Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy

Current Drug Metabolism

Volumn 8, Issue 6, 2007, Pages 554-562

  Fujita, Ken Ichi ^a   Sasaki, Yasutsuna ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

6 mercaptopurine; Anticancer drug; Candidate gene approach; Drug metabolizing enzymes; Genome wide approach; Irinotecan; Pharmacogenomics; Pharmacokinetics

Indexed keywords

4 HYDROXYTAMOXIFEN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOCHROME P450 INHIBITOR; DNA; DOCETAXEL; DRUG METABOLIZING ENZYME; ENDOXIFEN; ETOPOSIDE; FLUOROURACIL; GEFITINIB; IFOSFAMIDE; IMATINIB; IRINOTECAN; MERCAPTOPURINE; MESSENGER RNA; NORTAMOXIFEN; PACLITAXEL; TAMOXIFEN; TAMOXIFEN DERIVATIVE; TEGAFUR; TENIPOSIDE; THALIDOMIDE; THIOPURINE METHYLTRANSFERASE; UNCLASSIFIED DRUG; VINCA ALKALOID;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADJUVANT THERAPY; AREA UNDER THE CURVE; BLOOD TOXICITY; BONE MARROW SUPPRESSION; BREAST CANCER; CANCER RELAPSE; CLINICAL TRIAL; COLORECTAL CANCER; DIARRHEA; DNA MICROARRAY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CONTRAINDICATION; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG FEVER; DRUG LABELING; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; EARLY CANCER; ENZYME ACTIVITY; ETHNICITY; GENE EXPRESSION PROFILING; GENOTYPE; GILBERT DISEASE; HAPLOTYPE MAP; HETEROZYGOSITY; HIGH RISK PATIENT; HOMOZYGOSITY; HOT FLUSH; HUMAN; LEUKOPENIA; LUNG NON SMALL CELL CANCER; NEUTROPENIA; NONHUMAN; PHARMACOGENOMICS; POSTMENOPAUSE; REVIEW; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STUPOR;

ANIMALS; ANTINEOPLASTIC AGENTS; ENZYMES; HUMANS; PHARMACEUTICAL PREPARATIONS; PHARMACOGENETICS;

EID: 34547701952     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920007781368890     Document Type: Review

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