Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate

Journal of Neuroimmunology

Volumn 167, Issue 1-2, 2005, Pages 204-209

  Dörr, Jan ^a   Roth, Karl ^b   Zurbuchen, Urte ^b   Deisz, Rudolf ^b   Bechmann, Ingo ^b   Lehmann, Thomas Nicolas ^c   Meier, Susanne ^a   Nitsch, Robert ^b   Zipp, Frauke ^a  

^a Department of Radiology   (Germany)

^b University Medicine   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Apoptosis; Flupirtine maleate; Multiple sclerosis; Neuroprotection; TRAIL

Indexed keywords

ANALGESIC AGENT; FLUPIRTINE; FLUPIRTINE MALEATE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ARTICLE; BRAIN SLICE; BRAIN TISSUE; CELL CULTURE; DOSE RESPONSE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INFLAMMATION; NERVE CELL NECROSIS; NEUROPROTECTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

AMINOPYRIDINES; APOPTOSIS REGULATORY PROTEINS; CELL COUNT; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID AGONISTS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MEMBRANE GLYCOPROTEINS; N-METHYLASPARTATE; NEOCORTEX; NEURONS; NEUROPROTECTIVE AGENTS; PROPIDIUM; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 24144456276     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2005.06.027     Document Type: Article

References (22)

1. C. Bjartmar, R.P. Kinkel, G. Kidd, R.A. Rudick, and B.D. Trapp Axonal loss in normal-appearing white matter in a patient with acute MS Neurology 57 2001 1248 1252
2. G. Burgmaier, L.M. Schonrock, T. Kuhlmann, C. Richter-Landsberg, and W. Brück Association of increased bcl-2 expression with rescue from tumor necrosis factor-alpha-induced cell death in the oligodendrocyte cell line OLN-93 J. Neurochem. 75 2000 2270 2276
3. R.A. Deisz The GABA(B) receptor antagonist CGP 55845A reduces presynaptic GABA(B) actions in neocortical neurons of the rat in vitro Neuroscience 93 1999 1241 1249
4. J. Dörr, I. Bechmann, S. Waiczies, O. Aktas, H. Walczak, P.H. Krammer, R. Nitsch, and F. Zipp Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain J. Neurosci. 22 2002 RC209
5. J. Dörr, S. Waiczies, U. Wendling, B. Seeger, and F. Zipp Induction of TRAIL-mediated glioma cell death by human T cells J. Neuroimmunol. 122 2002 117 124
6. P. Hlavica, and G. Niebch Pharmacokinetics and biotransformation of the analgesic flupirtine in humans Arzneimittel-Forschung 35 1985 67 74
7. W.X. Huang, M.P. Huang, M.A. Gomes, and J. Hillert Apoptosis mediators fasL and TRAIL are upregulated in peripheral blood mononuclear cells in MS Neurology 55 2000 928 934
8. D.R. Lee, S.C. Helps, I.L. Gibbins, M. Nilsson, and N.R. Sims Losses of NG2 and NeuN immunoreactivity but not astrocytic markers during early reperfusion following severe focal cerebral ischemia Brain Res. 989 2003 221 230
9. J.D. Lunemann, S. Waiczies, S. Ehrlich, U. Wendling, B. Seeger, T. Kamradt, and F. Zipp Death ligand TRAIL induces no apoptosis but inhibits activation of human (auto)antigen-specific T cells J. Immunol. 168 2002 4881 4888
10. A. Martin-Villalba, I. Herr, I. Jeremias, M. Hahne, R. Brandt, J. Vogel, J. Schenkel, T. Herdegen, and K.M. Debatin CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons J. Neurosci. 19 1999 3809 3817
11. M. Matysiak, A. Jurewicz, D. Jaskolski, and K. Selmaj TRAIL induces death of human oligodendrocytes isolated from adult brain Brain 125 2002 2469 2480
12. Y. Miura, N. Misawa, Y. Kawano, H. Okada, Y. Inagaki, N. Yamamoto, M. Ito, H. Yagita, K. Okumura, H. Mizusawa, and Y. Koyanagi Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection Proc. Natl. Acad. Sci. U. S. A. 100 2003 2777 2782
13. R. Nitsch, I. Bechmann, R.A. Deisz, D. Haas, T.N. Lehmann, U. Wendling, and F. Zipp Human brain-cell death induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) Lancet 356 2000 827 828
14. K. Obermeier, G. Niebch, and K. Thiemer Pharmacokinetics and biotransformation of the analgesic flupirtine in the rat and dog Arzneimittel-Forschung 35 1985 60 67
15. S. Perovic, C. Schleger, G. Pergande, S. Iskric, H. Ushijima, P. Rytik, and W.E. Muller The triaminopyridine flupirtine prevents cell death in rat cortical cells induced by N-methyl-D-aspartate and gp120 of HIV-1 Eur. J. Pharmacol. 288 1994 27 33
16. S. Perovic, P. Pialoglou, H.C. Schroder, G. Pergande, and W.E. Muller Flupirtine increases the levels of glutathione and Bc1-2 in hNT (human Ntera/D1) neurons: mode of action of the drug-mediated anti-apoptotic effect Eur. J. Pharmacol. 317 1996 157 164
17. S. Perovic, H.C. Schroder, G. Pergande, H. Ushijima, and W.E. Muller Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126) Exp. Neurol. 147 1997 518 524
18. K. Rupalla, W. Cao, and J. Krieglstein Flupirtine protects neurons against excitotoxic or ischemic damage and inhibits the increase in cytosolic Ca2+ concentration Eur. J. Pharmacol. 294 1995 469 473
19. B.D. Trapp, J. Peterson, R.M. Ransohoff, R.A. Rudick, S. Mörk, and L. Bo Axonal transection in the lesions of multiple sclerosis N. Engl. J. Med. 338 1998 278 285
20. K.P. Wandinger, J.D. Lünemann, O. Wengert, J. Bellmann-Strobl, O. Aktas, A. Weber, E. Grundstrom, S. Ehrlich, K.D. Wernecke, H.D. Volk, and F. Zipp TNF-related apoptosis inducing ligand (TRAIL) as a potential response marker for interferon-beta treatment in multiple sclerosis Lancet 361 2003 2036 2043
21. U. Wendling, H. Walczak, J. Dörr, C. Jaboci, M. Weller, P.H. Krammer, and F. Zipp Expression of TRAIL receptors in human autoreactive and foreign antigen-specific T cells Cell Death Differ. 7 2000 637 644
22. S.R. Wiley, K.A. Schooley, P.J. Smolak, W.S. Din, C.P. Huang, J.K. Nicholl, G.R. Sutherland, T.D. Smith, C.T. Rauch, C.A. Smith, and R.G. Goodwin Identification and characterization of a new member of the TNF family that induces apoptosis Immunity 3 1995 673 682