
-
3042739342
-
TRAIL and chemotherapeutic drugs in cancer therapy
-
Wu XX, Ogawa O, Kakehi Y (2004) TRAIL and chemotherapeutic drugs in cancer therapy. Vitam Horm 67:365-383
-
(2004)
Vitam Horm
, vol.67
, pp. 365-383
-
-
Wu, X.X.1
Ogawa, O.2
Kakehi, Y.3
-
19
-
-
0035437171
-
TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic applications
-
Mitsiades CS, Treon SP, Mitsiades N, Shima Y, Richardson P, Schlossman R et al (2001) TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. Blood 98:795-804
-
(2001)
Blood
, vol.98
, pp. 795-804
-
-
Mitsiades, C.S.1
Treon, S.P.2
Mitsiades, N.3
Shima, Y.4
Richardson, P.5
Schlossman, R.6
-
20
-
-
0032717188
-
TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells
-
Gazitt Y (1999) TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells. Leukemia 13:1817-1824
-
(1999)
Leukemia
, vol.13
, pp. 1817-1824
-
-
Gazitt, Y.1
-
21
-
-
0034533011
-
Expression of tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors and sensitivity to TRAIL-induced apoptosis in primary B-cell acute lymphoblastic leukaemia cells
-
Clodi K, Wimmer D, Li Y, Goodwin R, Jaeger U, Mann G et al (2000) Expression of tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors and sensitivity to TRAIL-induced apoptosis in primary B-cell acute lymphoblastic leukaemia cells. Br J Haematol 111:580-586
-
(2000)
Br J Haematol
, vol.111
, pp. 580-586
-
-
Clodi, K.1
Wimmer, D.2
Li, Y.3
Goodwin, R.4
Jaeger, U.5
Mann, G.6
-
22
-
-
0037015675
-
Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia
-
MacFarlane M, Harper N, Snowden RT, Dyer MJ, Barnett GA, Pringle JH et al (2002) Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. Oncogene 21:6809-6818
-
(2002)
Oncogene
, vol.21
, pp. 6809-6818
-
-
MacFarlane, M.1
Harper, N.2
Snowden, R.T.3
Dyer, M.J.4
Barnett, G.A.5
Pringle, J.H.6
-
23
-
-
20344396647
-
TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL
-
Riccioni R, Pasquini L, Mariani G, Saulle E, Rossini A, Diverio D et al (2005) TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL. Haematologica 90:612-624
-
(2005)
Haematologica
, vol.90
, pp. 612-624
-
-
Riccioni, R.1
Pasquini, L.2
Mariani, G.3
Saulle, E.4
Rossini, A.5
Diverio, D.6
-
24
-
-
9844225051
-
Activity of TNF-related apoptosis-inducing ligand (TRAIL) in haematological malignancies
-
Snell V, Clodi K, Zhao S, Goodwin R, Thomas EK, Morris SW et al (1997) Activity of TNF-related apoptosis-inducing ligand (TRAIL) in haematological malignancies. Br J Haematol 99:618-624
-
(1997)
Br J Haematol
, vol.99
, pp. 618-624
-
-
Snell, V.1
Clodi, K.2
Zhao, S.3
Goodwin, R.4
Thomas, E.K.5
Morris, S.W.6
-
25
-
-
26444560914
-
MTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells
-
Panner A, James CD, Berger MS, Pieper RO (2005) mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. Mol Cell Biol 25:8809-8823
-
(2005)
Mol Cell Biol
, vol.25
, pp. 8809-8823
-
-
Panner, A.1
James, C.D.2
Berger, M.S.3
Pieper, R.O.4
-
26
-
-
0035739542
-
Enhanced apoptosis of soft tissue sarcoma cells with chemotherapy: A potential new approach using TRAIL
-
Clayer M, Bouralexis S, Evdokiou A, Hay S, Atkins GJ, Findlay DM (2001) Enhanced apoptosis of soft tissue sarcoma cells with chemotherapy: a potential new approach using TRAIL. J Orthop Surg (Hong Kong) 9:19-22
-
(2001)
J Orthop Surg (Hong Kong)
, vol.9
, pp. 19-22
-
-
Clayer, M.1
Bouralexis, S.2
Evdokiou, A.3
Hay, S.4
Atkins, G.J.5
Findlay, D.M.6
-
27
-
-
9144234147
-
TRAIL and its receptors as targets for cancer therapy
-
Yagita H, Takeda K, Hayakawa Y, Smyth MJ, Okumura K (2004) TRAIL and its receptors as targets for cancer therapy. Can Sci 95:777-783
-
(2004)
Can Sci
, vol.95
, pp. 777-783
-
-
Yagita, H.1
Takeda, K.2
Hayakawa, Y.3
Smyth, M.J.4
Okumura, K.5
-
28
-
-
6344246456
-
TNF-related apoptosis-inducing ligand (TRAIL): A potential candidate for combined treatment of hematological malignancies
-
Secchiero P, Vaccarezza M, Gonelli A, Zauli G (2004) TNF-related apoptosis-inducing ligand (TRAIL): a potential candidate for combined treatment of hematological malignancies. Curr Pharm Des 10:3673-3681
-
(2004)
Curr Pharm des
, vol.10
, pp. 3673-3681
-
-
Secchiero, P.1
Vaccarezza, M.2
Gonelli, A.3
Zauli, G.4
-
30
-
-
33845221022
-
TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma
-
Trauzold A, Siegmund D, Schniewind B, Sipos B, Egberts J, Zorenkov D et al (2006) TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma. Oncogene 25:7434-7439
-
(2006)
Oncogene
, vol.25
, pp. 7434-7439
-
-
Trauzold, A.1
Siegmund, D.2
Schniewind, B.3
Sipos, B.4
Egberts, J.5
Zorenkov, D.6
-
31
-
-
0036898832
-
Expression of TRAIL and TRAIL receptors in colon carcinoma: TRAIL-R1 is an independent prognostic parameter
-
Strater J, Hinz U, Walczak H, Mechtersheimer G, Koretz K, Herfarth C et al (2002) Expression of TRAIL and TRAIL receptors in colon carcinoma: TRAIL-R1 is an independent prognostic parameter. Clin Cancer Res 8:3734-3740
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3734-3740
-
-
Strater, J.1
Hinz, U.2
Walczak, H.3
Mechtersheimer, G.4
Koretz, K.5
Herfarth, C.6
-
32
-
-
0012937468
-
High level of cFLIP correlates with resistance to death receptor-induced apoptosis in bladder carcinoma cells
-
Jonsson G, Paulie S, Grandien A (2003) High level of cFLIP correlates with resistance to death receptor-induced apoptosis in bladder carcinoma cells. Anticancer Res 23:1213-1218
-
(2003)
Anticancer Res
, vol.23
, pp. 1213-1218
-
-
Jonsson, G.1
Paulie, S.2
Grandien, A.3
-
33
-
-
22344432122
-
Evaluating the expression and prognostic value of TRAIL-R1 and TRAIL-R2 in breast cancer
-
McCarthy MM, Sznol M, DiVito KA, Camp RL, Rimm DL, Kluger HM (2005) Evaluating the expression and prognostic value of TRAIL-R1 and TRAIL-R2 in breast cancer. Clin Cancer Res 11:5188-5194
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5188-5194
-
-
McCarthy, M.M.1
Sznol, M.2
Divito, K.A.3
Camp, R.L.4
Rimm, D.L.5
Kluger, H.M.6
-
34
-
-
33746076735
-
Survivin inhibits apoptosis induced by TRAIL, and the ratio between survivin and TRAIL receptors is predictive of recurrent disease in neuroblastoma
-
Azuhata T, Scott D, Griffith TS, Miller M, Sandler AD (2006) Survivin inhibits apoptosis induced by TRAIL, and the ratio between survivin and TRAIL receptors is predictive of recurrent disease in neuroblastoma. J Pediatr Surg 41:1431-1440
-
(2006)
J Pediatr Surg
, vol.41
, pp. 1431-1440
-
-
Azuhata, T.1
Scott, D.2
Griffith, T.S.3
Miller, M.4
Sandler, A.D.5
-
35
-
-
17544367410
-
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
-
Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 271:12687-12690
-
(1996)
J Biol Chem
, vol.271
, pp. 12687-12690
-
-
Pitti, R.M.1
Marsters, S.A.2
Ruppert, S.3
Donahue, C.J.4
Moore, A.5
Ashkenazi, A.6
-
36
-
-
0033911632
-
Production of recombinant TRAIL and TRAIL receptor: Fc chimeric proteins
-
Schneider P (2000) Production of recombinant TRAIL and TRAIL receptor: Fc chimeric proteins. Methods Enzymol 322:325-345
-
(2000)
Methods Enzymol
, vol.322
, pp. 325-345
-
-
Schneider, P.1
-
37
-
-
33646393778
-
Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs
-
Ganten TM, Koschny R, Sykora J, Schulze-Bergkamen H, Buchler P, Haas TL et al (2006) Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs. Clin Cancer Res 12:2640-2646
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2640-2646
-
-
Ganten, T.M.1
Koschny, R.2
Sykora, J.3
Schulze-Bergkamen, H.4
Buchler, P.5
Haas, T.L.6
-
38
-
-
28944449421
-
Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy
-
Sayers TJ, Murphy WJ (2006) Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy. Cancer Immunol Immunother 55:76-84
-
(2006)
Cancer Immunol Immunother
, vol.55
, pp. 76-84
-
-
Sayers, T.J.1
Murphy, W.J.2
-
39
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Marsters SA et al (1999) Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 104:155-162
-
(1999)
J Clin Invest
, vol.104
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
Leung, S.4
Lawrence, D.A.5
Marsters, S.A.6
-
40
-
-
0034812659
-
Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: Characterization of in vivo efficacy, pharmacokinetics, and safety
-
Kelley SK, Harris LA, Xie D, Deforge L, Totpal K, Bussiere J et al (2001) Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety. J Pharmacol Exp Ther 299:31-38
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 31-38
-
-
Kelley, S.K.1
Harris, L.A.2
Xie, D.3
Deforge, L.4
Totpal, K.5
Bussiere, J.6
-
41
-
-
0035050960
-
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions
-
Lawrence D, Shahrokh Z, Marsters S, Achilles K, Shih D, Mounho B et al (2001) Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat Med 7:383-385
-
(2001)
Nat Med
, vol.7
, pp. 383-385
-
-
Lawrence, D.1
Shahrokh, Z.2
Marsters, S.3
Achilles, K.4
Shih, D.5
Mounho, B.6
-
42
-
-
0034022160
-
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
-
Jo M, Kim TH, Seol DW, Esplen JE, Dorko K, Billiar TR et al (2000) Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med 6:564-567
-
(2000)
Nat Med
, vol.6
, pp. 564-567
-
-
Jo, M.1
Kim, T.H.2
Seol, D.W.3
Esplen, J.E.4
Dorko, K.5
Billiar, T.R.6
-
43
-
-
17944376030
-
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity
-
Ichikawa K, Liu W, Zhao L, Wang Z, Liu D, Ohtsuka T et al (2001) Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med 7:954-960
-
(2001)
Nat Med
, vol.7
, pp. 954-960
-
-
Ichikawa, K.1
Liu, W.2
Zhao, L.3
Wang, Z.4
Liu, D.5
Ohtsuka, T.6
-
44
-
-
0033721127
-
The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand
-
Ozoren N, Kim K, Burns TF, Dicker DT, Moscioni AD, El-Deiry WS (2000) The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res 60:6259-6265
-
(2000)
Cancer Res
, vol.60
, pp. 6259-6265
-
-
Ozoren, N.1
Kim, K.2
Burns, T.F.3
Dicker, D.T.4
Moscioni, A.D.5
El-Deiry, W.S.6
-
45
-
-
0036859738
-
Defining characteristics of Types I and II apoptotic cells in response to TRAIL
-
Ozoren N, El-Deiry WS (2002) Defining characteristics of Types I and II apoptotic cells in response to TRAIL. Neoplasia 4:551-557
-
(2002)
Neoplasia
, vol.4
, pp. 551-557
-
-
Ozoren, N.1
El-Deiry, W.S.2
-
46
-
-
0026547439
-
Hepatocytes in collagen sandwich: Evidence for transcriptional and translational regulation
-
Dunn JC, Tompkins RG, Yarmush ML (1992) Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation. J Cell Biol 116:1043-1053
-
(1992)
J Cell Biol
, vol.116
, pp. 1043-1053
-
-
Dunn, J.C.1
Tompkins, R.G.2
Yarmush, M.L.3
-
47
-
-
0021201874
-
Isolation, culture and characterization of adult human hepatocytes from surgical liver biopsies
-
Ballet F, Bouma ME, Wang SR, Amit N, Marais J, Infante R (1984) Isolation, culture and characterization of adult human hepatocytes from surgical liver biopsies. Hepatology 4:849-854
-
(1984)
Hepatology
, vol.4
, pp. 849-854
-
-
Ballet, F.1
Bouma, M.E.2
Wang, S.R.3
Amit, N.4
Marais, J.5
Infante, R.6
-
48
-
-
9244237679
-
TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice
-
Hao C, Song JH, Hsi B, Lewis J, Song DK, Petruk KC et al (2004) TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice. Cancer Res 64:8502-8506
-
(2004)
Cancer Res
, vol.64
, pp. 8502-8506
-
-
Hao, C.1
Song, J.H.2
Hsi, B.3
Lewis, J.4
Song, D.K.5
Petruk, K.C.6
-
49
-
-
0742272016
-
Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2
-
Mori E, Thomas M, Motoki K, Nakazawa K, Tahara T, Tomizuka K et al (2004) Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2. Cell Death Differ 11:203-207
-
(2004)
Cell Death Differ
, vol.11
, pp. 203-207
-
-
Mori, E.1
Thomas, M.2
Motoki, K.3
Nakazawa, K.4
Tahara, T.5
Tomizuka, K.6
-
50
-
-
33845920091
-
Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax
-
Liang X, Liu Y, Zhang Q, Gao L, Han L, Ma C et al (2007) Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax. J Immunol 178:503-510
-
(2007)
J Immunol
, vol.178
, pp. 503-510
-
-
Liang, X.1
Liu, Y.2
Zhang, Q.3
Gao, L.4
Han, L.5
Ma, C.6
-
51
-
-
33751535476
-
Blockade of TRAIL pathway ameliorates HBV-induced hepatocyte apoptosis in an acute hepatitis model
-
Liu YG, Liu SX, Liang XH, Zhang Q, Gao LF, Han LH et al (2007) Blockade of TRAIL pathway ameliorates HBV-induced hepatocyte apoptosis in an acute hepatitis model. Biochem Biophys Res Commun 352:329-334
-
(2007)
Biochem Biophys Res Commun
, vol.352
, pp. 329-334
-
-
Liu, Y.G.1
Liu, S.X.2
Liang, X.H.3
Zhang, Q.4
Gao, L.F.5
Han, L.H.6
-
52
-
-
27444433031
-
Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake
-
Mundt B, Wirth T, Zender L, Waltemathe M, Trautwein C, Manns MP et al (2005) Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake. Gut 54:1590-1596
-
(2005)
Gut
, vol.54
, pp. 1590-1596
-
-
Mundt, B.1
Wirth, T.2
Zender, L.3
Waltemathe, M.4
Trautwein, C.5
Manns, M.P.6
-
53
-
-
0037268529
-
Involvement of TRAIL and its receptors in viral hepatitis
-
Mundt B, Kuhnel F, Zender L, Paul Y, Tillmann H, Trautwein C et al (2003) Involvement of TRAIL and its receptors in viral hepatitis. Faseb J 17:94-96
-
(2003)
Faseb J
, vol.17
, pp. 94-96
-
-
Mundt, B.1
Kuhnel, F.2
Zender, L.3
Paul, Y.4
Tillmann, H.5
Trautwein, C.6
-
54
-
-
0034596514
-
Human brain-cell death induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL)
-
Nitsch R, Bechmann I, Deisz RA, Haas D, Lehmann TN, Wendling U et al (2000) Human brain-cell death induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL). Lancet 356:827-828
-
(2000)
Lancet
, vol.356
, pp. 827-828
-
-
Nitsch, R.1
Bechmann, I.2
Deisz, R.A.3
Haas, D.4
Lehmann, T.N.5
Wendling, U.6
-
55
-
-
24144456276
-
Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate
-
Dorr J, Roth K, Zurbuchen U, Deisz R, Bechmann I, Lehmann TN et al (2005) Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate. J Neuroimmunol 167:204-209
-
(2005)
J Neuroimmunol
, vol.167
, pp. 204-209
-
-
Dorr, J.1
Roth, K.2
Zurbuchen, U.3
Deisz, R.4
Bechmann, I.5
Lehmann, T.N.6
-
56
-
-
0035117038
-
Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells
-
Hao C, Beguinot F, Condorelli G, Trencia A, Van Meir EG, Yong VW et al (2001) Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells. Cancer Res 61:1162-1170
-
(2001)
Cancer Res
, vol.61
, pp. 1162-1170
-
-
Hao, C.1
Beguinot, F.2
Condorelli, G.3
Trencia, A.4
Van Meir, E.G.5
Yong, V.W.6
-
57
-
-
0033975513
-
Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes
-
Leverkus M, Neumann M, Mengling T, Rauch CT, Brocker EB, Krammer PH et al (2000) Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes. Cancer Res 60:553-559
-
(2000)
Cancer Res
, vol.60
, pp. 553-559
-
-
Leverkus, M.1
Neumann, M.2
Mengling, T.3
Rauch, C.T.4
Brocker, E.B.5
Krammer, P.H.6
-
58
-
-
0347624706
-
Tumor necrosis factor related apoptosis inducing ligand triggers apoptosis in dividing but not in differentiating human epidermal keratinocytes
-
Jansen BJ, Van Ruissen F, Cerneus S, Cloin W, Bergers M, Van Erp PE et al (2003) Tumor necrosis factor related apoptosis inducing ligand triggers apoptosis in dividing but not in differentiating human epidermal keratinocytes. J Invest Dermatol 121:1433-1439
-
(2003)
J Invest Dermatol
, vol.121
, pp. 1433-1439
-
-
Jansen, B.J.1
Van Ruissen, F.2
Cerneus, S.3
Cloin, W.4
Bergers, M.5
Van Erp, P.E.6
-
60
-
-
0012803054
-
Pathways involved in proliferating, senescent and immortalized keratinocyte cell death mediated by two different TRAIL preparations
-
Qin JZ, Bacon PE, Chaturvedi V, Bonish B, Nickoloff BJ (2002) Pathways involved in proliferating, senescent and immortalized keratinocyte cell death mediated by two different TRAIL preparations. Exp Dermatol 11:573-583
-
(2002)
Exp Dermatol
, vol.11
, pp. 573-583
-
-
Qin, J.Z.1
Bacon, P.E.2
Chaturvedi, V.3
Bonish, B.4
Nickoloff, B.J.5
-
61
-
-
85009895235
-
TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors
-
Plasilova M, Zivny J, Jelinek J, Neuwirtova R, Cermak J, Necas E et al (2002) TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. Leukemia 16:67-73
-
(2002)
Leukemia
, vol.16
, pp. 67-73
-
-
Plasilova, M.1
Zivny, J.2
Jelinek, J.3
Neuwirtova, R.4
Cermak, J.5
Necas, E.6
-
62
-
-
4544242734
-
Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells
-
Kim SH, Kim K, Kwagh JG, Dicker DT, Herlyn M, Rustgi AK et al (2004) Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells. J Biol Chem 279:40044-40052
-
(2004)
J Biol Chem
, vol.279
, pp. 40044-40052
-
-
Kim, S.H.1
Kim, K.2
Kwagh, J.G.3
Dicker, D.T.4
Herlyn, M.5
Rustgi, A.K.6
-
64
-
-
0036124153
-
Inflammatory cytokine regulation of TRAIL-mediated apoptosis in thyroid epithelial cells
-
Bretz JD, Mezosi E, Giordano TJ, Gauger PG, Thompson NW, Baker JR Jr (2002) Inflammatory cytokine regulation of TRAIL-mediated apoptosis in thyroid epithelial cells. Cell Death Differ 9:274-286
-
(2002)
Cell Death Differ
, vol.9
, pp. 274-286
-
-
Bretz, J.D.1
Mezosi, E.2
Giordano, T.J.3
Gauger, P.G.4
Thompson, N.W.5
Baker Jr., J.R.6
-
65
-
-
0037771278
-
TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis
-
Ichikawa K, Liu W, Fleck M, Zhang H, Zhao L, Ohtsuka T et al (2003) TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol 171:1061-1069
-
(2003)
J Immunol
, vol.171
, pp. 1061-1069
-
-
Ichikawa, K.1
Liu, W.2
Fleck, M.3
Zhang, H.4
Zhao, L.5
Ohtsuka, T.6
-
66
-
-
0036179391
-
TRAIL and its receptors in the colonic epithelium: A putative role in the defense of viral infections
-
Strater J, Walczak H, Pukrop T, Von Muller L, Hasel C, Kornmann M et al (2002) TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections. Gastroenterology 122:659-666
-
(2002)
Gastroenterology
, vol.122
, pp. 659-666
-
-
Strater, J.1
Walczak, H.2
Pukrop, T.3
Von Muller, L.4
Hasel, C.5
Kornmann, M.6
-
67
-
-
32844465568
-
In vitro efficacy of AdTRAIL gene therapy of bladder cancer is enhanced by trichostatin A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL
-
El-Zawahry A, Lu P, White SJ, Voelkel-Johnson C (2006) In vitro efficacy of AdTRAIL gene therapy of bladder cancer is enhanced by trichostatin A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL. Cancer Gene Ther 13:281-289
-
(2006)
Cancer Gene Ther
, vol.13
, pp. 281-289
-
-
El-Zawahry, A.1
Lu, P.2
White, S.J.3
Voelkel-Johnson, C.4
-
68
-
-
1242296922
-
Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2
-
Bremer E, Kuijlen J, Samplonius D, Walczak H, de Leij L, Helfrich W (2004) Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2. Int J Cancer 109:281-290
-
(2004)
Int J Cancer
, vol.109
, pp. 281-290
-
-
Bremer, E.1
Kuijlen, J.2
Samplonius, D.3
Walczak, H.4
De Leij, L.5
Helfrich, W.6
-
69
-
-
6944243903
-
Exceptionally potent anti-tumor bystander activity of an scFv:sTRAIL fusion protein with specificity for EGP2 toward target antigen-negative tumor cells
-
Bremer E, Samplonius D, Kroesen BJ, van Genne L, de Leij L, Helfrich W (2004) Exceptionally potent anti-tumor bystander activity of an scFv:sTRAIL fusion protein with specificity for EGP2 toward target antigen-negative tumor cells. Neoplasia 6:636-645
-
(2004)
Neoplasia
, vol.6
, pp. 636-645
-
-
Bremer, E.1
Samplonius, D.2
Kroesen, B.J.3
Van Genne, L.4
De Leij, L.5
Helfrich, W.6
-
70
-
-
17144382484
-
Target cell-restricted apoptosis induction of acute leukemic t cells by a recombinant tumor necrosis factor-related apoptosis-inducing ligand fusion protein with specificity for human CD7
-
Bremer E, Samplonius DF, Peipp M, van Genne L, Kroesen BJ, Fey GH et al (2005) Target cell-restricted apoptosis induction of acute leukemic t cells by a recombinant tumor necrosis factor-related apoptosis-inducing ligand fusion protein with specificity for human CD7. Cancer Res 65:3380-3388
-
(2005)
Cancer Res
, vol.65
, pp. 3380-3388
-
-
Bremer, E.1
Samplonius, D.F.2
Peipp, M.3
Van Genne, L.4
Kroesen, B.J.5
Fey, G.H.6
-
71
-
-
15444364588
-
Simultaneous inhibition of epidermal growth factor receptor (EGFR) signaling and enhanced activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-mediated apoptosis induction by an scFv:sTRAIL fusion protein with specificity for human EGFR
-
Bremer E, Samplonius DF, van Genne L, Dijkstra MH, Kroesen BJ, de Leij LF et al (2005) Simultaneous inhibition of epidermal growth factor receptor (EGFR) signaling and enhanced activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-mediated apoptosis induction by an scFv:sTRAIL fusion protein with specificity for human EGFR. J Biol Chem 280:10025-10033
-
(2005)
J Biol Chem
, vol.280
, pp. 10025-10033
-
-
Bremer, E.1
Samplonius, D.F.2
Van Genne, L.3
Dijkstra, M.H.4
Kroesen, B.J.5
De Leij, L.F.6
-
72
-
-
33748311988
-
A CD40-CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95
-
Assohou-Luty C, Gerspach J, Siegmund D, Muller N, Huard B, Tiegs G et al (2006) A CD40-CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95. J Mol Med 84:785-797
-
(2006)
J Mol Med
, vol.84
, pp. 785-797
-
-
Assohou-Luty, C.1
Gerspach, J.2
Siegmund, D.3
Muller, N.4
Huard, B.5
Tiegs, G.6
-
74
-
-
0141679399
-
Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model
-
Buchsbaum DJ, Zhou T, Grizzle WE, Oliver PG, Hammond CJ, Zhang S et al (2003) Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model. Clin Cancer Res 9:3731-3741
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3731-3741
-
-
Buchsbaum, D.J.1
Zhou, T.2
Grizzle, W.E.3
Oliver, P.G.4
Hammond, C.J.5
Zhang, S.6
-
75
-
-
10744220151
-
Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy
-
Takeda K, Yamaguchi N, Akiba H, Kojima Y, Hayakawa Y, Tanner JE et al (2004) Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy. J Exp Med 199:437-448
-
(2004)
J Exp Med
, vol.199
, pp. 437-448
-
-
Takeda, K.1
Yamaguchi, N.2
Akiba, H.3
Kojima, Y.4
Hayakawa, Y.5
Tanner, J.E.6
-
76
-
-
33744987907
-
Eradication of established tumors in mice by a combination antibody-based therapy
-
Uno T, Takeda K, Kojima Y, Yoshizawa H, Akiba H, Mittler RS et al (2006) Eradication of established tumors in mice by a combination antibody-based therapy. Nat Med 12:693-698
-
(2006)
Nat Med
, vol.12
, pp. 693-698
-
-
Uno, T.1
Takeda, K.2
Kojima, Y.3
Yoshizawa, H.4
Akiba, H.5
Mittler, R.S.6
-
77
-
-
21044441651
-
HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo
-
Pukac L, Kanakaraj P, Humphreys R, Alderson R, Bloom M, Sung C et al (2005) HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. Br J Cancer 92:1430-1441
-
(2005)
Br J Cancer
, vol.92
, pp. 1430-1441
-
-
Pukac, L.1
Kanakaraj, P.2
Humphreys, R.3
Alderson, R.4
Bloom, M.5
Sung, C.6
-
78
-
-
23644443543
-
New apoptosis drugs face critical test
-
Garber K (2005) New apoptosis drugs face critical test. Nat Biotechnol 23:409-411
-
(2005)
Nat Biotechnol
, vol.23
, pp. 409-411
-
-
Garber, K.1
-
79
-
-
0036467427
-
Increased susceptibility to tumor initiation and metastasis in tnf-related apoptosis-inducing ligand-deficient mice
-
Cretney E, Takeda K, Yagita H, Glaccum M, Peschon JJ, Smyth MJ (2002) Increased susceptibility to tumor initiation and metastasis in tnf-related apoptosis-inducing ligand-deficient mice. J Immunol 168:1356-1361
-
(2002)
J Immunol
, vol.168
, pp. 1356-1361
-
-
Cretney, E.1
Takeda, K.2
Yagita, H.3
Glaccum, M.4
Peschon, J.J.5
Smyth, M.J.6
-
80
-
-
0036687185
-
Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice
-
Sedger LM, Glaccum MB, Schuh JC, Kanaly ST, Williamson E, Kayagaki N et al (2002) Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice. Eur J Immunol 32:2246-2254
-
(2002)
Eur J Immunol
, vol.32
, pp. 2246-2254
-
-
Sedger, L.M.1
Glaccum, M.B.2
Schuh, J.C.3
Kanaly, S.T.4
Williamson, E.5
Kayagaki, N.6
-
81
-
-
0037226644
-
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer
-
Seki N, Hayakawa Y, Brooks AD, Wine J, Wiltrout RH, Yagita H et al (2003) Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer. Cancer Res 63:207-213
-
(2003)
Cancer Res
, vol.63
, pp. 207-213
-
-
Seki, N.1
Hayakawa, Y.2
Brooks, A.D.3
Wine, J.4
Wiltrout, R.H.5
Yagita, H.6
-
82
-
-
0036792685
-
TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy
-
Wajant H, Pfizenmaier K, Scheurich P (2002) TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy. Apoptosis 7:449-459
-
(2002)
Apoptosis
, vol.7
, pp. 449-459
-
-
Wajant, H.1
Pfizenmaier, K.2
Scheurich, P.3
-
83
-
-
33645091240
-
TNF-related apoptosis-inducing ligand as a therapeutic agent in autoimmunity and cancer
-
Cretney E, Shanker A, Yagita H, Smyth MJ, Sayers TJ (2006) TNF-related apoptosis-inducing ligand as a therapeutic agent in autoimmunity and cancer. Immunol Cell Biol 84:87-98
-
(2006)
Immunol Cell Biol
, vol.84
, pp. 87-98
-
-
Cretney, E.1
Shanker, A.2
Yagita, H.3
Smyth, M.J.4
Sayers, T.J.5
-
84
-
-
24144489702
-
Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL
-
Ganten TM, Koschny R, Haas TL, Sykora J, Li-Weber M, Herzer K et al (2005) Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL. Hepatology 42:588-597
-
(2005)
Hepatology
, vol.42
, pp. 588-597
-
-
Ganten, T.M.1
Koschny, R.2
Haas, T.L.3
Sykora, J.4
Li-Weber, M.5
Herzer, K.6
-
85
-
-
33947368690
-
TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window
-
Koschny R, Ganten TM, Sykora J, Haas TL, Sprick MR, Kolb A et al (2007) TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology 45:649-658
-
(2007)
Hepatology
, vol.45
, pp. 649-658
-
-
Koschny, R.1
Ganten, T.M.2
Sykora, J.3
Haas, T.L.4
Sprick, M.R.5
Kolb, A.6
-
86
-
-
28644440158
-
Histone deacetylase inhibitors: Discovery and development as anticancer agents
-
Marks PA, Dokmanovic M (2005) Histone deacetylase inhibitors: discovery and development as anticancer agents. Expert Opin Investig Drugs 14:1497-1511
-
(2005)
Expert Opin Investig Drugs
, vol.14
, pp. 1497-1511
-
-
Marks, P.A.1
Dokmanovic, M.2
-
87
-
-
33644876853
-
Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy
-
Schuchmann M, Schulze-Bergkamen H, Fleischer B, Schattenberg JM, Siebler J, Weinmann A et al (2006) Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy. Oncol Rep 15:227-230
-
(2006)
Oncol Rep
, vol.15
, pp. 227-230
-
-
Schuchmann, M.1
Schulze-Bergkamen, H.2
Fleischer, B.3
Schattenberg, J.M.4
Siebler, J.5
Weinmann, A.6
-
88
-
-
33645239495
-
HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL
-
Pathil A, Armeanu S, Venturelli S, Mascagni P, Weiss TS, Gregor M et al (2006) HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL. Hepatology 43:425-434
-
(2006)
Hepatology
, vol.43
, pp. 425-434
-
-
Pathil, A.1
Armeanu, S.2
Venturelli, S.3
Mascagni, P.4
Weiss, T.S.5
Gregor, M.6
-
89
-
-
21744448694
-
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1
-
MacFarlane M, Inoue S, Kohlhaas SL, Majid A, Harper N, Kennedy DB et al (2005) Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1. Cell Death Differ 12:773-782
-
(2005)
Cell Death Differ
, vol.12
, pp. 773-782
-
-
MacFarlane, M.1
Inoue, S.2
Kohlhaas, S.L.3
Majid, A.4
Harper, N.5
Kennedy, D.B.6
-
90
-
-
12744261484
-
Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies
-
Suppl 2
-
Inoue S, MacFarlane M, Harper N, Wheat LM, Dyer MJ, Cohen GM (2004) Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies. Cell Death Differ 11(Suppl 2):S193-S206
-
(2004)
Cell Death Differ
, vol.11
-
-
Inoue, S.1
MacFarlane, M.2
Harper, N.3
Wheat, L.M.4
Dyer, M.J.5
Cohen, G.M.6
-
91
-
-
13444306459
-
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
-
Nebbioso A, Clarke N, Voltz E, Germain E, Ambrosino C, Bontempo P et al (2005) Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nat Med 11:77-84
-
(2005)
Nat Med
, vol.11
, pp. 77-84
-
-
Nebbioso, A.1
Clarke, N.2
Voltz, E.3
Germain, E.4
Ambrosino, C.5
Bontempo, P.6
-
92
-
-
4344666663
-
Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
-
Nakata S, Yoshida T, Horinaka M, Shiraishi T, Wakada M, Sakai T (2004) Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells. Oncogene 23:6261-6271
-
(2004)
Oncogene
, vol.23
, pp. 6261-6271
-
-
Nakata, S.1
Yoshida, T.2
Horinaka, M.3
Shiraishi, T.4
Wakada, M.5
Sakai, T.6
-
93
-
-
3242725832
-
Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1)
-
Chopin V, Slomianny C, Hondermarck H, Le Bourhis X (2004) Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1). Exp Cell Res 298:560-573
-
(2004)
Exp Cell Res
, vol.298
, pp. 560-573
-
-
Chopin, V.1
Slomianny, C.2
Hondermarck, H.3
Le Bourhis, X.4
-
94
-
-
27744597128
-
Histone deacetylase inhibitors modulate renal cell carcinoma sensitivity to TRAIL/Apo-2L-induced apoptosis by enhancing TRAIL-R2 expression
-
VanOosten RL, Moore JM, Karacay B, Griffith TS (2005) Histone deacetylase inhibitors modulate renal cell carcinoma sensitivity to TRAIL/Apo-2L-induced apoptosis by enhancing TRAIL-R2 expression. Cancer Biother 4:1104-1112
-
(2005)
Cancer Biother
, vol.4
, pp. 1104-1112
-
-
Vanoosten, R.L.1
Moore, J.M.2
Karacay, B.3
Griffith, T.S.4
-
95
-
-
22744437647
-
HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma
-
Singh TR, Shankar S, Srivastava RK (2005) HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma. Oncogene 24:4609-4623
-
(2005)
Oncogene
, vol.24
, pp. 4609-4623
-
-
Singh, T.R.1
Shankar, S.2
Srivastava, R.K.3
-
96
-
-
33750994327
-
Upregulation of TRAIL-R2 is not involved in HDACi mediated sensitization to TRAIL-induced apoptosis
-
Inoue S, Twiddy D, Dyer MJ, Cohen GM (2006) Upregulation of TRAIL-R2 is not involved in HDACi mediated sensitization to TRAIL-induced apoptosis. Cell Death Differ 13:2160-2162
-
(2006)
Cell Death Differ
, vol.13
, pp. 2160-2162
-
-
Inoue, S.1
Twiddy, D.2
Dyer, M.J.3
Cohen, G.M.4
-
97
-
-
29244483111
-
TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies
-
MacFarlane M, Kohlhaas SL, Sutcliffe MJ, Dyer MJ, Cohen GM (2005) TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies. Cancer Res 65:11265-11270
-
(2005)
Cancer Res
, vol.65
, pp. 11265-11270
-
-
MacFarlane, M.1
Kohlhaas, S.L.2
Sutcliffe, M.J.3
Dyer, M.J.4
Cohen, G.M.5
-
98
-
-
0035195486
-
Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D
-
Olsson A, Diaz T, Aguilar-Santelises M, Osterborg A, Celsing F, Jondal M et al (2001) Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D. Leukemia 15:1868-1877
-
(2001)
Leukemia
, vol.15
, pp. 1868-1877
-
-
Olsson, A.1
Diaz, T.2
Aguilar-Santelises, M.3
Osterborg, A.4
Celsing, F.5
Jondal, M.6
-
99
-
-
0036624741
-
Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: Therapeutic applications
-
Mitsiades N, Mitsiades CS, Poulaki V, Chauhan D, Richardson PG, Hideshima T et al. (2002) Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications. Blood 99:4079-4086
-
(2002)
Blood
, vol.99
, pp. 4079-4086
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
Chauhan, D.4
Richardson, P.G.5
Hideshima, T.6
-
100
-
-
0037108712
-
Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice
-
Naka T, Sugamura K, Hylander BL, Widmer MB, Rustum YM, Repasky EA (2002) Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice. Cancer Res 62:5800-5806
-
(2002)
Cancer Res
, vol.62
, pp. 5800-5806
-
-
Naka, T.1
Sugamura, K.2
Hylander, B.L.3
Widmer, M.B.4
Rustum, Y.M.5
Repasky, E.A.6
-
101
-
-
27344456844
-
The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice
-
Hylander BL, Pitoniak R, Penetrante RB, Gibbs JF, Oktay D, Cheng J et al (2005) The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice. J Transl Med 3:22
-
(2005)
J Transl Med
, vol.3
, pp. 22
-
-
Hylander, B.L.1
Pitoniak, R.2
Penetrante, R.B.3
Gibbs, J.F.4
Oktay, D.5
Cheng, J.6
-
102
-
-
34447339050
-
TRAIL induces apoptosis in human colorectal adenoma cell lines and human colorectal adenomas
-
Jalving M, de Jong S, Koornstra JJ, Boersma-van Ek W, Zwart N, Wesseling J et al (2006) TRAIL induces apoptosis in human colorectal adenoma cell lines and human colorectal adenomas. Clin Cancer Res 12:4350-4356
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4350-4356
-
-
Jalving, M.1
De Jong, S.2
Koornstra, J.J.3
Boersma-Van Ek, W.4
Zwart, N.5
Wesseling, J.6
-
103
-
-
0036794875
-
Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis
-
Atkins GJ, Bouralexis S, Evdokiou A, Hay S, Labrinidis A, Zannettino AC et al (2002) Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis. Bone 31:448-456
-
(2002)
Bone
, vol.31
, pp. 448-456
-
-
Atkins, G.J.1
Bouralexis, S.2
Evdokiou, A.3
Hay, S.4
Labrinidis, A.5
Zannettino, A.C.6
-
104
-
-
0036605042
-
Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis
-
Evdokiou A, Bouralexis S, Atkins GJ, Chai F, Hay S, Clayer M et al (2002) Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. Int J Cancer 99:491-504
-
(2002)
Int J Cancer
, vol.99
, pp. 491-504
-
-
Evdokiou, A.1
Bouralexis, S.2
Atkins, G.J.3
Chai, F.4
Hay, S.5
Clayer, M.6
-
105
-
-
0242509305
-
Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs normal human cells
-
Van Valen F, Fulda S, Schafer KL, Truckenbrod B, Hotfilder M, Poremba C et al (2003) Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs normal human cells. Int J Cancer 107:929-940
-
(2003)
Int J Cancer
, vol.107
, pp. 929-940
-
-
Van Valen, F.1
Fulda, S.2
Schafer, K.L.3
Truckenbrod, B.4
Hotfilder, M.5
Poremba, C.6
-
106
-
-
0037305877
-
Proteasome Inhibition Results in TRAIL Sensitization of Primary Keratinocytes by Removing the Resistance-Mediating Block of Effector Caspase Maturation
-
Leverkus M, Sprick MR, Wachter T, Mengling T, Baumann B, Serfling E et al (2003) Proteasome Inhibition Results in TRAIL Sensitization of Primary Keratinocytes by Removing the Resistance-Mediating Block of Effector Caspase Maturation. Mol Cell Biol 23:777-790
-
(2003)
Mol Cell Biol
, vol.23
, pp. 777-790
-
-
Leverkus, M.1
Sprick, M.R.2
Wachter, T.3
Mengling, T.4
Baumann, B.5
Serfling, E.6
-
107
-
-
4344607589
-
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs
-
Suppl 1
-
Ganten TM, Haas TL, Sykora J, Stahl H, Sprick MR, Fas SC et al (2004) Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell Death Differ 11(Suppl 1):S86-S96
-
(2004)
Cell Death Differ
, vol.11
-
-
Ganten, T.M.1
Haas, T.L.2
Sykora, J.3
Stahl, H.4
Sprick, M.R.5
Fas, S.C.6
-
108
-
-
21144438719
-
Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells
-
Hyer ML, Croxton R, Krajewska M, Krajewski S, Kress CL, Lu M et al (2005) Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. Cancer Res 65:4799-4808
-
(2005)
Cancer Res
, vol.65
, pp. 4799-4808
-
-
Hyer, M.L.1
Croxton, R.2
Krajewska, M.3
Krajewski, S.4
Kress, C.L.5
Lu, M.6
-
109
-
-
33750312678
-
Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA
-
Qin JZ, Xin H, Sitailo LA, Denning MF, Nickoloff BJ (2006) Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA. Cancer Res 66:9636-9645
-
(2006)
Cancer Res
, vol.66
, pp. 9636-9645
-
-
Qin, J.Z.1
Xin, H.2
Sitailo, L.A.3
Denning, M.F.4
Nickoloff, B.J.5
-
110
-
-
12144288466
-
Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt
-
Schulze-Bergkamen H, Brenner D, Krueger A, Suess D, Fas SC, Frey CR et al (2004) Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt. Hepatology 39:645-654
-
(2004)
Hepatology
, vol.39
, pp. 645-654
-
-
Schulze-Bergkamen, H.1
Brenner, D.2
Krueger, A.3
Suess, D.4
Fas, S.C.5
Frey, C.R.6
-
111
-
-
33747831850
-
The essential role of the mitochondria-dependent death-signaling cascade in chemotherapy-induced potentiation of Apo2L/TRAIL cytotoxicity in cultured thoracic cancer cells: Amplified caspase 8 is indispensable for combination-mediated massive cell death
-
Nguyen DM, Yeow WS, Ziauddin MF, Baras A, Tsai W, Reddy RM et al (2006) The essential role of the mitochondria-dependent death-signaling cascade in chemotherapy-induced potentiation of Apo2L/TRAIL cytotoxicity in cultured thoracic cancer cells: amplified caspase 8 is indispensable for combination-mediated massive cell death. Cancer J 12:257-273
-
(2006)
Cancer J
, vol.12
, pp. 257-273
-
-
Nguyen, D.M.1
Yeow, W.S.2
Ziauddin, M.F.3
Baras, A.4
Tsai, W.5
Reddy, R.M.6
-
112
-
-
0011444717
-
Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types
-
Zhang XD, Nguyen T, Thomas WD, Sanders JE, Hersey P (2000) Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types. FEBS Lett 482:193-199
-
(2000)
FEBS Lett
, vol.482
, pp. 193-199
-
-
Zhang, X.D.1
Nguyen, T.2
Thomas, W.D.3
Sanders, J.E.4
Hersey, P.5
-
113
-
-
0037457474
-
Enhancement of TRAIL/Apo2L-mediated apoptosis by adriamycin through inducing DR4 and DR5 in renal cell carcinoma cells
-
Wu XX, Kakehi Y, Mizutani Y, Nishiyama H, Kamoto T, Megumi Y et al (2003) Enhancement of TRAIL/Apo2L-mediated apoptosis by adriamycin through inducing DR4 and DR5 in renal cell carcinoma cells. Int J Cancer 104:409-417
-
(2003)
.Int J Cancer
, vol.104
, pp. 409-417
-
-
Wu, X.X.1
Kakehi, Y.2
Mizutani, Y.3
Nishiyama, H.4
Kamoto, T.5
Megumi, Y.6
-
114
-
-
2642511659
-
Low-dose UV-radiation sensitizes keratinocytes to TRAIL-induced apoptosis
-
Qin JZ, Bacon P, Panella J, Sitailo LA, Denning MF, Nickoloff BJ (2004) Low-dose UV-radiation sensitizes keratinocytes to TRAIL-induced apoptosis. J Cell Physiol 200:155-166
-
(2004)
J Cell Physiol
, vol.200
, pp. 155-166
-
-
Qin, J.Z.1
Bacon, P.2
Panella, J.3
Sitailo, L.A.4
Denning, M.F.5
Nickoloff, B.J.6
-
115
-
-
0032530612
-
Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
-
Griffith TS, Chin WA, Jackson GC, Lynch DH, Kubin MZ (1998) Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. J Immunol 161:2833-2840
-
(1998)
J Immunol
, vol.161
, pp. 2833-2840
-
-
Griffith, T.S.1
Chin, W.A.2
Jackson, G.C.3
Lynch, D.H.4
Kubin, M.Z.5
-
116
-
-
0032582673
-
Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand
-
Kothny-Wilkes G, Kulms D, Poppelmann B, Luger TA, Kubin M, Schwarz T (1998) Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand. J Biol Chem 273:29247-29253
-
(1998)
J Biol Chem
, vol.273
, pp. 29247-29253
-
-
Kothny-Wilkes, G.1
Kulms, D.2
Poppelmann, B.3
Luger, T.A.4
Kubin, M.5
Schwarz, T.6
-
117
-
-
0037219276
-
Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis
-
Taimr P, Higuchi H, Kocova E, Rippe RA, Friedman S, Gores GJ (2003) Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology 37:87-95
-
(2003)
Hepatology
, vol.37
, pp. 87-95
-
-
Taimr, P.1
Higuchi, H.2
Kocova, E.3
Rippe, R.A.4
Friedman, S.5
Gores, G.J.6
-
118
-
-
85047697089
-
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in normal prostate epithelial cells
-
Nesterov A, Ivashchenko Y, Kraft AS (2002) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in normal prostate epithelial cells. Oncogene 21:1135-1140
-
(2002)
Oncogene
, vol.21
, pp. 1135-1140
-
-
Nesterov, A.1
Ivashchenko, Y.2
Kraft, A.S.3
-
119
-
-
0041845009
-
TRAIL induces apoptosis and inflammatory gene expression in human endothelial cells
-
Li JH, Kirkiles-Smith NC, McNiff JM, Pober JS (2003) TRAIL induces apoptosis and inflammatory gene expression in human endothelial cells. J Immunol 171:1526-1533
-
(2003)
J Immunol
, vol.171
, pp. 1526-1533
-
-
Li, J.H.1
Kirkiles-Smith, N.C.2
McNiff, J.M.3
Pober, J.S.4
-
120
-
-
0033104741
-
Functional analysis of TRAIL receptors using monoclonal antibodies
-
Griffith TS, Rauch CT, Smolak PJ, Waugh JY, Boiani N, Lynch DH et al (1999) Functional analysis of TRAIL receptors using monoclonal antibodies. J Immunol 162:2597-2605
-
(1999)
J Immunol
, vol.162
, pp. 2597-2605
-
-
Griffith, T.S.1
Rauch, C.T.2
Smolak, P.J.3
Waugh, J.Y.4
Boiani, N.5
Lynch, D.H.6
-
121
-
-
0035871757
-
Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4
-
Chuntharapai A, Dodge K, Grimmer K, Schroeder K, Marsters SA, Koeppen H et al (2001) Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4. J Immunol 166:4891-4898
-
(2001)
J Immunol
, vol.166
, pp. 4891-4898
-
-
Chuntharapai, A.1
Dodge, K.2
Grimmer, K.3
Schroeder, K.4
Marsters, S.A.5
Koeppen, H.6
-
122
-
-
0037417134
-
Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway
-
Ohtsuka T, Buchsbaum D, Oliver P, Makhija S, Kimberly R, Zhou T (2003) Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway. Oncogene 22:2034-2044
-
(2003)
Oncogene
, vol.22
, pp. 2034-2044
-
-
Ohtsuka, T.1
Buchsbaum, D.2
Oliver, P.3
Makhija, S.4
Kimberly, R.5
Zhou, T.6
-
123
-
-
0642275474
-
An antibody against DR4 (TRAIL-R1) in combination with doxorubicin selectively kills malignant but not normal prostate cells
-
Voelkel-Johnson C (2003) An antibody against DR4 (TRAIL-R1) in combination with doxorubicin selectively kills malignant but not normal prostate cells. Cancer Biother 2:283-290
-
(2003)
Cancer Biother
, vol.2
, pp. 283-290
-
-
Voelkel-Johnson, C.1
-
124
-
-
20244378961
-
Enhanced apoptosis and tumor regression induced by a direct agonist antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2
-
Motoki K, Mori E, Matsumoto A, Thomas M, Tomura T, Humphreys R et al (2005) Enhanced apoptosis and tumor regression induced by a direct agonist antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2. Clin Cancer Res 11:3126-3135
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3126-3135
-
-
Motoki, K.1
Mori, E.2
Matsumoto, A.3
Thomas, M.4
Tomura, T.5
Humphreys, R.6
-
125
-
-
0035353207
-
Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by selective up-regulation of TRAIL-R1
-
Di Pietro R, Secchiero P, Rana R, Gibellini D, Visani G, Bemis K et al (2001) Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by selective up-regulation of TRAIL-R1. Blood 97:2596-2603
-
(2001)
Blood
, vol.97
, pp. 2596-2603
-
-
Di Pietro, R.1
Secchiero, P.2
Rana, R.3
Gibellini, D.4
Visani, G.5
Bemis, K.6
-
126
-
-
0036582832
-
Doxorubicin enhances TRAIL-induced apoptosis in prostate cancer
-
Wu XX, Kakehi Y, Mizutani Y, Kamoto T, Kinoshita H, Isogawa Y et al (2002) Doxorubicin enhances TRAIL-induced apoptosis in prostate cancer. Int J Oncol 20:949-954
-
(2002)
Int J Oncol
, vol.20
, pp. 949-954
-
-
Wu, X.X.1
Kakehi, Y.2
Mizutani, Y.3
Kamoto, T.4
Kinoshita, H.5
Isogawa, Y.6
|