Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway

Oncogene

Volumn 22, Issue 13, 2003, Pages 2034-2044

  Ohtsuka, Toshiaki ^a   Buchsbaum, Donald ^b   Oliver, Patsy ^b   Makhija, Sharmila ^c   Kimberly, Robert ^d   Zhou, Tong ^d  

^a DAIICHI SANKYO CO   (Japan)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d University of Alabama at Birmingham   (United States)

Author keywords

Apoptosis; Chemotherapy; JNK; Mitochondria; TRAIL receptor

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; CELL MARKER; CELL SURFACE RECEPTOR; CISPLATIN; CYTOCHROME C; DEATH RECEPTOR ANTIBODY; DOXORUBICIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 4; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2E12; MONOCLONAL ANTIBODY TRA 8; PACLITAXEL; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; ACETYLCYSTEINE; CARRIER PROTEIN; DIABLO PROTEIN, HUMAN; DNA FRAGMENT; ENZYME INHIBITOR; MAP2K4 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; SIGNAL PEPTIDE; TNFRSF10A PROTEIN, HUMAN; TNFRSF10B PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR CELL LINE; ADENOCARCINOMA; ANTIBODY SPECIFICITY; BREAST TUMOR; CELL CULTURE; CELL MEMBRANE POTENTIAL; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; IMMUNOLOGY; INTRACELLULAR MEMBRANE; PATHOLOGY; PHYSIOLOGY;

ACETYLCYSTEINE; ADENOCARCINOMA; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CARRIER PROTEINS; CASPASES; CISPLATIN; CYTOCHROME C GROUP; DNA FRAGMENTATION; DOXORUBICIN; DRUG SYNERGISM; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HUMANS; INTRACELLULAR MEMBRANES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PACLITAXEL; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; TUMOR CELLS, CULTURED;

EID: 0037417134     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206290     Document Type: Article

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