Hepatocyte Growth Factor Induces Mcl-1 in Primary Human Hepatocytes and Inhibits CD95-Mediated Apoptosis via Akt

Hepatology

Volumn 39, Issue 3, 2004, Pages 645-654

  Schulze Bergkamen, Henning ^a   Brenner, Dirk ^a   Krueger, Andreas ^a,d   Suess, Dorothee ^a   Fas, Stefanie C ^a   Frey, Christian R ^a   Dax, Andreas ^c   Zink, Dorothea ^b   Büchler, Peter ^c   Müller, Martina ^c   Krammer, Peter H ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b German Genome Resource Center RZPD   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADENOVIRUS VECTOR; FAS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN MCL 1; SCATTER FACTOR; STAT3 PROTEIN;

APOPTOSIS; ARTICLE; AUTOIMMUNE HEPATITIS; CELL SURVIVAL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIVER CELL; MITOCHONDRIAL MEMBRANE; MYELOID LEUKEMIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; VIRUS INDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD95; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; HUMANS; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 12144288466     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20138     Document Type: Article

References (50)

1. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001;104:487-501.
2. Faubion WA, Gores GJ. Death receptors in liver biology and pathobiology. HEPATOLOGY 1999;29:1-4.
3. Galle PR, Hofmann WJ, Walczak H, Schaller H, Otto G, Stremmel W, Krammer PL, et al. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med 1995;182:1223-1230.
4. Schulze-Bergkamen H, Untergasser A, Dax A, Vogel H, Buchler P, Klar E, Lehnert T, et al. Primary human hepatocytes - a valuable tool for investigation of apoptosis and hepatitis B virus infection. J Hepatol 2003;38:736-744.
5. Nagata S. Biddable death. Nat Cell Biol 1999;1:E143-E145.
6. Galle PR, Krammer PH. CD95-induced apoptosis in human liver disease. Semin Liver Dis 1998;18:141-151.
7. Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J, Chen J, et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003;9:347-351.
8. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J 1998;17:1675-1687.
9. Li S, Zhao Y, He X, Kim TH, Kuharsky DK, Rabinowich H, Chen J, et al. Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J Biol Chem 2002;277:26912-26920.
10. Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 1999;400:886-891.
11. Trusolino L, Pugliese L, Comoglio PM. Interactions between scatter factors and their receptors: hints for therapeutic applications. FASEB J 1998;12:1267-1280.
12. Zarnegar R, Michalopoulos GK. The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis. J Cell Biol 1995;129:1177-1180.
13. Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A, Tashiro K, et al. Molecular cloning and expression of human hepatocyte growth factor. Nature 1989;342:440-443.
14. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997;276:60-66.
15. Kosai K, Matsumoto K, Nagata S, Tsujimoto Y, Nakamura T. Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor. Biochem Biophys Res Commun 1998;244:683-690.
16. Okano J, Shiota G, Kawasaki H. Protective action of hepatocyte growth factor for acute liver injury caused by D-galactosamine in transgenic mice. HEPATOLOGY 1997;26:1241-1249.
17. Ueki T, Kaneda Y, Tsutsui H, Nakanishi K, Sawa Y, Morishita R, Matsumoto K, et al. Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat Med 1999;5:226-230.
18. Xue F, Takahara T, Yata Y, Minemura M, Morioka CY, Takahara S, Yamato E, et al. Attenuated acute liver injury in mice by naked hepatocyte growth factor gene transfer into skeletal muscle with electroporation. Gut 2002;50:558-562.
19. Wang X, DeFrances MC, Dai Y, Pediaditakis P, Johnson C, Bell A, Michalopoulos GK, et al. A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Mol Cell 2002;9:411-421.
20. Roberts RA, James NH, Cosulich SC. The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis. HEPATOLOGY 2000;31:420-427.
21. Toker A. Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol Pharmacol 2000;57:652-658.
22. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-241.
23. Pap M, Cooper GM. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem 1998;273:19929-19932.
24. Conner EA, Teramoto T, Wirth PJ, Kiss A, Garfield S, Thorgeirsson SS. HGF-mediated apoptosis via p53/bax-independent pathway activating JNK1. Carcinogenesis 1999;20:583-590.
25. Trauth BC, Klas C, Peters AM, Matzku S, Moller P, Falk W, Debatin KM, et al. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 1989;245:301-305.
26. Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J, Rosenzweig A, et al. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem 2002;277:37670-37677.
27. Hussain RF, Nouri AM, Oliver RT. A new approach for measurement of cytotoxicity using colorimetric assay. J Immunol Methods 1993;160:89-96.
28. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991;139:271-279.
29. Scaffidi C, Medema JP, Krammer PH, Peter ME. FL1CE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. J Biol Chem 1997;272:26953-26958.
30. Scaffidi C, Schmitz I, Zha J, Korsmeyer SJ, Krammer PH, Peter ME. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem 1999;274:22532-22538.
31. Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998;94:491-501.
32. Sun XM, Bratton SB, Butterworth M, MacFarlane M, Cohen GM. Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein. J Biol Chem 2002;277:11345-11351.
33. Craig RW. MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis. Leukemia 2002;16:444-454.
34. Wang JM, Chao JR, Chen W, Kuo ML, Yen JJ, Yang-Yen HF. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol 1999;19:6195-6206.
35. Huang HM, Huang CJ, Yen JJ. Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways. Blood 2000;96:1764-1771.
36. Liu H, Ma Y, Cole SM, Zander C, Chen KH, Karras J, Pope RM. Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival. Blood 2003;102:344-352.
37. Krueger A, Baumann S, Krammer PH, Kirchhoff S. FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol Cell Biol 2001;21:8247-8254.
38. Kaplowitz N. Mechanisms of liver cell injury. J Hepatol 2000;32(Suppl 1):39-47.
39. Tsubouchi H, Kawakami S, Hirono S, Miyazaki H, Kimoto M, Arima T, Sekiyama K, et al. Prediction of outcome in fulminant hepatic failure by serum human hepatocyte growth factor. Lancet 1992;340:307.
40. Senaldi G, Shaklee CL, Simon B, Rowan CG, Lacey DL, Hartung T. Keratinocyte growth factor protects murine hepatocytes from tumor necrosis factor-induced apoptosis in vivo and in vitro. HEPATOLOGY 1998;27:1584-1591.
41. Webster CR, Anwer MS. Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes. HEPATOLOGY 2001;33:608-615.
42. Kosai K, Matsumoto K, Funakoshi H, Nakamura T. Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. HEPATOLOGY 1999;30:151-159.
43. Amicone L, Spagnoli FM, Spath G, Giordano S, Tommasini C, Bernardini S, De Luca W, et al. Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes. EMBO J 1997;16:495-503.
44. Panka DJ, Mano T, Suhara T, Walsh K, Mier JW. Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells. J Biol Chem 2001;276:6893-6896.
45. Schoemaker MH, Gommans WM, de la Rosa LC, Homan M, Klok P, Trautwein C, Van Goor L, et al. Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. J Hepatol 2003;39:153-161.
46. Kuo ML, Chuang SE, Lin MT, Yang SY. The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6. Oncogene 2001;20:677-685.
47. Ng J, Cantrell D. STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727. J Biol Chem 1997;272:24542-24549.
48. Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, et al. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis. Mol Biol Cell 2001;12:2629-2645.
49. Kane LP, Shapiro VS, Stokoe D, Weiss A. Induction of NF-kappaB by the Akt/PKB kinase. Curr Biol 1999;9:601-604.
50. Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell 2002;111:293-303.