-
1
-
-
14644407525
-
The role of apoptosis in cancer development and treatment response
-
Brown JM, Attardi LD. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 2005;5:231-7.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 231-237
-
-
Brown, J.M.1
Attardi, L.D.2
-
2
-
-
33748203767
-
p53 potentiates hippocampal neuronal death caused by global ischemia
-
Yonekura I, Takai K, Asai A, Kawahara N, Kirino T. p53 potentiates hippocampal neuronal death caused by global ischemia. J Cereb Blood Flow Metab 2006;26:1332-40.
-
(2006)
J Cereb Blood Flow Metab
, vol.26
, pp. 1332-1340
-
-
Yonekura, I.1
Takai, K.2
Asai, A.3
Kawahara, N.4
Kirino, T.5
-
3
-
-
18344388668
-
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase
-
Lau A, Swinbank KM, Ahmed PS, et al. Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase. Nat Cell Biol 2005;7:493-500.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 493-500
-
-
Lau, A.1
Swinbank, K.M.2
Ahmed, P.S.3
-
4
-
-
3142534591
-
Initiating cellular stress responses
-
Bakkenist CJ, Kastan MB. Initiating cellular stress responses. Cell 2004;118:9-17.
-
(2004)
Cell
, vol.118
, pp. 9-17
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
5
-
-
4444339751
-
ATM and ataxia telangiectasia
-
McKinnon PJ. ATM and ataxia telangiectasia. EMBO Rep 2004;5:772-6.
-
(2004)
EMBO Rep
, vol.5
, pp. 772-776
-
-
McKinnon, P.J.1
-
6
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Bartkova J, Horejsi Z, Koed K, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005;434:907-13.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
-
7
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova J, Horejsi Z, Koed K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005;434:864-70.
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
-
8
-
-
15844426692
-
Atm-deficient mice: A paradigm of ataxia telangiectasia
-
Barlow C, Hirotsune S, Paylor R, et al. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 1996;86:159-71.
-
(1996)
Cell
, vol.86
, pp. 159-171
-
-
Barlow, C.1
Hirotsune, S.2
Paylor, R.3
-
9
-
-
28244461575
-
Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectasia mutated
-
Cowell IG, Durkacz BW, Tilby MJ. Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectasia mutated. Biochem Pharmacol 2005;71:13-20.
-
(2005)
Biochem Pharmacol
, vol.71
, pp. 13-20
-
-
Cowell, I.G.1
Durkacz, B.W.2
Tilby, M.J.3
-
10
-
-
33646792565
-
Radiosensitization of tumor cells by modulation of ATM kinase
-
Choi EK, Ji IM, Lee SR, et al. Radiosensitization of tumor cells by modulation of ATM kinase. Int J Radiat Biol 2006;82:277-83.
-
(2006)
Int J Radiat Biol
, vol.82
, pp. 277-283
-
-
Choi, E.K.1
Ji, I.M.2
Lee, S.R.3
-
11
-
-
33744924482
-
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
-
Zhao Y, Thomas HD, Batey MA, et al. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res 2006;66:5354-62.
-
(2006)
Cancer Res
, vol.66
, pp. 5354-5362
-
-
Zhao, Y.1
Thomas, H.D.2
Batey, M.A.3
-
12
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 2006;5:671-88.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
13
-
-
0037115523
-
Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy
-
Eshleman JS, Carlson BL, Mladek AC, Kastner BD, Shide KL, Sarkaria JN. Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy. Cancer Res 2002;62:7291-7.
-
(2002)
Cancer Res
, vol.62
, pp. 7291-7297
-
-
Eshleman, J.S.1
Carlson, B.L.2
Mladek, A.C.3
Kastner, B.D.4
Shide, K.L.5
Sarkaria, J.N.6
-
14
-
-
33846262588
-
Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: Possible role for thrombosis
-
Weppler SA, Krause M, Zyromska A, Lambin P, Baumann M, Wouters BG. Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: possible role for thrombosis. Radiother Oncol 2007;82:96-104.
-
(2007)
Radiother Oncol
, vol.82
, pp. 96-104
-
-
Weppler, S.A.1
Krause, M.2
Zyromska, A.3
Lambin, P.4
Baumann, M.5
Wouters, B.G.6
-
15
-
-
0141885091
-
The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation
-
Tirado OM, Mateo-Lozano S, Sanders S, Dettin LE, Notario V. The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation. Cancer Res 2003;63:6290-8.
-
(2003)
Cancer Res
, vol.63
, pp. 6290-6298
-
-
Tirado, O.M.1
Mateo-Lozano, S.2
Sanders, S.3
Dettin, L.E.4
Notario, V.5
-
16
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756-60.
-
(2006)
Nature
, vol.444
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
-
17
-
-
33846821915
-
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
-
Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 2007;11:175-89.
-
(2007)
Cancer Cell
, vol.11
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
18
-
-
0032499199
-
A proteolytic system that compensates for loss of proteasome function
-
Glas R, Bogyo M, McMaster JS, Gaczynska M, Ploegh HL. A proteolytic system that compensates for loss of proteasome function. Nature 1998;392:618-22.
-
(1998)
Nature
, vol.392
, pp. 618-622
-
-
Glas, R.1
Bogyo, M.2
McMaster, J.S.3
Gaczynska, M.4
Ploegh, H.L.5
-
19
-
-
0033548055
-
A giant protease with potential to substitute for some functions of the proteasome
-
Geier E, Pfeifer G, Wilm M, et al. A giant protease with potential to substitute for some functions of the proteasome. Science 1999;283:978-81.
-
(1999)
Science
, vol.283
, pp. 978-981
-
-
Geier, E.1
Pfeifer, G.2
Wilm, M.3
-
20
-
-
0035097842
-
c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells
-
Gavioli R, Frisan T, Vertuani S, Bornkamm GW, Masucci MG. c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells. Nat Cell Biol 2001;3:283-8.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 283-288
-
-
Gavioli, R.1
Frisan, T.2
Vertuani, S.3
Bornkamm, G.W.4
Masucci, M.G.5
-
21
-
-
0037529368
-
Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis
-
Hong X, Lei L, Glas R. Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis. J Exp Med 2003;197:1731-43.
-
(2003)
J Exp Med
, vol.197
, pp. 1731-1743
-
-
Hong, X.1
Lei, L.2
Glas, R.3
-
22
-
-
23944471148
-
Tripeptidyl-peptidase II: A multi-purpose peptidase
-
Tomkinson B, Lindas AC. Tripeptidyl-peptidase II: a multi-purpose peptidase. Int J Biochem Cell Biol 2005;37:1933-7.
-
(2005)
Int J Biochem Cell Biol
, vol.37
, pp. 1933-1937
-
-
Tomkinson, B.1
Lindas, A.C.2
-
23
-
-
0032563205
-
Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster
-
Renn SC, Tomkinson B, Taghert PH. Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. J Biol Chem 1998;273:19173-82.
-
(1998)
J Biol Chem
, vol.273
, pp. 19173-19182
-
-
Renn, S.C.1
Tomkinson, B.2
Taghert, P.H.3
-
24
-
-
18744374439
-
A giant protease with a twist: The TPPII complex from Drosophila studied by electron microscopy
-
Rockel B, Peters J, Kuhlmorgen B, Glaeser RM, Baumeister W. A giant protease with a twist: the TPPII complex from Drosophila studied by electron microscopy. EMBO J 2002;21:5979-84.
-
(2002)
EMBO J
, vol.21
, pp. 5979-5984
-
-
Rockel, B.1
Peters, J.2
Kuhlmorgen, B.3
Glaeser, R.M.4
Baumeister, W.5
-
25
-
-
1842785206
-
A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation
-
Reits E, Neijssen J, Herberts C, et al. A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation. Immunity 2004;20:495-506.
-
(2004)
Immunity
, vol.20
, pp. 495-506
-
-
Reits, E.1
Neijssen, J.2
Herberts, C.3
-
26
-
-
33746215297
-
Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation
-
York IA, Bhutani N, Zendzian S, Goldberg AL, Rock KL. Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation. J Immunol 2006;177:1434-43.
-
(2006)
J Immunol
, vol.177
, pp. 1434-1443
-
-
York, I.A.1
Bhutani, N.2
Zendzian, S.3
Goldberg, A.L.4
Rock, K.L.5
-
27
-
-
0033796540
-
Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis
-
Hilbi H, Puro RJ, Zychlinsky A. Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis. Infect Immun 2000;68:5502-8.
-
(2000)
Infect Immun
, vol.68
, pp. 5502-5508
-
-
Hilbi, H.1
Puro, R.J.2
Zychlinsky, A.3
-
28
-
-
13944269123
-
Mitotic infidelity and centrosome duplication errors in cells overexpressing tripeptidyl-peptidase II
-
Stavropoulou V, Xie J, Henriksson M, Tomkinson B, Imreh S, Masucci MG. Mitotic infidelity and centrosome duplication errors in cells overexpressing tripeptidyl-peptidase II. Cancer Res 2005;65:1361-8.
-
(2005)
Cancer Res
, vol.65
, pp. 1361-1368
-
-
Stavropoulou, V.1
Xie, J.2
Henriksson, M.3
Tomkinson, B.4
Imreh, S.5
Masucci, M.G.6
-
29
-
-
33745181130
-
TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints
-
Stavropoulou V, Vasquez V, Cereser B, Freda E, Masucci MG. TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints. Biochem Biophys Res Commun 2006;346:415-25.
-
(2006)
Biochem Biophys Res Commun
, vol.346
, pp. 415-425
-
-
Stavropoulou, V.1
Vasquez, V.2
Cereser, B.3
Freda, E.4
Masucci, M.G.5
-
30
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002;296:550-3.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
31
-
-
0023572164
-
Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type
-
Tomkinson B, Wernstedt C, Hellman U, Zetterqvist O. Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type. Proc Natl Acad Sci USA 1987;84:7508-12.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 7508-7512
-
-
Tomkinson, B.1
Wernstedt, C.2
Hellman, U.3
Zetterqvist, O.4
-
32
-
-
0034730126
-
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity
-
Wang EW, Kessler BM, Borodovsky A, et al. Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity. Proc Natl Acad Sci U SA 2000;97:9990-5.
-
(2000)
Proc Natl Acad Sci U SA
, vol.97
, pp. 9990-9995
-
-
Wang, E.W.1
Kessler, B.M.2
Borodovsky, A.3
-
33
-
-
13344281002
-
Characterization and inhibition of a cholecystokinin-inactivating serine peptidase
-
Rose C, Vargas F, Facchinetti P, et al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 1996;380:403-9.
-
(1996)
Nature
, vol.380
, pp. 403-409
-
-
Rose, C.1
Vargas, F.2
Facchinetti, P.3
-
34
-
-
0031046294
-
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins
-
Bork P, Hofmann K, Bucher P, Neuwald AF, Altschul SF, Koonin EV. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J 1997;11:68-76.
-
(1997)
FASEB J
, vol.11
, pp. 68-76
-
-
Bork, P.1
Hofmann, K.2
Bucher, P.3
Neuwald, A.F.4
Altschul, S.F.5
Koonin, E.V.6
-
35
-
-
0142240342
-
BRCT repeats as phosphopeptide-binding modules involved in protein targeting
-
Manke IA, Lowery DM, Nguyen A, Yaffe MB. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science 2003;302:636-9.
-
(2003)
Science
, vol.302
, pp. 636-639
-
-
Manke, I.A.1
Lowery, D.M.2
Nguyen, A.3
Yaffe, M.B.4
-
36
-
-
0142147272
-
The BRCT domain is a phospho-protein binding domain
-
Yu X, Chini CC, He M, Mer G, Chen J. The BRCT domain is a phospho-protein binding domain. Science 2003;302:639-42.
-
(2003)
Science
, vol.302
, pp. 639-642
-
-
Yu, X.1
Chini, C.C.2
He, M.3
Mer, G.4
Chen, J.5
-
37
-
-
20044390541
-
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
-
Viniegra JG, Martinez N, Modirassari P, et al. Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. J Biol Chem 2005;280:4029-36.
-
(2005)
J Biol Chem
, vol.280
, pp. 4029-4036
-
-
Viniegra, J.G.1
Martinez, N.2
Modirassari, P.3
-
38
-
-
4644359805
-
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
-
Feng J, Park J, Cron P, Hess D, Hemmings BA. Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem 2004;279:41189-96.
-
(2004)
J Biol Chem
, vol.279
, pp. 41189-41196
-
-
Feng, J.1
Park, J.2
Cron, P.3
Hess, D.4
Hemmings, B.A.5
-
39
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
40
-
-
1242317030
-
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)
-
Dan HC, Sun M, Kaneko S, et al. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem 2004;279:5405-12.
-
(2004)
J Biol Chem
, vol.279
, pp. 5405-5412
-
-
Dan, H.C.1
Sun, M.2
Kaneko, S.3
-
41
-
-
24144443517
-
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
-
Gasser S, Orsulic S, Brown EJ, Raulet DH. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 2005;436:1186-90.
-
(2005)
Nature
, vol.436
, pp. 1186-1190
-
-
Gasser, S.1
Orsulic, S.2
Brown, E.J.3
Raulet, D.H.4
-
42
-
-
29244484430
-
Radiation and new molecular agents part I: Targeting ATM-ATR checkpoints, DNA repair, and the proteasome
-
Choudhury A, Cuddihy A, Bristow RG. Radiation and new molecular agents part I: targeting ATM-ATR checkpoints, DNA repair, and the proteasome. Semin Radiat Oncol 2006;16:51-8.
-
(2006)
Semin Radiat Oncol
, vol.16
, pp. 51-58
-
-
Choudhury, A.1
Cuddihy, A.2
Bristow, R.G.3
-
43
-
-
34547645268
-
Methods of use for tripeptidyl-peptidase II inhibitors as anticancer agents. International/Publication
-
number WO 03/105835 A1. Dec. 2003
-
Munger K, Duensing S. Methods of use for tripeptidyl-peptidase II inhibitors as anticancer agents. International/Publication number WO 03/105835 A1. Dec. 2003.
-
-
-
Munger, K.1
Duensing, S.2
-
44
-
-
0034023407
-
Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells
-
Dantuma NP, Lindsten K, Glas R, Jellne M, Masucci MG. Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells. Nat Biotechnol 2000;18:538-43.
-
(2000)
Nat Biotechnol
, vol.18
, pp. 538-543
-
-
Dantuma, N.P.1
Lindsten, K.2
Glas, R.3
Jellne, M.4
Masucci, M.G.5
-
45
-
-
0345256634
-
The role of p53 in chemosensitivity and radiosensitivity
-
El-Deiry WS. The role of p53 in chemosensitivity and radiosensitivity. Oncogene 2003;22:7486-95.
-
(2003)
Oncogene
, vol.22
, pp. 7486-7495
-
-
El-Deiry, W.S.1
-
46
-
-
4944255743
-
Post-translational modification of p53 in tumorigenesis
-
Bode AM, Dong Z. Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 2004;4:793-805.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 793-805
-
-
Bode, A.M.1
Dong, Z.2
-
47
-
-
24644447853
-
Enhanced radiation damage of tumor vasculature by mTOR inhibitors
-
Shinohara ET, Cao C, Niermann K, et al. Enhanced radiation damage of tumor vasculature by mTOR inhibitors. Oncogene 2005;24:5414-22.
-
(2005)
Oncogene
, vol.24
, pp. 5414-5422
-
-
Shinohara, E.T.1
Cao, C.2
Niermann, K.3
-
48
-
-
0031469819
-
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
-
Boehm T, Folkman J, Browder T, O'Reilly MS. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 1997;390:404-7.
-
(1997)
Nature
, vol.390
, pp. 404-407
-
-
Boehm, T.1
Folkman, J.2
Browder, T.3
O'Reilly, M.S.4
-
49
-
-
34247875990
-
Centrosomal localization of DNA damage checkpoint proteins
-
Zhang S, Hemmerich P, Grosse F. Centrosomal localization of DNA damage checkpoint proteins. J Cell Biochem 2006;101:451-65.
-
(2006)
J Cell Biochem
, vol.101
, pp. 451-465
-
-
Zhang, S.1
Hemmerich, P.2
Grosse, F.3
-
50
-
-
15244345068
-
Inhibitor-based validation of a homology model of the active-site of tripeptidyl peptidase II
-
De Winter H, Breslin H, Miskowski T, Kavash R, Somers M. Inhibitor-based validation of a homology model of the active-site of tripeptidyl peptidase II. J Mol Graph Model 2005;23:409-18.
-
(2005)
J Mol Graph Model
, vol.23
, pp. 409-418
-
-
De Winter, H.1
Breslin, H.2
Miskowski, T.3
Kavash, R.4
Somers, M.5
|